4-Hydroxyphenethyl alcohol supplier

Name
4-Hydroxyphenethyl alcohol
EINECS 207-930-8
CAS No. 501-94-0
Article Data94
CAS DataBase
Density 1.168 g/cm³
Solubility slightly soluble in water
Melting Point 89-92 °C(lit.)
Formula C₈H₁₀O₂
Boiling Point 287.8 °C at 760 mmHg
Molecular Weight 138.166
Flash Point 143.2 °C
Transport Information
Appearance off-white to light beige crystals or crystalline
Safety 26-37/39-24/25-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Phenethylalcohol, p-hydroxy- (7CI,8CI);Tyrosol (6CI);2-(4-Hydroxyphenyl)ethanol;2-(4-Hydroxyphenyl)ethyl alcohol;2-(p-Hydroxyphenyl)ethanol;4-(2-Hydroxyethyl)phenol;Benzeneethanol,4-hydroxy-;NSC 59876;Tyrosol C;p-(2-Hydroxyethyl)phenol;p-HPEA;p-Hydroxyphenethylalcohol;p-Tyrosol;b-(4-Hydroxyphenyl)ethanol;b-(p-Hydroxyphenyl)ethanol;4-Hydroxyphenylethanol;
PSA 40.46000
LogP 0.92700

Synthetic route

: 156-38-7
4-hydroxyphenylacetate

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate; Trimethyl borate; dimethyl sulfate In tetrahydrofuran at 20℃; for 1.5h;	98%
With sodium tetrahydroborate; iodine In tetrahydrofuran for 2h; Heating;	88%
With lithium aluminium tetrahydride In tetrahydrofuran at 67℃; for 2.5h;	88%

: 7400-08-0
p-Coumaric Acid

A: 156-38-7
4-hydroxyphenylacetate

B: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With β-D-glucose; oxygen for 18h; Reagent/catalyst; Enzymatic reaction;	A n/a B 97.3%

: 1-methylsulfanylmethoxy-4-(2-methylsulfanylmethoxy-ethyl)-benzene

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With methanol; iodine at 50℃; for 3.5h;	96%

: 1-(2-methoxy-ethoxymethoxy)-4-[2-(2-methoxy-ethoxymethoxy)-ethyl]-benzene

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With methanol; iodine at 50℃; for 48h;	96%

: 96013-68-2
tert-butyl(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenoxy)dimethylsilane

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With methanol; trimethylsilyl bromide at 20℃; for 5h; chemoselective reaction;	95%
With antimonypentachloride; water In acetonitrile at 20℃; for 0.166667h;	92%
With iron(III) p-toluenesulfonate hexahydrate In methanol for 26.25h; Reflux;	84%

: 1-(2-trimethylsilanyl-ethoxymethoxy)-4-[2-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-benzene

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With methanol; iodine at 50℃; for 10h;	95%

: 1-methoxymethoxy-4-(2-methoxymethoxy-ethyl)-benzene

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With methanol; iodine at 50℃; for 34h;	94%

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With methanol; Na/SiO2 In tetrahydrofuran at 0 - 25℃; Bouveault-Blanc reduction; Inert atmosphere;	93%
With 5 wt% Re/TiO2; hydrogen In octane at 200℃; under 37503.8 Torr; for 24h; Autoclave; chemoselective reaction;	91%
With sodium tetrahydroborate In water for 8h; Ambient temperature;	90%

: 14140-15-9
4-(2-bromoethyl)phenol

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
Stage #1: 4-(2-bromoethyl)phenol With sodium acetate In water for 3h; Reflux; Stage #2: With sodium hydroxide In water for 0.5h; Inert atmosphere; Reflux;	88%

: 2-[4-(4-nitro-benzyloxy)-phenyl]-ethanol

A: 501-94-0
p-hydroxyphenethyl alcohol

B: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With magnesium In methanol at 20℃; for 10h;	A 83% B n/a

: 1223454-88-3
4-[2-(2-chloroacetyl)oxoethyl]phenyl-2-chloroacetate

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at 0 - 20℃; Inert atmosphere;	81%

: C14H18O6

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at 20℃; for 1h;	81%

: 1-methoxymethoxy-4-(2-methoxymethoxy-ethyl)-benzene

A: 501-94-0
p-hydroxyphenethyl alcohol

B: 4-(2-methoxymethoxy-ethyl)-phenol

Conditions

Conditions	Yield
sodium hydrogen sulfate; silica gel In dichloromethane at 20℃; for 1.5h;	A 12% B 76%

: 14199-15-6
Methyl 4-hydroxyphenylacetate

A: 501-94-0
p-hydroxyphenethyl alcohol

B: 7339-87-9
4-hydroxyphenylacetaldehyde

Conditions

Conditions	Yield
With diisobutylaluminium hydride In toluene at -78℃; for 5h;	A 10% B 75%

: 3673-68-5
2-(3,5-di-t-butyl-4-hydroxyphenyl)ethanol

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
at 285 - 295℃; for 19h; Inert atmosphere;	72%

: 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-diphenyl-silanyloxy)-benzene

A: 501-94-0
p-hydroxyphenethyl alcohol

B: 96013-93-3
2-[4'-(tert-butyldiphenylsilyloxy)phenyl]ethanol

Conditions

Conditions	Yield
With bismuth oxide perchlorate In dichloromethane at 45℃; for 3h;	A n/a B 65%

: 3673-68-5
2-(3,5-di-t-butyl-4-hydroxyphenyl)ethanol

A: 106-44-5
p-cresol

B: 13196-10-6
benzofuran-5-ol

C: 123-07-9
4-Ethylphenol

D: 501-94-0
p-hydroxyphenethyl alcohol

E: 1240059-73-7
1-[4-(2-hydroxyethyl)phenoxy]-2-(4'-hydroxyphenyl)ethane

F: 501123-58-6
di[2-(4-hydroxyphenyl)]ethyl ether

G: C24H34O3

H: 117516-54-8
6-tert-butyl-5-hydroxybenzofuran

I: 108-95-2
phenol

Conditions

Conditions	Yield
at 295 - 298℃; for 22h; Inert atmosphere;	A n/a B n/a C n/a D 55% E n/a F 40 g G n/a H n/a I n/a

...Expand

: 67-56-1
methanol

: 4-(trimethylsilylmethyl)phenyl methanesulfonate

A: 106-44-5
p-cresol

B: 501-94-0
p-hydroxyphenethyl alcohol

C: 617-94-7
1-methyl-1-phenylethyl alcohol

D: 60-12-8
2-phenylethanol

E: 17177-63-8
4-tolyl mesylate

Conditions

Conditions	Yield
With acetone Irradiation; Inert atmosphere;	A n/a B 8% C 8% D 8% E 23%

...Expand

: 51-67-2
tyrosamine

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With yeast

: 6631-69-2
4-hydroxy-phenethyl iodide

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With water; silver(l) oxide

: 28145-35-9
4-(2-chloroethyl)phenol

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With sodium acetate; acetic acid Erwaermen des Reaktionsprodukts mit Natronlauge;

: 539-15-1
N,N-dimethyltyramine

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With yeast

: 156-39-8
4-Hydroxyphenylpyruvic acid

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With yeast
Multi-step reaction with 2 steps 1: aq. phosphate buffer / 37 °C / Green chemistry; Enzymatic reaction 2: aq. phosphate buffer / 37 °C / Green chemistry; Enzymatic reaction View Scheme

: 60-18-4
L-tyrosine

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With vinegar bacteria
Stage #1: L-tyrosine With recombinant parsley (Petroselinum crispum) aromatic acetaldehyde synthese Q06086 at 25℃; for 1h; pH=6.8; aq. phosphate buffer; Enzymatic reaction; Stage #2: With sodium tetrahydroborate In ethanol at 25℃; for 0.0833333h;
Multi-step reaction with 3 steps 1: aq. phosphate buffer / 37 °C / Green chemistry; Enzymatic reaction 2: aq. phosphate buffer / 37 °C / Green chemistry; Enzymatic reaction 3: aq. phosphate buffer / 37 °C / Green chemistry; Enzymatic reaction View Scheme

: 556-02-5, 556-03-6, 34537-57-0, 55520-40-6, 96946-98-4, 60-18-4
›Tyr

: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
durch gaerende Hefe;
bei der Hefegaerung;
With lactic acid bacteria
Einw. von lebender Hefe bei der alkohol. Vergaerung des Zuckers;
Multi-step reaction with 2 steps 1: 270 °C / 12 - 25 Torr 2: yeast View Scheme

: 67-56-1
methanol

: 97549-57-0, 94492-23-6
osmanthuside B

A: 501-94-0
p-hydroxyphenethyl alcohol

B: 3943-97-3
methyl 4-hydroxycinnamate

Conditions

Conditions	Yield
With acetyl chloride for 0.5h; Heating;

...Expand

: 67-56-1
methanol

: 142998-21-8
fraxiformoside

A: 501-94-0
p-hydroxyphenethyl alcohol

B: 108789-18-0
isoligustroside

Conditions

Conditions	Yield
for 40h; Heating;	A 13.8 mg B 53.2 mg

...Expand

: 35897-92-8
ligstroside

A: 2280-44-6
D-Glucose

B: 501-94-0
p-hydroxyphenethyl alcohol

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 60℃; for 2h;	A n/a B 2 mg

: 94414-03-6
4-[2-(acetyloxy)ethyl]-4-hydroxy-2,5-cyclohexadien-1-one

A: 501-94-0
p-hydroxyphenethyl alcohol

B: 93675-85-5, 101489-38-7
rengyol

C: 101489-38-7
trans-1-(2-hydroxyethyl)cyclohexane-1,4-diol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol Ambient temperature;	A 25 mg B 15 mg C 11 mg

...Expand

: 501-94-0
p-hydroxyphenethyl alcohol

: 14140-15-9
4-(2-bromoethyl)phenol

Conditions

Conditions	Yield
With PS-triphenylphosphine; bromine In dichloromethane at 0℃; for 1h;	100%
With diphenylphosphino-polystyrene; carbon tetrabromide In dichloromethane at 40℃; for 3.5h;	100%
With hydrogen bromide In water at 80℃; for 16h;	100%

: 108-05-4
vinyl acetate

: 501-94-0
p-hydroxyphenethyl alcohol

: 58556-55-1
2-(4-hydroxyphenyl)ethyl acetate

Conditions

Conditions	Yield
With Candida cylindracea lipase In hexane for 4h;	100%
With Candida antartica lipase B In tetrahydrofuran at 20℃; for 4h; Enzymatic reaction; chemoselective reaction;	100%
With 1,3-dichlorotetrabutyldistannoxane In tetrahydrofuran at 30℃; for 24h;	99%

: 501-94-0
p-hydroxyphenethyl alcohol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 96013-68-2
tert-butyl(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenoxy)dimethylsilane

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 3h;	100%
With 1H-imidazole In N,N-dimethyl-formamide Ambient temperature;	89%
With 1H-imidazole In dichloromethane; N,N-dimethyl-formamide

: 501-94-0
p-hydroxyphenethyl alcohol

: 10597-60-1
hydroxytyrosol

Conditions

Conditions	Yield
With polymer-supported IBX In dimethyl carbonate at 20℃; for 1h; chemoselective reaction;	100%
With β-D-glucose; oxygen In aq. phosphate buffer at 37℃; pH=7.0; Enzymatic reaction;	97.5%
Stage #1: p-hydroxyphenethyl alcohol at 20℃; for 1h; Stage #2: With sodium dithionite; water for 0.5h;	90%

: 501-94-0
p-hydroxyphenethyl alcohol

: 106-89-8
epichlorohydrin

: 104857-48-9
1-[4-(2-hydroxyethyl)phenoxy]-2,3-epoxypropane

Conditions

Conditions	Yield
With potassium carbonate In toluene; acetonitrile	100%
With potassium carbonate In butanone for 15h; Heating;	86%
Stage #1: p-hydroxyphenethyl alcohol; epichlorohydrin at 80℃; for 1h; Stage #2: With sodium hydroxide at 20℃;	74%

: 501-94-0
p-hydroxyphenethyl alcohol

: 616-38-6
carbonic acid dimethyl ester

: 953422-33-8
2-(4'-hydroxyphenyl)ethyl methyl carbonate

Conditions

Conditions	Yield
With sulfuric acid for 7h; Reflux;	100%
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; for 7.5h;	100%
With Amberlyst 15 for 12h; Reflux;	99%

: 501-94-0
p-hydroxyphenethyl alcohol

: 541-41-3
chloroformic acid ethyl ester

: 1119076-06-0
carbonic acid ethyl ester 4-(2-hydroxy-ethyl)-phenyl ester

Conditions

Conditions	Yield
With triethylamine In acetonitrile at -80 - 20℃; Inert atmosphere;	100%
With sodium hydroxide In water at -5 - 20℃; for 5h;	92%
With sodium hydroxide at -5 - 50℃; for 5h;	92%
With sodium hydroxide In water at -5 - 20℃; for 6h;	83.3%

: 501-94-0
p-hydroxyphenethyl alcohol

: 616-38-6
carbonic acid dimethyl ester

: 1796-64-1
4-methoxyphenethyl methyl carbonate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; for 24h;	100%

: 123-20-6
vinyl n-butyrate

: 501-94-0
p-hydroxyphenethyl alcohol

: 386263-87-2
2-(4-hydroxylphenyl)ethyl butyrate

Conditions

Conditions	Yield
With Candida antartica lipase B In tetrahydrofuran at 20℃; for 4h; Enzymatic reaction; chemoselective reaction;	100%
With Novozym 435 at 40℃; for 1h; Enzymatic reaction;

: 501-94-0
p-hydroxyphenethyl alcohol

: 611-19-8
1-chloro-2-(chloromethyl)benzene

: 1228930-61-7
2-(4-(2-chlorobenzyloxy)phenyl)ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 24h; Reflux;	100%

: 501-94-0
p-hydroxyphenethyl alcohol

: 64-19-7
acetic acid

: 58556-55-1
2-(4-hydroxyphenyl)ethyl acetate

Conditions

Conditions	Yield
With Candida antarctica at 45℃; for 24h;	100%
With Candida antarctica lipase B at 45℃; for 24h; Enzymatic reaction;	100%
With lipase from Staphylococcus xylosus immobilized onto CaCO3 for 120h; Enzymatic reaction;
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 48h; Inert atmosphere;

: 501-94-0
p-hydroxyphenethyl alcohol

: 802294-64-0
propionic acid

: 2′-(4-hydroxyphenyl)ethylpropanoate

Conditions

Conditions	Yield
With Candida antarctica at 45℃; for 24h;	100%
With lipase from Staphylococcus xylosus immobilized onto CaCO3 for 120h; Enzymatic reaction;
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 48h; Inert atmosphere;

: 3377-92-2
vinyl pivalate

: 501-94-0
p-hydroxyphenethyl alcohol

: 141923-61-7
4-(2-hydroxyethyl)phenyl pivalate

Conditions

Conditions	Yield
With rubidium fluoride In acetonitrile at 80℃; for 3h; regiospecific reaction;	100%

: 406-95-1
2,2,2-trifluoroethyl acetate

: 501-94-0
p-hydroxyphenethyl alcohol

: 58556-55-1
2-(4-hydroxyphenyl)ethyl acetate

Conditions

Conditions	Yield
With cesium fluoride In acetonitrile at 80℃; for 24h; Reagent/catalyst;	100%

: 501-94-0
p-hydroxyphenethyl alcohol

: 107-92-6
butyric acid

: 386263-87-2
2-(4-hydroxylphenyl)ethyl butyrate

Conditions

Conditions	Yield
With Candida antarctica at 45℃; for 24h;	100%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 24h;

: 501-94-0
p-hydroxyphenethyl alcohol

: 109-52-4
valeric acid

: tyrosol pentanoate

Conditions

Conditions	Yield
With Candida antarctica at 45℃; for 24h;	100%

: 501-94-0
p-hydroxyphenethyl alcohol

: 78-93-3
butanone

: 2′-(4-hydroxyphenyl)ethylpropanoate

Conditions

Conditions	Yield
With Candida antarctica lipase B at 45℃; for 24h; Enzymatic reaction;	100%

: 501-94-0
p-hydroxyphenethyl alcohol

: 107-87-9
2-Pentanone

: 386263-87-2
2-(4-hydroxylphenyl)ethyl butyrate

Conditions

Conditions	Yield
With Candida antarctica lipase B at 45℃; for 24h; Enzymatic reaction;	100%

: 591-78-6
n-hexan-2-one

: 501-94-0
p-hydroxyphenethyl alcohol

: tyrosol pentanoate

Conditions

Conditions	Yield
With Candida antarctica lipase B at 45℃; for 24h; Enzymatic reaction;	100%

: 501-94-0
p-hydroxyphenethyl alcohol

: 100-39-0
benzyl bromide

: 61439-59-6
2-(4-benzyloxyphenyl)ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 18h; Heating;	99.3%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	98%
With potassium carbonate In acetone Reflux;	98%

: 501-94-0
p-hydroxyphenethyl alcohol

: 108-24-7
acetic anhydride

: 60037-42-5
2-(4-acetoxyphenyl)ethyl acetate

Conditions

Conditions	Yield
With pyridine at 20℃; for 24h; Inert atmosphere;	99%
cerium triflate In acetonitrile at 20℃; for 0.2h;	98%
With tributylphosphine at 30℃; for 4h; other reagents: Sc(OTf)3, 4-(dimethylamino)pyridine/pyridine;	95%

: 501-94-0
p-hydroxyphenethyl alcohol

: 100-44-7
benzyl chloride

: 61439-59-6
2-(4-benzyloxyphenyl)ethanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 65℃; for 24h;	99%
Stage #1: p-hydroxyphenethyl alcohol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: benzyl chloride With tetra-(n-butyl)ammonium iodide at 20℃; for 18h;	88%
In ethanol for 9h; Heating;

: 501-94-0
p-hydroxyphenethyl alcohol

: 10472-24-9
methyl 2-oxocyclopentane-1-carboxylate

: 2-oxo-cyclopentanecarboxylic acid 2-(4-hydroxy-phenyl)-ethyl ester

Conditions

Conditions	Yield
With N,N-3-diethylaminopropylated silica gel In xylene for 3h; Heating;	99%

: 501-94-0
p-hydroxyphenethyl alcohol

: 74058-21-2
4-(2-Hydroxyethyl)cyclohexanol

Conditions

Conditions	Yield
With borax; hydrogen; palladium 10% on activated carbon In isopropyl alcohol at 80℃; under 7500.75 Torr; for 22h;	99%

: 3-[4-(4-allyloxycarbonylmethylphenoxy)piperidine-1-carbonyl]-1-methyl-3H-imidazol-1-ium iodide

: 501-94-0
p-hydroxyphenethyl alcohol

: 4-(tert-butyldimethylsilanyloxy)piperidine-1-carboxylic acid 4-(2-hydroxyethyl)phenyl ester

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane at 20℃; for 16h;	99%

: 501-94-0
p-hydroxyphenethyl alcohol

: 6631-69-2
4-hydroxy-phenethyl iodide

Conditions

Conditions	Yield
With chloro-trimethyl-silane; sodium iodide In acetonitrile at 70℃; for 16h;	99%
With chloro-trimethyl-silane; sodium iodide In acetonitrile at 70℃; for 24h; Inert atmosphere;	95%
With 1H-imidazole; iodine; triphenylphosphine In diethyl ether; acetonitrile at 20℃; for 4h;	91%
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 0 - 20℃; Inert atmosphere;	70%
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 20℃; for 4h;

: 501-94-0
p-hydroxyphenethyl alcohol

: 2131-61-5
p-nitrophenyl isothiocyanate

: 1033617-70-7
C15H14N2O4S

Conditions

Conditions	Yield
Stage #1: p-hydroxyphenethyl alcohol With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: p-nitrophenyl isothiocyanate In tetrahydrofuran at 20℃; for 18h; Further stages.;	99%

: 501-94-0
p-hydroxyphenethyl alcohol

: 1579-72-2
2,2,2-trifluoroethyl benzoate

: 2-(4-hydroxyphenyl)ethyl benzoate

Conditions

Conditions	Yield
With (μ-oxo)bis[(1,2-ethanediamino-N,N'-bis(salicylidene))iron(III)] In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;	99%

: 501-94-0
p-hydroxyphenethyl alcohol

: 141-78-6
ethyl acetate

: 58556-55-1
2-(4-hydroxyphenyl)ethyl acetate

Conditions

Conditions	Yield
With sodium hydrogen sulfate In hexane for 26h; Heating;	98%
With sodium hydrogen sulfate; silica gel In hexane Heating;	98%
With toluene-4-sulfonic acid at 80℃; for 5h; Reagent/catalyst; Temperature;	98.9%

: 501-94-0
p-hydroxyphenethyl alcohol

: 30320-27-5
perfluoro(4-methyl-3-isopropyl-2-pentene)

: 4-(perfluoro(4-methyl-3-isopropyl-2-penten-2-yl))oxyphenylethanol

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran for 4h; Inert atmosphere; Reflux;	98.6%

4-Hydroxyphenethyl alcohol Chemical Properties

Molecule structure of 4-Hydroxyphenethyl alcohol (CAS NO.501-94-0):

IUPAC Name: 4-(2-Hydroxyethyl)phenol
Molecular Weight: 138.1638 g/mol
Molecular Formula: C₈H₁₀O₂
Density: 1.168 g/cm³
Melting Point: 89-92 °C(lit.)
Boiling Point: 287.8 °C at 760 mmHg
Flash Point: 143.2 °C
Index of Refraction: 1.577
Molar Refractivity: 39.21 cm³
Molar Volume: 118.1 cm³
Surface Tension: 50.8 dyne/cm
Enthalpy of Vaporization: 55.66 kJ/mol
Vapour Pressure: 0.00113 mmHg at 25 °C
Water Solubility: slightly soluble
XLogP3: 0.4
H-Bond Donor: 2
H-Bond Acceptor: 2
Rotatable Bond Count: 2
Tautomer Count: 2
Exact Mass: 138.06808
MonoIsotopic Mass: 138.06808
Topological Polar Surface Area: 40.5
Heavy Atom Count: 10
Canonical SMILES: C1=CC(=CC=C1CCO)O
InChI: InChI=1S/C8H10O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,9-10H,5-6H2
InChIKey: YCCILVSKPBXVIP-UHFFFAOYSA-N
EINECS: 207-930-8
Product Categories: Alcohols and Derivatives; Benzhydrols, Benzyl & Special Alcohols; Benzene derivates; Alkohols; API intermediates

4-Hydroxyphenethyl alcohol Uses

4-Hydroxyphenethyl alcohol (CAS NO.501-94-0) is used as pharmaceutical intermediates.

4-Hydroxyphenethyl alcohol Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39-24/25-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 10
Hazard Note: Irritant
HS Code: 29072900

4-Hydroxyphenethyl alcohol Specification

4-Hydroxyphenethyl alcohol (CAS NO.501-94-0) is also named as 2-(4-Hydroxyphenyl)ethanol ; NSC 59876 ; p-Hydroxyphenethyl alcohol ; 4-Hydroxyphenethyl alcohol ; Benzeneethanol, 4-hydroxy- . 4-Hydroxyphenethyl alcohol (CAS NO.501-94-0) is off-white to light beige crystals or crystalline.

Product Name

4-Hydroxyphenethyl alcohol

Synthetic route

4-Hydroxyphenethyl alcohol Chemical Properties

4-Hydroxyphenethyl alcohol Uses

4-Hydroxyphenethyl alcohol Safety Profile

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