4-Chloro-3-nitrophenyl methyl sulfone supplier

Name
4-Chloro-3-nitrophenyl methyl sulfone
EINECS 202-557-7
CAS No. 97-07-4
Article Data7
CAS DataBase
Density 1.52 g/cm³
Solubility
Melting Point 125-129 ºC
Formula C₇H₆ClNO₄S
Boiling Point 414.179 °C at 760 mmHg
Molecular Weight 235.648
Flash Point 204.288 °C
Transport Information
Appearance
Safety
Risk Codes R20/21/22; R36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms Sulfone,4-chloro-3-nitrophenyl methyl (6CI,7CI,8CI);1-Chloro-4-(methylsulfonyl)-2-nitrobenzene;2-Chloro-5-(methylsulfonyl)-1-nitrobenzene;3-Nitro-4-chlorophenyl methyl sulfone;4-(Methylsulfonyl)-2-nitrochlorobenzene;NSC 25818;
PSA 88.34000
LogP 3.25570

Synthetic route

: 98-57-7
4-chlorophenyl methyl sulfone

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 25℃; for 2h;	99.7%
(nitration);

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium sulfite; sodium hydrogencarbonate / water / 4 h / 75 °C 1.2: 15 h / 105 - 107 °C 2.1: sulfuric acid; nitric acid / 2 h / 25 °C View Scheme

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 917562-22-2
C12H13NO8S

Conditions

Conditions	Yield
Stage #1: malonic acid dimethyl ester With potassium tert-butylate In tert-butyl alcohol Stage #2: 1-chloro-4-methanesulfonyl-2-nitrobenzene In tert-butyl alcohol at 20℃; for 15h; Heating / reflux;	100%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 6320-02-1
2-bromothiophenol

: 2'-Brom-2-nitro-4-methylsulfonyl-diphenylsulfid

Conditions

Conditions	Yield
In ethanol at 40 - 80℃; for 0.5h;	99%
With sodium hydroxide

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 105-34-0
methyl 2-cyanoacetate

: methyl 2-cyano-2-(4-(methylsulfonyl)-2-nitrophenyl)acetate

Conditions

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide at 60℃; for 1h;	96%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 616-30-8, 13552-31-3
3-Amino-1,2-propanediol

: 120381-40-0
4-(β,γ-dihydroxypropylamino-3-nitro)phenyl methyl sulfone

Conditions

Conditions	Yield
In dimethyl sulfoxide	95%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 2557-78-0
2-fluorothiophenol

: 129846-91-9
2-(2-fluorophenylthio)-5-(methylsulfonyl)nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 4h;	95%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 693-05-0
N-(2-cyanoethyl)-N-methylamine

: 81689-46-5
3-[(4-Methanesulfonyl-2-nitro-phenyl)-methyl-amino]-propionitrile

Conditions

Conditions	Yield
In butan-1-ol at 118℃; for 2h;	91%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 108-88-3
toluene

: C14H14ClNO2S

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; hydrogen In water; toluene at 160℃; under 30003 Torr; for 36h; Autoclave;	84%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 39930-15-9
(3-chlorophenyl)(pyridin-2-yl)methanamine

: (rac)-N-((3-chlorophenyl)(pyridin-2-yl)methyl)-4-(methylsulfonyl)-2-nitroaniline

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 130℃; for 0.5h; Sealed tube; Microwave irradiation;	83%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 154714-19-9
5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 862298-42-8
2,2-dimethyl-5-[4-(methylsulfonyl)-2-nitrophenoxy]-4H-1,3-benzodioxin-4-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 7h;	80%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 108-00-9
N,N-dimethylethylenediamine

: 120381-41-1
4-(β-dimethylaminoethyl)amino-3-nitrophenyl methyl sulfone

Conditions

Conditions	Yield
In dimethyl sulfoxide; ethyl acetate	78%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 99-36-5
1-methoxycarbonyl-3-methylbenzene

: C16H16ClNO4S

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; hydrogen In water; toluene at 160℃; under 30003 Torr; for 36h; Autoclave;	73%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 2557-78-0
2-fluorothiophenol

A: 129846-93-1
4-(ethylthio)-3-nitrophenyl methyl sulfone

B: 129846-91-9
2-(2-fluorophenylthio)-5-(methylsulfonyl)nitrobenzene

C: 129846-92-0
3,4-bis(2-fluorophenylthio)phenyl methyl sulfone

D: di(4-(methylsulfonyl)-2-nitrophenyl) sulfide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3.5h;	A 4.96% B 63% C 8.03 g D 1.50 g
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3.5h;	A 4.96 g B 63% C 8.03 g D 1.50 g

...Expand

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 21539-47-9
3-ethylamino propionitrile

A: 21355-97-5
3-nitro-4-ethylaminophenyl methyl sulfone

B: 81676-76-8
2-nitro-4-methylsulfonyl-N-ethyl-N-β-cyanoethylaniline

Conditions

Conditions	Yield
In methanol for 42h; Heating;	A 43% B 56%

...Expand

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 104-10-9
2-(4'-aminophenyl)ethyl alcohol

: 2-{4-[4-(methylsulfonyl)-2-nitroanilino]phenyl}ethanol

Conditions

Conditions	Yield
With sodium carbonate In ethanol at 100℃; for 16h;	34%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 1822-66-8
3,4-dihydroxythiophene-2,5-dicarboxylic acid diethyl ester

: 6-(methylsulfonyl)benzo[b]thieno[3,4-e][1,4]dioxine

Conditions

Conditions	Yield
With potassium carbonate; lithium bromide In N,N-dimethyl acetamide at 200℃; for 1h; Microwave irradiation; Sealed tube; Inert atmosphere;	20.9%

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 64-17-5
ethanol

: 20277-69-4
sodium methansulfinate

: 1,4-bis-methanesulfonyl-2-nitro-benzene

...Expand

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 6421-88-1
2-(4-aminophenoxy)ethanol

: 2-[4-(4-methanesulfonyl-2-nitro-anilino)-phenoxy]-ethanol

Conditions

Conditions	Yield
With ethanol; sodium carbonate

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 20277-69-4
sodium methansulfinate

: 1,4-bis-methanesulfonyl-2-nitro-benzene

Conditions

Conditions	Yield
With ethanol

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 124-41-4
sodium methylate

: 20945-69-1
4-methanesulfonyl-1-methoxy-2-nitro-benzene

Conditions

Conditions	Yield
With methanol

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 21081-73-2
1-ethoxy-4-methanesulfonyl-2-nitro-benzene

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 453-72-5
1-fluoro-4-methanesulfonyl-2-nitrobenzene

Conditions

Conditions	Yield
With potassium fluoride at 180℃;

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 100620-98-2
bis-(4-methanesulfonyl-2-nitro-phenyl)-sulfide

Conditions

Conditions	Yield
With alkali sulfide

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 104-94-9
4-methoxy-aniline

: 92192-70-6
(4-methanesulfonyl-2-nitro-phenyl)-(4-methoxy-phenyl)-amine

Conditions

Conditions	Yield
With ethanol

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 62-53-3
aniline

: 16588-01-5
(4-methanesulfonyl-2-nitro-phenyl)-phenyl-amine

Conditions

Conditions	Yield
With ethanol

: 75-15-0
carbon disulfide

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 61700-73-0
2-chloro-5-methanesulfonyl-benzothiazole

Conditions

Conditions	Yield
(i) Na2S3, (ii) /BRN= 1098293/, (iii) SO2Cl2; Multistep reaction;

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 18543-01-6
1-(4-(methylsulfonyl)-2-nitrophenyl)piperidine

Conditions

Conditions	Yield
With /BRN= 102438/ In dimethyl sulfoxide at 45℃; Rate constant;

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 693-05-0
N-(2-cyanoethyl)-N-methylamine

A: 30388-44-4
methyl 4-methyl-amino-3-nitrophenyl sulfone

B: 81689-46-5
3-[(4-Methanesulfonyl-2-nitro-phenyl)-methyl-amino]-propionitrile

Conditions

Conditions	Yield
In butan-1-ol at 118℃; for 40h;

...Expand

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 5351-04-2
3-diethylaminopropionitrile

A: 37899-75-5
hydrochloride of 3-diethylaminopropionitrile

B: 81676-67-7
N,N-diethyl-4-(methylsulfonyl)-2-nitroaniline

C: 107-13-1
acrylonitrile

Conditions

Conditions	Yield
In i-Amyl alcohol

...Expand

: 97-07-4
1-chloro-4-methanesulfonyl-2-nitrobenzene

: 140-89-6
potassium ethyl xanthogenate

: Dithiocarbonic acid O-ethyl ester S-(4-methanesulfonyl-2-nitro-phenyl) ester

Conditions

Conditions	Yield
In ethanol for 18h; Ambient temperature;

4-Chloro-3-nitrophenyl methyl sulfone Chemical Properties

Molecular Structure:

Molecular Formula: C₇H₆ClNO₄S
Molecular Weight: 235.6448
IUPAC Name: 1-Chloro-4-methylsulfonyl-2-nitrobenzene
Synonyms of 4-Chloro-3-nitrophenyl methyl sulfone (CAS NO.97-07-4): 3-Nitro-4-chlorophenyl methyl sulfone ; EINECS 202-557-7 ; NSC 25818 ; 1-Chloro-4-(methylsulphonyl)-2-nitrobenzene ; Benzene, 1-chloro-4-(methylsulfonyl)-2-nitro- ; Sulfone, 4-chloro-3-nitrophenyl methyl (8CI)
CAS NO: 97-07-4
Product Categories: Benzene derivates
Index of Refraction: 1.572
Molar Refractivity: 51.05 cm³
Molar Volume: 155 cm³
Surface Tension: 52.6 dyne/cm
Density: 1.52 g/cm³
Flash Point: 204.3 °C
Enthalpy of Vaporization: 64.12 kJ/mol
Boiling Point: 414.2 °C at 760 mmHg
Vapour Pressure of 4-Chloro-3-nitrophenyl methyl sulfone (CAS NO.97-07-4): 1.09E-06 mmHg at 25°C

Product Name

4-Chloro-3-nitrophenyl methyl sulfone

Synthetic route

4-Chloro-3-nitrophenyl methyl sulfone Chemical Properties

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