Product Name

  • Name

    4-(2-Aminoethyl)morpholine

  • EINECS 218-011-6
  • CAS No. 2038-03-1
  • Article Data59
  • CAS DataBase
  • Density 1.002 g/cm3
  • Solubility soluble in water
  • Melting Point 24 °C
  • Formula C6H14N2O
  • Boiling Point 202.6 °C at 760 mmHg
  • Molecular Weight 130.19
  • Flash Point 76.3 °C
  • Transport Information UN 2735 8/PG 2
  • Appearance clear colorless to pale yellow liq. after melting
  • Safety 26-36/37/39-45-22
  • Risk Codes 22-34-43-24-40-23/24/25
  • Molecular Structure Molecular Structure of 2038-03-1 (4-(2-Aminoethyl)morpholine)
  • Hazard Symbols CorrosiveC, ToxicT
  • Synonyms Morpholine,4-(2-aminoethyl)- (6CI,7CI,8CI);1-(2-Aminoethyl)morpholine;1-Amino-2-morpholinoethane;2-(4-Morpholino)ethylamine;2-(4-Morpholinyl)ethanamine;2-(4-Morpholinyl)ethylamine;2-(Morpholin-4-yl)ethaneamine;2-Morpholino-1-ethanamine;2-Morpholinoethaneamine;2-Morpholinoethylamine;4-Morpholineethanamine;4-Aminoethylmorpholine;N-(2-Aminoethyl)morpholine;N-(b-Aminoethyl)morpholine;[2-(Morpholin-4-yl)ethyl]amine;b-Morpholinoethylamine;
  • PSA 38.49000
  • LogP -0.08450

Synthetic route

2-(2-morpholin-4-ylethyl)-1H-isoindole-1,3(2H)-dione
6820-90-2

2-(2-morpholin-4-ylethyl)-1H-isoindole-1,3(2H)-dione

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 24h; Reflux;95%
With hydrazine hydrate In ethanol at 20℃; Reflux;95%
With hydrogenchloride
With hydrazine hydrate In ethanol Reflux;
With hydrazine hydrate In ethanol for 18h; Reflux;
ethylenediamine
107-15-3

ethylenediamine

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With sodium carbonate In acetonitrile for 24h; Heating;95%
4-(2-benzyloxycarbonylaminoethyl)-N-morpholine

4-(2-benzyloxycarbonylaminoethyl)-N-morpholine

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20 - 25℃; for 5h; Large scale;91.3%
3-(morpholin-4-yl)propionic acid hydrazide
59737-33-6

3-(morpholin-4-yl)propionic acid hydrazide

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With trifluoroacetic acid; sodium nitrite In water at 0 - 80℃; Curtius rearrangement;87%
4-(2-azido-ethyl)-morpholine
660395-39-1

4-(2-azido-ethyl)-morpholine

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 30℃; for 18h; Inert atmosphere;77%
4-morpholinoacetonitrile
5807-02-3

4-morpholinoacetonitrile

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 3.33333h;72%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 3h; Reflux;72%
With lithium aluminium tetrahydride In tetrahydrofuran for 3h; Reflux;72%
With ethanol; sodium; toluene
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 3h; Reflux;
ethyleneimine
151-56-4

ethyleneimine

morpholine
110-91-8

morpholine

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With ethanol; sulfuric acid
With ethanol; sulfuric acid
morpholine
110-91-8

morpholine

chloroethylamine
689-98-5

chloroethylamine

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

N-(2-chlorethyl)morpholine
3240-94-6

N-(2-chlorethyl)morpholine

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With ammonium hydroxide
Multi-step reaction with 2 steps
1: toluene
2: aqueous HCl
View Scheme
4-morpholinoacetonitrile
5807-02-3

4-morpholinoacetonitrile

A

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

B

bis(2-morpholinylethyl)amine
200623-49-0

bis(2-morpholinylethyl)amine

Conditions
ConditionsYield
With methanol; nickel at 50℃; under 88260.9 Torr; Hydrogenation;
With ammonia; nickel Hydrogenation;
With ammonia; cobalt at 90℃; under 180 Torr; Hydrogenation;
ethylenediamine
107-15-3

ethylenediamine

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

A

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

B

1,2-dimorpholylethane
1723-94-0

1,2-dimorpholylethane

C

bis-[2-(2-amino-ethylamino)-ethyl]-ether
80042-24-6

bis-[2-(2-amino-ethylamino)-ethyl]-ether

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

A

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

B

1,2-dimorpholylethane
1723-94-0

1,2-dimorpholylethane

Conditions
ConditionsYield
With ethylenediamine
With ethylenediamine
morpholine
110-91-8

morpholine

2-chloroethanamine hydrochloride
870-24-6

2-chloroethanamine hydrochloride

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With sodium hydroxide 1) H2O; Yield given. Multistep reaction;
morpholinoethyl amide
5625-98-9

morpholinoethyl amide

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether Ambient temperature;24.05 g
(2-Morpholin-4-yl-ethylamino)-diphenyl-methanol
80500-16-9

(2-Morpholin-4-yl-ethylamino)-diphenyl-methanol

A

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

B

benzophenone
119-61-9

benzophenone

Conditions
ConditionsYield
With water In acetonitrile at 30℃; Rate constant;
ethylenediamine
107-15-3

ethylenediamine

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

A

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

B

4,4'-ethanediyl-di-morpholine

4,4'-ethanediyl-di-morpholine

6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid 2-morpholin-4-yl-ethylamide
57796-58-4

6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid 2-morpholin-4-yl-ethylamide

A

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

B

6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid
57796-33-5

6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid

morpholine
110-91-8

morpholine

ethanolamine
141-43-5

ethanolamine

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
With HZSM-5 In water at 300℃; Temperature;
4-(2-chloroethyl)morpholine hydrochride
3647-69-6

4-(2-chloroethyl)morpholine hydrochride

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium azide / acetonitrile; water / 80 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 30 °C / Inert atmosphere
View Scheme
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

methyl 3-<(2'-morpholinoethyl)amino>but-2-enoate

methyl 3-<(2'-morpholinoethyl)amino>but-2-enoate

Conditions
ConditionsYield
In methanol at 25℃; for 10h;100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

moclobemide
71320-77-9

moclobemide

Conditions
ConditionsYield
With tetramethylorthosilicate In toluene at 110℃; for 1h; Inert atmosphere;100%
With zirconocene dichloride In toluene at 110℃; for 24h; Inert atmosphere; sealed tube;86%
With [((CH3)5Cp)2Zr(H2O)2OSO2C8F17]+[OSO2C8F17]-*THF In tetrahydrofuran at 100℃; for 12h; Catalytic behavior; Reagent/catalyst; Temperature;85%
3-nitroindeno[1,2-c]isochromene-5,11-dione
884902-28-7

3-nitroindeno[1,2-c]isochromene-5,11-dione

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

5,6-dihydro-6-(2-morpholinyl-1-ethyl)-3-nitro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline

5,6-dihydro-6-(2-morpholinyl-1-ethyl)-3-nitro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline

Conditions
ConditionsYield
In chloroform at 20℃; for 16h;100%
In chloroform at 20℃; for 16h;100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(2-morpholin-4-yl-ethyl)-carbamic acid tert-butyl ester

(2-morpholin-4-yl-ethyl)-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With indium(III) bromide at 30 - 35℃; for 0.0833333h;100%
With perchloric acid at 30 - 35℃; for 0.0833333h;100%
In water at 20℃;94%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

4-phenyl-1-butylamine
13214-66-9

4-phenyl-1-butylamine

3-bromomethylbenzoic acid
6515-58-8

3-bromomethylbenzoic acid

C32H39N3O4

C32H39N3O4

Conditions
ConditionsYield
Multistep reaction.;100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

C17H15FO5

C17H15FO5

formaldehyd
50-00-0

formaldehyd

4-[5-(4-fluorobenzyl)furan-2-carbonyl]-3-hydroxy-1-(2-morpholine-4-ylethyl)-1,5-dihydropyrrol-2-one

4-[5-(4-fluorobenzyl)furan-2-carbonyl]-3-hydroxy-1-(2-morpholine-4-ylethyl)-1,5-dihydropyrrol-2-one

Conditions
ConditionsYield
In 1,4-dioxane100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

pyridine-4-carboxaldehyde-[2-(4-morpholinyl)ethyl]imine
165806-88-2

pyridine-4-carboxaldehyde-[2-(4-morpholinyl)ethyl]imine

Conditions
ConditionsYield
With magnesium sulfate100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

pyridine-4-carboxaldehyde-[2-(4-morpholinyl)ethyl]imine
165806-88-2

pyridine-4-carboxaldehyde-[2-(4-morpholinyl)ethyl]imine

Conditions
ConditionsYield
100%
100%
100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

trifluoromethanesulfonic acid 2-nitronaphthalen-1-yl ester
253270-06-3

trifluoromethanesulfonic acid 2-nitronaphthalen-1-yl ester

(2-morpholin-4-yl-ethyl)-(2-nitro-naphthalen-1-yl)-amine
934976-13-3

(2-morpholin-4-yl-ethyl)-(2-nitro-naphthalen-1-yl)-amine

Conditions
ConditionsYield
In acetonitrile at 150℃; for 0.0833333h; microwave irradiation;100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

N-(2-iodopyrimidin-5-yl)-2-methyl-5-nitrobenzamide

N-(2-iodopyrimidin-5-yl)-2-methyl-5-nitrobenzamide

2-methyl-N-(2-(2-morpholinoethylamino)pyrimidin-5-yl)-5-nitrobenzamide
925896-88-4

2-methyl-N-(2-(2-morpholinoethylamino)pyrimidin-5-yl)-5-nitrobenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In Isopropyl acetate at 70℃; for 4h;100%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 70℃; for 4h;
3-butoxy-4-(hydroxy-methyl-amino)-cyclobut-3-ene-1,2-dione
871917-43-0

3-butoxy-4-(hydroxy-methyl-amino)-cyclobut-3-ene-1,2-dione

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

3-(hydroxy-methyl-amino)-4-(2-morpholin-4-yl-ethylamino)-cyclobut-3-ene-1,2-dione
1078060-52-2

3-(hydroxy-methyl-amino)-4-(2-morpholin-4-yl-ethylamino)-cyclobut-3-ene-1,2-dione

Conditions
ConditionsYield
In methanol at 20℃; for 5h; Combinatorial reaction / High throughput screening (HTS);100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

4-(5-methyl-2-phenyl-1H-indole-7-yl)amino-cyclohexane-1-carboxylic acid
1120333-44-9

4-(5-methyl-2-phenyl-1H-indole-7-yl)amino-cyclohexane-1-carboxylic acid

4-(5-methyl-2-phenyl-1H-indol-7-ylamino)-cyclohexanecarboxylic acid (2-morpholin-4-yl-ethyl)-amide

4-(5-methyl-2-phenyl-1H-indol-7-ylamino)-cyclohexanecarboxylic acid (2-morpholin-4-yl-ethyl)-amide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 8h;100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

methyl 3-(chlorosulfonyl)-4-methoxybenzoate
192323-12-9

methyl 3-(chlorosulfonyl)-4-methoxybenzoate

methyl 4-methoxy-3-(N-(2-morpholinoethyl)sulfamoyl)benzoate
1610860-95-1

methyl 4-methoxy-3-(N-(2-morpholinoethyl)sulfamoyl)benzoate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h;100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

3-bromo-5-chlorosalicylaldehyde
19652-32-5

3-bromo-5-chlorosalicylaldehyde

2-bromo-4-chloro-6-[(2-morpholin-4-ylethylimino)methyl]phenol
1118461-58-7

2-bromo-4-chloro-6-[(2-morpholin-4-ylethylimino)methyl]phenol

Conditions
ConditionsYield
In methanol for 1h; Reflux;100%
In ethanol at 20℃; for 0.5h;
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Isopropenyl acetate
108-22-5

Isopropenyl acetate

N-(2-morpholinoethyl)acetamide
101724-54-3

N-(2-morpholinoethyl)acetamide

Conditions
ConditionsYield
In neat (no solvent) at 20℃; for 0.666667h; Green chemistry;100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

vinyl benzoate
769-78-8

vinyl benzoate

N-(2-morpholinoethyl)benzamide
4476-13-5

N-(2-morpholinoethyl)benzamide

Conditions
ConditionsYield
In neat (no solvent) at 20℃; for 0.666667h; Green chemistry;100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

1,4-benzenediacetyl dichloride
21062-19-1

1,4-benzenediacetyl dichloride

N,N’-bis(2-(morpholin-4-yl)ethyl)-1,4-di(aminocarbonylmethyl)benzene

N,N’-bis(2-(morpholin-4-yl)ethyl)-1,4-di(aminocarbonylmethyl)benzene

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

ethyl 5-((2S,4aR,6R,7R,8R,8aR)-8-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-7-hydroxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)-1,3,4-oxadiazole-2-carboxylate

ethyl 5-((2S,4aR,6R,7R,8R,8aR)-8-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-7-hydroxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)-1,3,4-oxadiazole-2-carboxylate

5-((2S,4aR,6R,7R,8R,8aR)-8-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-7-hydroxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)-N-(2-morpholinoethyl)-1,3,4-oxadiazole-2-carboxamide

5-((2S,4aR,6R,7R,8R,8aR)-8-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-7-hydroxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)-N-(2-morpholinoethyl)-1,3,4-oxadiazole-2-carboxamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 16.5h;100%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

3-Chloro-6-(4-chloro-phenyl)-4-phenyl-pyridazine
116776-62-6

3-Chloro-6-(4-chloro-phenyl)-4-phenyl-pyridazine

[6-(4-Chloro-phenyl)-4-phenyl-pyridazin-3-yl]-(2-morpholin-4-yl-ethyl)-amine

[6-(4-Chloro-phenyl)-4-phenyl-pyridazin-3-yl]-(2-morpholin-4-yl-ethyl)-amine

Conditions
ConditionsYield
for 6h; Heating;99%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

N-Methylisatoic anhydride
10328-92-4

N-Methylisatoic anhydride

2-Methylamino-N-(2-morpholin-4-yl-ethyl)-benzamide
185409-41-0

2-Methylamino-N-(2-morpholin-4-yl-ethyl)-benzamide

Conditions
ConditionsYield
With isatoic anhydride resin In dichloromethane Ambient temperature; 1.) 14 h; 2.) 90 min;99%
In 1,4-dioxane at 60℃; for 3h;76.9%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

4-fluoro-3-nitrobenzoyl chloride
400-94-2

4-fluoro-3-nitrobenzoyl chloride

4-fluoro-N-(2-morpholin-4-yl-ethyl)-3-nitro-benzamide

4-fluoro-N-(2-morpholin-4-yl-ethyl)-3-nitro-benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 23℃; for 1h;99%
In tetrahydrofuran at 0℃; for 2h; Inert atmosphere;88%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

3-chloro-6-isopropyl-1,2,4-benzotriazine 1-oxide
763132-25-8

3-chloro-6-isopropyl-1,2,4-benzotriazine 1-oxide

6-isopropyl-N-[3-(4-morpholinyl)ethyl]-1,2,4-benzotriazin-3-amine 1-oxide

6-isopropyl-N-[3-(4-morpholinyl)ethyl]-1,2,4-benzotriazin-3-amine 1-oxide

Conditions
ConditionsYield
In 1,2-dimethoxyethane for 8h; Heating;99%
In methanol; 1,2-dimethoxyethane99%
In 1,2-dimethoxyethane for 2h; Heating / reflux;99%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

5-bromo-2-toluenesulfonyl chloride
139937-37-4

5-bromo-2-toluenesulfonyl chloride

4-bromo-2-methyl-N-(2-morpholin-4-yl-ethyl)benzene sulfonamide
869663-64-9

4-bromo-2-methyl-N-(2-morpholin-4-yl-ethyl)benzene sulfonamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 40℃; for 18h;99%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Methyl 4-chlorobenzoate
1126-46-1

Methyl 4-chlorobenzoate

moclobemide
71320-77-9

moclobemide

Conditions
ConditionsYield
With sodium t-butanolate In neat (no solvent) at 20℃; for 1h; Inert atmosphere; Schlenk technique; Green chemistry;99%
With lithium hexamethyldisilazane In tetrahydrofuran; toluene at 23℃; for 15h; Inert atmosphere; chemoselective reaction;90%
With zirconium(IV) oxide In diethylene glycol dimethyl ether at 160℃; under 3750.38 Torr; Flow reactor; Green chemistry;80%
In diethyl ether
With family VIII carboxylesterase EstCE1 In dimethyl sulfoxide at 25℃; for 42h; Enzymatic reaction;
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

tert-butyl acetoacetate
1694-31-1

tert-butyl acetoacetate

(Z)-tert-butyl 3-(2-morpholinoethylamino)but-2-enoate
1240195-04-3

(Z)-tert-butyl 3-(2-morpholinoethylamino)but-2-enoate

Conditions
ConditionsYield
With silica gel at 20℃; for 18h;99%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

1-(4-fluorobenzyl)-5-(methoxycarbonyl)-1H-pyrrolo[2,3-c]pyridine-3-carboxylic acid
932396-34-4

1-(4-fluorobenzyl)-5-(methoxycarbonyl)-1H-pyrrolo[2,3-c]pyridine-3-carboxylic acid

methyl 1-(4-fluorobenzyl)-3-((2-(morpholin-4-yl)ethyl)carbamoyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate
1261531-19-4

methyl 1-(4-fluorobenzyl)-3-((2-(morpholin-4-yl)ethyl)carbamoyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Conditions
ConditionsYield
Stage #1: 1-(4-fluorobenzyl)-5-(methoxycarbonyl)-1H-pyrrolo[2,3-c]pyridine-3-carboxylic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;
Stage #2: 4-(2-AMINOETHYL)MORPHOLINE In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
99%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

ethyl 1-(2-bromoethyl)-3-phenyl-1H-pyrazole-5-carboxylate
1101861-35-1

ethyl 1-(2-bromoethyl)-3-phenyl-1H-pyrazole-5-carboxylate

5-(2-morpholinoethyl)-2-phenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one
1310071-08-9

5-(2-morpholinoethyl)-2-phenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

Conditions
ConditionsYield
With potassium iodide for 0.0166667h; Microwave irradiation;99%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

ethyl 1-(2-bromoethyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylate
1101861-37-3

ethyl 1-(2-bromoethyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylate

2-(4-chlorophenyl)-5-(2-morpholinoethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one
1310071-12-5

2-(4-chlorophenyl)-5-(2-morpholinoethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

Conditions
ConditionsYield
With potassium iodide for 0.0166667h; Microwave irradiation;99%
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

2-acetylpyridine
1122-62-9

2-acetylpyridine

(2-morpholin-4-ylethyl)-(1-pyridin-2-ylethylidene)amine
1310040-01-7

(2-morpholin-4-ylethyl)-(1-pyridin-2-ylethylidene)amine

Conditions
ConditionsYield
In methanol for 0.5h; Reflux;99%
In ethanol for 2h; Reflux;61.5%
In methanol
4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

1-Chloro-4-iodobenzene
637-87-6

1-Chloro-4-iodobenzene

carbon monoxide
201230-82-2

carbon monoxide

moclobemide
71320-77-9

moclobemide

Conditions
ConditionsYield
With triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 80℃; for 18h; Glovebox; Sealed tube; Inert atmosphere;99%
With 1,4-diaza-bicyclo[2.2.2]octane; 9-{[5-(diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl]diphenyl-λ4-phosphanyl}-O-methanesulfonyl-8-methyl-8λ4-aza-9-palladatricyclo[8.4.0.02,7]tetradeca-1(14),2,4,6,10,12-hexaene-9,9-bis(ylium)-10-uid-9-olate In tetrahydrofuran at 80℃; for 16h; Sealed tube;98%
With potassium carbonate In toluene at 120℃; under 1034.32 Torr; for 24h;94%

4-(2-Aminoethyl)morpholine Chemical Properties

Molecular Formula: C6H14N2O
Molar mass: 130.19 g/mol
EINECS: 218-011-6
Density: 1.002 g/cm3
Flash Point: 76.3 °C
Index of Refraction: 1.473
Melting point: 24 °C
Water solubility: Soluble
Boiling Point: 202.6 °C at 760 mmHg
Vapour Pressure: 0.289 mmHg at 25°C
Appearance: Clear colorless to pale yellow liq. after melting
Product categories: Heterocyclic Building Blocks;Morpholines
Structure of 4-(2-Aminoethyl)morpholine (2038-03-1):
           
XLogP3-AA: -1.1
H-Bond Donor: 1
H-Bond Acceptor: 3
IUPAC Name: 2-Morpholin-4-ylethanamine
Canonical SMILES: C1COCCN1CCN
InChI: InChI=1S/C6H14N2O/c7-1-2-8-3-5-9-6-4-8/h1-7H2
InChIKey: RWIVICVCHVMHMU-UHFFFAOYSA-N

4-(2-Aminoethyl)morpholine Toxicity Data With Reference

1.    

skn-rbt 10 mg/24H open

    JIHTAB    Journal of Industrial Hygiene and Toxicology. 26 (1944),269.
2.    

eye-rbt 50 µg/24H SEV

    85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,888.
3.    

orl-rat LD50:3000 mg/kg

    JIHTAB    Journal of Industrial Hygiene and Toxicology. 26 (1944),269.
4.    

scu-mus LD50:2145 mg/kg

    JIHTAB    Journal of Industrial Hygiene and Toxicology. 26 (1944),269.
5.    

skn-gpg LD50:300 mg/kg

    JIHTAB    Journal of Industrial Hygiene and Toxicology. 26 (1944),269.

Carcinogenicity of 4-(2-Aminoethyl)morpholine (2038-03-1) hasn't been listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65. And its toxicological properties have not been fully investigated.You can see actual entry in RTECS for complete information.

4-(2-Aminoethyl)morpholine Consensus Reports

Reported in EPA TSCA Inventory.

4-(2-Aminoethyl)morpholine Safety Profile

Poison by skin contact. Moderately toxic by ingestion and subcutaneous routes. A skin and severe eye irritant. Moderately flammable when exposed to heat, flame, or oxidizing materials. To fight fire, use alcohol foam, dry chemical. When heated to decomposition it emits toxic fumes of NOx.
 

Hazard Note: Toxic
Hazard Codes: C,T
Risk Statements:
22:  Harmful if swallowed
23:  Toxic by inhalation
24:  Toxic in contact with skin
25:  Toxic if swallowed
34:  Causes burns
43:  May cause sensitization by skin contact
Safety Statements:
22:  Do not breathe dust
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
39:  Wear eye/face protection
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

4-(2-Aminoethyl)morpholine Specification

 4-(2-Aminoethyl)morpholine (2038-03-1) also can be called 2-(Morpholin-4-yl)ethanamin ; 4-Morpholineethanamine ; N-Aminoethylmorpholine ; 2-(morpholin-4-yl)ethanamine .It is hazardous,so the first aid measures and others should be known.Such as: When on the skin: first,should  flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing. Secondly,Get shoesmedical aid . Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.Then get medical aid soon.While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Give artificial respiration while not breathing. When breathing is difficult, give oxygen.And as soon as to get medical aid. Then you have the ingesting of the product : Do not induce vomiting and get medical aid immediately.Notes to physician: Treat supportively and symptomatically.
In addition, 4-(2-Aminoethyl)morpholine (2038-03-1) can be stable under normal temperature and pressure conditions.It is not compatible with strong oxidizing agents,acids, acid chlorides, acid anhydrides,and you must not take it with incompatible materials,moisture. And also prevent it to broken down into hazardous decomposition products: oxides of nitrogen,carbon monoxide.

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