4-Chloro-2-Nitrobenzoic Acid supplier

Name
4-Chloro-2-nitrobenzoic acid
EINECS 228-483-5
CAS No. 6280-88-2
Article Data18
CAS DataBase
Density 1.602 g/cm³
Solubility water: 0.53 g/100 mL (15 °C)
Melting Point 141-143 °C(lit.)
Formula C₇H₄ClNO₄
Boiling Point 357 °C at 760 mmHg
Molecular Weight 201.566
Flash Point 169.7 °C
Transport Information UN 2811 6.1/PG 3
Appearance light yellow to light yellow-green crystalline
Safety 26-36-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Nitro-4-chlorobenzoicacid;NSC 6158;
PSA 83.12000
LogP 2.46960

Synthetic route

: 34662-32-3
4-chloro-2-nitrobenzonitrile

: 6280-88-2
4-chloro-2-nitro-benzoic acid

Conditions

Conditions	Yield
With sulfuric acid
With sulfuric acid
With sulfuric acid
Multi-step reaction with 2 steps 1: sulfuric acid 2: sulfuric acid View Scheme

: 89-59-8
4-chloro-2-nitrotoluene

: 6280-88-2
4-chloro-2-nitro-benzoic acid

Conditions

Conditions	Yield
With nitric acid at 200℃;
With pyridine; potassium permanganate; water
With potassium permanganate

: 2001-16-3
4-chloro-1-ethyl-2-nitrobenzene

: 6280-88-2
4-chloro-2-nitro-benzoic acid

Conditions

Conditions	Yield
With potassium permanganate

: 41994-91-6
4-chloro-2-nitrobenzoic amide

: 6280-88-2
4-chloro-2-nitro-benzoic acid

Conditions

Conditions	Yield
With sulfuric acid

: 89-59-8
4-chloro-2-nitrotoluene

: 7697-37-2
nitric acid

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 89-59-8
4-chloro-2-nitrotoluene

potassium permanganate: potassium permanganate

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 89-63-4
4-Chloro-2-nitroaniline

: 6280-88-2
4-chloro-2-nitro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: durch Austausch von NH2 gegen CN nach Sandmeyer 2: concentrated sulfuric acid View Scheme
Multi-step reaction with 2 steps 2: sulfuric acid View Scheme
Multi-step reaction with 2 steps 1: copper (II)-sulfate; alkali cyanide; water; sulfuric acid; Wasser / Edukt 4: Natriumnitrit 2: aqueous sulfuric acid View Scheme

: 622-98-0
4-chloro(ethylbenzene)

: 6280-88-2
4-chloro-2-nitro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid 2: KMnO4 View Scheme

: 88-72-2
1-methyl-2-nitrobenzene

: 6280-88-2
4-chloro-2-nitro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SbCl5; chlorine / <40 2: nitric acid / 200 °C View Scheme

: 119-32-4
4-Methyl-3-nitroanilin

: 6280-88-2
4-chloro-2-nitro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: KMnO4 View Scheme
Multi-step reaction with 2 steps 2: nitric acid / 200 °C View Scheme

: 74-11-3
para-chlorobenzoic acid

: 6280-88-2
4-chloro-2-nitro-benzoic acid

Conditions

Conditions	Yield
With nitric acid In water at 60℃; for 6h; Cooling with ice;

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 41995-04-4
4-chloro-2-nitro-benzoyl chloride

Conditions

Conditions	Yield
With thionyl chloride In toluene for 3h; Heating;	100%
With thionyl chloride In DMF (N,N-dimethyl-formamide) at 26 - 65℃; for 5h;	100%
With thionyl chloride at 80℃; Inert atmosphere;	90%

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 77-78-1
dimethyl sulfate

: 42087-80-9
methyl 4-chloro-2-nitrobenzoate

Conditions

Conditions	Yield
With potassium carbonate In acetone for 0.5h; Esterification; Heating;	100%

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 41994-91-6
4-chloro-2-nitrobenzoic amide

Conditions

Conditions	Yield
With ammonium hydroxide; thionyl chloride In dichloromethane; ethyl acetate	99%
With ammonium hydroxide; thionyl chloride 1.) PhMe, reflux; Multistep reaction;
Multi-step reaction with 2 steps 1: thionyl chloride / toluene; dimethylformamide / Heating 2: 30 percent aq. NH3 / dioxane / 20 °C View Scheme

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 66937-55-1
N-cyclohexylglycine t-butyl ester

: tert-butyl 2-[(4-chloro-2-nitrobenzoyl)cyclohexylamino]acetate

Conditions

Conditions	Yield
With triethylamine; HATU In N,N-dimethyl-formamide for 12h;	98%

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 41513-04-6
2-chloro-5-bromonitrobenzene

Conditions

Conditions	Yield
With trichloroisocyanuric acid; bromine In tetrachloromethane at 10 - 100℃; for 18h; Photolysis;	96%
With copper(l) iodide; oxygen; copper(I) bromide In dimethyl sulfoxide at 160℃; under 760.051 Torr; for 30h; Schlenk technique; Sealed tube;	81%
With 2.9-dimethyl-1,10-phenanthroline; oxygen; copper diacetate; silver sulfate; sodium bromide In dimethyl sulfoxide at 160℃; under 760.051 Torr; for 20h; Schlenk technique;	64%

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 104-88-1
4-chlorobenzaldehyde

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: N-(2-(tert-butylamino)-1-(4-chlorophenyl)-2-oxoethyl)-4-chloro-N-(3,4-dimethoxyphenethyl)-2-nitrobenzamide

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	95%

...Expand

: 61-54-1
tryptamine

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 104-88-1
4-chlorobenzaldehyde

: N-(2-(1H-indol-3-yl)ethyl)-N-(2-(tert-butylamino)-1-(4-chlorophenyl)-2-oxoethyl)-4-chloro-2-nitrobenzamide

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	95%

...Expand

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 64-04-0
phenethylamine

: 284487-93-0
4-chloro-2-nitro-N-phenethylbenzamide

Conditions

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 60℃; for 4h;	94%
With pyridine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate In N,N-dimethyl-formamide for 1h;

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 2953-58-4
N,N-dimethyl-4-chloro-2-nitrobenzamide

Conditions

Conditions	Yield
With trichlorophosphate at 120℃; for 1h; Sealed tube;	94%
With trichlorophosphate at 120℃; for 1h;	94%
With dipotassium peroxodisulfate; (p-cymene)ruthenium(II) chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene at 160℃; for 24h;	37%
With potassium thiosulfate; [RhCl2(p-cymene)]2; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene at 160℃; for 24h; Inert atmosphere; Sealed tube;	37%

: 98-10-2
benzenesulfonamide

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: N-(2-nitro-4-chloro-benzoyl)-benzenesulfonamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	93%

: 13669-42-6
3-quinolylcarboxaldehyde

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: N-(2-(tert-butylamino)-2-oxo-1-(quinolin-3-yl)ethyl)-4-chloro-N-(3,4-dimethoxyphenethyl)-2-nitrobenzamide

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	93%

...Expand

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 22996-18-5
(4-chloro-2-nitrophenyl)methanol

Conditions

Conditions	Yield
With dimethylsulfide borane complex In tetrahydrofuran at 80℃; for 3h; Inert atmosphere;	91%
With dimethylsulfide borane complex In tetrahydrofuran at 80℃; for 3h; Inert atmosphere;	52%
With boron dimethyl-trifluoro sulphide In tetrahydrofuran at 0 - 60℃; Inert atmosphere;
With borane-THF In tetrahydrofuran at 0 - 20℃; for 72h;

: 67-56-1
methanol

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 42087-80-9
methyl 4-chloro-2-nitrobenzoate

Conditions

Conditions	Yield
With thionyl chloride for 6h;	90%
With thionyl chloride at 0 - 50℃; for 24h; Inert atmosphere;	67%
With sulfuric acid Reflux;

: 1121-60-4
pyridine-2-carbaldehyde

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 54149-39-2
O-(2-Methoxy-ethyl)-hydroxylamine

: N-(2-(tert-butylamino)-2-oxo-1-(pyridin-2-yl)ethyl)-4-chloro-N-(2-methoxyethyl)-2-nitrobenzamide

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	90%

...Expand

: 61-54-1
tryptamine

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 885463-77-4
4-chloro-N-[2-(1H-indol-3-yl)ethyl]-2-nitrobenzamide

Conditions

Conditions	Yield
Stage #1: 4-chloro-2-nitro-benzoic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; Stage #2: tryptamine In N,N-dimethyl-formamide at 20℃; for 12h;	89%

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 123-11-5
4-methoxy-benzaldehyde

: 22483-09-6
2,2-dimethoxyethylamine

: N-(2-(tert-butylamino)-1-(4-methoxyphenyl)-2-oxoethyl)-4-chloro-N-(2,2-dimethoxyethyl)-2-nitrobenzamide

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	89%

...Expand

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 5446-05-9
4-chloro-2-nitroiodobenzene

Conditions

Conditions	Yield
With copper(l) iodide; oxygen In dimethyl sulfoxide at 160℃; under 760.051 Torr; for 30h; Reagent/catalyst; Solvent; Schlenk technique; Sealed tube;	87%
With 2.9-dimethyl-1,10-phenanthroline; oxygen; copper (I) acetate; silver sulfate; sodium iodide In dimethyl sulfoxide at 160℃; for 24h; Schlenk technique;	72%
With 2.9-dimethyl-1,10-phenanthroline; oxygen; copper diacetate; silver sulfate; sodium iodide In dimethyl sulfoxide at 160℃; under 760.051 Torr; for 20h; Schlenk technique;	72%

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 5-bromo-2-chloro-4-(piperazin-1-yl)pyrimidine dihydrochloride

: (4-(5-bromo-2-chloropyrimidin-4-yl)piperazin-1-yl)(4-chloro-2-nitrophenyl)methanone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 30℃; for 16h;	87%

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 123-11-5
4-methoxy-benzaldehyde

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: N-(2-(tert-butylamino)-1-(4-methoxyphenyl)-2-oxoethyl)-4-chloro-N-(3,4-dimethoxyphenethyl)-2-nitrobenzamide

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	87%

...Expand

: 1075-47-4
4-methylphenylglyoxal

: 931-53-3
Cyclohexyl isocyanide

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 5003-71-4
3-bromopropylamine hydrochloride

: 1-(4-chloro-2-nitrobenzoyl)-N-cyclohexyl-2-(4-methylbenzoyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
Stage #1: 4-methylphenylglyoxal; Cyclohexyl isocyanide; 4-chloro-2-nitro-benzoic acid; 3-bromopropylamine hydrochloride With sodium hydroxide In methanol at 20℃; for 24h; Stage #2: With caesium carbonate In methanol at 20℃; for 1h;	87%

...Expand

: 931-53-3
Cyclohexyl isocyanide

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 5003-71-4
3-bromopropylamine hydrochloride

: 1076-95-5
p-methoxyphenylglyoxal

: 1-(4-chloro-2-nitrobenzoyl)-N-cyclohexyl-2-(4-methoxybenzoyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
Stage #1: Cyclohexyl isocyanide; 4-chloro-2-nitro-benzoic acid; 3-bromopropylamine hydrochloride; p-methoxyphenylglyoxal With sodium hydroxide In methanol at 20℃; for 24h; Stage #2: With caesium carbonate In methanol at 20℃; for 1h;	86%

...Expand

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 123-11-5
4-methoxy-benzaldehyde

: 54149-39-2
O-(2-Methoxy-ethyl)-hydroxylamine

: N-(2-(tert-butylamino)-1-(4-methoxyphenyl)-2-oxoethyl)-4-chloro-N-(2-methoxyethyl)-2-nitrobenzamide

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	84%

...Expand

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 107-18-6
allyl alcohol

: allyl 4-chloro-2-nitrobenzoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Steglich Esterification;	83%

: 534-22-5
2-methylfuran

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 1045704-63-9
2-methyl-5-(4-chloro-2-nitrophenyl)-furan

Conditions

Conditions	Yield
With palladium(II) trifluoroacetate; triphenylphosphine; silver carbonate In 1,2-dimethoxyethane; dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere; Glovebox;	83%

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 84518-77-4
ethyl 1,2,3,4-tetrahydro-β-carboline-3-carboxylate

: 130472-81-0
2-(4-Chloro-2-nitro-benzoyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane for 3h; Ambient temperature;	82%

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 56978-50-8
4,4'-dichloro-2,2'-dinitrobiphenyl

Conditions

Conditions	Yield
With copper(l) iodide In dimethyl sulfoxide at 140℃; for 20h; Catalytic behavior; Solvent; Reagent/catalyst; Inert atmosphere;	82%
With triphenylphosphine; silver carbonate; palladium dichloride In dimethyl sulfoxide at 130℃; for 6h; Inert atmosphere;	77%

: 273-53-0
benzoxazole

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 2-(4-chloro-2-nitrophenyl)benzo[d]oxazole

Conditions

Conditions	Yield
With 1,10-Phenanthroline; caesium carbonate; copper(l) chloride; silver(l) oxide In N,N-dimethyl-formamide at 110℃; for 23h; Inert atmosphere;	81%
With 1,10-Phenanthroline; di-tert-butyl peroxide; oxygen; potassium carbonate; copper(I) bromide In toluene at 140℃; for 24.25h; Molecular sieve; Schlenk technique; Sealed tube; regioselective reaction;	78%
With bis(tricyclohexylphosphine)nickel(II) dichloride; N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride; silver carbonate; p-benzoquinone at 170℃; for 24h; Sealed tube;	72%

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 108-98-5
thiophenol

: 4548-56-5
4-chloro-2-nitrophenyl phenyl sulfide

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; oxygen; potassium carbonate In dimethyl sulfoxide at 140℃; for 24h; Molecular sieve;	81%

: 7304-32-7
2-fluoro-5-nitrobenzoic acid

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 1393456-33-1
C12H6ClFN2O4

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); silver carbonate; tricyclohexylphosphine In 1,2-dimethoxyethane; dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere;	80%

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 5680-79-5
glycine ethyl ester hydrochloride

: 59259-01-7
2-<2-(1,3-dioxolanyl)>benzaldehyde

: 1426688-04-1
4-(2-(tert-butyl)-3-oxo-2,3-dihydroisoquinolin-4-yl)-8-chloro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Conditions

Conditions	Yield
Stage #1: tert-butylisonitrile; 4-chloro-2-nitro-benzoic acid; glycine ethyl ester hydrochloride; 2-<2-(1,3-dioxolanyl)>benzaldehyde With sodium carbonate In methanol at 20℃; for 12h; Ugi Condensation; Inert atmosphere; Stage #2: With perchloric acid In water; acetonitrile at 20℃; for 8h; Inert atmosphere; Stage #3: With acetic acid; zinc In water; acetonitrile at 60℃; for 8h; Inert atmosphere;	80%

Yield

Stage #1: tert-butylisonitrile; 4-chloro-2-nitro-benzoic acid; glycine ethyl ester hydrochloride; 2-<2-(1,3-dioxolanyl)>benzaldehyde With sodium carbonate In methanol at 20℃; for 12h; Ugi Condensation; Inert atmosphere;
Stage #2: With perchloric acid In water; acetonitrile at 20℃; for 8h; Inert atmosphere;
Stage #3: With acetic acid; zinc In water; acetonitrile at 60℃; for 8h; Inert atmosphere;

80%

...Expand

4-Chloro-2-Nitrobenzoic Acid Chemical Properties

Molecular Formula: C₇H₄ClNO₄Molecular Weight: 201.56
EINECS: 228-483-5
Melting point: 141-143 °C(lit.)
Density: 1.5
Flash point: >100°C
Appearance: Slightly yellow powder.
Solubility in water: Very soluble
4-Chloro-2-nitrobenzoic acid's(6280-88-2) Synonyms: 2-Nitro-4-chlorobenzoic acid;4-CHLORO-2-NITROBENZOIC ACID;Benzoic acid, 4-chloro-2-nitro-;4-Chloro-2-nitrobenzoic acid, 97+%;4,2-CNBA;4-Chloro-2-Nitrobenzoic;4-CHLORO-2-NITROBENZOIC ACID 98+%
4-Chloro-2-nitrobenzoic acid's(6280-88-2) Structural formula:

4-Chloro-2-Nitrobenzoic Acid Uses

4-Chloro-2-nitrobenzoic acid(6280-88-2) can be used as pharmaceutical intermediate.

4-Chloro-2-Nitrobenzoic Acid Safety Profile

Safety Information for 4-Chloro-2-nitrobenzoic acid(6280-88-2)
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-24/25
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
Hazard Note Irritant
HS Code 29163900

4-Chloro-2-Nitrobenzoic Acid Specification

Stability and Reactivity for 4-Chloro-2-nitrobenzoic acid(6280-88-2)
【Disposal Code】4
【Incompatibilities】Oxidizing agents, strong bases.
【Stability】Stable at room temperature in closed containers under normal storage and handling conditions.
【Decomposition】Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Transport Information for 4-Chloro-2-nitrobenzoic acid(6280-88-2)
【HS Code】2916 39 00

Product Name

4-Chloro-2-nitrobenzoic acid

Synthetic route

4-Chloro-2-Nitrobenzoic Acid Chemical Properties

4-Chloro-2-Nitrobenzoic Acid Uses

4-Chloro-2-Nitrobenzoic Acid Safety Profile

4-Chloro-2-Nitrobenzoic Acid Specification

Related Products

Hot Products