4,4'-Dihydroxybenzophenone supplier

Name
4,4'-Dihydroxybenzophenone
EINECS 210-288-1
CAS No. 611-99-4
Article Data65
CAS DataBase
Density 1.302 g/cm³
Solubility insoluble in water
Melting Point 213-215 °C(lit.)
Formula C₁₃H₁₀O₃
Boiling Point 444.8 °C at 760 mmHg
Molecular Weight 214.221
Flash Point 237 °C
Transport Information
Appearance off-white to beige fine crystalline powder
Safety 26-36/37-37/39-36
Risk Codes 36/37/38-43
Molecular Structure
Hazard Symbols Xi
Synonyms Benzophenone,4,4'-dihydroxy- (7CI,8CI);4,4'-Dihydroxydiphenylketone;4,4'-Hydroxybenzophenone;Bis(4-hydroxyphenyl) ketone;Bis(4-hydroxyphenyl)methanone;Bis(p-hydroxy)benzophenone;HBP (ketone);NSC 2831;p,p'-Dihydroxybenzophenone;4,4-dihydoxy-benzophenone;
PSA 57.53000
LogP 2.32880

Synthetic route

: 17696-62-7
Phenyl 4-hydroxybenzoate

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With aluminum (III) chloride In carbon disulfide for 6h; Concentration; Fries Phenol Ester Rearrangement; Reflux;	97%

: 90-96-0
bis(p-methoxyphenyl)methanone

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With 2-(diethylamino)ethanethiol hydrochloride; sodium t-butanolate In N,N-dimethyl-formamide for 2h; Heating;	92%
With potassium carbonate; 3-mercaptopropionic acid In ISOPROPYLAMIDE at 150℃; for 18h;	89%
Stage #1: bis(p-methoxyphenyl)methanone With potassium carbonate; 3-mercaptopropionic acid In ISOPROPYLAMIDE at 150℃; for 18h; Stage #2: With hydrogenchloride In water	89%
With aluminum tri-bromide; benzene

: 201230-82-2
carbon monoxide

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; oxygen; copper(l) chloride In N,N-dimethyl-formamide at 80℃; for 24h; Schlenk technique;	91%

4-amino-5-chloro-1-phenylpyridazin-6-one (chloridazon): 4-amino-5-chloro-1-phenylpyridazin-6-one (chloridazon)

: 1698-53-9
4,5-dichloro-1-phenylpyridazin-6-one

A: 611-99-4
4,4'-Dihydroxybenzophenone

B: 1698-60-8
chloridazon

Conditions

Conditions	Yield
In water	A n/a B 89.5%

...Expand

: 69552-26-7
bis(4-hydroxyphenyl)methanol

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With C6H4MoNO7(1-)*C19H42N(1+); oxygen In water at 100℃; for 20h; Green chemistry; chemoselective reaction;	79%

: methane sulfonic acid

: 108-95-2
phenol

: 99-96-7
4-hydroxy-benzoic acid

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
In cyclohexane	70%
In cyclohexane

...Expand

: 28141-24-4
4-hydroxybenzoyl chloride

: 108-95-2
phenol

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With titanium(IV) oxide for 0.00694444h; Friedel Crafts acylation; Microwave irradiation;	70%

: 108-95-2
phenol

: 99-96-7
4-hydroxy-benzoic acid

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With methanesulfonic acid In toluene at 120℃; for 12h;	67%
With PPA
With tin(IV) chloride

: 124678-79-1
2,2′‐[(carbonylbis(4,1‐phenylene))bis(oxy)]diacetic acid

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
Stage #1: 2,2′‐[(carbonylbis(4,1‐phenylene))bis(oxy)]diacetic acid With triethylamine In N,N-dimethyl-formamide; toluene for 3h; Curtius rearrangement; Heating; Stage #2: With potassium hydroxide; glycerol In ethanol; N,N-dimethyl-formamide; toluene for 2h; Heating; Further stages.;	51%

: C27H24FeO3

A: 153125-32-7
4-hydroxy-1-ferrocenylbutan-1-one

B: 611-99-4
4,4'-Dihydroxybenzophenone

C: 4,4'-(3-ferrocenyl-5,6-dihydro-2H-pyran-2,2-diyl)diphenol

D: 5-hydroxy-1,1-bis(4-hydroxyphenyl)-1-ferrocenylpentan-2-one

Conditions

Conditions	Yield
With silver(l) oxide In acetone at 20℃; for 0.166667h;	A n/a B 34% C 15% D 30%

...Expand

: 2-ferrocenyl-1,1-bis-(4-hydroxyphenyl)-5-hydroxy-pent-1-ene

A: 153125-32-7
4-hydroxy-1-ferrocenylbutan-1-one

B: 611-99-4
4,4'-Dihydroxybenzophenone

C: 4,4'-(3-ferrocenyl-5,6-dihydro-2H-pyran-2,2-diyl)diphenol

D: 5-hydroxy-1,1-bis(4-hydroxyphenyl)-1-ferrocenylpentan-2-one

E: C27H24FeO3

F: C27H26FeO4

G: C27H24FeO3

Conditions

Conditions	Yield
Stage #1: 2-ferrocenyl-1,1-bis-(4-hydroxyphenyl)-5-hydroxy-pent-1-ene With silver(l) oxide In acetone Stage #2: With hydrogenchloride In acetone	A 25% B 23% C 10% D 28% E 1% F 18% G 18%

...Expand

: 18920-70-2
4-hydroxy-4'-nitrobenzophenone

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
aufeinanderfolgende Reduktion, Diazotierung und Verkochung der Diazoniumsalzloesung;

: 4181-97-9
phenyl 4-methoxybenzoate

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With aluminium trichloride at 140℃;

: 603-45-2
aurin

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With sodium hydroxide; air

: 603-45-2
aurin

A: 611-99-4
4,4'-Dihydroxybenzophenone

B: 108-95-2
phenol

Conditions

Conditions	Yield
With water at 220 - 250℃;

: 467-62-9
pararosaniline

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With water at 270℃;

: 611-98-3
4,4'-diaminobenzophenone

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With cis-nitrous acid

: 81-90-3
phenolphthalin

A: 611-99-4
4,4'-Dihydroxybenzophenone

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 76-82-4
(4-Amino-3-methyl-phenyl)-bis-(4-amino-phenyl)-methanol

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With water at 270℃;

: 143-74-8
phenol red

A: 611-99-4
4,4'-Dihydroxybenzophenone

B: 108-95-2
phenol

Conditions

Conditions	Yield
bei der Kalischmelze;

: 874501-10-7
2-hydroxy-5-(4-hydroxy-benzoyl)-benzoic acid

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With quinoline; copper

: 859963-85-2
2,2'-dihydroxy-5,5'-carbonyl-di-isophthalic acid

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With quinoline

: 118-55-8
phenyl Salicylate

A: 606-12-2
4-[(2-hydroxyphenyl)carbonyl]phenol

B: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With tin(IV) chloride

: 100-07-2
4-methoxy-benzoyl chloride

: 100-66-3
methoxybenzene

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With carbon disulfide; aluminium trichloride und Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts mit AlCl3 in Toluol auf 120grad;

: 90-98-2
4,4'-Dichlorobenzophenone

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With sodium hydroxide; water; copper(II) oxide at 150 - 250℃; im Kupfer-Autoklaven;

: 69-72-7
salicylic acid

: 108-95-2
phenol

A: 606-12-2
4-[(2-hydroxyphenyl)carbonyl]phenol

B: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With tin(IV) chloride

...Expand

: 56-23-5
tetrachloromethane

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

: 108-95-2
phenol

A: 102-09-0
bis(phenyl) carbonate

B: 606-12-2
4-[(2-hydroxyphenyl)carbonyl]phenol

C: 611-99-4
4,4'-Dihydroxybenzophenone

...Expand

: 56-23-5
tetrachloromethane

: 108-95-2
phenol

A: 606-12-2
4-[(2-hydroxyphenyl)carbonyl]phenol

B: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With zinc(II) chloride at 120℃;

...Expand

: 6290-82-0
4,4'-diacetoxy-benzophenone

: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
With acetic acid at 160 - 170℃;

: 77-09-8
phenolphthalein

potassium hydroxide: potassium hydroxide

A: 119-61-9
benzophenone

B: 611-99-4
4,4'-Dihydroxybenzophenone

Conditions

Conditions	Yield
beim Schmelzen;

...Expand

: 611-99-4
4,4'-Dihydroxybenzophenone

: 100-44-7
benzyl chloride

: 40076-84-4
4,4'-bis(benzyloxy)benzophenone

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 50℃; for 3.5h;	100%
With sodium hydroxide

: 2969-81-5
4-bromoethylbutanoate

: 611-99-4
4,4'-Dihydroxybenzophenone

: 928663-94-9
4-{4-[4-(3-ethoxycarbonyl-propoxy)-benzoyl]-phenoxy}-butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 12h; Heating;	100%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 111983-37-0
bis(4-((tert-butyldimethylsilyl)oxy)phenyl)methanone

Conditions

Conditions	Yield
With 1H-imidazole; dmap In dichloromethane; N,N-dimethyl-formamide for 3h;	99%
Stage #1: tert-butyldimethylsilyl chloride With 1H-imidazole In dichloromethane at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 4,4'-Dihydroxybenzophenone In dichloromethane at 20℃; for 3h; Inert atmosphere;	98%
With 1H-imidazole In N,N-dimethyl-formamide for 3h;	97%
With 1H-imidazole In dichloromethane at 20℃;	95%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 502-42-1
cycloheptanone

: 14303-48-1
4,4'-(cycloheptylidenemethanediyl)diphenol

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 3h; McMurry Reaction; Heating / reflux;	99%
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 3h; Heating / reflux;	99%
With titanium tetrachloride; zinc In tetrahydrofuran for 2h; McMurry coupling; Heating;	83%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 105-36-2
ethyl bromoacetate

: 1032106-36-7
4,4’-bis(ethoxycarbonylmethoxy)benzophenone

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 18h;	99%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 106-95-6
allyl bromide

: 136074-26-5
bis(4-(allyloxy)phenyl)methanone

Conditions

Conditions	Yield
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 24h;	99%
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 24h;	99%
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 24h;	99%
Stage #1: 4,4'-Dihydroxybenzophenone With potassium carbonate In acetone for 6h; Stage #2: allyl bromide In acetone for 24h; Reflux;	75%
With potassium carbonate In tetrahydrofuran; tetrachloromethane at 60℃; for 24h; Inert atmosphere;	5.78 g

: 611-99-4
4,4'-Dihydroxybenzophenone

: 6084-58-8
O-isobutylhydroxylamine hydrochloride

: bis(4-hydroxyphenyl)methanone O-isobutyl oxime

Conditions

Conditions	Yield
In ethanol at 20℃; Inert atmosphere;	99%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 4-(4'-diphenoxy)diphosphite benzophenone

Conditions

Conditions	Yield
With triethylamine In benzene at 20 - 30℃; for 1h; Inert atmosphere;	99%
Stage #1: 4,4'-Dihydroxybenzophenone With triethylamine at 20 - 30℃; for 0.5h; Inert atmosphere; Stage #2: chlorophosphoric acid diphenyl ester at 20 - 30℃; for 1h;
Stage #1: 4,4'-Dihydroxybenzophenone With triethylamine In 5,5-dimethyl-1,3-cyclohexadiene for 0.5h; Inert atmosphere; Stage #2: chlorophosphoric acid diphenyl ester In 5,5-dimethyl-1,3-cyclohexadiene at 20 - 30℃; for 1h;
Stage #1: 4,4'-Dihydroxybenzophenone With triethylamine In 5,5-dimethyl-1,3-cyclohexadiene at 20 - 30℃; for 0.5h; Inert atmosphere; Stage #2: chlorophosphoric acid diphenyl ester In 5,5-dimethyl-1,3-cyclohexadiene at 20 - 30℃; for 1h;

: 611-99-4
4,4'-Dihydroxybenzophenone

: 1499-21-4
Diphenylphosphinic chloride

: 4,4'-bisdiphenylphosphinyloxyl benzophenone

Conditions

Conditions	Yield
Stage #1: 4,4'-Dihydroxybenzophenone With triethylamine In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: Diphenylphosphinic chloride In tetrahydrofuran at 0 - 20℃; for 2h;	99%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 106-93-4
ethylene dibromide

: 288248-52-2
4,4’-bis(2-bromoethoxy)benzophenone

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetone for 96h; Inert atmosphere;	98%
With potassium carbonate In acetone Reflux;	87%
With potassium carbonate In acetone for 24h; Reflux;	70%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 4,4'-carbonylbis(4,1-phenylene) disulfofluoridate

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; triethylamine In dichloromethane at 20℃; for 12h;	98%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 100-39-0
benzyl bromide

: 40076-84-4
4,4'-bis(benzyloxy)benzophenone

Conditions

Conditions	Yield
With potassium carbonate In methanol; chloroform for 48h; Heating;	97%
With sodium hydride In N,N-dimethyl-formamide at 100℃; for 1h;	96.9%
With ethanol; sodium ethanolate

: 111-25-1
1-bromo-hexane

: 611-99-4
4,4'-Dihydroxybenzophenone

: 1108157-34-1
4,4’-bis(hexylphenyl)benzophenone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 48h; Williamson ether synthesis; Reflux;	97%
With tetrabutylammomium bromide; potassium carbonate In acetone for 48h; Concentration; Williamson Ether Synthesis; Reflux;	92%
With potassium carbonate In N,N-dimethyl-formamide for 48h; Reflux;	75%
With potassium carbonate In N,N-dimethyl-formamide Heating;

: 611-99-4
4,4'-Dihydroxybenzophenone

: 199484-75-8
1-bromo-3,7R,11R,15-tetramethylhexadecane

: 4,4'-bis(2,3-dihydrophytyloxy)benzophenone

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 5h;	97%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 5h;
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 5h;

: 611-99-4
4,4'-Dihydroxybenzophenone

: 58479-61-1
tert-butylchlorodiphenylsilane

: Bis(4-(tert-butyldiphenylsilyloxy)phenyl)methanone

Conditions

Conditions	Yield
Stage #1: tert-butylchlorodiphenylsilane With 1H-imidazole In dichloromethane at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 4,4'-Dihydroxybenzophenone In dichloromethane at 20℃; for 3h; Inert atmosphere;	97%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 93-55-0
1-phenyl-propan-1-one

: 91221-46-4
1,1-bis(4-hydroxyphenyl)-2-phenyl-1-butene

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran at 0℃; for 2h; McMurry reaction; Inert atmosphere; Reflux; Darkness;	96%
With titanium tetrachloride; zinc In tetrahydrofuran McMurry Reaction; Inert atmosphere;	94%
With titanium tetrachloride; zinc In tetrahydrofuran for 2h; Heating;	91%

: 4221-99-2
(S)-2-butanol

: 611-99-4
4,4'-Dihydroxybenzophenone

: 851133-26-1
4,4’-bis[(R)-sec-butyloxy]benzophenone

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; Mitsunobu coupling;	96%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; for 27.5h; Inert atmosphere;	93%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 19829-31-3
1-(3-bromophenyl)-1-propanone

: 938073-85-9
4,4'-(2-(3-bromophenyl)-1-butene-1,1-diyl)diphenol

Conditions

Conditions	Yield
Stage #1: 4,4'-Dihydroxybenzophenone; 1-(3-bromophenyl)-1-propanone In tetrahydrofuran at 20℃; for 3h; Heating / reflux; Stage #2: McMurry Reaction;	96%

: 10342-83-3
4'-Bromopropiophenone

: 611-99-4
4,4'-Dihydroxybenzophenone

: 938070-41-8
4,4'-[2-(4-bromophenyl)-1-butene-1,1-diyl]diphenol

Conditions

Conditions	Yield
With zinc; titanium tetrachloride In tetrahydrofuran at 20℃; for 3h; McMurry Reaction; Heating / reflux;	96%

: 62010-78-0
(Propionylcyclopentadienyl)tricarbonylmanganese

: 611-99-4
4,4'-Dihydroxybenzophenone

: 933445-72-8
1,1-di(4-hydroxyphenyl)-2-cymantrenylbut-1-ene

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran (Ar); using Schlenk techniques; addn. dropwise of TiCl4 to suspn. of Zn in THF at 0°C; reflux for 2 h; addn. dropwise soln. of 4,4'-dihydroxybenzophenone and (CO)3Mn(C5H4COC2H5) in THF; reflux for 2 h; cooling to room temp., stirring with H2O and CH2Cl2; treatment with diluted HCl; decanting, extn. of aq. layer with CH2Cl2; drying of combined org. layers over MgSO4, concn. under reduced pressure, chromy. on silica gel with CH2Cl2; elem. anal.;	96%

Yield

With titanium tetrachloride; zinc In tetrahydrofuran (Ar); using Schlenk techniques; addn. dropwise of TiCl4 to suspn. of Zn in THF at 0°C; reflux for 2 h; addn. dropwise soln. of 4,4'-dihydroxybenzophenone and (CO)3Mn(C5H4COC2H5) in THF; reflux for 2 h; cooling to room temp., stirring with H2O and CH2Cl2; treatment with diluted HCl; decanting, extn. of aq. layer with CH2Cl2; drying of combined org. layers over MgSO4, concn. under reduced pressure, chromy. on silica gel with CH2Cl2; elem. anal.;

96%

: propionyl ruthenocene

: 611-99-4
4,4'-Dihydroxybenzophenone

: 933445-70-6
1,1-di(4-hydroxyphenyl)-2-ruthenocenylbut-1-ene

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran (Ar); using Schlenk techniques; addn. dropwise of TiCl4 to suspn. of Zn in THF at 0°C; reflux for 2 h; addn. dropwise soln. of 4,4'-dihydroxybenzophenone and (C5H5)Ru(C5H4COC2H5) in THF; reflux for 2 h; cooling to room temp., stirring with H2O and CH2Cl2; treatment with diluted HCl; decanting, extn. of aq. layer with CH2Cl2; drying of combined org. layers over MgSO4, concn. under reduced pressure, chromy. on silica gel with CH2Cl2; elem. anal.;	96%

Yield

With titanium tetrachloride; zinc In tetrahydrofuran (Ar); using Schlenk techniques; addn. dropwise of TiCl4 to suspn. of Zn in THF at 0°C; reflux for 2 h; addn. dropwise soln. of 4,4'-dihydroxybenzophenone and (C5H5)Ru(C5H4COC2H5) in THF; reflux for 2 h; cooling to room temp., stirring with H2O and CH2Cl2; treatment with diluted HCl; decanting, extn. of aq. layer with CH2Cl2; drying of combined org. layers over MgSO4, concn. under reduced pressure, chromy. on silica gel with CH2Cl2; elem. anal.;

96%

: 6169-06-8
(S)-2-Octanol

: 611-99-4
4,4'-Dihydroxybenzophenone

: 4,4’-bis[(R)-2-octyloxy]benzophenone

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; for 17.5h; Inert atmosphere;	96%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 244768-32-9
4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile

: 4-{4-[4-(4-hydroxybenzoyl)phenoxy]pyrimidin-2-ylamino}benzonitrile

Conditions

Conditions	Yield
Stage #1: 4,4'-Dihydroxybenzophenone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	96%

: 456-03-1
1-(4-fluorophenyl)propan-1-one

: 611-99-4
4,4'-Dihydroxybenzophenone

: 4,4'-(2-(4-fluorophenyl)but-1-ene-1,1-diyl)diphenol

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran at 0 - 20℃; for 5h; McMurry Reaction; Inert atmosphere; Reflux;	96%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 936-59-4
3-chloropropiophenone

: 4,4'-(4"-chloro-2"-phenylbut-1"-ene-1",1"-diyl)diphenol

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran at 0 - 20℃; for 5h; McMurry Reaction; Inert atmosphere; Reflux;	96%
With titanium tetrachloride; zinc In tetrahydrofuran for 2.5h; McMurry Reaction; Inert atmosphere; Reflux;	70%
With titanium tetrachloride; zinc In tetrahydrofuran McMurry Reaction;

: 611-99-4
4,4'-Dihydroxybenzophenone

: 1-((12-bromododecyl)oxy)-4-((4-(4-pentylcyclohexyl)phenyl)ethynyl)benzene

: C87H114O5

Conditions

Conditions	Yield
With potassium carbonate In methanol Reflux;	95.3%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 106-96-7
propargyl bromide

: 18296-80-5
(4,4'-bis(prop-2-yn-1-yloxy))benzophenone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 3h; Heating;	95%
With potassium carbonate In acetone for 24h; Heating;	95%
With potassium carbonate In acetone for 24h; Reflux;	83%
With potassium carbonate In acetone for 24h; Reflux;	83%
Stage #1: 4,4'-Dihydroxybenzophenone With potassium carbonate In acetone for 0.5h; Reflux; Stage #2: propargyl bromide for 20h; Reflux;	72%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 611-70-1
phenyl isopropyl ketone

: 1,1-bis (4-hydroxyphenyl)-2-phenylbut-3-methyl-1-ene

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran at 0 - 20℃; for 5h; McMurry Reaction; Inert atmosphere; Reflux;	95%
With titanium tetrachloride; zinc In tetrahydrofuran at -10 - 20℃; for 5.5h; McMurry Reaction; Heating / reflux; dark;	89%
With titanium tetrachloride; zinc In tetrahydrofuran for 2.5h; McMurry Reaction; Inert atmosphere; Reflux;	89%
With titanium tetrachloride; zinc In tetrahydrofuran at -10 - 0℃; for 2.5h; Inert atmosphere; Reflux;	89%

: 611-99-4
4,4'-Dihydroxybenzophenone

: 6226-25-1
2,2,2-trifluoroethyl trifluoromethanesulphonate

: 4,4'-bis(2,2,2-trifluoroethoxy)benzophenone

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide	95%

4,4'-Dihydroxybenzophenone Chemical Properties

IUPAC Name: bis(4-hydroxyphenyl)methanone
Empirical Formula: C₁₃H₁₀O₃
Molecular Weight: 214.2167g/mol
EINECS: 210-288-1
Structure of Methanone,bis(4-hydroxyphenyl)- (CAS NO.611-99-4):

Index of Refraction: 1.647
Molar Refractivity: 59.8 cm³
Molar Volume: 164.4 cm³
Polarizability: 23.71×10^-24cm³
Surface Tension: 59.6 dyne/cm
Density: 1.302 g/cm³
Flash Point: 237 °C
Enthalpy of Vaporization: 72.98 kJ/mol
Melting Point: 213-215 °C(lit.)
Boiling Point: 444.8 °C at 760 mmHg
Vapour Pressure: 1.58E-08 mmHg at 25°C
Water Solubility: insoluble
Product Categories: Aromatic Benzophenones & Derivatives (substituted);Benzophenones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research;C13 to C14;Carbonyl Compounds;Ketones;AlcoholsPolymerization Initiators;Benzophenone;Monomers;Organic Photoinitiators;Polymer Science
Canonical SMILES: C1=CC(=CC=C1C(=O)C2=CC=C(C=C2)O)O
InChI: InChI=1S/C13H10O3/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8,14-15H
InChIKey: RXNYJUSEXLAVNQ-UHFFFAOYSA-N

4,4'-Dihydroxybenzophenone Uses

The main application of Methanone,bis(4-hydroxyphenyl)- is used as a UV light stabalizer. It is used extensively in cosmetics, plastics, films, adhesives and coatings, optical fiber, and printed circuit boards. Methanone,bis(4-hydroxyphenyl)- works by absorbing the Ultraviolet RADIATION and preventing the formation of free radicals.

4,4'-Dihydroxybenzophenone Production

Ph(CO₂)Ph → (HOC₆H₄)₂CO
The preparation method of 4,4`dihydroxybenzophenone includes rearranging Ph p-hydroxybenzoate in the presence of catalyst at a molar ratio of 1:(0.1-1) in organic solvent at 70-170?C for 3-20 h; separating; and recrystalizing. to obtain 4,4'-dihydroxybenzophenone, wherein Ph p-hydroxybenzoate is prepared. by acetylating p-hydroxybenzoic acid to generate p-acetoxybenzoic acid; chlorinating to generate p-acetoxybenzoyl chloride; and reacting with PHENOL and deacetylating to obtain Ph p-hydroxybenzoate.

4,4'-Dihydroxybenzophenone Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD	intraperitoneal	> 500mg/kg (500mg/kg)		"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 4, Pg. 376, 1952.

4,4'-Dihydroxybenzophenone Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38-43
R36/37/38:Irritating to eyes, respiratory system and skin.
R43:May cause sensitization by skin contact.
Safety Statements: 26-36/37-37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
S37/39:Wear suitable gloves and eye/face protection.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DJ0880000
HS Code: 29145000

4,4'-Dihydroxybenzophenone Specification

Methanone,bis(4-hydroxyphenyl)- , its cas register number is 611-99-4. It also can be called 4,4'-Dihydroxybenzophenone
4,4'-Dihydroxydiphenyl ketone ; 4-08-00-02452 (Beilstein Handbook Reference) ; AI3-00127 ; Bis(4-hydroxyphenyl) ketone ; Bis(p-hydroxy)benzophenone ; HBP (ketone) ; NSC 2831 ; p,p'-Dihydroxybenzophenone . Methanone,bis(4-hydroxyphenyl)- (CAS NO.611-99-4) is a off-white to beige fine crystalline powder.

Product Name

4,4'-Dihydroxybenzophenone

Synthetic route

4,4'-Dihydroxybenzophenone Chemical Properties

4,4'-Dihydroxybenzophenone Uses

4,4'-Dihydroxybenzophenone Production

4,4'-Dihydroxybenzophenone Toxicity Data With Reference

4,4'-Dihydroxybenzophenone Safety Profile

4,4'-Dihydroxybenzophenone Specification

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