4-Methylthiazole supplier | CasNO.693-95-8

Name
4-Methylthiazole
EINECS 211-764-1
CAS No. 693-95-8
Article Data41
CAS DataBase
Density 1.121 g/cm³
Solubility
Melting Point 134 °C
Formula C₄H₅NS
Boiling Point 134.3 °C at 760 mmHg
Molecular Weight 99.1564
Flash Point 37.3 °C
Transport Information UN 1993 3/PG 3
Appearance Clear colourless to slightly yellow liquid
Safety 16-26-39
Risk Codes 37.3°C
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 4-Methyl-1,3-thiazole;NSC 42976;Thiazole, 4-methyl-;
PSA 41.13000
LogP 1.45150

Synthetic route

: 20485-41-0
4-methylthiazole-5-carboxylic acid

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With acetic acid In N,N-dimethyl-formamide at 105 - 110℃; for 8h; Reagent/catalyst; Temperature; Green chemistry;	95%
With acetic acid; silver carbonate In dimethyl sulfoxide at 120℃; for 16h;	100 %Spectr.

: 5685-06-3
4-methylthiazole-2-thiol

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With hydrogenchloride; dihydrogen peroxide In water at 45℃; for 1.5h; Temperature;	78%
With hydrogenchloride; dihydrogen peroxide

: 1603-91-4
4-methylthiazol-2-ylamine

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
Stage #1: 4-methylthiazol-2-ylamine With sulfuric acid; sodium nitrite In water at -15 - -10℃; for 4h; Stage #2: With sodium hypophosphite In water at -10 - -5℃; for 6h; Temperature;	72%

: 6407-34-7, 19885-74-6
methyl-1 ethylideneamine

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With sulfur dioxide; soda-lime; zirconium(IV) oxide at 450℃;	70%

: 52558-99-3
4-methyl-3-thiazoline

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With ethanol; iron(III) chloride

: 32497-10-2
4-methyl-2(3H)-thiazolone

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With zinc bei der Destillation;
bei der Zinkstaub-Destillation;

: 5685-06-3
4-methylthiazole-2(3H)-thione

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With dihydrogen peroxide

: 14542-16-6
4-methyl-1,3-thiazole-2-carboxylic acid

: 693-95-8
4-Methylthiazole

: 26847-01-8
2-chloro-4-methyl-1,3-thiazole

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With acetic acid; zinc

: 14397-08-1
2-hydrazinyl-4-methylthiazole hydrochloride

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With water; mercury(II) oxide
With hydrogenchloride; dihydrogen peroxide

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 78-95-5
chloroacetone

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With tetraphosphorus decasulfide In benzene
With tetraphosphorus decasulfide

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 598-31-2
1-bromoacetone

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With 1,4-dioxane; tetraphosphorus decasulfide

: 64-17-5
ethanol

: 115-08-2
thiocarboxamide

: 78-95-5
chloroacetone

: 693-95-8
4-Methylthiazole

...Expand

: 115-08-2
thiocarboxamide

: 78-95-5
chloroacetone

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With ethanol

: 78-95-5
chloroacetone

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With sodium hydrogensulfide; ethanol Erwaermen des Reaktionsprodukts mit Formamid und NaOH;

: 57516-12-8
methyl-4 thiazole-I2

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
In tetrachloromethane at 24.9℃; Equilibrium constant; investigated in different solvents by electronic absorption spectra;

: 693-90-3
4-methylisothiazole

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
In ethanol Ambient temperature; Irradiation;
With TEA In methanol for 0.5h; Irradiation;	32 % Chromat.

2-oxy-4-methyl-thiazole: 2-oxy-4-methyl-thiazole

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
bei der Zinkstaub-Destillation;

: 5685-06-3
4-methylthiazole-2(3H)-thione

: 7722-84-1
dihydrogen peroxide

: 693-95-8
4-Methylthiazole

diazotized 2-amino-4-methyl-thiazole: diazotized 2-amino-4-methyl-thiazole

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With ethanol

: 52558-99-3
4-methyl-3-thiazoline

sulfur: sulfur

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
at 140℃;

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 78-95-5
chloroacetone

P2S5: P2S5

: 693-95-8
4-Methylthiazole

...Expand

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 108-88-3
toluene

: 598-31-2
1-bromoacetone

P2S5: P2S5

: 693-95-8
4-Methylthiazole

...Expand

: 3029-48-9
thiocyanoacetone

zinc: zinc

: 693-95-8
4-Methylthiazole

cobalt phthalocyanine disulfonate: cobalt phthalocyanine disulfonate

: 5685-06-3
4-methylthiazole-2-thiol

: 693-95-8
4-Methylthiazole

Conditions

Conditions	Yield
With sodium hydroxide

: 132963-45-2
trichloro(4-methylthiazole)gold(III)

: lithium chloride

A: 693-95-8
4-Methylthiazole

: 3145-91-3
lithium tetrachloroaurate

Conditions

Conditions	Yield
In methanol; dichloromethane; water Kinetics; addn. of Au-complex in dichloromethane to LiCl+HClO4 in methanol:water (95:5 v/v) at 25 °C; detected by UV;

...Expand

: 132963-45-2
trichloro(4-methylthiazole)gold(III)

: 16887-00-6
chloride

A: 693-95-8
4-Methylthiazole

: tetrachloroaurate(III)(1-)

Conditions

Conditions	Yield
In methanol; dichloromethane; water Kinetics; addn. of Au-complex in dichloromethane to LiCl+HClO4 in methanol:water (95:5 v/v) at 25 °C; detected by UV;

...Expand

: [platinum(II) (2,2':6,2''-terpyridine) (4-methylthiazole)] (perchlorate)2

: lithium chloride

A: 693-95-8
4-Methylthiazole

: 166268-05-9
[Pt(2,2':6',2''-terpyridine)Cl]ClO4

Conditions

Conditions	Yield
With methanesulfonic acid In methanol; N,N-dimethyl-formamide Kinetics; Pt-complex in DMF added to a methanolic soln. of chloride ion at 25°C in a thermostated cell in a spectrophotometer;

...Expand

: 7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-8-(pyrrolidin-1-ylmethyl)coumarin

A: 693-95-8
4-Methylthiazole

B: 124-38-9
carbon dioxide

C: 1062446-56-3
3-methyl-4H-1,4-thiazine

Conditions

Conditions	Yield
With silica gel at 20 - 750℃; Kinetics;

...Expand

: 693-95-8
4-Methylthiazole

: 74-88-4
methyl iodide

: 24300-70-7
3,4-dimethylthiazolinium iodide

Conditions

Conditions	Yield
In tetrahydrofuran at 90℃; for 48h;	100%
In methanol; ethyl acetate at 20℃; for 36h;	61%

: 693-95-8
4-Methylthiazole

: 54022-76-3
2-chloro-1-(4-morpholino)propan-1-one

: 1375709-69-5
2-chloro-1-(4-methylthiazol-2-yl)propan-1-one

Conditions

Conditions	Yield
Stage #1: 4-Methylthiazole With n-butyllithium In diethyl ether; n-heptane; toluene at -78℃; for 0.5h; Stage #2: 2-chloro-1-(4-morpholino)propan-1-one In diethyl ether; hexane; toluene at -78 - 20℃; Stage #3: With water; sodium hydrogencarbonate In diethyl ether; hexane; toluene	100%

: 693-95-8
4-Methylthiazole

: pentafluorophenyl(tetrahydrothiophene)gold(I)

: [Au(C6F5)(4-methylthiazole)]2

Conditions

Conditions	Yield
In diethyl ether (Ar); addn. of ligand to a soln. of gold complex in Et2O, stirring for 1.5 h at room temp.; evapn., extn. with Et2O, filtration through anhyd. MgSO4, evapn., recrystn. by layering a soln. in Et2O with hexane; elem. anal.;	99%

: 693-95-8
4-Methylthiazole

: 104-92-7
1-bromo-4-methoxy-benzene

: 5-(4-methoxyphenyl)-4-methylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	99%
With C23H20ClFeN3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 140℃; for 10h; Reagent/catalyst; regioselective reaction;	79%
With palladium(II) trimethylacetate; caesium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Schlenk technique; Inert atmosphere; regioselective reaction;	71%

: 693-95-8
4-Methylthiazole

: 623-00-7
4-bromobenzenecarbonitrile

: 122957-57-7
4-(4-methyl-1,3-thiazol-5-yl)benzonitrile

Conditions

Conditions	Yield
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 19h; Inert atmosphere;	99%
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 19h; Inert atmosphere;	99%
With potassium acetate; palladium diacetate at 150℃; for 19h; Inert atmosphere;	99%

: 693-95-8
4-Methylthiazole

: 460-00-4
1-Bromo-4-fluorobenzene

: 623577-48-0
5-(4-fluorophenyl)-4-methylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	99%
With C23H20ClFeN3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 140℃; for 10h; Reagent/catalyst; regioselective reaction;	94%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	83%

: 693-95-8
4-Methylthiazole

: 135145-81-2
3,4,6-tri-O-triisopropylsilyl-1-iodo-D-glucal

: 2-((2R,3R,4R)-3,4-bis((triisopropylsilyl)oxy)-2-(((triisopropylsilyl)oxy)methyl)-3,4-dihydro-2H-pyran-6-yl)-4-methylthiazole

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; palladium diacetate; lithium tert-butoxide In 1,4-dioxane at 100℃; for 24h; Schlenk technique; Inert atmosphere; regioselective reaction;	99%

: 693-95-8
4-Methylthiazole

: 53939-30-3
5-bromo-2-chloropyridine

: 5-(6-chloropyridin-3-yl)-4-methylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	99%

: 693-95-8
4-Methylthiazole

: gold(III) tetrachloride trihydrate

: 132963-45-2
trichloro(4-methylthiazole)gold(III)

Conditions

Conditions	Yield
In methanol; water addn. of 4-methylthiazole in methanol to soln. of HAuCl4*3H2O in water, neutralised with equimolar NaHCO3;; filtration, washed (water, methanol), recrystd. (dichloromethane), elem. anal.;	98%

: 693-95-8
4-Methylthiazole

: 106-39-8
bromochlorobenzene

: 1127217-94-0
5-(4-chlorophenyl)-4-methylthiazole

Conditions

Conditions	Yield
With C68H65Cl2N3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; regioselective reaction;	98%
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	94%
With C23H20ClFeN3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 140℃; for 10h; Reagent/catalyst; regioselective reaction;	92%

: 693-95-8
4-Methylthiazole

: 84254-99-9
1-benzyl-4-(3-chlorophenylamino)piperidine-4-carbonitrile

: 690273-75-7
[1-benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl]-(3-chlorophenyl)amine

Conditions

Conditions	Yield
Stage #1: 4-Methylthiazole With sec.-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.333333h; Stage #2: 1-benzyl-4-(3-chlorophenylamino)piperidine-4-carbonitrile In tetrahydrofuran; hexane at -78 - 0℃; for 0.5h; Stage #3: With water In tetrahydrofuran; hexane	98%

: 693-95-8
4-Methylthiazole

: 1122-91-4
4-bromo-benzaldehyde

: 1330767-26-4
4-(4-methylthiazol-5-yl)benzaldehyde

Conditions

Conditions	Yield
With C68H65Cl2N3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; regioselective reaction;	98%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	97%
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	92%

: 693-95-8
4-Methylthiazole

: 108-86-1
bromobenzene

: 19968-61-7
4-methyl-5-phenyl-1,3-thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	98%
With C22H18ClFeN3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 140℃; for 10h; Reagent/catalyst; Solvent; Temperature; Time; regioselective reaction;	94%
With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 20h; Inert atmosphere;	73%
With palladium(II) trimethylacetate; caesium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Schlenk technique; Inert atmosphere; regioselective reaction;	57%
With C42H42Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 24h;

: 693-95-8
4-Methylthiazole

: 4595-59-9
5-bromopyrimidine

: 4-methyl-5-(pyrimidin-5-yl)thiazole

Conditions

Conditions	Yield
With {N,N-(1,2-diphenylethane-1,2-diylidene)bis(2-benzhydryl-4,6-dimthylaniline)}dichloropalladium; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; Catalytic behavior;	98%
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	87%
With C32H33Cl2NOPd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	82%

: 693-95-8
4-Methylthiazole

: 586-78-7
para-nitrophenyl bromide

: 25021-61-8
4-methyl-5-(4-nitrophenyl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	98%
With C23H20ClFeN3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 140℃; for 10h; Reagent/catalyst; regioselective reaction;	96%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	82%
With C42H42Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 24h;
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 150℃; for 15h; Inert atmosphere;

: 693-95-8
4-Methylthiazole

: 847728-89-6
(S)-tert-butyl (1-(4-bromophenyl)ethyl)carbamate

: tert-butyl N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamate

Conditions

Conditions	Yield
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 120℃; for 2h; Inert atmosphere;	98%
With palladium diacetate; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 18h; Inert atmosphere;	82.3%
With potassium acetate; palladium diacetate In N,N-dimethyl acetamide at 90℃; for 18h; Inert atmosphere;	82.3%

: 693-95-8
4-Methylthiazole

: 625-92-3
3,5-dibromopyridine

: 3,5-bis(4-methylthiazol-5-yl)pyridine

Conditions

Conditions	Yield
With {N,N-(1,2-diphenylethane-1,2-diylidene)bis(2-benzhydryl-4,6-dimthylaniline)}dichloropalladium; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; Catalytic behavior;	98%
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	97%

: 693-95-8
4-Methylthiazole

: 13472-85-0
2-methoxy-5-bromopyridine

: 5-(6-methoxypyridin-3-yl)-4-methylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	98%

: 693-95-8
4-Methylthiazole

: 402-43-7
p-trifluoromethylphenyl bromide

: 4-methyl-5-(4-(trifluoromethyl)phenyl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	97%
With C34H48Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 8h;	89%
With tris [tris(3,5-bis(trifluoromethyl)phenyl)phosphine]palladium(0); potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 140℃; for 3h; regioselective reaction;	78%
With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 20h; Inert atmosphere;	75%
With C42H42Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 100℃; for 24h;

: 693-95-8
4-Methylthiazole

: tetrafluoroboric acid

: 149-73-5
trimethyl orthoformate

: 3,4-dimethylthiazol-3-ium tetrafluoroborate

Conditions

Conditions	Yield
In water at 0 - 110℃; for 23h;	97%

...Expand

: 693-95-8
4-Methylthiazole

: tetrafluoroboric acid

: 588-43-2
Tributyl orthoformate

: 3-butyl-4-methylthiazol-3-ium tetrafluoroborate

Conditions

Conditions	Yield
In water at 0 - 140℃; for 30h;	97%

...Expand

: 693-95-8
4-Methylthiazole

: 1532-97-4
4-bromoisoquinoline

: 5-(isoquinolin-4-yl)-4-methylthiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	97%

: 693-95-8
4-Methylthiazole

: 25662-28-6
1-(carboxymethoxy)cyclopentadiene

: methyl 5-(4-methylthiazol-5-yl)cyclopent-1-enecarboxylate

Conditions

Conditions	Yield
Stage #1: 4-Methylthiazole With C37H24F2N6O2Pd In dichloromethane at 20℃; for 0.333333h; Stage #2: 1-(carboxymethoxy)cyclopentadiene With 1,1,1,3',3',3'-hexafluoro-propanol; silver(I) acetate; palladium diacetate; N-acetylglycine In dichloromethane at 80℃; for 30h; Sealed tube;	96%

: 693-95-8
4-Methylthiazole

: 3964-04-3
4-bromoquinoline

: 4-methyl-5-(quinolin-4-yl)thiazole

Conditions

Conditions	Yield
With C82H77Cl2N3O2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	96%

: 693-95-8
4-Methylthiazole

: 100-52-7
benzaldehyde

: 54918-64-8
2-(α-hydroxybenzyl)-4-methylthiazole

Conditions

Conditions	Yield
Stage #1: 4-Methylthiazole With n-butyllithium In tetrahydrofuran at -78℃; Stage #2: benzaldehyde In tetrahydrofuran at -78 - 20℃; for 1h;	95%
With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran; hexane at -78℃; for 1h;	79%

: 693-95-8
4-Methylthiazole

: 114389-49-0
4-methyl-thiazole-5-sulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide In 1,2-dichloro-ethane for 5h; Heating;	95%
With sulfuric acid; sulfur trioxide at 200℃;

: 693-95-8
4-Methylthiazole

: 125402-79-1
4-methyl-5-chlorothiazole

Conditions

Conditions	Yield
With N-chloro-succinimide; Perbenzoic acid In tetrachloromethane for 1h; Heating;	95%

: 693-95-8
4-Methylthiazole

: 626-55-1
3-Bromopyridine

: 3-(4-methylthiazol-5-yl)-pyridine

Conditions

Conditions	Yield
With {N,N-(1,2-diphenylethane-1,2-diylidene)bis(2-benzhydryl-4,6-dimthylaniline)}dichloropalladium; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 12h; Catalytic behavior;	95%
With C23H20ClFeN3Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 140℃; for 10h; Reagent/catalyst; regioselective reaction;	92%
With C32H33Cl2NOPd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 130℃; for 4h;	90%

: 693-95-8
4-Methylthiazole

: 972-17-8
1-benzyl-4-(o-toluidino)piperidine-4-carbonitrile

: [1-benzyl-4-(4-methylthiazol-2-yl)-4-piperidinyl](2-methylphenyl)amine

Conditions

Conditions	Yield
Stage #1: 4-Methylthiazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.333333h; Stage #2: 1-benzyl-4-(o-toluidino)piperidine-4-carbonitrile at -78 - 0℃; for 0.5h;	95%

4-Methylthiazole Chemical Properties

Molecular Structure of 4-Methylthiazole (CAS NO.693-95-8):

IUPAC Name: 4-Methyl-1,3-thiazole
Canonical SMILES: CC1=CSC=N1
InChI: InChI=1S/C4H5NS/c1-4-2-6-3-5-4/h2-3H,1H3
InChIKey: QMHIMXFNBOYPND-UHFFFAOYSA-N
Molecular Weight: 99.1542 [g/mol]
Molecular Formula: C₄H₅NS
XLogP3: 1
H-Bond Donor: 0
H-Bond Acceptor: 1
EINECS: 211-764-1
Index of Refraction: 1.535
Molar Refractivity: 27.55 cm³
Molar Volume: 88.4 cm³
Surface Tension: 39.9 dyne/cm
Density: 1.121 g/cm³
Flash Point: 37.3 °C
Enthalpy of Vaporization: 37.58 kJ/mol
Boiling Point: 134.3 °C at 760 mmHg
Vapour Pressure: 10 mmHg at 25 °C
Appearance: Clear colourless to slightly yellow liquid
storage temp.: Flammables area
Product Categories: Thiazoles; thiazole Flavor; Building Blocks; Heterocyclic Building Blocks; Alphabetical Listings; Flavors and Fragrances; M-N

4-Methylthiazole Uses

4-Methylthiazole (CAS NO.693-95-8) is used as medicine, fragrance intermediates.

4-Methylthiazole Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	360uL/kg (0.36mL/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 182, 1992.

4-Methylthiazole Safety Profile

Safety Information of 4-Methylthiazole (CAS NO.693-95-8):
Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 10-22-37/38-41
R10:Flammable.
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin.
R41:Risk of serious damage to the eyes.
Safety Statements: 16-26-39
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39:Wear eye / face protection.
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
RTECS: XJ5096000
TSCA: T
HazardClass: 3
PackingGroup: III

4-Methylthiazole Specification

4-Methylthiazole (CAS NO.693-95-8), its Synonyms are Thiazole, 4-methyl- ; 4-Methyl thiazole ; 4-Methyl-1,3-thiazole .

Product Name

4-Methylthiazole

Synthetic route

4-Methylthiazole Chemical Properties

4-Methylthiazole Uses

4-Methylthiazole Toxicity Data With Reference

4-Methylthiazole Safety Profile

4-Methylthiazole Specification

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