4-Vinylpyridine supplier | CasNO.100-43-6

Name
4-Vinylpyridine
EINECS 202-852-0
CAS No. 100-43-6
Article Data43
CAS DataBase
Density 0.968 g/cm³
Solubility 29 g /L (20 °C) in water
Melting Point < 25oC
Formula C₇H₇N
Boiling Point 173.627 °C at 760 mmHg
Molecular Weight 105.139
Flash Point 51.667 °C
Transport Information UN 3073 6.1/PG 2
Appearance dark brown to yellow liquid
Safety 23-26-36/37/39-45-28A-16
Risk Codes 10-25-34-42/43-23/25
Molecular Structure
Hazard Symbols T
Synonyms Pyridine,4-vinyl- (8CI);2-(4-Pyridyl)ethylene;4-Ethenylpyridine;NSC18256;g-Vinylpyridine;Pyridine, 4-ethenyl-;
PSA 12.89000
LogP 1.72460

Synthetic route

: 1120-87-2
4-bromopyridin

: tetramethyldivinyldisiloxane

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With C25H39P; tetrabutyl ammonium fluoride; palladium diacetate In tetrahydrofuran at 25℃; for 24h; Hiyama Coupling; Schlenk technique; Inert atmosphere;	99%

: 2629-72-3
4-(3-Hydroxypropyl)pyridine

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With methoxy(cyclooctadiene)rhodium(I) dimer; N,N-Dimethylacrylamide; 3-Methoxybenzoic acid; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 90℃; for 24h; Inert atmosphere; Glovebox; Sealed tube; chemoselective reaction;	85%

: 5344-27-4
4-(2-hydroxyethyl)pyridine

: 648894-30-8
methyl 2-[2-(3,5-dimethylphenyl)-3-((1S)-1-methyl-2-{[(2,4-nitrophenyl)sulfonyl]amino}ethyl)-1H-indol-5-yl]-2-methylpropanoate

A: 100-43-6
4-vinylpyridine

B: methyl 2-(2-(3,5-dimethylphenyl)-3-{(1S)-2-[[(,4-dinitrophenyl)sulfonyl](2-pyridin-4-ylethyl)amino]-1-methylethyl}-1H-indol-5-yl)-2-methylpropanoate

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 10℃;	A n/a B 84%

...Expand

: 19524-06-2
4-bromopyridine hydrochloride

: potassium vinyltrifluoroborate

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With C17H36ClN6NiP2(1+)*Cl(1-); potassium tert-butylate In toluene at 120℃; for 16h; Suzuki-Miyaura Coupling; Inert atmosphere;	84%

: 181219-01-2
4-pyridineboronic acid pinacol ester

vinylmagnesium halide: vinylmagnesium halide

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
Stage #1: 4-pyridineboronic acid pinacol ester; vinylmagnesium halide In tetrahydrofuran at -78 - 20℃; for 2.25h; Inert atmosphere; Stage #2: With trifluoroacetyl chloride In tetrahydrofuran at -78 - -40℃; for 18.5h; Inert atmosphere; Further stages;	76%

: 19524-06-2
4-bromopyridine hydrochloride

: 75927-49-0
pinacol vinylboronate

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate In 1,4-dioxane; water at 100℃; Inert atmosphere;	55.55%

: 108-89-4
picoline

: 67-56-1
methanol

A: 100-43-6
4-vinylpyridine

B: 536-75-4
4-Ethylpyridine

C: 108-47-4
2,4-lutidine

Conditions

Conditions	Yield
Cs exchanged zeolite at 450℃; Product distribution; investigation of the heterogeneous vapor-phase alkylation of γ-picoline with methanol over Na+, K+, Rb+, or Cs+ exchanged X- or Y-type zeolite in an atmosphere of nitrogen;	A 3.7% B 27.1% C 13.8%

...Expand

: 34064-35-2
4-(oxiran-2-yl)pyridine

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With potassium thioacyanate In ethanol; water for 46h; Ambient temperature;	5%

: 108-89-4
picoline

: 50-00-0
formaldehyd

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With water; hydrogen at 215℃; anschl. mit NaOH und 2-Amino-phenol unter vermindertem Druck auf Siedetemperatur;
With water at 275℃; beim Leiten ueber mit Zinkfluorid impraegniertes Al2O3;
Cs-ZSM-5 at 200 - 400℃; for 4 - 8h;

: 5344-27-4
4-(2-hydroxyethyl)pyridine

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With potassium hydroxide unter Ausschluss von Licht und anschl. Erwaermen unter 12 Torr auf Siedetemperatur;
With potassium hydroxide at 175℃; under 30 Torr;

: 64-17-5
ethanol

: 4-(2-iodo-ethyl)-pyridine; picrate

: 100-43-6
4-vinylpyridine

: 536-75-4
4-Ethylpyridine

: 124-38-9
carbon dioxide

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
at 700℃; beim Leiten ueber mit Cer(IV)-oxid impraegniertes Silicagel;
at 700℃; beim Leiten ueber mit Wolfram(VI)-oxid impraegniertes Silicagel;

: 28148-48-3
2-(pyridin-4-yl)ethyl chloride

KOH-solution: KOH-solution

: 100-43-6
4-vinylpyridine

picrate of 4-<β-iodo-ethyl>-pyridine: picrate of 4-<β-iodo-ethyl>-pyridine

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With methanol; alkaline solution
With water
With ethanol

: 7732-18-5
water

: 4-(2-iodo-ethyl)-pyridine; picrate

: 100-43-6
4-vinylpyridine

: N-[2-(4-pyridyl)ethyl]quinuclidinium bromide

A: 100-76-5
Quinuclidine

B: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With 1H-imidazole; imidazolium buffer; potassium chloride In water at 50℃; pH=6.29; Kinetics; Further Variations:; pH-values; Reagents; buffer concentration;
With potassium chloride; water at 50℃; Kinetics;
With potassium hydroxide; potassium chloride In water at 50℃; Kinetics; Further Variations:; Reagents; Elimination;

: 497914-04-2
4-(2-fluoroethyl)pyridine

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With acetohydroxamate buffer; potassium chloride at 50℃; pH=8.70; Kinetics; Further Variations:; Temperatures; Reagents; pH-values;

: 400759-02-6
N-[2-(4-pyridyl)ethyl]quinuclidinium

A: 100-76-5
Quinuclidine

B: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With Quinuclidine; quinuclidinium buffer; potassium chloride In water at 50℃; pH=10.1; Kinetics; Further Variations:; pH-values;

: 400759-02-6
N-[2-(4-pyridyl)ethyl]quinuclidinium

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With potassium chloride; zinc(II) chloride In water at 50℃; pH=5.2 - 6.35; Kinetics; Equilibrium constant;

: 28148-48-3
2-(pyridin-4-yl)ethyl chloride

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With hydroxide In water; acetonitrile at 25℃; Kinetics; Further Variations:; solvent ratios;

: 872-85-5
pyridine-4-carbaldehyde

A: 100-43-6
4-vinylpyridine

B permanganate: permanganate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 15 percent / NaOH, TEBA / benzene / 24 h / Ambient temperature 2: 5 percent / KSCN / ethanol; H2O / 46 h / Ambient temperature View Scheme

: 108-89-4
picoline

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: water; hydrogen / 220 °C / 44130.5 Torr 2: KOH / unter Ausschluss von Licht und anschl. Erwaermen unter 12 Torr auf Siedetemperatur View Scheme
With formaldehyd; Rb-ZSM-5 (SiO2/Al2O3=30) at 300℃; for 4h;
With formaldehyd; Ca-ZSM-5 (SiO2/Al2O3=30) at 300℃; for 4h;

: hexahydro-7-[2-(pyridin-4-yl)-ethyl]-1H-azepin-2-one

A: 100-43-6
4-vinylpyridine

B: 4-[2-(hexahydro-7-imino-1H-azepin-2-yl)ethyl]-1-methylpyridinium chloride

: 84206-31-5
W(CO)5(4-vinylpyridine)

: 109-67-1
1-penten

A: 100-43-6
4-vinylpyridine

B: 53261-74-8
W(CO)5(1-pentene)

Conditions

Conditions	Yield
In further solvent(s) Irradiation (UV/VIS); irrdn. (λ 436 nm) of degassed isopentane soln. of educt contg. 1-pentene; monitored by IR and UV;

...Expand

: 82769-08-2, 75687-40-0
poly{Ru(2,2'-bipyridine)2(4-vinylpyridine)2}(2+)

: 16887-00-6
chloride

A: 100-43-6
4-vinylpyridine

B: 1190978-30-3, 75675-25-1, 82838-49-1
poly{Ru(2,2'-bipyridine)2(4-vinylpyridine)Cl}(1+)

Conditions

Conditions	Yield
In water Irradiation (UV/VIS); photolysis of polymer on electrode surface by irradn. with Hg lamp,; product detected by cyclic voltammetry;

...Expand

: 7234-39-1
N,N-dimethyldithiocarbamate

: 145552-45-0, 130728-17-5
poly{Ru(4,4',5,5'-tetramethyl-2,2'-bipyridine)2(4-vinylpyridine)2}(2+)

A: 100-43-6
4-vinylpyridine

B: Ru(Me4bpy)2(dtmc)}(1+)

Conditions

Conditions	Yield
In water Kinetics; Irradiation (UV/VIS); photolysis of polymer on electrode surface by irradn. with Hg lamp, 15-45 min, 0.1M aq. soln. of dmtc(1-), rinsing of electrode in water and acetonitrile; process detected by UV;

...Expand

: 872-85-5
pyridine-4-carbaldehyde

: 2065-66-9
methyl-triphenylphosphonium iodide

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With potassium tert-butylate In benzene at 20℃; Wittig Olefination; Inert atmosphere; Reflux;

: 872-85-5
pyridine-4-carbaldehyde

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With Methyltriphenylphosphonium bromide; potassium carbonate In 1,4-dioxane for 16h; Reflux;

: 1120-87-2
4-bromopyridin

: 75927-49-0
pinacol vinylboronate

: 100-43-6
4-vinylpyridine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; cesium fluoride In 1,4-dioxane; water at 85℃; for 12h; Inert atmosphere;

: 100-43-6
4-vinylpyridine

: 91-60-1
2-Naphthalenethiol

: 21070-67-7
4-(2-phenylsulfanyl-ethyl)-pyridine

Conditions

Conditions	Yield
In benzene for 6h; Heating;	100%

: 100-43-6
4-vinylpyridine

divinylbenzene: divinylbenzene

poly(4-vynylpyridine), cross-linked with divinylbenzene (5 mol percent): poly(4-vynylpyridine), cross-linked with divinylbenzene (5 mol percent)

Conditions

Conditions	Yield
With azobisisobutyronitrile In various solvent(s) at 80℃; for 4h;	100%

: 100-43-6
4-vinylpyridine

: 54073-94-8
4-hydroxy-3,5-diiodo-benzoic acid ethyl ester

: 1415748-03-6
C23H20N2O3

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; C16H36N; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 100℃; Inert atmosphere;	100%

: 100-43-6
4-vinylpyridine

: 75-15-0
carbon disulfide

: 109-89-7
diethylamine

: 2-(pyridin-4-yl)ethyl diethylcarbamodithioate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 6h; Green chemistry; regioselective reaction;	100%

...Expand

: 123-75-1
pyrrolidine

: 100-43-6
4-vinylpyridine

: 75-15-0
carbon disulfide

: 2-(pyridin-4-yl)ethyl pyrrolidine-1-carbodithioate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 6h; Green chemistry; regioselective reaction;	100%

...Expand

: 100-43-6
4-vinylpyridine

: 75-15-0
carbon disulfide

: 75-31-0
isopropylamine

: 2-(pyridin-4-yl)ethyl isopropylcarbamodithioate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 6h; Green chemistry; regioselective reaction;	100%

...Expand

: 100-43-6
4-vinylpyridine

: 55400-67-4
3-Trifluoromethyl-benzenesulfonic acid 3-trifluoromethyl-phenyl ester

: C14H10F3NO2S

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl acetamide Irradiation;	100%

: 100-43-6
4-vinylpyridine

: 1154061-81-0
trichloro(hydrido)bis(4-vinylpyridine)silicon

Conditions

Conditions	Yield
With trichlorosilane In toluene at -78 - 20℃; Inert atmosphere;	99.5%

: 100-43-6
4-vinylpyridine

: 10025-78-2
trichlorosilane

: 1154061-81-0
trichloro(hydrido)bis(4-vinylpyridine)silicon

Conditions

Conditions	Yield
In toluene at -78 - 20℃;	99.5%

: 110-91-8
morpholine

: 100-43-6
4-vinylpyridine

: 28487-18-5
N-[2-(4-pyridyl)ethyl]morpholine

Conditions

Conditions	Yield
With zinc(II) nitrate hexahydrate In acetonitrile at 25℃; for 12h; Sealed tube; Green chemistry;	99%
With NPs-Fe3O4-DE-bmim3PW In dichloromethane at 20℃; for 2h;	79%
With triphenylphosphine; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate In tetrahydrofuran for 20h; Alkylation; Heating;	44%

: 100-43-6
4-vinylpyridine

: 111-88-6
Octanethiol

: 105163-69-7
1-octyl 2-(4-pyridyl)ethyl sulfide

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at 20℃; for 6h;	99%
	23%

: 100-43-6
4-vinylpyridine

: 91-60-1
2-Naphthalenethiol

: 105163-70-0
2-naphthyl 2-(4-pyridyl)ethyl sulfide

Conditions

Conditions	Yield
In benzene for 6h; Heating;	99%

: 100-43-6
4-vinylpyridine

: 1309609-43-5
6-bromo-N-ethyl-N-phenylpyridin-2-amine

: (E)-N-ethyl-N-phenyl-6-(2-(pyridin-4-yl)vinyl)pyridine-2-amine

Conditions

Conditions	Yield
With dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium(II); potassium carbonate In N,N-dimethyl-formamide; toluene at 140℃; for 2h; Heck reaction;	99%
With dichloro{bis[1,1’,1’’-(phosphinetriyl)tripiperidine]}palladium(II); tetrabutylammomium bromide; potassium carbonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 100℃; for 32h; Heck Reaction; Schlenk technique; Glovebox; Inert atmosphere; Green chemistry;	98%

: 100-43-6
4-vinylpyridine

: Fe(octaphenyltetraazaporphinate)

: Fe(octaphenyltetraazaporphinate)(4-vinylpyridine)2

Conditions

Conditions	Yield
In neat (no solvent) standing in vapor of amine (room temp., 2 days);	99%
In benzene addn. of amine to Fe-complex; distn. off of excess amine and solvent (after 24 h), drying (vac., room temp.);

: 100-43-6
4-vinylpyridine

: ammonium hexafluorophosphate

: trans-[Ru(II)(2,9-di(pyrid-2'-yl)-1,10-phenanthroline)Cl2]*H2O

: trans-[Ru(II)(2,9-di(pyrid-2'-yl)-1,10-phenanthroline)(4-vinylpyridine)2](PF6)2*0.5H2O

Conditions

Conditions	Yield
In ethanol; water refluxing a mixt. of Ru complex and ligand in ethanol/water for 2 d, concn., addn. of NH4PF6; washing ppt. with H2O, recrystn. (acetone/H2O); elem. anal.;	99%

...Expand

: 100-43-6
4-vinylpyridine

: (E)-N-(4-methoxyphenyl)-1-(1-methyl-1H-indol-3-yl)methanimine

: (E)-N-(4-methoxyphenyl)-1-(1-methyl-2-(1-(pyridin-4-yl)ethyl)-1H-indol-3-yl)methanimine

Conditions

Conditions	Yield
With tetrakis(trimethylphosphine)cobalt(0) In toluene at 170℃; for 1h; Microwave irradiation;	99%

: 100-43-6
4-vinylpyridine

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 65373-43-5
1-(2,4-dimethoxyphenyl)-3-(pyridin-4-yl)propan-1-ol

Conditions

Conditions	Yield
With [2,2]bipyridinyl; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; lanthanum(lll) triflate In acetonitrile at 23℃; for 18h; Inert atmosphere; Sealed tube; Irradiation; regioselective reaction;	99%

: 100-43-6
4-vinylpyridine

: 4707-71-5
Phenanthrene-9-carboxaldehyde

: 1-(phenanthren-9-yl)-3-(pyridin-4-yl)propan-1-ol

Conditions

Conditions	Yield
With [2,2]bipyridinyl; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; lanthanum(lll) triflate In acetonitrile at 23℃; for 18h; Inert atmosphere; Sealed tube; Irradiation; regioselective reaction;	99%

: 100-43-6
4-vinylpyridine

: 3,4,5-trimethoxybenzaldehyde hydrazone

: C17H21NO3

Conditions

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 1,2-bis(dimethylphosphanyl)ethane; lithium tert-butoxide In tetrahydrofuran at 80℃; for 12h; Inert atmosphere; regioselective reaction;	99%

: 100-43-6
4-vinylpyridine

: 24091-03-0
2-naphthaldehyde hydrazone

: C18H17N

Conditions

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 1,2-bis(dimethylphosphanyl)ethane; lithium tert-butoxide In tetrahydrofuran at 80℃; for 12h; Inert atmosphere; regioselective reaction;	99%

: 100-43-6
4-vinylpyridine

: 62-53-3
aniline

: 28683-44-5
N-(2-(pyridin-4-yl)ethyl)aniline

Conditions

Conditions	Yield
With DE-PrIm-HPW (6b) In acetonitrile at 50℃; for 2h; Reagent/catalyst; Michael Addition;	98%
With NPs-Fe3O4-DE-bmim3PW In dichloromethane at 20℃; for 2h;	95%
With methanol; acetic acid
With acetic acid at 130℃;

: 100-43-6
4-vinylpyridine

: 13297-41-1
3-butyl-1-methylquinoxalin-2(1H)-one

: 112828-56-5
2a-Butyl-4-methyl-1-pyridin-4-yl-2,2a-dihydro-1H,4H-azeto[1,2-a]quinoxalin-3-one

Conditions

Conditions	Yield
In benzene for 15h; Ambient temperature; Irradiation;	98%

: 100-43-6
4-vinylpyridine

: 230618-41-4
2-bromo-6-(pyrrolidin-1-yl)pyridine

: (E)-2-(2-(pyridin-4-yl)vinyl)-6-(pyrrolidin-1-yl)pyridine

Conditions

Conditions	Yield
With dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium(II); potassium carbonate In N,N-dimethyl-formamide; toluene at 140℃; for 3h; Heck reaction;	98%

: 100-43-6
4-vinylpyridine

: 75-15-0
carbon disulfide

: 109-73-9
N-butylamine

: 2-(pyridin-4-yl)ethyl butylcarbamodithioate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 6h; Green chemistry; regioselective reaction;	98%

...Expand

: 100-43-6
4-vinylpyridine

: 401514-50-9
o-fluorobenzaldehyde hydrazone

: C14H14FN

Conditions

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 1,2-bis(dimethylphosphanyl)ethane; lithium tert-butoxide In tetrahydrofuran at 80℃; for 12h; Inert atmosphere; regioselective reaction;	98%

: 100-43-6
4-vinylpyridine

: 696-62-8
para-iodoanisole

: 722-21-4, 6043-46-5, 46739-60-0
(E)-4-(4-methoxystyryl)pyridine

Conditions

Conditions	Yield
With potassium carbonate; cross-linked Pd-plug In N,N-dimethyl-formamide at 115℃; Heck-Mizoroki coupling reaction;	97%
With triethylamine; palladium diacetate In acetonitrile at 100℃; for 72h; Yield given;

: 100-43-6
4-vinylpyridine

: 591-50-4
iodobenzene

: 5097-93-8
trans-4-styrylpyride

Conditions

Conditions	Yield
With potassium carbonate; cross-linked Pd-plug In N,N-dimethyl-formamide at 115℃; Heck-Mizoroki coupling reaction;	97%
With triethylamine; N-acetyl-3,5-bis(phenylthiomethyl)aniline-palladium(II)-Cl In N,N-dimethyl-formamide at 110℃; for 6h; Heck reaction;	94%
With 2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenylamine; cetyltrimethylammonim bromide; palladium diacetate; potassium carbonate In N,N-dimethyl acetamide; water at 140℃; for 40h; Mizoroki-Heck reaction; Inert atmosphere;	94%

: 100-43-6
4-vinylpyridine

: 4181-20-8
tris(4-iodophenyl)amine

: tris[4-(4-pyridylethenyl)phenyl]amine

Conditions

Conditions	Yield
With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine In acetonitrile at 6℃; Heating;	97%
With tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium diacetate In water; N,N-dimethyl-formamide at 70℃; for 48h; Heck coupling reaction;	66%

: 100-43-6
4-vinylpyridine

: 14495-51-3
2-bromo-5-chlorotoluene

: 1370449-38-9
(E)-4-(4-chloro-2-methylstyryl)pyridine

Conditions

Conditions	Yield
With dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium; potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 140℃; for 16h; Mizoroki-Heck reaction; Inert atmosphere;	97%

4-Vinylpyridine Consensus Reports

Reported in EPA TSCA Inventory.

4-Vinylpyridine Specification

The 4-Vinylpyridine, with the CAS registry number 108-10-1,is also known as gamma-Vinylpyridine. It belongs to the product categories of Vinyl Halides, Amines, Amides, and Other Vinyl Monomers. Its EINECS number is 202-852-0. This chemical's molecular formula is C7H7N and molecular weight is 105.14. What's more,Its systematic name is 4-Vinylpyridine.It is a dark brown to yellow liquid which is stable,incompatible with strong acids,strong oxidizing agents.It is a reagent for blocking cysteine function in proteins.4-Vinylpyridine can be used as organic intermediate and pharmaceutical intermediate. It can also be used as monomer in the manufacturing of polymer.

Physical properties about 4-Vinylpyridine are:
(1)ACD/LogP: 1.824; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.58; (4)ACD/LogD (pH 7.4): 1.82; (5)ACD/BCF (pH 5.5): 8.08; (6)ACD/BCF (pH 7.4): 14.18; (7)ACD/KOC (pH 5.5): 131.94; (8)ACD/KOC (pH 7.4): 231.65; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.563; (13)Molar Refractivity: 35.268 cm3; (14)Molar Volume: 108.605 cm3; (15)Polarizability: 13.981 10-24cm3 ; (16)Surface Tension: 36.1959991455078 dyne/cm; (17)Density: 0.968 g/cm3; (18)Flash Point: 51.667 °C; (19)Enthalpy of Vaporization: 39.315 kJ/mol; (20)Boiling Point: 173.627 °C at 760 mmHg; (21)Vapour Pressure: 1.67900002002716 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:C=Cc1ccncc1;
(2)Std. InChI:InChI=1S/C7H7N/c1-2-7-3-5-8-6-4-7/h2-6H,1H2;
(3)Std. InChIKey:KFDVPJUYSDEJTH-UHFFFAOYSA-N.

Safety Information of 4-Vinylpyridine:
The 4-Vinylpyridine is flammable and causes burns ,so keep away from sources of ignition - No smoking .And it may cause sensitization by inhalation and skin contact ,so do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .When you use it ,wear suitable protective clothing, gloves and eye/face protection .In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) ,and in case of contact with eyes, rinse immediately with plenty of water and seek medical advice .

The toxicity data of 4-Vinylpyridine are as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	100mg/kg (100mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
guinea pig	LD50	oral	321mg/kg (321mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: AGGRESSION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 55, 1984.
guinea pig	LDLo	skin	500mg/kg (500mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 845, 1986.
mammal (species unspecified)	LD50	oral	216mg/kg (216mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
mouse	LC50	inhalation	380mg/m3/2H (380mg/m3)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: AGGRESSION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 55, 1984.
mouse	LD50	oral	161mg/kg (161mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: AGGRESSION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(6), Pg. 55, 1984.
rat	LC50	inhalation	170mg/m3 (170mg/m3)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(9-10), Pg. 64, 1992.
rat	LD50	oral	100mg/kg (100mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 845, 1986.

Product Name

4-Vinylpyridine

Synthetic route

4-Vinylpyridine Consensus Reports

4-Vinylpyridine Specification

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