4-Chloro-1,2-diaminobenzene supplier

Name
4-Chloro-1,2-diaminobenzene
EINECS 202-456-8
CAS No. 95-83-0
Article Data93
CAS DataBase
Density 1.345 g/cm³
Solubility 16 g/L (20 °C) in water
Melting Point 70-75 °C
Formula C₆H₇ClN₂
Boiling Point 300.2 °C at 760 mmHg
Molecular Weight 142.588
Flash Point 135.4 °C
Transport Information UN 2811
Appearance brown crystalline solid or powder
Safety 26-36/37
Risk Codes 36/37/38-40
Molecular Structure
Hazard Symbols Xn
Synonyms o-Phenylenediamine,4-chloro- (6CI,7CI,8CI);1,2-Diamino-4-chlorobenzene;2-Amino-4-chloroaniline;2-Amino-4-chlorobenzenamine;2-Amino-5-chloroaniline;3,4-Diamino-1-chlorobenzene;3,4-Diaminochlorobenzene;3-Chloro-1,6-phenylenediamine;4-Chloro-1,2-benzenediamine;
PSA 52.04000
LogP 2.66680

Synthetic route

: 89-63-4
4-Chloro-2-nitroaniline

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
With samarium; 1,1’-di-n-octyl-4,4’-bipyridinium dibromide In methanol at 20℃; for 5.5h;	99%
With iron(III)-acetylacetonate; hydrazine hydrate In methanol at 150℃; for 0.133333h; Microwave irradiation; chemoselective reaction;	98%
With palladium/alumina; hydrogen In ethanol at 125℃; for 8h; Flow reactor;	96%

: 610-40-2
3,4-dinitro-chlorobenzene

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
With sodium tetrahydroborate; C16H18Cl2N4O2Pd In water at 27℃; for 0.25h;	99%
With hydrogenchloride; tin
With sodium tetrahydroborate In water at 20℃; for 40h;

: 1635-61-6
5-chloro-2-nitroaniline

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
With hydrogen at 130℃; under 750.075 Torr; for 6h; chemoselective reaction;	99%
With iron(III)-acetylacetonate; hydrazine hydrate In methanol under 25502.6 Torr; chemoselective reaction;	98%
With 5%-palladium/activated carbon; hydrazine hydrate In methanol at 20℃; for 0.0833333h;	93%

: 17348-69-5
5-chlorobenzofurazan-1-oxide

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
With Saccharomyces cerevisiae BY In methanol at 20℃; for 6.5h; pH=7.0; aq. buffer; Enzymatic reaction;	90%
With ammonium sulfate; magnesium In methanol Ambient temperature;	85%

: 2207-32-1
5-chloro-2,1,3-benzothiadiazole

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
With methanol; samarium diiodide In tetrahydrofuran at 20℃; for 0.25h;	82%

: (5-chloro-2-nitro-phenyl)-(3,5-di-tert-butyl-2-methoxy-phenyl)-diazene

A: 893397-17-6
3,5-di-tert-butyl-2-methoxyaniline

B: 95-83-0
4-Chloro-1,2-phenylenediamine

C: 271788-60-4
2-[3,5-bis(1,1-dimethylethyl)-2-methoxyphenyl]-5-chloro-2H-benzotriazole

D: 2-[3,5-bis(1,1-dimethylethyl)-2-methoxyphenyl]-5-chloro-1-oxido-2H-benzotriazole

Conditions

Conditions	Yield
With lithium perchlorate In methanol; dichloromethane at 20℃; Cyclization; Electrolysis;	A n/a B n/a C 1% D 79%

...Expand

: 89-63-4
4-Chloro-2-nitroaniline

A: 95-83-0
4-Chloro-1,2-phenylenediamine

B: C12H12Cl2N4

Conditions

Conditions	Yield
With samarium; iodine; ammonium chloride In tetrahydrofuran; water at 20℃; for 6h; Reduction;	A 74% B 14%

: (5-chloro-2-nitro-phenyl)-(3,5-di-tert-butyl-2-methoxy-phenyl)-diazene

A: 893397-17-6
3,5-di-tert-butyl-2-methoxyaniline

B: 95-83-0
4-Chloro-1,2-phenylenediamine

C: 271788-60-4
2-[3,5-bis(1,1-dimethylethyl)-2-methoxyphenyl]-5-chloro-2H-benzotriazole

Conditions

Conditions	Yield
With sodium hydroxide; lithium perchlorate In tetrahydrofuran; water at 20℃; Cyclization; Electrolysis;	A n/a B n/a C 63%

...Expand

: (4-chloro-2-nitro-phenyl)-(3,5-di-tert-butyl-2-methoxy-phenyl)-diazene

A: 893397-17-6
3,5-di-tert-butyl-2-methoxyaniline

B: 95-83-0
4-Chloro-1,2-phenylenediamine

C: 271788-60-4
2-[3,5-bis(1,1-dimethylethyl)-2-methoxyphenyl]-5-chloro-2H-benzotriazole

D: 2-[3,5-bis(1,1-dimethylethyl)-2-methoxyphenyl]-6-chloro-1-oxido-2H-benzotriazole

Conditions

Conditions	Yield
With lithium perchlorate In methanol; dichloromethane at 20℃; Cyclization; Electrolysis;	A n/a B n/a C 12% D 60%
With sodium hydroxide; lithium perchlorate In tetrahydrofuran; water at 20℃; Cyclization; Electrolysis;	A n/a B n/a C 45% D 28%

...Expand

: 52184-29-9
2-nitro-4-chloro-2'-hydroxy-3',5'-di-tert-butylazobenzene

A: 95-83-0
4-Chloro-1,2-phenylenediamine

B: 1643-39-6
2-amino-4,6-di-tertbutylphenol

C: 3864-99-1
2-(5'-chloro-2'H-benzotriazol-2'-yl)-4,6-di-tert-butylphenol

Conditions

Conditions	Yield
With 2-bromo-2-nitropropane; zinc In methanol; dichloromethane for 4h; Ambient temperature;	A n/a B n/a C 88 % Chromat.

...Expand

: 2,4-di-tert-butyl-6-(5-chloro-2-nitro-phenylazo)-phenol

A: 95-83-0
4-Chloro-1,2-phenylenediamine

B: 1643-39-6
2-amino-4,6-di-tertbutylphenol

C: 3864-99-1
2-(5'-chloro-2'H-benzotriazol-2'-yl)-4,6-di-tert-butylphenol

Conditions

Conditions	Yield
With 2-bromo-2-nitropropane; zinc In methanol; dichloromethane for 3.5h; Ambient temperature;	A n/a B n/a C 79 % Chromat.

...Expand

: 64-17-5
ethanol

: 64-19-7
acetic acid

: 117616-89-4
2-(4-chloro-2-nitro-phenylhydrazono)-3-oxo-butyric acid anilide

zinc dust: zinc dust

A: 95-83-0
4-Chloro-1,2-phenylenediamine

B 3.6-dimethyl-2.5-dihydro-pyrazine-dicarboxylic acid-(2.5)-dianilide: 3.6-dimethyl-2.5-dihydro-pyrazine-dicarboxylic acid-(2.5)-dianilide

...Expand

: 610-40-2
3,4-dinitro-chlorobenzene

A: 1635-61-6
5-chloro-2-nitroaniline

B: 95-83-0
4-Chloro-1,2-phenylenediamine

C: 89-63-4
4-Chloro-2-nitroaniline

Conditions

Conditions	Yield
With tin(ll) chloride In methanol; water Title compound not separated from byproducts;	A 23.66 % Chromat. B 12.20 % Chromat. C 11.03 % Chromat.

...Expand

: 881-51-6
N-(4-chloro-2-nitrophenyl)-acetamide

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2SO4 2: H2NNH2.H2O / Raney Ni View Scheme
Multi-step reaction with 2 steps 1: aqueous sulfuric acid 2: nickel; ethanol / Hydrogenation View Scheme

: 106-47-8
4-chloro-aniline

nitrogen: nitrogen

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 2.) H2SO4/HNO3 2: H2SO4 3: H2NNH2.H2O / Raney Ni View Scheme

: 1635-61-6
5-chloro-2-nitroaniline

: 7440-66-6
zinc

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
In diethyl ether

5-Chloro-2-[2'-(benzimidazol-5"-yl)benzimidazol-5'-yl]-benzimidazole: 5-Chloro-2-[2'-(benzimidazol-5"-yl)benzimidazol-5'-yl]-benzimidazole

: 1635-61-6
5-chloro-2-nitroaniline

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
With stannous chloride In ethanol

: 5228-61-5
5-bromo-2-nitroaniline

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate 2: palladium on activated charcoal; ammonium formate / Reflux View Scheme

: 610-40-2
3,4-dinitro-chlorobenzene

A: 95-83-0
4-Chloro-1,2-phenylenediamine

B: 95-54-5
1,2-diamino-benzene

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrazine hydrate In methanol at 20℃; for 0.0833333h; Overall yield = 90 %;

: 1615-07-2
5-chloro-1H,3H-2,1,3-benzothiadiazole 2,2-dioxide

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
With sulfuric acid; water In acetonitrile at 85℃; Kinetics; Reagent/catalyst; Temperature;

: 4887-95-0
2,6-dichloro-1H-1,3-benzimidazole

: 95-83-0
4-Chloro-1,2-phenylenediamine

Conditions

Conditions	Yield
With hydrazine hydrate at 110℃;

: 64-18-6
formic acid

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 4887-82-5
5-chloro-1H-benzimidazole

Conditions

Conditions	Yield
With hydrogenchloride In water for 3h; Reflux;	100%
at 110℃; for 4h;	95%
With tetrabutyl-ammonium chloride In water; toluene at 160℃; for 0.25h; Microwave irradiation;	89%

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 431-03-8
dimethylglyoxal

: 17911-93-2
6-chloro-2,3-dimethyl-quinoxaline

Conditions

Conditions	Yield
With zirconium(IV) chloride In methanol at 20℃; for 0.0833333h;	100%
With hydrogen fluoride In water at 20℃; for 0.666667h;	98%
With 1-methyl-3-(3-trimethoxysilylpropyl)imidazolium hydrogen sulfate immobilized on cellulose In water at 20℃; for 0.05h; Green chemistry;	98%

: 78-39-7
Triethyl orthoacetate

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 2818-69-1
5-chloro-2-methyl-1H-benzimidazole

Conditions

Conditions	Yield
With zirconium(IV) chloride In methanol at 20℃; for 3h;	100%
With ammonium chloride In ethanol Inert atmosphere; Reflux; Green chemistry;	96%
With gallium(III) triflate at 20℃; for 0.416667h;	86%
With zirconium(IV) oxychloride octahydrate for 0.116667h; Microwave irradiation;	84%
With H-Y-zeolite In ethanol for 10h; Heating;	74%

: 30992-29-1
Boc-Aib-OH

: 927679-54-7
(1α,5α,6α)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

: 95-83-0
4-Chloro-1,2-phenylenediamine

: C16H19ClN4O*(x)ClH

Conditions

Conditions	Yield
Stage #1: Boc-Aib-OH; 4-Chloro-1,2-phenylenediamine With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In tetrahydrofuran at 20℃; for 72h; Stage #2: With trifluoroacetic acid In dichloromethane for 2h; Stage #3: (1α,5α,6α)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid Further stages;	100%

...Expand

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 3019-71-4
Trichloroacetyl isocyanate

A: 2,2,2-trichloro-N-(5-chloro-1H-benzimidazol-2-yl)acetamide

B: 2,2,2-trichloro-N-(6-chloro-1H-benzimidazol-2-yl)acetamide

Conditions

Conditions	Yield
In dichloromethane at -10 - 20℃; Overall yield = 85 %;	A 100% B n/a

...Expand

: 1083427-54-6
C12H15IO2

: 95-83-0
4-Chloro-1,2-phenylenediamine

: C30H33ClI2N2O2

Conditions

Conditions	Yield
In ethanol at 80℃; for 8h; Inert atmosphere;	100%

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 134-81-6
benzil

: 36305-60-9
2,3-diphenyl-6-chloroquinoxaline

Conditions

Conditions	Yield
With ZnO-loaded mesoporous silica (KIT-6) (aged at 130 °C and containing 10 wt% ZnO) In methanol at 20℃; for 0.166667h;	99%
With sulfated titania (TiO2-SO42-) In ethanol at 20℃; for 0.75h;	98.5%
With hydrogen fluoride In water at 20℃; for 0.75h;	98%

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 94-97-3
5-chlorobenzotriazole

Conditions

Conditions	Yield
With K10 Montmorillonite Clay; sodium nitrite In neat (no solvent, solid phase) at 110℃; for 1h; Microwave irradiation; Green chemistry;	99%
With tert.-butylnitrite In acetonitrile at 27 - 29℃; for 0.25h;	97%
With acetic acid In water at 70 - 80℃; for 0.416667h;	86%

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 67-64-1
acetone

: 7-chloro-2,2,4-trimethyl-2,3-dihydro-1H-benzo[b][1,4]diazepine

Conditions

Conditions	Yield
With ZnPcOC6F5-APTES(at)SiO2 at 20℃; for 0.416667h; Catalytic behavior;	99%
With silica gel-supported sulfuric acid In acetonitrile at 20℃; for 0.833333h;	94%
at 26 - 30℃; for 3.5h; Ionic liquid;	90%

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 77771-02-9
3-bromo-4-fluorobenzaldehyde

: C14H9BrClFN2

Conditions

Conditions	Yield
With C23H3BF16N2O In toluene at 25℃; for 3h; Green chemistry;	99%

: 103-82-2
phenylacetic acid

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 7118-63-0
2-benzyl-5-chloro-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With hydrogenchloride for 7.5h; Heating;	98%
With boric acid In 5,5-dimethyl-1,3-cyclohexadiene for 16h; Reflux;	65%
With hydrogenchloride at 150 - 160℃;
hydrogenchloride at 110 - 130℃;

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 95-92-1
oxalic acid diethyl ester

: 6639-79-8
6-chloroquinoxaline-2,3(1H,4H)-dione

Conditions

Conditions	Yield
for 16h; Heating;	98%
Reflux;	96%
Reflux;	96%

: 100-52-7
benzaldehyde

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 4926-65-2
5-chloro-2-phenyl-1H-benzimidazole

Conditions

Conditions	Yield
With oxygen; cobalt(II) hydroxide In ethanol at 20℃; for 4h;	98%
With sodium metabisulfite In N,N-dimethyl acetamide at 100℃; for 2h;	95.8%
With ferric hydrogen sulphate In ethanol at 20℃; for 0.833333h; chemoselective reaction;	90%

: 35578-47-3
4,4'-dibromobenzil

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 1094618-65-1
2,3-bis(4-bromophenyl)-6-chloroquinoxaline

Conditions

Conditions	Yield
With heteropoly-12-tungstophosphoric acid 40% H3[PW12O40]*12H2O supported on graphitic carbon nitride (g-C3N4) In water at 20℃; for 0.5h; Green chemistry;	98%
With titanium silicate In methanol at 20℃; for 1h;	95%
With niobium pentachloride In ethanol at 20℃; for 0.05h;	93%
With 2-methylenesuccinic acid In water at 20℃; for 1h; Schlenk technique; Green chemistry;	85%

: 27318-90-7
1,10-phenanthroline-5,6-dione

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 511243-54-2
11-chloro-dipyrido[3,2-a:2′,3′-c]phenazine

Conditions

Conditions	Yield
With sulfated titania (TiO2-SO42-) In ethanol at 20℃; for 0.166667h;	98%
With sulfate loaded TiO2 for 0.05h; Microwave irradiation; Neat (no solvent);	98%
With sulfated TiO2-P25 (Degussa titania) for 0.0583333h; Microwave irradiation; Neat (no solvent);	97%

: 131543-46-9
Glyoxal

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 5448-43-1
6-chloroquinoxaline

Conditions

Conditions	Yield
With hydrogen fluoride In water at 20℃; for 0.75h;	98%
In water at 20℃; for 0.5h; Green chemistry;	92%
In water at 20℃; for 1h;	90%
With sodium metabisulfite; sodium hydrogen sulfate In water at 70℃;

: 579-39-5
1,2-bis(4-fluorophenyl)ethane-1,2-dione

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 361149-74-8
2,3-bis-(4-fluorophenyl)-6-chloroquinoxaline

Conditions

Conditions	Yield
With hydrogen fluoride In water at 20℃; for 0.5h;	98%
With titanium silicate In methanol at 20℃; for 1h;	98%
With sodium bromate; sodium hydrogensulfite In water at 20℃;	0.48 g

: 22711-21-3
4-methoxybenzil

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 6-chloro-2-(4-methoxyphenyl)-3-phenylquinoxaline

Conditions

Conditions	Yield
With acetic acid In ethanol at 22 - 25℃; for 1h; Irradiation;	98%

: 73790-20-2
4,4'-bis(trifluoromethyl)benzil

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 6-chloro-2,3-bis(4-(trifluoromethyl)phenyl)quinoxaline

Conditions

Conditions	Yield
With hydrogen fluoride In water at 20℃; for 0.5h;	98%

: 5438-36-8
5-iodovaniline

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 4'-(5-chloro-1H-benzo[d]imidazole-2-yl)-2'-iodo-6'-methoxyphenol

Conditions

Conditions	Yield
With sodium metabisulfite In ethanol; water at 20℃; for 2h;	98%
With sodium metabisulfite In N,N-dimethyl-formamide for 4h; Reflux;	85.1%

: 98-03-3
thiophene-2-carbaldehyde

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 27503-77-1
5-chloro-2-(thiophen-2-yl)-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With polyamine dendrimer with glycerol initiated polyepichlorohydrin; air In ethanol at 20℃; for 0.05h;	97%
With sodium metabisulfite In N,N-dimethyl-formamide at 130℃; for 0.2h; Microwave irradiation;	67.8%
With bentonite clay In acetonitrile at 20℃; for 1h;	64%
In nitrobenzene
With copper diacetate In methanol Heating;

: 98-01-1
furfural

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 79324-86-0
5-Chloro-2-furan-2-yl-1-furan-2-ylmethyl-1H-benzoimidazole

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 6h;	97%

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 762-42-5
dimethyl acetylenedicarboxylate

: 88075-40-5
7-chloro-3-methoxycarbonylmethylene-2-oxo-1,2,3,4-tetrahydroquinoxaline

Conditions

Conditions	Yield
In ethanol at 20℃; for 0.5h;	97%
In methanol Ambient temperature;	83.2%
In 1,4-dioxane Heating;

: 492-94-4
furil

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 70976-04-4
6-chloro-2,3-di(furan-2-yl)-quinoxaline

Conditions

Conditions	Yield
With gallium(III) triflate In ethanol at 20℃; for 0.166667h;	97%
In methanol; acetic acid at 160℃; for 0.0833333h; Irradiation;	95%
With 1-(propyl-3-sulfonate) 3-methylimidazol(3H)-1-ium phosphotungstate In water at 20℃; for 0.2h; Reagent/catalyst; Time;	94%

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 1226-42-2
1,2-bis(4-methoxyphenyl)-1,2-ethanedione

: 6-chloro-2,3-bis(4-methoxyphenyl)quinoxaline

Conditions

Conditions	Yield
With zirconium(IV) chloride In methanol at 20℃; for 2h;	97%
With silica-supported stannous chloride In methanol at 20℃; for 1h;	97%
With silica-supported bismuth(III) chloride In methanol at 20℃; for 1.5h; Catalytic behavior;	95%

: 100-52-7
benzaldehyde

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 4926-65-2
6‐chloro‐2‐phenyl‐1H-benzoimidazole

Conditions

Conditions	Yield
With [3-(1-methylimidazolium-3-yl)propane-1-sulfonate]3PW12O40; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide at 40℃; for 10h;	97%
With water extract of onion In ethanol; water at 20℃; for 12h; Green chemistry;	91%
With sulfonated graphene oxide (GO-HSO3) In neat (no solvent) at 20℃; for 7h; chemoselective reaction;	81%
With AlKIT-5 In acetonitrile for 6h; Reflux;	80%
Reflux;	64%

: 1184-90-3
aminoiminomethanesulfonic acid

: 95-83-0
4-Chloro-1,2-phenylenediamine

: 5418-93-9
5-chloro-1H-benzo[d]imidazol-2-amine

Conditions

Conditions	Yield
at 60℃;	97%

4-Chloro-1,2-diaminobenzene Chemical Properties

IUPAC Name: 4-Chlorobenzene-1,2-diamine
Synonyms of 4-Chloro-1,2-diaminobenzene (CAS NO.95-83-0): 1,2-Benzenediamine, 4-chloro- ; 4-Chlorbenzol-1,2-diamin ; 4-Chloro-1,2-benzenediamine ; 4-Chloro-1,2-diaminobenzene ; 4-Chlorobenzene-1,2-diamine
Molecular Structure :
Molecular Formula: C₆H₇ClN₂
Molecular Weight : 142.59
CAS NO: 95-83-0
EINECS : 202-456-8
H bond acceptors: 2
H bond donors: 4
Freely Rotating Bonds: 2
Polar Surface Area: 6.48 Å²
Molar Refractivity: 39.62 cm³
Molar Volume: 105.9 cm³
Index of Refraction:1.67
Surface Tension: 59.9 dyne/cm
Density: 1.345 g/cm³
Flash Point: 135.4 °C
Enthalpy of Vaporization: 54.03 kJ/mol
Boiling Point: 300.2 °C at 760 mmHg
Vapour Pressure: 0.00114 mmHg at 25°C
Melting point : 70-75°C
Water solubility : 16 g/L (20°C)
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
Appearance: 4-Chloro-1,2-diaminobenzene (CAS NO.95-83-0) is brown crystalline solid or powder.
SMILES: Clc1cc(N)c(N)cc1
InChI: InChI=1/C6H7ClN2/c7-4-1-2-5(8)6(9)3-4/h1-3H,8-9H2
InChIKey: BXIXXXYDDJVHDL-UHFFFAOYAR
Std. InChI: InChI=1S/C6H7ClN2/c7-4-1-2-5(8)6(9)3-4/h1-3H,8-9H2
Std. InChIKey: BXIXXXYDDJVHDL-UHFFFAOYSA-N

4-Chloro-1,2-diaminobenzene Production

Raw materials :Etanol-->Sodium hydroxide-->Diethyl ether-->Stannous chloride dihydrate-->5-Chloro-2-nitroaniline
Preparation Products :Vat Brown 5R

4-Chloro-1,2-diaminobenzene Toxicity Data With Reference

1.	mma-sat 10 µg/plate	ENMUDM Environmental Mutagenesis. 7 (Suppl 5)(1985),1.
2.	mma-esc 1 mg/plate	ENMUDM Environmental Mutagenesis. 7 (Suppl 5)(1985),1.
3.	dnd-hmn:fbr 50 µmol/L	MUREAV Mutation Research. 127 (1984),107.
4.	cyt-mus-ipr 100 mg/kg	ENMUDM Environmental Mutagenesis. 8 (Suppl 6)(1986),53.
5.	orl-rat TDLo:135 g/kg/77 W-C:CAR	CRNGDP Carcinogenesis. 1 (1980),495.

4-Chloro-1,2-diaminobenzene Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 27 , 1982,p. 81.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 27 , 1982,p. 81.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); Clear Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-63 ,1978. . Reported in EPA TSCA Inventory.

4-Chloro-1,2-diaminobenzene Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 36/37/38-40
R36/37/38: Irritating to eyes, respiratory system and skin.
R40: Limited evidence of a carcinogenic effect.
Safety Statements: 26-36/37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
RIDADR: 2811
WGK Germany: 3
RTECS: SS8850000
F: 8
Hazard Note: Irritant

4-Chloro-1,2-diaminobenzene Specification

1.Air & Water Reactions: 4-Chloro-1,2-diaminobenzene may be sensitive to prolonged exposure to air and light. Insoluble in water.
2.Reactivity Profile : 4-Chloro-1,2-diaminobenzene (CAS NO.95-83-0) is incompatible with strong oxidizers. 4-Chloro-1,2-diaminobenzene reacts with alpha-ketoacids to form quinoxalones.

Product Name

4-Chloro-1,2-diaminobenzene

Synthetic route

4-Chloro-1,2-diaminobenzene Chemical Properties

4-Chloro-1,2-diaminobenzene Production

4-Chloro-1,2-diaminobenzene Toxicity Data With Reference

4-Chloro-1,2-diaminobenzene Consensus Reports

4-Chloro-1,2-diaminobenzene Safety Profile

4-Chloro-1,2-diaminobenzene Specification

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