4-TERT-BUTYLBENZALDEHYDE supplier

Name
4-tert-Butylbenzaldehyde
EINECS 213-367-9
CAS No. 939-97-9
Article Data274
CAS DataBase
Density 0.966 g/cm³
Solubility Soluble in water.
Melting Point 245-246 °C
Formula C₁₁H₁₄O
Boiling Point 240.8 °C at 760 mmHg
Molecular Weight 162.232
Flash Point 96.9 °C
Transport Information UN 3082 9/PG 3
Appearance clear to pale yellow liquid
Safety 36/37-60-61
Risk Codes 22-43-50/53
Molecular Structure
Hazard Symbols Xn,N,Xi
Synonyms 4-(1,1-Dimethylethyl)benzaldehyde;Benzaldehyde,p-tert-butyl- (6CI,7CI,8CI);p-tert-Butylbenzaldehyde;para-tert-Butylbenzaldehyde;
PSA 17.07000
LogP 2.79660

Synthetic route

: 877-65-6
4-tert-Butylbenzyl alcohol

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With 1H-imidazole; sodium periodate; manganese(III)-porphyrin complex immobilized on polystyrene In water; acetonitrile at 20℃; for 1.16667h;	100%
With oxygen In 1,3,5-trimethyl-benzene at 60℃; under 760.051 Torr; for 7h; Solvent; Reagent/catalyst;	100%
With titanium(IV) oxide; oxygen at 29.84℃; under 760.051 Torr; for 6h; Sealed tube; Irradiation;	99%

: 1710-98-1
p-tert-butyl benzoyl chloride

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With polymethylhydrosiloxane; trifuran-2-yl-phosphane; tetrabutyl ammonium fluoride; potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran; water at 20℃; for 1h;	99%
With diethylene glycol dimethyl ether; lithium tri-t-butoxyaluminum hydride
With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal In ethyl acetate at 25℃; under 760 Torr; for 1.75h; Yield given;
Multi-step reaction with 2 steps 1: dichloromethane / 0.5 h / 20 °C / Cooling with ice 2: Schwartz's reagent / tetrahydrofuran / 0.5 h / 20 °C View Scheme

: 1746-23-2
4-tert-Butylstyrene

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With p-PPh2-C6H4-(OCH2CH2)n-O-C6H4-PPh2-p; ozone Product distribution; various catalysts;	98%
Stage #1: 4-tert-Butylstyrene With oxygen; ozone In dichloromethane at -78℃; Stage #2: With poly(ethylene glycol)-triphenylphosphine In dichloromethane at -78 - 20℃;	98%
With oxygen; benzoic acid; sodium nitrite In toluene at 80℃; for 20h; Reagent/catalyst; Solvent; Temperature;	82%

: 180261-48-7
4-tert-butyl benzene carbaldehyde oxime

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With iron(III) chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In water; toluene at 60℃; under 760.051 Torr; for 3h;	98%

: 624286-50-6
(4-tert-butylbenzyloxy)trimethylsilane

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With trinitratocerium(IV) bromate for 0.7h; Heating;	97%
With copper(II) nitrate trihydrate; water; silica gel; potassium bromide at 90℃; for 0.5h; Neat (no solvent);	87%

: 3972-65-4
1-bromo-4-tert-butylbenzene

: 201230-82-2
carbon monoxide

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium diacetate; propyl di-tert-butylphosphinite In toluene at 100℃; under 3750.38 Torr; for 20h; Inert atmosphere;	97%

: 19692-45-6
4-tert-butylbenzyl chloride

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With 1-dodecyl-3-methylimidazolium iron chloride; periodic acid at 30℃; for 1.5h;	96%
With potassium hydroxide; cetyltrimethylammonim bromide; potassium nitrate In water for 4h; pH=10 - 11; Reflux;	90%
With potassium nitrite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; potassium bromide In water for 4h; Reflux;	90%
With sodium nitrate; acetic acid In water for 3.5h; Reflux;	90%
With hexamethylenetetramine; sulfuric acid; sodium carbonate In ethanol; water; toluene	11.8 g (60%)

: 98-51-1
4-tert-butyltoluene

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In fluorobenzene; dimethyl sulfoxide at 80℃; for 8h;	95%
With ammonium cerium(IV) nitrate In water; acetic acid at 85 - 95℃; for 1.5h;	94%
With carbon tetrabromide; oxygen In acetonitrile at 20℃; for 3h; Irradiation; Green chemistry;	90%

: 19099-48-0
1,1-bis(4-t-butylphenyl)methane

: 80077-60-7
1-azidononane

A: 939-97-9
4-tert-Butylbenzaldehyde

B: 1225826-38-9
4-tert-butyl-N-nonylaniline

Conditions

Conditions	Yield
With water; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; iron(II) chloride at 60℃; for 5h;	A 85% B 94%

...Expand

: N-(4-tert-butylbenzyl)-4-tert-butylaniline

A: 939-97-9
4-tert-Butylbenzaldehyde

B: 769-92-6
4-tert-Butylaniline

Conditions

Conditions	Yield
Stage #1: N-(4-tert-butylbenzyl)-4-tert-butylaniline With oxygen; toluene-4-sulfonic acid; dimethyl sulfoxide In toluene at 100℃; for 119h; Green chemistry; Stage #2: With hydrogenchloride In water at 20℃; for 1h; Reagent/catalyst; Temperature; Green chemistry;	A 93% B 94%

: 64-18-6
formic acid

: 35779-04-5
1-tert-butyl-4-iodobenzene

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
Stage #1: formic acid; 1-tert-butyl-4-iodobenzene With palladium diacetate; acetic anhydride; tricyclohexylphosphine In N,N-dimethyl-formamide at 30℃; for 1h; Inert atmosphere; Green chemistry; Stage #2: With triethylamine In N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere; Green chemistry;	93%
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; tricyclohexylphosphine In N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere; Sealed tube;	72%

: 98-51-1
4-tert-butyltoluene

A: 939-97-9
4-tert-Butylbenzaldehyde

B: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

Conditions

Conditions	Yield
With N-hydroxyphthalimide; oxygen; cobalt(II) acetate In acetic acid at 25℃; under 760 Torr; for 20h;	A 2% B 91%
With N-hydroxyphthalimide; oxygen; cobalt(II) acetate In acetonitrile at 25℃; under 760 Torr; for 20h;	A 4% B 77%
With oxygen; acetic acid; N-hydroxyphthalimide at 100℃; for 6h; Product distribution / selectivity;	A 3.8% B 66.5%

: potassium tert-butyltrifluoroboranuide

: 1122-91-4
4-bromo-benzaldehyde

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; nickel(II) bis(2,2,6,6-tetramethylheptane-3,5-dionate); Ir(dF(CF3)ppy)2(bpy)PF6; zinc dibromide In N,N-dimethyl acetamide at 27℃; for 48h; Inert atmosphere; Irradiation;	91%

: 18880-00-7
1-(bromomethyl)-4-(1,1-dimethylethyl)benzene

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With potassium hydrogencarbonate; dimethyl sulfoxide for 0.0583333h; Microwave irradiation;	90%
With carbon dioxide; copper(II) nitrate
With ethanol; carbon dioxide; hexamethylenetetramine
With 4-methylmorpholine N-oxide at 20℃; for 4h; Reflux;	246.6 mg
Multi-step reaction with 2 steps 1: eosin y; oxygen / dimethyl sulfoxide / 12 h / 25 °C / Irradiation 2: eosin y / dimethyl sulfoxide / 24 h / 80 °C / Irradiation View Scheme

: 39895-55-1
4-(1,1-dimethylethyl)-benzenemethanamine

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With cercosporin; oxygen In methanol at 20℃; Schlenk technique; Irradiation; Green chemistry; chemoselective reaction;	89%
With copper(I) 2-hydroxy-3-methylbenzoate; oxygen; ascorbic acid In N,N-dimethyl acetamide at 45℃; for 2h; chemoselective reaction;	70%
With dipotassium peroxodisulfate; tris(bipyridine)ruthenium(II) dichloride hexahydrate; water In acetonitrile at 20℃; for 12h; Sealed tube; Irradiation; Green chemistry;

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 35779-04-5
1-tert-butyl-4-iodobenzene

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
Stage #1: tert-butylisonitrile; 1-tert-butyl-4-iodobenzene With triethylsilane; palladium diacetate; sodium carbonate; CyJohnPhos In N,N-dimethyl-formamide at 65℃; for 8h; Inert atmosphere; Sealed tube; Green chemistry; Stage #2: With water Green chemistry;	88%

: C14H20S2

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With eosin y In water; acetonitrile at 20℃; for 4h; Irradiation;	88%

: 32857-63-9
4-t-butylphenylacetic acid

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With oxygen; copper diacetate In dimethyl sulfoxide at 120℃; for 18h; Sealed tube;	87%
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20 - 25℃; for 6h; Irradiation;	76%
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; N,N,N',N'-tetramethylguanidine In acetonitrile at 20℃; for 6h; Irradiation;	55%
With water; copper dichloride at 250℃; under 30003 Torr; for 0.17h; Sealed tube; Green chemistry;	94 %Chromat.

: 49543-63-7
4-tert-butylbenzyl mercaptan

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; tetrakis(pyridine)silver(II) peroxodisulfate; oxygen In N,N-dimethyl-formamide at 23℃; under 760.051 Torr; Irradiation;	87%

: 3395-87-7
1-(1,1-dimethylethyl)-4-(methoxymethyl)benzene

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With nitric acid In dichloromethane at 20℃; for 1h;	86%

: 35779-04-5
1-tert-butyl-4-iodobenzene

: 82102-37-2
9-methyl-9H-fluorene-9-carbonyl chloride

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With dichloro(1,5-cyclooctadiene)palladium(II); N-Methyldicyclohexylamine; potassium formate; tetra-(n-butyl)ammonium iodide; tricyclohexylphosphine tetrafluoroborate; bis(dibenzylideneacetone)-palladium(0); tri tert-butylphosphoniumtetrafluoroborate In acetonitrile at 80℃; for 18h; Sealed tube; Glovebox; Inert atmosphere;	86%

: 3972-65-4
1-bromo-4-tert-butylbenzene

: 124-38-9
carbon dioxide

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With rhodium(III) iodide; dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); hydrogen; acetic anhydride; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 100℃; for 24h; Autoclave;	85%
With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 100℃; under 7500.75 Torr; for 20h; Autoclave; Green chemistry;	81%

: 4-(tert-butyl)benzoyl fluoride

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With triethylsilane; palladium diacetate; tricyclohexylphosphine In toluene at 100℃; for 20h; Inert atmosphere; Sealed tube;	85%

: 72390-21-7
1-tert-butoxymethyl-4-tert-butylbenzene

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With N-hydroxyphthalimide; nitrogen(II) oxide In acetonitrile at 60℃; for 10h;	84%
	84%

: 67-56-1
methanol

: 79135-54-9, 114530-47-1, 123356-27-4, 64392-50-3
(E)-1,1'-(1,2-ethenediyl)bis(4-butyl)benzene

A: 939-97-9
4-tert-Butylbenzaldehyde

B: 26537-19-9
methyl 4-tert-butylbenzoate

Conditions

Conditions	Yield
With iodine; oxygen; trifluoroacetic acid In ethyl acetate for 20h; Solvent; Reagent/catalyst; Irradiation;	A 84% B 7 %Spectr.

...Expand

: 84434-23-1
3-(4-(tert-butyl)phenyl)acrylaldehyde

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With pyrrolidine; water In acetonitrile at 20℃; for 12h; Inert atmosphere;	83%

: (4-t-butylphenyl)(chloro)methyl p-tolyl sulfoxide

A: 939-97-9
4-tert-Butylbenzaldehyde

B: 103-19-5
di(p-tolyl) disulfide

Conditions

Conditions	Yield
In 1,4-dioxane for 12h; Heating;	A 82% B 66%

: 201230-82-2
carbon monoxide

: 35779-04-5
1-tert-butyl-4-iodobenzene

: 939-97-9
4-tert-Butylbenzaldehyde

Conditions

Conditions	Yield
With rhodium(III) chloride trihydrate; hydrogen; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 90℃; under 7500.75 Torr; for 12h; Autoclave;	81%

: 939-97-9
4-tert-Butylbenzaldehyde

: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

Conditions

Conditions	Yield
With hydrogen bromide; oxygen In acetonitrile at 20℃; for 5h; UV-irradiation;	100%
With tert.-butylhydroperoxide; potassium tert-butylate In water at 60℃; for 5h;	96%
With N-Bromosuccinimide; oxygen In ethyl acetate at 20℃; Irradiation;	93%

: 939-97-9
4-tert-Butylbenzaldehyde

: 877-65-6
4-tert-Butylbenzyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at 25℃; for 0.5h;	100%
With sodium tetrahydroborate In ethanol at 20℃; for 0.5h; Inert atmosphere;	100%
With sodium tetrahydroborate In ethanol at 20℃; for 0.5h; Inert atmosphere;	100%

: 939-97-9
4-tert-Butylbenzaldehyde

: 557-20-0
diethylzinc

: 127896-25-7
1-(4-tert-butylphenyl)propan-1-ol

Conditions

Conditions	Yield
With (R,R)-(2,4,6-Me3C6H2-CH=N-CH(Ph))2; (R)-(+)-3,3'-diphenyl-[1,1'-binaphthalene]-2,2'-diol In hexane; dichloromethane 1.) -78 deg C, 4 h, 2.) -20 deg, 1 h;	100%
With (1R,2R)-N,N'-bis[(2,4,6-trimethylphenyl)methylene]-1,2-cyclohexane-diamine; (R)-(+)-3,3'-diphenyl-[1,1'-binaphthalene]-2,2'-diol In hexane; dichloromethane at -78 - -20℃; for 5h;	100%
With titanium(IV) isopropylate at 80℃; for 1h; Time; Inert atmosphere;	60 %Chromat.
With magnesium chloride at 80℃; for 0.5h; Reagent/catalyst; Inert atmosphere;	24.2 %Chromat.

: 939-97-9
4-tert-Butylbenzaldehyde

: 2234-16-4
1-(2,4-dichlorophenyl)ethan-1-one

: 3-(4-tert-butyl-phenyl)-1-(2,4-dichloro-phenyl)-propenone

Conditions

Conditions	Yield
With sodium hydroxide for 1.5h;	100%

: 939-97-9
4-tert-Butylbenzaldehyde

: 107-11-9
1-amino-2-propene

: 250376-72-8
Allyl-[1-(4-tert-butyl-phenyl)-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 20h;	100%

: 856889-57-1
N-[3-fluoro-4-(4-morpholinyl)phenyl]-N-(4-piperidinylmethyl)-N'-(tetrahydro-2H-pyran-4-yl)urea

: 939-97-9
4-tert-Butylbenzaldehyde

: N-[(1-{[4-(1,1-dimethylethyl)phenyl]methyl}-4-piperidinyl)methyl]-N-[3-fluoro-4-(4-morpholinyl)phenyl]-N'-(tetrahydro-2H-pyran-4-yl)urea

Conditions

Conditions	Yield
With MP-triacetoxyborohydride In dichloromethane at 20℃; for 18h; MP-triacetoxyborohydride;	100%

: 939-97-9
4-tert-Butylbenzaldehyde

: 1826-67-1
vinyl magnesium bromide

: 863029-85-0
1-(4-(tert-butyl)phenyl)prop-2-en-1-ol

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere;	100%
Stage #1: 4-tert-Butylbenzaldehyde; vinyl magnesium bromide In tetrahydrofuran at 20℃; for 20h; Heating / reflux; Stage #2: With water; ammonium chloride
In tetrahydrofuran at 0℃; for 1h;

: 939-97-9
4-tert-Butylbenzaldehyde

: 2039-67-0
2-(3-methoxyphenyl)-1-ethanamine

: (4-tert-butyl-benzyl)-[2-(3-methoxy-phenyl)-ethyl]-amine

Conditions

Conditions	Yield
Stage #1: 4-tert-Butylbenzaldehyde; 2-(3-methoxyphenyl)-1-ethanamine With potassium carbonate In methanol at 20℃; for 2h; Heating / reflux; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 3h; Heating / reflux; Stage #3: With hydrogenchloride In methanol; water	100%

: 939-97-9
4-tert-Butylbenzaldehyde

: 404-70-6
2-(3-Fluorophenyl)ethylamine

: (4-tert-butyl-benzyl)-[2-(3-fluoro-phenyl)-ethyl]-amine

Conditions

Conditions	Yield
Stage #1: 4-tert-Butylbenzaldehyde; 2-(3-Fluorophenyl)ethylamine In methanol at 20℃; for 2.5h; Heating / reflux; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 3.08h; Heating / reflux; Stage #3: With hydrogenchloride In methanol; water at 20℃;	100%

: 939-97-9
4-tert-Butylbenzaldehyde

: 13078-79-0
2-(3-chlorophenyl)ethylamine

: 875305-16-1
(4-tert-butyl-benzyl)-[2-(3-chloro-phenyl)-ethyl]-amine

Conditions

Conditions	Yield
Stage #1: 4-tert-Butylbenzaldehyde; 2-(3-chlorophenyl)ethylamine In methanol at 20℃; for 3h; Heating / reflux; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 4.08h; Heating / reflux; Stage #3: With hydrogenchloride In methanol; water at 20℃;	100%

: 939-97-9
4-tert-Butylbenzaldehyde

: 1583-88-6
4-fluoro-2-phenethylamine

: 875305-06-9
(4-tert-butyl-benzyl)-[2-(4-fluoro-phenyl)-ethyl]-amine

Conditions

Conditions	Yield
Stage #1: 4-tert-Butylbenzaldehyde; 4-fluoro-2-phenethylamine In methanol at 20℃; for 4.5h; Heating / reflux; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 2.08h; Heating / reflux; Stage #3: With hydrogenchloride In methanol; water at 20℃;	100%

: 939-97-9
4-tert-Butylbenzaldehyde

: 3261-62-9
2-(p-tolyl)ethylamine

: 875305-08-1
(4-tert-butyl-benzyl)-(2-p-tolyl-ethyl)-amine

Conditions

Conditions	Yield
Stage #1: 4-tert-Butylbenzaldehyde; 2-(p-tolyl)ethylamine In methanol at 20℃; for 3h; Heating / reflux; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 2.38h; Heating / reflux; Stage #3: With hydrogenchloride In methanol; water at 20℃;	100%

: 875305-55-8
2-(2-fluoro-5-trifluoromethyl-phenyl)-ethylamine hydrochloride

: 939-97-9
4-tert-Butylbenzaldehyde

: 875305-54-7
(4-tert-butyl-benzyl)-[2-(2-fluoro-5-trifluoromethyl-phenyl)-ethyl]-amine

Conditions

Conditions	Yield
Stage #1: 2-(2-fluoro-5-trifluoromethyl-phenyl)-ethylamine hydrochloride; 4-tert-Butylbenzaldehyde With potassium carbonate In methanol at 20℃; for 3h; Heating / reflux; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 2.58h; Heating / reflux;	100%

: 939-97-9
4-tert-Butylbenzaldehyde

: 2579-20-6
cis, trans-1,3-dimethylaminocyclohexane

: 1217526-91-4
C30H42N2

Conditions

Conditions	Yield
In methanol at 20℃; Molecular sieve;	100%
In methanol at 20℃; Molecular sieve;

: 939-97-9
4-tert-Butylbenzaldehyde

: 74-89-5
methylamine

: 144023-42-7
C12H17N

Conditions

Conditions	Yield
at 20℃; for 12h;	100%

: 945717-05-5
2-(4-Chloro-3-Ethyl-Phenyl)-Ethyl-Amine-Hydrochloride

: 939-97-9
4-tert-Butylbenzaldehyde

: 1352659-88-1
[1-(4-tert-butyl-phenyl)-meth-(E)-ylidene]-[2-(4-chloro-3-ethyl-phenyl)-ethyl]-amine

Conditions

Conditions	Yield
Stage #1: 2-(4-Chloro-3-Ethyl-Phenyl)-Ethyl-Amine-Hydrochloride With sodium hydroxide In water; ethyl acetate Stage #2: 4-tert-Butylbenzaldehyde In ethyl acetate at 20℃; for 2h;	100%
With sodium hydroxide In water; ethyl acetate at 20℃; for 2h;	100%

: 939-97-9
4-tert-Butylbenzaldehyde

: tert-butyl 1-(2-bromobenzyl)hydrazine-1-carboxylate

: C23H29BrN2O2

Conditions

Conditions	Yield
In ethanol at 20℃;	100%

: 939-97-9
4-tert-Butylbenzaldehyde

: 1730-25-2
allylmagnesium bromide

: 106027-36-5
1-(4-(tert-butyl)phenyl)but-3-en-1-ol

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether at 0 - 20℃;	100%
With indium In tetrahydrofuran; diethyl ether at 0℃; Inert atmosphere;

: 141-82-2
malonic acid

: 939-97-9
4-tert-Butylbenzaldehyde

: 1208-65-7
4-tert-butyl-trans-cinnamic acid

Conditions

Conditions	Yield
Stage #1: malonic acid; 4-tert-Butylbenzaldehyde With piperidine; pyridine Knoevenagel-Doebner reaction; Reflux; Stage #2: With hydrogenchloride In water Cooling with ice; optical yield given as %de;	99%
With piperidine; pyridine for 2h; Knoevenagel condensation; Reflux;	88%
With piperidine; pyridine	87%

: 939-97-9
4-tert-Butylbenzaldehyde

: (1R,2R)-1,2-diaminocyclohexane tartrate

: (1R,2R)-N,N'-bis(4-tert-butylbenzylidene)-1,2-diaminocyclohexane

Conditions

Conditions	Yield
With potassium carbonate In ethanol; water for 5.5h; Heating;	99%
With potassium carbonate

: 3699-66-9
ethyl 2-diethoxyphosphorylpropionate

: 939-97-9
4-tert-Butylbenzaldehyde

: ethyl (E)-3-(4-(tert-butyl)phenyl)-2-methylacrylate

Conditions

Conditions	Yield
Stage #1: ethyl 2-diethoxyphosphorylpropionate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: 4-tert-Butylbenzaldehyde In tetrahydrofuran; hexane at 0 - 20℃; Inert atmosphere;	99%
Stage #1: ethyl 2-diethoxyphosphorylpropionate With sodium hydride In tetrahydrofuran at 0 - 25℃; Stage #2: 4-tert-Butylbenzaldehyde In tetrahydrofuran for 1h; Heating;
With sodium hydride In tetrahydrofuran; mineral oil at -78 - 20℃; for 3h;

: 939-97-9
4-tert-Butylbenzaldehyde

: 4210-32-6
4-tert-butyl benzonitrile

Conditions

Conditions	Yield
With ammonium sulfate; sodium carbonate; sulfur In dimethyl sulfoxide at 120℃; for 10h; Sealed tube;	99%
With pyridine; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ammonium peroxydisulfate; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; ammonium carbamate In water; acetonitrile at 20℃; for 24h; Irradiation; Sealed tube;	98%
Stage #1: 4-tert-Butylbenzaldehyde With pyridine; 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at 26℃; for 0.0833333h; Stage #2: With 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate In dichloromethane at 26℃; for 18h;	97%

: 858124-31-9
3-(diethoxyphosphorylmethyl)-4-methoxybenzamide

: 939-97-9
4-tert-Butylbenzaldehyde

: 3-[(E)-2-(4-tert-butylphenyl)vinyl]-4-methoxybenzamide

Conditions

Conditions	Yield
With sodium tert-pentoxide In N,N-dimethyl-formamide at 20℃; for 1h; Horner-Wadsworth-Emmons olefination;	99%

: 939-97-9
4-tert-Butylbenzaldehyde

: 123-46-6
girard's reagent T

: 66932-77-2
diisopropyl (2-oxo-2-(pyrrolidin-1-yl)ethyl)phosphonate

A: C16H26N3O(1+)*Cl(1-)

B: 535945-57-4
C17H23NO

C: di-isopropylphosphonate anion

Conditions

Conditions	Yield
Stage #1: 4-tert-Butylbenzaldehyde; diisopropyl (2-oxo-2-(pyrrolidin-1-yl)ethyl)phosphonate With potassium tert-butylate In tetrahydrofuran at 20℃; for 6h; Horner-Wadsworth-Emmons Olefination; Stage #2: girard's reagent T In tetrahydrofuran; methanol stereoselective reaction;	A n/a B 99% C n/a

...Expand

: 939-97-9
4-tert-Butylbenzaldehyde

: 98-51-1
4-tert-butyltoluene

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In methanol at 25℃; under 760.051 Torr; for 0.833333h;	99%

: 109-80-8
1.3-propanedithiol

: 939-97-9
4-tert-Butylbenzaldehyde

: C14H20S2

Conditions

Conditions	Yield
With silica gel; toluene-4-sulfonic acid In dichloromethane Reflux;	99%
With boron trifluoride diethyl etherate In dichloromethane Inert atmosphere;
With boron trifluoride diethyl etherate In dichloromethane at 0 - 25℃;

: 939-97-9
4-tert-Butylbenzaldehyde

: 108-91-8
cyclohexylamine

: (E)-N-(4-tert-butylbenzylidene)cyclohexanamine

Conditions

Conditions	Yield
In neat (no solvent) at 60℃; for 0.0666667h; Microwave irradiation;	99%

: 110-59-8
pentanonitrile

: 939-97-9
4-tert-Butylbenzaldehyde

: N-(4-(tert-butyl)benzyl)pentan-1-aminium chloride

Conditions

Conditions	Yield
Stage #1: pentanonitrile; 4-tert-Butylbenzaldehyde With hydrogen In 2-methyltetrahydrofuran at 100℃; under 11251.1 Torr; for 20h; High pressure; Autoclave; Stage #2: With hydrogenchloride In diethyl ether	99%

4-TERT-BUTYLBENZALDEHYDE Chemical Properties

MF: C₁₁H₁₄O
MW: 162.23
EINECS: 213-367-9
Product Categories: Aromatic Aldehydes & Derivatives (substituted);Aldehydes;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Pharmaceutical Intermediate;C10 to C21;Carbonyl Compounds
bp: 130 °C25 mm Hg(lit.)
density: 0.97 g/mL at 25 °C(lit.)
refractive index: n20/D 1.53(lit.)
Fp: 214 °F
Sensitive: Air & Light Sensitive
BRN: 1906461

4-TERT-BUTYLBENZALDEHYDE's Synonyms: LABOTEST-BB LT00689343;AKOS BBS-00003171;4-TERT-BUTYLBENZALDEHYDE;P-TERT-BUTYL BENZALDEHYDE;TIMTEC-BB SBB008564;4-(1,1-DIMETHYLETHYL)-BENZALDEHYD;4-(1,1-DIMETHYLETHYL)-BENZALDEHYDE;BENZALDEHYDE,-(1,1-DIMETHYLETHYL)-

4-TERT-BUTYLBENZALDEHYDE Toxicity Data With Reference

Hazards Identification
Inhalation:Inhalation of material may be harmful.
Skin: may cause burns.
Eyes:may cause burns.
Hazards:Containers may explode when heated.
EC Risk Phrase:R 22 43
EC Safety Phrase:S 23 36/37
UN (DOT):3334

4-TERT-BUTYLBENZALDEHYDE Safety Profile

4-TERT-BUTYLBENZALDEHYDE's afety Information
Hazard Codes Xn,N,Xi
RIDADR UN 3082 9/PG 3
WGK Germany 2
F 8-9-23
Hazard Note Irritant
HazardClass 9
PackingGroup III

4-TERT-BUTYLBENZALDEHYDE Specification

4-TERT-BUTYLBENZALDEHYDE's Accidental Release Measures
Small spills/leaks:Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent dust cloud. Avoid inhalation of ASBESTOS dust.
Stability and Reactivity
Combustion Products:Fire may produce irritating, corrosive and/or toxic gases.

Product Name

4-tert-Butylbenzaldehyde

Synthetic route

4-TERT-BUTYLBENZALDEHYDE Chemical Properties

4-TERT-BUTYLBENZALDEHYDE Toxicity Data With Reference

4-TERT-BUTYLBENZALDEHYDE Safety Profile

4-TERT-BUTYLBENZALDEHYDE Specification

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