4-Thiazolecarboxylic acid supplier

Name
4-Thiazolecarboxylic acid
EINECS 628-056-7
CAS No. 3973-08-8
Article Data25
CAS DataBase
Density 1.525 g/cm³
Solubility
Melting Point 195-199 °C(lit.)
Formula C₄H₃NO₂S
Boiling Point 319.2 °C at 760 mmHg
Molecular Weight 129.139
Flash Point 146.9 °C
Transport Information
Appearance
Safety 36/37
Risk Codes 43
Molecular Structure
Hazard Symbols Xi
Synonyms 1,3-Thiazole-4-carboxylicacid;NSC 195467;
PSA 78.43000
LogP 0.84130

Synthetic route

: 59418-09-6
4-thiazolecarboxylate methyl ester

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide for 1h; Reflux;	96.1%

: 70-23-5
ethyl Bromopyruvate

: 17356-08-0
thiourea

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
Stage #1: ethyl Bromopyruvate; thiourea In water at 40℃; for 5h; Stage #2: With hydrogenchloride; sodium nitrite In water for 2h; Temperature; Concentration;	94%

: 693-95-8
4-Methylthiazole

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
at 30℃; for 16h; Pseudomonas putida ATCC 33015;	80%
With potassium permanganate In water at 55℃; for 22h; Reagent/catalyst; Temperature;	70.2%

: 1113-59-3
bromopyruvic acid

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
Stage #1: formamide With tetraphosphorus decasulfide In tetrahydrofuran at 30℃; for 3h; Stage #2: bromopyruvic acid In tetrahydrofuran at 40 - 50℃; for 3h;	22%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 22358-80-1
thiazole 2,5-dicarboxylic acid

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
at 153.9℃; Rate constant; sowie bei 164.7.Decarboxylation;

: 100367-77-9
ethyl 2-bromothiazole-4-carboxylate

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide anschliessend Hydrieren an Raney-Nickel;

: 89791-92-4
2-propionyl-thiazole-4-carboxylic acid

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
With sulfuric acid at 180℃;

: 89791-92-4
2-propionyl-thiazole-4-carboxylic acid

A: 3973-08-8
Thiazole-4-carboxylic acid

B: 89379-29-3
thiazole-2,4-dicarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide; potassium permanganate

: 89379-29-3
thiazole-2,4-dicarboxylic acid

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
at 140 - 144℃; Decarboxylation;

: 22358-80-1
thiazole 2,5-dicarboxylic acid

: 108-24-7
acetic anhydride

: 3973-08-8
Thiazole-4-carboxylic acid

: 22358-80-1
thiazole 2,5-dicarboxylic acid

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
at 180℃;

: 7113-13-5
[2,4']bithiazolyl-4-carboxylic acid hydrazide

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
(i) NaNO2, aq. HCl, AcOH, (ii) Ac2O, (iii) aq. HCl; Multistep reaction;

: 7647-01-0
hydrogenchloride

: 89379-29-3
thiazole-2,4-dicarboxylic acid

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
Decarboxylation;

: 115-08-2
thiocarboxamide

: 1113-59-3
bromopyruvic acid

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
In tetrahydrofuran at 45 - 50℃; for 5.5h;	3.59 g

: 14527-43-6
ethyl thiazole-4-carboxylate

: 3973-08-8
Thiazole-4-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 26787-78-0
amoxicillin

A: 3973-08-8
Thiazole-4-carboxylic acid

B: 740742-98-7
5,5-Dimethyl-4,5-dihydro-thiazole-4-carboxylic acid

C: 64-18-6
formic acid

D: 79-14-1
glycolic Acid

E: 110-94-1
1,5-pentanedioic acid

F: 124-04-9
Adipic acid

G: 80-69-3
tartronic acid

H: 473-81-4
glyceric acid

I: 471-47-6
oxamic acid

J: 110-15-6
succinic acid

K: 1378848-02-2
C5H8O6S

L: 15573-67-8
pisolithin A

M: C9H10N2O4

N: C9H12N2O5S

O: C8H10N2O6S

P: C9H14N2O7S

Q: C9H12N2O6S

R: C8H10N2O4S

S: C10H12N2O7S

T: C15H21N3O4S

U: C15H18N2O4S

V: C14H21N3O3S

W: C8H12N2O4S

X: C8H10N2O5S

Y: C6H10O7S

Z: C6H7NO4S

[: C6H11NO3S

\: C6H9NO3S

]: 144-62-7
oxalic acid

^: 64-19-7
acetic acid

_: 802294-64-0
propionic acid

`: 127-17-3
2-oxo-propionic acid

a: 87-69-4
tartaric acid

b: 551-16-6
6-aminopenicillanic acid

c: 65-85-0
benzoic acid

d: 298-12-4
Glyoxilic acid

e: 2-hydroxy-3-(4-hydroxyphenyl)pyrazine

f: 6915-18-0
2-butenedioic acid

g: 107-92-6
butyric acid

h: 57457-65-5
(4S)-2t-{(R)-[(R)-2-amino-2-(4-hydroxy-phenyl)-acetylamino]-carboxy-methyl}-5,5-dimethyl-thiazolidine-4r-carboxylic acid

i: 99-96-7
4-hydroxy-benzoic acid

Conditions

Conditions	Yield
With Ru/CNT; sodium hydroxide for 8h; Reagent/catalyst; Electrolysis;

...Expand

: 3973-08-8
Thiazole-4-carboxylic acid

: 3745-79-7
1,3-thiazole-4-carbonyl chloride

Conditions

Conditions	Yield
With thionyl chloride for 2h; Heating / reflux;	99%
With thionyl chloride for 2h; Reflux;	80.5%
With thionyl chloride

: 54-96-6
3,4-diaminopyridine

: 3973-08-8
Thiazole-4-carboxylic acid

: 65911-26-4
4-(1H-imidazo[4,5-c]pyridin-2-yl)thiazole

Conditions

Conditions	Yield
With PPA at 180℃; for 2h;	98%

: 452-58-4
2,3-Diaminopyridine

: 3973-08-8
Thiazole-4-carboxylic acid

: 1848-82-4
4-(1H-imidazo[4,5-b]pyridin-2-yl)thiazole

Conditions

Conditions	Yield
With PPA at 180℃; for 2h;	97%

: 3973-08-8
Thiazole-4-carboxylic acid

: 64-17-5
ethanol

: 14527-43-6
ethyl thiazole-4-carboxylate

Conditions

Conditions	Yield
With thionyl chloride at 80℃; Cooling with ice;	96%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;	87.6%

: 3973-08-8
Thiazole-4-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1037746-91-0
tert-butyl 1,3-thiazole-4-carboxylate

Conditions

Conditions	Yield
Stage #1: Thiazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 50℃; for 1h; Stage #2: tert-butyl alcohol With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 60℃; for 48h;	94%
Stage #1: Thiazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 50℃; for 1h; Inert atmosphere; Stage #2: tert-butyl alcohol With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 60℃; for 48h; Inert atmosphere;	94%

: 3973-08-8
Thiazole-4-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1235406-42-4
thiazol-4-ylaminocarboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine at 0℃; Reflux;	94%
With diphenyl phosphoryl azide; triethylamine In tert-butyl alcohol for 16h; Inert atmosphere; Reflux;	94%
With diphenylphosphoranyl azide; triethylamine for 18h; Curtius Rearrangement; Reflux;	77.4%

: 3973-08-8
Thiazole-4-carboxylic acid

: 1146084-66-3
tert-butyl (2-aminothiazol-4-yl)methylcarbamate

: tert-butyl(2-(thiazole-4-carboxamido)thiazol-4-yl)methylcarbamate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	94%

: 15206-55-0
methyl 2-oxo-2-phenylacetate

: 3973-08-8
Thiazole-4-carboxylic acid

: 2-methoxy-2-oxo-1-phenylethyl thiazole-4-carboxylate

Conditions

Conditions	Yield
With phenylsilane; 2,2,3,4,4-pentamethyl-1-(pyrrolidin-1-yl)phosphetane 1-oxide In 1,2-dichloro-ethane at 80℃; for 20h; Sealed tube; chemoselective reaction;	94%

: 3973-08-8
Thiazole-4-carboxylic acid

: 95-54-5
1,2-diamino-benzene

: 148-79-8
thiabendazole

Conditions

Conditions	Yield
Stage #1: 1,2-diamino-benzene With polyphosphoric acid at 150℃; Inert atmosphere; Stage #2: Thiazole-4-carboxylic acid at 230℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;	88%
With polyphosphoric acid for 3h; Reflux;

: 3973-08-8
Thiazole-4-carboxylic acid

: 7589-27-7
2-(4-Fluorophenyl)ethanol

: 4-fluorophenethyl thiazole-4-carboxylate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;	87.6%

: 3973-08-8
Thiazole-4-carboxylic acid

: 108-93-0
cyclohexanol

: cyclohexyl thiazole-4-carboxylate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;	87.49%

: 3973-08-8
Thiazole-4-carboxylic acid

: (S)-allyl 2-(allyloxy)-4-(2-(allyloxy)-4-(4-(2-(4-aminobenzamido)-3-cyanopropanamido)benzamido)-3-methoxybenzamido)-3-methoxybenzoate

: C47H43N7O11S

Conditions

Conditions	Yield
Stage #1: Thiazole-4-carboxylic acid With 2,4,6-trimethyl-pyridine; bis(trichloromethyl) carbonate In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Stage #2: (S)-allyl 2-(allyloxy)-4-(2-(allyloxy)-4-(4-(2-(4-aminobenzamido)-3-cyanopropanamido)benzamido)-3-methoxybenzamido)-3-methoxybenzoate With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 12h;	86%

: 3973-08-8
Thiazole-4-carboxylic acid

: 298201-68-0
2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-ylamine

: 1120368-16-2
C20H13N5OS

Conditions

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;	85%

: 3973-08-8
Thiazole-4-carboxylic acid

: 57441-02-8
17β-estradiol-3-t-butyldimethylsilyl ether

: 1083177-79-0
C28H39NO3SSi

Conditions

Conditions	Yield
With dmap; 2-methyl-6-nitrobenzoic anhydride; triethylamine In tetrahydrofuran at 20℃; for 1h;	84%

: 3973-08-8
Thiazole-4-carboxylic acid

: 111-26-2
hexan-1-amine

: N-hexylthiazole-4-carboxamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;	83.7%

: 3973-08-8
Thiazole-4-carboxylic acid

: 479255-66-8
cyclohexyl 2-amino-2-deoxy-1-thio-α-D-glucopyranoside

: cyclohexyl 2-deoxy-2-(thiazole-4-carbonylamino)-1-thio-α-D-glucopyranoside

Conditions

Conditions	Yield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0 - 23℃; for 3h;	83%

: 3973-08-8
Thiazole-4-carboxylic acid

: 4-chloro-3-(oxazolo[4,5-b]pyridin-2-yl)benzenamine

: 1448806-17-4
N-(4-chloro-3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)thiazole-4-carboxamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 45℃; Inert atmosphere;	83%

: 3973-08-8
Thiazole-4-carboxylic acid

: 71-36-3
butan-1-ol

: butyl thiazole-4-carboxylate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;	83%

: 3973-08-8
Thiazole-4-carboxylic acid

: 1452-15-9
thiazole-4-carbonitrile

Conditions

Conditions	Yield
Stage #1: Thiazole-4-carboxylic acid With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; ammonium chloride Stage #2: With triethylamine; trifluoroacetic anhydride at 0 - 20℃; for 6h;	83%

: 3973-08-8
Thiazole-4-carboxylic acid

: 2039-67-0
2-(3-methoxyphenyl)-1-ethanamine

: N-(3-methoxyphenethyl)thiazole-4-carboxamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;	82.4%

: 3973-08-8
Thiazole-4-carboxylic acid

: 1092395-11-3
N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide

: 1092393-75-3
N-{6-[5-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)-2-methylphenoxy][1,2,4]triazolo[1,5-a]pyridin-2-yl}-1,3-thiazole-4-carboxamide

Conditions

Conditions	Yield
Stage #1: Thiazole-4-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran at 20℃; for 1h; Stage #2: N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide With pyridine at 20℃; for 16h;	82%

: 286-18-0
7-azabicyclo[4.1.0]heptane

: 3973-08-8
Thiazole-4-carboxylic acid

: 1372857-68-5
7-azabicyclo[4.1.0]heptan-7-yl(thiazol-4-yl)methanone

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere;	82%

: 3973-08-8
Thiazole-4-carboxylic acid

: 4-[(2S',6S')-6'-(4-((6-aminohexyl)oxy)butyl)tetrahydropyran-2-yl]-1-[(2S'',6S'')-6''-(4-hydroxybutyltetrahydropyran-2-yl)methyl]-1H-1,2,3-triazole

: N-(6-(4-((2S,6S)-6-((4-((2S,6S)-6-(4-(benzyloxy)butyl)tetrahydro-2H-pyran-2-yl)-1H-1,2,3-triazol-1-yl)methyl)tetrahydro-2H-pyran-2-yl)butoxy)hexyl)thiazole-4-carboxamide

Conditions

Conditions	Yield
Stage #1: Thiazole-4-carboxylic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.166667h; Stage #2: 4-[(2S',6S')-6'-(4-((6-aminohexyl)oxy)butyl)tetrahydropyran-2-yl]-1-[(2S'',6S'')-6''-(4-hydroxybutyltetrahydropyran-2-yl)methyl]-1H-1,2,3-triazole In dichloromethane at 20℃;	82%

: 67-56-1
methanol

: 3973-08-8
Thiazole-4-carboxylic acid

: 59418-09-6
4-thiazolecarboxylate methyl ester

Conditions

Conditions	Yield
With thionyl chloride at -15℃; Reflux; Inert atmosphere;	81%
With thionyl chloride at -15℃; Inert atmosphere; Reflux;	81%
With sulfuric acid
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;

: 3973-08-8
Thiazole-4-carboxylic acid

: 156-87-6
propan-1-ol-3-amine

: 3-hydroxypropyl thiazole-4-carboxylate

Conditions

Conditions	Yield
With propane-1,3-diyl dinitrite In tetrahydrofuran at 100℃; under 12929 Torr; for 0.5h;	81%

: 3973-08-8
Thiazole-4-carboxylic acid

: diethyl 4-(6-hydroxyhexan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

: diethyl 2,6-dimethyl-4-(6-((thiazole-4-carbonyl)oxy)hexan-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h;	80%

: 3973-08-8
Thiazole-4-carboxylic acid

: thiazole-4-carbonyl azide

Conditions

Conditions	Yield
Stage #1: Thiazole-4-carboxylic acid With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.25h; Stage #2: With sodium azide In tetrahydrofuran for 0.25h;	79%

4-Thiazolecarboxylic acid Chemical Properties

IUPAC Name: 1,3-thiazole-4-carboxylic acid (3973-08-8)
Synonyms: 1,3-Thiazole-4-carboxylic acid ; Akos bb-9161 ; 4-Carboxythiazole ; 4-Thiazolecarboxylic acid ; Timtec-bb sbb010166 ; Thiazole-4-carboxylic acid ; 4-Thiazolecarboxylic acid 3973-8-8 ; 1,3-Thiazole-4-carboxylic acid 3973-8-8
CAS: 3973-08-8
MF: C₄H₃NO₂S
MW: 129.14
MS:
Product Categories: blocks ; Carboxes ; Thiazoles ; Sulphur Derivatives ; Carboxylic Acids ; Thiazoles, Isothiazoles &Benzothiazoles ; Carboxylic Acids ; Thiazoles, Isothiazoles & Benzothiazoles ; Building Blocks ; Heterocyclic Building Blocks
Mol File: 3973-08-8.mol
Surface Tension: 72 dyne/cm Density: 1.525 g/cm³
Flash Point: 146.9 °C Enthalpy of Vaporization: 59.21 kJ/mol
Boiling Point: 319.2 °C at 760 mmHg Vapour Pressure: 0.000143 mmHg at 25°C
MP:195-199 °C(lit.)

4-Thiazolecarboxylic acid Uses

1.4-Thiazolecarboxylic acid (93973-08-8) is an intermediate of fungicide thiabendazole.
2.4-Thiazolecarboxylic acid (93973-08-8) is used as a medicine, pesticide intermediates, organic synthesis reagents .

4-Thiazolecarboxylic acid Production

Its preparation method is to use formamide with P2S5 in ethylene glycol dimethyl ether (CH₃OCH₂CH₂OCH₃) reaction to obtain thiocarboxamide (HCSNH₂), and then, halogenate with pyruvate for product.

4-Thiazolecarboxylic acid Safety Profile

Hazard Codes: Xi
Risk Statements: 43
43: 4-Thiazolecarboxylic acid (93973-08-8) may cause sensitization by skin contact
Safety Statements : 36/37
36/37: Wear suitable protective clothing and gloves
WGK Germany: 3

4-Thiazolecarboxylic acid Specification

4-Thiazolecarboxylic acid (93973-08-8) is a colorless solid, not dissolve in water.

Product Name

4-Thiazolecarboxylic acid

Synthetic route

4-Thiazolecarboxylic acid Chemical Properties

4-Thiazolecarboxylic acid Uses

4-Thiazolecarboxylic acid Production

4-Thiazolecarboxylic acid Safety Profile

4-Thiazolecarboxylic acid Specification

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