4-Methylmorpholine N-oxide supplier

Name
4-Methylmorpholine N-oxide
EINECS 231-391-8
CAS No. 7529-22-8
Article Data40
CAS DataBase
Density 1,14 g/cm³
Solubility Soluble in water, methanol, ethanol, acetone, ethers and dimethylsulfoxide.
Melting Point 180-184 °C
Formula C₅H₁₁NO₂
Boiling Point 118-119 °C
Molecular Weight 117.148
Flash Point 118-119ºC
Transport Information
Appearance Clear colorless to yellow solution
Safety 26-36/37
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 4-Methylmorpholine4-oxide;4-Methylmorpholine oxide;N-Methylmorpholine N-oxide;N-Methylmorpholine oxide;N-methylmorpholineN-oxide;NMMO;NMO;NSC 73198;NSC 82153;4-Methylmorpholine N-oxide;
PSA 38.66000
LogP -0.08020

Synthetic route

: 109-02-4
4-methyl-morpholine

: 7529-22-8
4-methylmorpholine N-oxide

Conditions

Conditions	Yield
With 4-hydroperoxy-5-ethyl-3-methyllumiflavine In tert-butyl alcohol at 30℃; Rate constant;	100%
With carbon dioxide; phosphoric acid; dihydrogen peroxide under 7500.75 Torr; for 0.133333h; Reagent/catalyst; Pressure; Time; Autoclave;	100%
With dihydrogen peroxide; benzonitrile; Mg-Al-O-t-Bu HT (Catalyst B) In methanol; water at 65℃; for 0.5h; Product distribution / selectivity;	98%

: 109-02-4
4-methyl-morpholine

: 76847-41-1
3-bromo-4,5-dihydro-5-hydroperoxy-4,4-dimethyl-3,5-diphenyl-3H-pyrazole

A: 76847-42-2
3-bromo-4,5-dihydro-5-hydroxy-4,4-dimethyl-3,5-diphenyl-3H-pyrazole

B: 7529-22-8
4-methylmorpholine N-oxide

Conditions

Conditions	Yield
In chloroform-d1 at 34℃; Rate constant;	A n/a B 95 % Spectr.

...Expand

: 109-02-4
4-methyl-morpholine

: 72229-10-8
cis-3-bromo-4,5-dihydro-5-hydroperoxy-4,4-dimethyl-3,5-diphenyl-3H-pyrazole

: 7529-22-8
4-methylmorpholine N-oxide

Conditions

Conditions	Yield
In chloroform at 34℃; Rate constant; Mechanism; other α-azo hydroperoxides; oxidation of other amines, PhS, and olefins; var. solvents, deuterium isotope effect;

: 109-02-4
4-methyl-morpholine

: 107743-45-3
C17H16(2)HBrN2O2

: 7529-22-8
4-methylmorpholine N-oxide

Conditions

Conditions	Yield
In chloroform at 34℃; Rate constant; Mechanism; other α-azo hydroperoxides; oxidation of other amines, Ph2S, and olefins; var. solvent, deuterium isotope effect;

: 4-[6-hydroxy-2,7,8-trimethyl-2-(4,8,12-trimethyl-tridecyl)-chroman-5-ylmethyl]-4-methyl-morpholin-4-ium; iodide

: 7529-22-8
4-methylmorpholine N-oxide

Conditions

Conditions	Yield
With sodium percarbonate In hexane; dichloromethane; acetonitrile at 50℃; for 1h; Substitution; Oxidation;

: 201609-30-5
2a-(4-Pentenyl)-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

: 7529-22-8
4-methylmorpholine N-oxide

: 201609-31-6
2a-(3-Formylpropyl)-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

Conditions

Conditions	Yield
With sodium periodate; osmium(VIII) oxide In 1,4-dioxane; water	100%

: 7529-22-8
4-methylmorpholine N-oxide

: 180977-02-0
N-[4-nitro-2-phenylbenzoyl]-methionine methyl ester

: 4-Nitro-2-phenylbenzoyl-[1'(S)-ethoxycarbonyl-3'-methylsulfonyl]propyl amide

Conditions

Conditions	Yield
With osmium(VIII) oxide In water; acetone; tert-butyl alcohol	100%

: 7529-22-8
4-methylmorpholine N-oxide

: 77-78-1
dimethyl sulfate

: N-methoxy-N-methylmorpholinium methyl sulfate

Conditions

Conditions	Yield
In acetonitrile	100%

: 64-67-5
diethyl sulfate

: 7529-22-8
4-methylmorpholine N-oxide

: N-ethoxy-N-methylmorpholinium ethyl sulfate

Conditions

Conditions	Yield
In acetonitrile for 24h;	100%

2,6-anhydro-3-azido-1,4-di-O-benzyl-3,5-dideoxy-D-arabino-hex-5-enitol: 2,6-anhydro-3-azido-1,4-di-O-benzyl-3,5-dideoxy-D-arabino-hex-5-enitol

: 7529-22-8
4-methylmorpholine N-oxide

: 4-azido-4-deoxy-3,6-di-O-benzyl-D-galactopyranose

Conditions

Conditions	Yield
Stage #1: 2,6-anhydro-3-azido-1,4-di-O-benzyl-3,5-dideoxy-D-arabino-hex-5-enitol With osmium(VIII) oxide; water In tetrahydrofuran; tert-butyl alcohol at 20℃; for 0.5h; Stage #2: 4-methylmorpholine N-oxide In tetrahydrofuran; tert-butyl alcohol for 28.5h;	100%

: C18H32GeN2SSi

: 7529-22-8
4-methylmorpholine N-oxide

: C18H32GeN2OSSi

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 12h;	97%

Resin-OsO4: Resin-OsO4

Hydroquinidine 1,4-phthalazinediyl diether (DHQD)2PHAL: Hydroquinidine 1,4-phthalazinediyl diether (DHQD)2PHAL

Resin-OsO4(0.01 eq wt): Resin-OsO4(0.01 eq wt)

: 103-30-0
(E)-1,2-diphenyl-ethene

: 7529-22-8
4-methylmorpholine N-oxide

: 52340-78-0
(R,R)-hydroxybenzoin

Conditions

Conditions	Yield
In water; acetone	96%
In water; acetone	96%

...Expand

: 103-30-0
(E)-1,2-diphenyl-ethene

: 7529-22-8
4-methylmorpholine N-oxide

: 52340-78-0
(R,R)-hydroxybenzoin

Conditions

Conditions	Yield
In water; acetone	96%

: 224309-64-2
tert-butyl N-(4-hydroxycyclohexyl)carbamate

: 114615-82-6
tetrapropylammonium perruthennate

: 7529-22-8
4-methylmorpholine N-oxide

: 179321-49-4
N-(tert-butoxycarbonyl)-4-aminocyclohexanone

Conditions

Conditions	Yield
molecular sieves In dichloromethane; ethyl acetate	96%

...Expand

: 69517-44-8
trismethyluranium

: 7529-22-8
4-methylmorpholine N-oxide

: C19H57N3OSi6U

Conditions

Conditions	Yield
In diethyl ether at -21℃; for 0.5h; Inert atmosphere;	96%

: benzyl cyclopent-3-enyl(methyl)carbamate

: 7529-22-8
4-methylmorpholine N-oxide

A: 1225384-36-0
benzyl (1S,3R,4S)-3,4-dihydroxycyclopentyl(methyl)carbamate

B: C14H19NO4

Conditions

Conditions	Yield
With osmium(VIII) oxide In water; acetone; tert-butyl alcohol at 20℃;	A 96% B n/a

...Expand

: 143-66-8
sodium tetraphenyl borate

: 7529-22-8
4-methylmorpholine N-oxide

: C24H20B(1-)*C5H12NO2(1+)

Conditions

Conditions	Yield
With acetic acid In water at 20℃; for 0.25h;	96%

: 7-(6-exo-(methoxymethoxy)-3-phenyl-3a-(1-phenylvinyl)-1,3a,4,5,6,6a-hexahydropentalen-2-yl)heptan-1-ol

: 7529-22-8
4-methylmorpholine N-oxide

: C32H40O4

Conditions

Conditions	Yield
With tetrapropylammonium perruthennate In water; acetonitrile	96%

: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

: 7529-22-8
4-methylmorpholine N-oxide

: 448953-11-5
N-{3-[[4-(allyloxy)benzyl](benzyl)amino]-2-methylphenyl}methanesulfonamide

: N-(3-{benzyl[4-(2,3-dihydroxypropoxy)benzyl]amino}-2-methylphenyl)methanesulfonamide

Conditions

Conditions	Yield
With sodium hydrogen sulfate; osmium(VIII) oxide In water; ethyl acetate; acetone; tert-butyl alcohol	95%

...Expand

: C33H38GeN2OSi

: 7529-22-8
4-methylmorpholine N-oxide

: C66H76Ge2N4O4Si2

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 18h;	95%

: 114615-82-6
tetrapropylammonium perruthennate

: 7529-22-8
4-methylmorpholine N-oxide

: 220367-72-6
(4S)-4-(2-methyl-3(RS)-hydroxybut-2-yl)-2,2-dimethyl[1,3]dioxane

: 220367-71-5
(4S)-4-(2-methyl-3-oxobut-2-yl)-2,2-dimethyl[1,3]dioxane

Conditions

Conditions	Yield
molecular sieve In dichloromethane	94.5%

...Expand

: 156918-57-9
1-(9-Decenyl)-3,7-dimethylxanthine

: 7529-22-8
4-methylmorpholine N-oxide

1-(9',10'-dihydroxydecyl)-3,7-dimethylxanthine: 1-(9',10'-dihydroxydecyl)-3,7-dimethylxanthine

Conditions

Conditions	Yield
With osmium(VIII) oxide In water; acetone; tert-butyl alcohol	93%

: 156918-57-9
1-(9-Decenyl)-3,7-dimethylxanthine

: 7529-22-8
4-methylmorpholine N-oxide

A: 156918-13-7
1-(9',10'-dihydroxydecyl)-3,7-dimethylxanthine

B: 159431-48-8
1-(7-acetoxy-8-bromooctyl)3,7-dimethylxanthine

Conditions

Conditions	Yield
In water; acetone; tert-butyl alcohol	A 93% B n/a

...Expand

: C33H38GeN2OSSi

: 7529-22-8
4-methylmorpholine N-oxide

: C66H76Ge2N4O4Si2

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 12h;	93%

: 7529-22-8
4-methylmorpholine N-oxide

: 379228-74-7
6,6-Dimethyloct-1-yn-7-en-4-ol

: C11H16O2

Conditions

Conditions	Yield
Stage #1: 6,6-Dimethyloct-1-yn-7-en-4-ol With dicobalt octacarbonyl In dichloromethane at 20℃; for 4h; Stage #2: 4-methylmorpholine N-oxide In dichloromethane at 0℃; for 4h; Temperature;	92.4%

4-Methylmorpholine N-oxide Specification

The 4-Methylmorpholine N-oxide, with the CAS registry number 7529-22-8, is also known as N-Methyl morpholine-N-oxide; NMO.It belongs to the product categories of Heterocycles;Aromatic Morpholines;Oxidation;Synthetic Organic Chemistry. This chemical's molecular formula is C₅H₁₁NO₂ and molecular weight is 117.15. What's more,Its systematic name is 4-Methylmorpholine 4-oxide. The 4-Methylmorpholine N-oxide may cause damage to health. It is Irritating to eyes, respiratory system and skin.When you use it ,wear suitable protective clothing and gloves.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Physical properties about 4-Methylmorpholine N-oxide are: (1)ACD/LogP: -1.636; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.74; (4)ACD/LogD (pH 7.4): -1.64; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 2.42; (8)ACD/KOC (pH 7.4): 3.06; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0.

You can still convert the following datas into molecular structure:
(1)SMILES:C[N+]1(CCOCC1)[O-];
(2)Std. InChI:InChI=1S/C5H11NO2/c1-6(7)2-4-8-5-3-6/h2-5H2,1H3;
(3)Std. InChIKey:LFTLOKWAGJYHHR-UHFFFAOYSA-N.

Product Name

4-Methylmorpholine N-oxide

Synthetic route

4-Methylmorpholine N-oxide Specification

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