Conditions | Yield |
---|---|
With selenium; 1,5-Diazabicyclo[5.4.0]undec-5-ene In tetrahydrofuran at 90℃; | 100% |
With selenium; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 100℃; under 22800 Torr; for 30h; | 100% |
With selenium; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 100℃; under 22800 Torr; for 30h; Mechanism; carbonylation of alkyl aryl ketones with CO using stoichiometric amount of Se, variation of temperature and solvent; | 100% |
With triethylamine In tetrahydrofuran at 80℃; under 7355.08 Torr; for 4h; | 95% |
With nitrobenzene; 1,8-diazabicyclo[5.4.0]undec-7-ene; selenium In tetrahydrofuran at 90℃; under 22800 Torr; for 30h; Mechanism; catalytic carbonylation of alkyl aryl ketones with CO by Se in the presence of oxidizing agent; | 68% |
4-allyloxy-2H-chromen-2-one
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With sodium hydrogen telluride; acetic acid In ethanol for 2h; Heating; | 99% |
With ammonium formate; palladium on activated charcoal In methanol for 1.5h; Heating; | 95% |
With iodine In dimethyl sulfoxide at 120℃; for 0.5h; | 78% |
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water | 96% |
Conditions | Yield |
---|---|
With sodium hydride In toluene at 0℃; for 4.5h; Reflux; | 95% |
With sodium hydride In toluene at 100℃; for 3h; | 85% |
Stage #1: o-hydroxyacetophenone With sodium hydride In toluene; mineral oil Stage #2: Diethyl carbonate In toluene; mineral oil Reflux; Stage #3: With hydrogenchloride In water | 85% |
2-oxo-2H-chromen-4-yl propionate
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With sodium hydrogen telluride In ethanol for 0.5h; Quantum yield; Heating; buffer: deoxygen. acetic acid; | 95% |
4-(piperidin-1-yl)-2H-chromen-2-one
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With hydrogenchloride for 0.5h; Product distribution; Heating; | 94% |
3-carbethoxy-4-hydroxycoumarin
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With sulfuric acid In ethanol; water at 100 - 105℃; for 1h; Hydrolysis; decarboxylation; | 90.5% |
3-acetyl-chroman-2,4-dione
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With sulfuric acid In ethanol; water for 1h; Deacetylation; Heating; | 90.2% |
N,N-diethyl-3-(2-hydroxyphenyl)-3-oxopropanamide
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With trifluoroacetic acid In toluene for 1h; Heating; | 89% |
A
4-hydroxy[1]benzopyran-2-one
B
3-(2-Hydroxy-phenyl)-N,N-dimethyl-3-oxo-propionamide
Conditions | Yield |
---|---|
With sodium hydroxide In acetonitrile at 50℃; for 0.5h; | A 7% B 87% |
With sodium hydrogencarbonate In acetonitrile at 50℃; for 1h; | A 25% B 66% |
o-hydroxyacetophenone
carbonic acid dimethyl ester
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With sodium hydride In toluene at 100℃; for 3h; | 84% |
malonic acid monophenyl ester
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With Eaton’s reagent at 70℃; for 1h; | 80% |
With Eaton’s reagent In water for 2h; Reflux; | 63% |
With eaton’s reagent at 70℃; for 4h; Neat (no solvent); | |
With Eaton’s reagent at 60 - 70℃; |
A
4-hydroxy[1]benzopyran-2-one
B
3-(2-Hydroxy-phenyl)-N,N-dimethyl-3-oxo-propionamide
Conditions | Yield |
---|---|
With sodium hydroxide In acetonitrile at 50℃; for 1h; | A 14% B 77% |
With water In acetonitrile at 50℃; for 1h; | A 69% B 29% |
C24H18O7
A
4-hydroxy[1]benzopyran-2-one
B
dimethyl 2-(4-methylphenyl)furan-3,4-dicarboxylate
Conditions | Yield |
---|---|
With hydrogenchloride In methanol Heating; | A 77% B 68% |
n-butyl magnesium bromide
A
4-hydroxy[1]benzopyran-2-one
B
4-butyl-2H-1-benzopyran-2-one
Conditions | Yield |
---|---|
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; iron(III)-acetylacetonate In tetrahydrofuran at 0℃; for 0.166667h; Reagent/catalyst; Inert atmosphere; | A 21% B 70% |
Conditions | Yield |
---|---|
With sodium hydride In toluene at 100℃; for 3h; | 69% |
2-trichloromethyl-4-chromone
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With potassium hydroxide In methanol for 0.5h; Hydrolysis; Heating; | 65% |
2-acetylphenyl 2-chlorobenzoate
methyl chloroformate
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
Stage #1: 2-acetylphenyl 2-chlorobenzoate With sodium hydride In N,N-dimethyl-formamide at 100℃; for 6h; Inert atmosphere; Stage #2: methyl chloroformate In N,N-dimethyl-formamide | 59% |
3-(phenyl-λ3-iodanylidene)chromane-2,4-dione
A
4-hydroxy[1]benzopyran-2-one
B
3,4-Dihydroxy-2-oxo-2H<1>benzopyran
Conditions | Yield |
---|---|
With acetic acid for 0.0833333h; Heating; | A n/a B 13% C 51% |
3-(phenyl-λ3-iodanylidene)chromane-2,4-dione
acetic acid
A
4-hydroxy[1]benzopyran-2-one
B
3,4-Dihydroxy-2-oxo-2H<1>benzopyran
Conditions | Yield |
---|---|
for 0.0833333h; Heating; | A n/a B 13% C 51% |
Conditions | Yield |
---|---|
With zinc(II) chloride; trichlorophosphate at 60 - 65℃; for 48h; | 50% |
With zinc(II) chloride; trichlorophosphate at 60 - 70℃; | 48% |
With zinc(II) chloride; trichlorophosphate at 60 - 65℃; | 41% |
2-amino-3-formylchromone
A
4-hydroxy[1]benzopyran-2-one
B
2-(4-oxo-4H-[1]benzopyran-3-yl) [1] benzopyrano[3,2-e]pyrimidin-5(5H)-one
C
Bis-<1>benzopyrano<2,3-b:3',2'-e>pyridin-5(5H),7(7H)-dion
Conditions | Yield |
---|---|
hydrogenchloride In isopropyl alcohol for 30h; | A 26% B 1% C 38% |
4-chloro-3-nitro-chromen-2-one
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With pyridine; sodium dithionite In water | 27% |
3-(phenyl-λ3-iodanylidene)chromane-2,4-dione
A
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With trifluoroacetic acid Heating; | A n/a B 25% |
4-(o-hydroxybenzoyl)-pyrazolone-5
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
With hydrogenchloride at 100℃; for 10h; | 15.6% |
A
4-hydroxy[1]benzopyran-2-one
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 20℃; | A n/a B 13% |
A
4-hydroxy[1]benzopyran-2-one
B
N-[2-(trifluoromethyl)phenyl]-1,3,4-thiadiazole-2-carboxamide
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 20℃; | A n/a B 9% |
Conditions | Yield |
---|---|
With sodium at 165 - 175℃; |
sodium ethanolate
o-hydroxyacetophenone
Diethyl carbonate
4-hydroxy[1]benzopyran-2-one
sodium ethanolate
o-hydroxyacetophenone
Diethyl carbonate
benzene
4-hydroxy[1]benzopyran-2-one
4-hydroxy[1]benzopyran-2-one
4-methoxy-benzaldehyde
3,3-(4'-methoxybenzylidene)bis(4-hydroxycoumarin)
Conditions | Yield |
---|---|
With 4-sulfophthalic acid In water at 80℃; for 0.416667h; Catalytic behavior; Green chemistry; | 100% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; for 16h; | 99% |
With phosphotungstic acid In water at 80℃; for 0.383333h; domino Knoevenagel type condensation/Michael reaction; | 99% |
4-hydroxy[1]benzopyran-2-one
4-chlorobenzaldehyde
3,3'-(4-chlorophenylmethylene)-bis-4-hydroxycoumarin
Conditions | Yield |
---|---|
With glycerol-based carbon sulfonic acid In ethanol; water at 80℃; for 0.333333h; Solvent; Temperature; Concentration; | 100% |
With silica-supported Preyssler acid nanoparticles In ethanol at 25℃; for 0.333333h; | 99% |
With cholin hydroxide In water at 50℃; for 2h; | 99% |
4-hydroxy[1]benzopyran-2-one
benzaldehyde
3,3'-phenylmethylene-bis-4-hydroxycoumarin
Conditions | Yield |
---|---|
With cholin hydroxide In water at 50℃; for 1h; Catalytic behavior; Temperature; Reagent/catalyst; | 100% |
With 4-sulfophthalic acid In water at 80℃; for 0.5h; Catalytic behavior; Green chemistry; | 99% |
With C19H40KNO8S(2+)*2C2F3O2(1-) In ethanol; water for 0.5h; Reagent/catalyst; Reflux; | 98% |
Conditions | Yield |
---|---|
With pyridine In benzene | 100% |
4-hydroxy[1]benzopyran-2-one
3-methoxy-benzaldehyde
3,3'-((3-methoxyphenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
Conditions | Yield |
---|---|
With 4-sulfophthalic acid In water at 80℃; for 0.333333h; Catalytic behavior; Green chemistry; | 100% |
With piperidine In ethanol at 20℃; for 4h; | 98% |
With 4-aminobenzene sulfonic acid In water at 80℃; for 0.366667h; Green chemistry; | 96% |
4-hydroxy[1]benzopyran-2-one
4-bromo-benzaldehyde
acetonitrile
N-[(4-bromophenyl)(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]acetamide
Conditions | Yield |
---|---|
With chlorosulfonic acid at 20℃; for 1h; | 100% |
Stage #1: 4-hydroxy[1]benzopyran-2-one; 4-bromo-benzaldehyde; acetonitrile With phosphorus pentaoxide; Hexamethyldisiloxane at 20℃; for 3h; Stage #2: With water cooling; Further stages.; | 90% |
pyrrolidine
4-hydroxy[1]benzopyran-2-one
benzaldehyde
4-hydroxy-3-(phenyl(pyrrolidin-1-yl)methyl)-2H-chromen-2-one
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 2h; Mannich Aminomethylation; | 100% |
With zinc(II) oxide In water at 25℃; for 0.416667h; | 93% |
With Triton X-100 In water at 20℃; for 6h; Mannich type reaction; | 90% |
4-hydroxy[1]benzopyran-2-one
C8H7NO5
malononitrile
2-amino-3-cyano-4-(3'-nitrobenzoyl)-4H,5H-pyrano[3,2-c]chromene-5-one
Conditions | Yield |
---|---|
With zinc(II) oxide In ethanol; water at 20℃; for 1.83333h; Reflux; Green chemistry; | 100% |
With ammonium dihydrogen phosphate In ethanol; water at 20℃; for 1.5h; Reflux; | 85% |
With ammonium ferrous sulphate hexahydrate In ethanol; water at 20℃; for 2.33333h; Reflux; Green chemistry; chemoselective reaction; | 85% |
With titanium(IV) oxide In ethanol; water at 20℃; for 2h; Reflux; Green chemistry; | 80% |
Conditions | Yield |
---|---|
With iodine; dimethyl sulfoxide In neat (no solvent) at 80℃; for 5h; | 100% |
With sodium tetrafluoroborate; potassium iodide In acetonitrile at 60℃; for 6h; Temperature; Electrolysis; | 94% |
4-hydroxy[1]benzopyran-2-one
thiophenol
4-hydroxy-3-(phenylsulfanyl)-2H-chromen-2-one
Conditions | Yield |
---|---|
With iodine; dimethyl sulfoxide In neat (no solvent) at 80℃; for 5h; | 100% |
With iodine In dimethyl sulfoxide at 80℃; for 3h; | 92% |
With tetrabutylammomium bromide; iodine; oxygen; bovine serum albumin In water at 50℃; for 8h; Green chemistry; |
Conditions | Yield |
---|---|
With C23H24N2O6S*Li(1+) In tetrahydrofuran; dimethyl sulfoxide at 0℃; for 48h; Reagent/catalyst; Michael Addition; | 99% |
With lipase In water at 50℃; for 168h; Temperature; Michael Addition; Enzymatic reaction; | 99.1% |
With N-ethyl-N,N-diisopropylamine In water for 20h; Michael Addition; Reflux; | 93% |
4-hydroxy[1]benzopyran-2-one
salicylaldehyde
3,3'‑(2‑hydroxyphenylmethylene)bis(4‑hydroxy‑2H‑chromen-2‑one)
Conditions | Yield |
---|---|
With cholin hydroxide In water at 50℃; for 1h; | 99% |
With phosphotungstic acid In water at 80℃; for 0.333333h; domino Knoevenagel type condensation/Michael reaction; | 98% |
With Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H) In ethanol; water for 0.5h; | 98% |
4-hydroxy[1]benzopyran-2-one
(E/Z)-3,7-dimethyl-2,6-octadienal
2-methyl-2-(4-methylpent-3-enyl)-2H,5H-pyrano<3,2-c><1>benzopyran-5-one
Conditions | Yield |
---|---|
With 2,4,8,10-Tetra-tert-butyl-6-hydroxydibenzo[d,f][1,3,2]dioxaphosphepine 6-oxide; sodium sulfate In toluene at 60℃; Inert atmosphere; | 99% |
With 2,4,8,10-Tetra-tert-butyl-6-hydroxydibenzo[d,f][1,3,2]dioxaphosphepine 6-oxide; sodium sulfate In toluene at 60℃; Inert atmosphere; regioselective reaction; | 99% |
With ethylenediamine diacetic acid In methanol for 3h; Ambient temperature; | 70% |
With water at 80℃; for 6h; Domino Knoevenagel/6ϖ-electrocyclization; | 64% |
Conditions | Yield |
---|---|
With 4-(dimethylamino)pyridine hydrochloride In toluene at 60℃; for 4h; | 99% |
Stage #1: 4-hydroxy[1]benzopyran-2-one With manganese(II) iodide; naphthalene; lithium In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Stage #2: acetic anhydride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; | 85% |
With potassium tropolonato In acetonitrile at 70℃; for 4h; | 72% |
4-hydroxy[1]benzopyran-2-one
4-nitrobenzaldehdye
4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)-(4-nitro-phenyl)-methyl]-chromen-2-one
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethylguanidinium acetate at 25℃; for 2h; | 99% |
With copper chromite nanoparticles In water at 20℃; for 0.0166667h; Green chemistry; | 99% |
With 1,4-diazabicyclo[2.2.2]octane hydroacetate In water at 80℃; for 0.0833333h; Green chemistry; | 99% |
4-hydroxy[1]benzopyran-2-one
4-dimethylamino-benzaldehyde
3,3′‐[(4‐dimethylaminophenyl)methylene]bis(4‐hydroxy‐2H‐chromen‐2‐one)
Conditions | Yield |
---|---|
With 2H4N2*2H(1+)*F6Si(2-) In ethanol for 0.0333333h; Reflux; Green chemistry; | 99% |
With glycerol-based carbon sulfonic acid In ethanol; water at 80℃; for 0.25h; | 96% |
With lemon juice In water at 27 - 30℃; for 2.5h; | 96% |
4-hydroxy[1]benzopyran-2-one
4-chlorobenzaldehyde
malononitrile
2-amino-4-(4-chlorophenyl)-4,5-dihydro-5-oxopyrano[3,2-c]chromene-3-carbonitrile
Conditions | Yield |
---|---|
With Lipase from Thermomyces lanuginosus immobilized on particle silica gel In water; dimethyl sulfoxide at 45℃; for 16h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; | 99% |
With urea functionalized silica coated magneticcor shell Fe3-xTixO4 nanoparticle In ethanol; water for 0.25h; Reagent/catalyst; Reflux; | 98% |
With perchloric acid modified cellulose In neat (no solvent) at 70℃; for 0.1h; Green chemistry; | 98% |
Conditions | Yield |
---|---|
With 1,4-diazabicyclo[2.2.2]octane hydroacetate In water at 80℃; for 0.1h; Green chemistry; | 99% |
In ethanol for 24h; Heating; | 97% |
With sulfonic acid-functionalized mesoporous silica nanoparticles In water at 80℃; for 0.25h; Green chemistry; | 95% |
Conditions | Yield |
---|---|
With 1,4-diazabicyclo[2.2.2]octane hydroacetate In water at 80℃; for 0.0833333h; Green chemistry; | 99% |
With sulfuric acid-modified polyethyleneglycol-6000 In neat (no solvent) at 70℃; for 0.0666667h; Knoevenagel Condensation; Green chemistry; | 98% |
In water at 150℃; for 0.166667h; Microwave irradiation; | 86% |
Conditions | Yield |
---|---|
With cholin hydroxide In water at 50℃; for 1h; | 99% |
With phosphotungstic acid In water at 80℃; for 0.25h; domino Knoevenagel type condensation/Michael reaction; | 98% |
With sulfonic acid-functionalized mesoporous silica nanoparticles In water at 80℃; for 0.166667h; Green chemistry; | 98% |
Conditions | Yield |
---|---|
With 1,4-diazabicyclo[2.2.2]octane hydroacetate In water at 80℃; for 0.0333333h; Green chemistry; | 99% |
With Triton X-100 In water at 20℃; for 6h; Knoevenagel Condensation; Green chemistry; | 98% |
In toluene at 90℃; for 0.25h; Reagent/catalyst; | 98% |
4-hydroxy[1]benzopyran-2-one
butyraldehyde
3,3'-(butane-1,1-diyl)bis(4-hydroxy-2H-chromen-2-one).
Conditions | Yield |
---|---|
With 1,4-diazabicyclo[2.2.2]octane hydroacetate In water at 80℃; for 0.1h; Green chemistry; | 99% |
With poly(2-acrylamido-2-methylpropanesulphonic acid-co-acrylamide) supported on magnetite nanoparticles In toluene at 90℃; for 0.55h; | 94% |
In toluene at 90℃; for 0.5h; Reagent/catalyst; | 94% |
Conditions | Yield |
---|---|
With Trametes versicolor laccase; oxygen In acetate buffer at 20℃; for 3h; pH=4.37; | 99% |
With laccase from Trametes versicolor at 20℃; for 3h; pH=4.4; aq. acetate buffer; Enzymatic reaction; regioselective reaction; | 99% |
With sodium acetate; potassium hexacyanoferrate(III) In water for 1h; Michael addition reaction; | 95% |
With laccase In aq. phosphate buffer at 20℃; for 24h; pH=7.15; Enzymatic reaction; | 76% |
Conditions | Yield |
---|---|
at 80℃; for 2h; | 99% |
With silica supported zirconium hydrogen sulfate In neat (no solvent) at 60℃; for 0.75h; | 99% |
With TiO2-carbon nanotubes nanocomposite In water at 20℃; for 2h; Green chemistry; | 98% |
isoquinoline
4-hydroxy[1]benzopyran-2-one
Cyclohexyl isocyanide
C25H24N2O3
Conditions | Yield |
---|---|
In water at 70℃; for 12h; | 99% |
4-hydroxy[1]benzopyran-2-one
2-octen-1-al
C17H18O3
Conditions | Yield |
---|---|
With 2,4,8,10-Tetra-tert-butyl-6-hydroxydibenzo[d,f][1,3,2]dioxaphosphepine 6-oxide; sodium sulfate In toluene at 60℃; Inert atmosphere; regioselective reaction; | 99% |
4-hydroxy[1]benzopyran-2-one
(E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one
(4R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)-3,4-dihydropyrano[3,2-c]chromen-5-(2H)one
Conditions | Yield |
---|---|
With C29H29F6N3OS In toluene for 5h; Michael addition; optical yield given as %ee; enantioselective reaction; | 99% |
4-hydroxy[1]benzopyran-2-one
methyl benzylidenepyruvate
Conditions | Yield |
---|---|
With C29H29F6N3OS In diethyl ether at 20℃; for 2h; Michael addition; optical yield given as %ee; enantioselective reaction; | 99% |
With C37H31F6N3S at 20℃; for 12h; Solvent; Michael Addition; enantioselective reaction; | 92% |
Reported in EPA TSCA Inventory.
1.Introduction of 4-Hydroxycoumarin
The 4-Hydroxycoumarin, with the CAS NO of 1076-38-6, is a kind of White crystal. It has synonyms of 4-Hydroxy-2H-1-benzopyran-2-one;Benzotetronic acid;2H-1-Benzopyran-2-one,4-hydroxy-;Coumarin, 4-hydroxy-;4-Coumarinol;2-hydroxychromen-4-one;Coumarin, 4-hydroxy- (8CI) and 2H-1-Benzopyran-2-one, 4-hydroxy-. 4-Hydroxycoumarin should be stored in shady and cool warehouse and mainly used as pharmaceutical Intermediates.
2.Properties of 4-Hydroxycoumarin
(1) Nominal Mass: 162 Da (2) Average Mass: 162.1421 Da (3) Monoisotopic Mass: 162.031694 Da
(4) Index of Refraction: 1.66 (5) Molar Refractivity: 41.353 cm3 (6) Molar Volume: 112.076 cm3
(7) Surface Tension: 65.563 dyne/cm (8) Density: 1.447 g/cm3 (9) Flash Point: 165.353 °C
(10) Enthalpy of Vaporization: 63.022 kJ/mol (11) Boiling Point: 352.41 °C at 760 mmHg (12) Vapour Pressure: 0 mmHg at 25°C
3.Structure descriptors of 4-Hydroxycoumarin
IUPAC Name: 4-hydroxychromen-2-one
InChI: InChI=1S/C9H6O3/c10-7-5-9(11)12-8-4-2-1-3-6(7)8/h1-5,10H
InChIKey: VXIXUWQIVKSKSA-UHFFFAOYSA-N
Canonical SMILES : C1=CC=C2C(=C1)C(=CC(=O)O2)O
4.Safety information of 4-Hydroxycoumarin
Hazard Codes: XnXi
Risk Statements: 22-36/37/38
R22: Harmful if swallowed
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
WGK Germany: 3
RTECS: DJ3100000
Hazard Note: Irritant
5.Toxity information of 4-Hydroxycoumarin
1. | orl-mus LD50:2 g/kg | MPHEAE Medicina et Pharmacologia Experimentalis. 17 (1967),497. | ||
2. | ipr-mus LD50:2000 mg/kg | APTOA6 Acta Pharmacologica et Toxicologica. 2 (1946),109. | ||
3. | scu-mus LD50:750 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 128 (1960),126. |
Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. When heated to decomposition it emits acrid smoke and fumes.
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