5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride supplier

Name
Prasugrel
EINECS 601-365-4
CAS No. 115473-15-9
Article Data9
CAS DataBase
Density
Solubility
Melting Point 210 °C
Formula C₇H₁₀ClNOS
Boiling Point 364.3 °C at 760 mmHg
Molecular Weight 191.681
Flash Point 174.1 °C
Transport Information
Appearance Cream solid
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine.Hydrochloride;Thieno[3,2-c]pyridin-2(4H)-one,5,6,7,7a-tetrahydro-, hydrochloride (1:1);
PSA 54.40000
LogP 1.67890

Synthetic route

: 109904-26-9
5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water; acetone at 25 - 50℃; for 1h;	99%
With hydrogenchloride In ethanol at 45℃; Solvent; Inert atmosphere;	76%
With hydrogenchloride; water In acetone at 56℃; for 3h;

: 109904-25-8
5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c]pyridine

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions

Conditions	Yield
Stage #1: N-trityl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine With N,N,N,N,-tetramethylethylenediamine; n-hexyllithium In toluene at 0℃; Large scale; Stage #2: With boric acid tributyl ester In toluene at 0℃; for 1h; Large scale; Further stages;	86.1%
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 1.2: 1 h / 0 - 15 °C / Inert atmosphere 1.3: 2 h / 0 - 30 °C 2.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C View Scheme
Multi-step reaction with 2 steps 1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 1.2: -5 - 10 °C 2.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C View Scheme
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 1.2: 1 h / 0 - 15 °C 1.3: 1.75 h / 0 - 30 °C / Reflux 2.1: hydrogenchloride / acetone / 4.5 h / 25 - 30 °C / Reflux View Scheme

: 28783-41-7
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 9 h / 0 - 5 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 2.2: 1 h / 0 - 15 °C / Inert atmosphere 2.3: 2 h / 0 - 30 °C 3.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 12 - 28 °C 2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 2.2: -5 - 10 °C 3.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 9 h / 0 - 5 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 2.2: 1 h / 0 - 15 °C 2.3: 1.75 h / 0 - 30 °C / Reflux 3.1: hydrogenchloride / acetone / 4.5 h / 25 - 30 °C / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: potassium carbonate / 1,4-dioxane / 0.5 h / 80 °C 1.2: 1 h 2.1: copper dichloride / methanol / 4 h 3.1: methanol / 24 h / Inert atmosphere; Reflux 4.1: hydrogenchloride / methanol / 12 h / 20 °C View Scheme

: 30433-91-1
[2-(2-thyenyl)ethyl]amine

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C 3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 3.2: -5 - 10 °C 4.1: hydrogenchloride / water; acetone / 1 h / 25 - 50 °C View Scheme

: 230301-73-2
6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: copper dichloride / methanol / 4 h 2: methanol / 24 h / Inert atmosphere; Reflux 3: hydrogenchloride / methanol / 12 h / 20 °C View Scheme

: 2-methoxy-5-tert-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 20℃; for 12h;	6.5 g

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 150322-38-6
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Conditions

Conditions	Yield
With ammonium bicarbonate In dichloromethane at 5 - 20℃;	98%
With copper(l) iodide; sodium carbonate; XPhos In 1,4-dioxane at 60℃; for 3h; Reagent/catalyst; Temperature; Inert atmosphere;	90.2%
With potassium phosphate; iodine In 1,4-dioxane at 80℃; for 4h; Temperature; Time; Reagent/catalyst;	87.6%

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 1147350-75-1
2-Oxoclopidogrel

Conditions

Conditions	Yield
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;	70%
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;	70%
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With water; potassium carbonate In dichloromethane for 0.166667h; Stage #2: (R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester In dichloromethane for 6h; Reflux;
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;	18.1 g
With potassium carbonate In acetonitrile at 25 - 35℃; for 12h;	25.4 g

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: (R)-2-(2-chlorophenyl)-2-(4-nitro sulfonyloxy)acetic acid methyl ester-d3

: (2S)-2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridine-5(2H,4H,6H)-yl)acetic acid methyl ester-d3

Conditions

Conditions	Yield
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;	70%
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;	70%

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 85259-19-4
methyl 2-bromo-2-(2-chlorophenyl)acetate

: (SR)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Conditions

Conditions	Yield
With potassium hydrogencarbonate In acetonitrile at 20℃;	62%
With potassium hydrogencarbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 2h;

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 84040-29-9
2-bromo-2-cyclopropyl-1-phenylethan-1-one

: 5-(α-cyclopropylcarbonylbenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno(3,2-c)pyridine

Conditions

Conditions	Yield
With potassium hydrogencarbonate In acetonitrile at 10 - 15℃;	60%

: (R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

A: 1360591-38-3
(S)-(2-chlorophenyl)(2-hydroxy-6,7-dihydro-4H-thiophene[3,2-c]pyridin-5-yl)acetic acid methyl ester

B: C16H16ClNO3S

Conditions

Conditions	Yield
With potassium hydrogencarbonate In acetonitrile for 15h; Inert atmosphere;	A 54% B n/a

...Expand

: 178688-43-2
α-cyclopropylcarbonyl-2-fluorobenzyl chloride

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 150322-38-6
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Conditions

Conditions	Yield
With sodium carbonate In acetonitrile at 60℃; for 12h; Inert atmosphere;	52%
With sodium carbonate In acetonitrile at 60℃; for 12h; Molecular sieve; Inert atmosphere;	50%

: 90055-47-3
methyl 2-chloro-2-(2-chlorophenyl)acetate

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: (SR)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Conditions

Conditions	Yield
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium hydrogencarbonate; sodium iodide In N,N-dimethyl-formamide at 55℃; for 0.05h; Inert atmosphere; Stage #2: methyl 2-chloro-2-(2-chlorophenyl)acetate In N,N-dimethyl-formamide at 55℃; for 0.166667h; Inert atmosphere;	44%

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 108-24-7
acetic anhydride

: 5-acetyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 5℃; for 1h; Inert atmosphere;	20.03%

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 1184181-48-3
2,4-dihydroxy-5- isopropylbenzoic acid

: 5-(2,4-dihydroxy-5-isopropylbenzoyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 40℃; for 4h;	10%

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 108-24-7
acetic anhydride

: 150322-43-3
prasugel

Conditions

Conditions	Yield
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile at 25 - 30℃; for 0.5h; Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 25 - 30℃; for 6h; Stage #3: acetic anhydride With triethylamine In acetonitrile at 0 - 30℃; for 6.5h;
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With sodium hydrogencarbonate In N,N-dimethyl-formamide at 50 - 55℃; for 2h; Stage #2: acetic anhydride In N,N-dimethyl-formamide at 10 - 45℃;

...Expand

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 150322-39-7
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride

Conditions

Conditions	Yield
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile at 25 - 30℃; for 0.5h; Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 25 - 30℃; for 7h; Stage #3: With hydrogenchloride In ethyl acetate; acetone at 25 - 30℃; for 1h;
Stage #1: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetone; acetonitrile at 25 - 30℃; for 7.5h; Stage #2: With hydrogenchloride In ethyl acetate; acetone at 25 - 30℃; for 1h;

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: CS-747 hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 6 h / 25 - 30 °C 1.3: 6.5 h / 0 - 30 °C 2.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere View Scheme

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 150322-43-3
prasugel

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C View Scheme
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C 3.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 3.2: 6 h / 0 - 5 °C View Scheme
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 6 h / 25 - 30 °C 1.3: 0 - 30 °C 2.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 2.2: 6 h / 0 - 5 °C View Scheme

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: CS-747 hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3.33 h / 10 - 30 °C 3.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere View Scheme
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C 3.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 3.2: 6 h / 0 - 5 °C 4.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 25 - 55 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 6 h / 25 - 30 °C 1.3: 0 - 30 °C 2.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 2.2: 6 h / 0 - 5 °C 3.1: hydrogenchloride / ethyl acetate; acetone / 0.75 h / 0 - 5 °C View Scheme

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 150322-39-7
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 2.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C 3.1: ammonia / dichloromethane; water / 0 - 30 °C 3.2: 1 h / 25 - 30 °C View Scheme

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 1243654-57-0
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide

Conditions

Conditions	Yield
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile at 25 - 30℃; for 0.5h; Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 25 - 30℃; for 6h; Stage #3: With hydrogen bromide In water; acetone at 0 - 30℃;
Stage #1: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride With potassium carbonate In acetonitrile for 0.5h; Stage #2: 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone In acetonitrile at 10 - 15℃; for 2.5h; Stage #3: With hydrogen bromide In water; acetone at 0 - 30℃; for 3h;

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 18162-48-6
tert-butyldimethylsilyl chloride

: 2-(tert-butyldimethylsilyloxy)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 150322-38-6
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: triethylamine / dichloromethane / 20 °C / Inert atmosphere 3: hydrogenchloride; water / ethyl acetate / 20 °C View Scheme

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 952340-38-4
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: triethylamine / dichloromethane / 20 °C / Inert atmosphere View Scheme

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 18162-48-6
tert-butyldimethylsilyl chloride

: C13H23NOSSi*ClH

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 28 - 30℃; for 1.75h;

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: C15H12FNO7S

: 5-(α-methoxycarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c ]pyridine

Conditions

Conditions	Yield
With potassium hydrogencarbonate In acetonitrile at 20℃;

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: C15H12ClNO7S

: 1360923-54-1
(R)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Conditions

Conditions	Yield
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: (R)-methyl 2-(2-chlorophenyl)-2-(4-nitrophenylsulfonyloxy)-acetate

: (SR)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate

Conditions

Conditions	Yield
With potassium hydrogencarbonate In acetonitrile at 20℃; for 26h; Inert atmosphere;

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 142026-00-4, 87119-37-7
methyl 2-phenyl-2-(((p-nitrophenyl)sulfonyl)oxy)acetate

: 109904-28-1
Methyl alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno [3,2-c] 5-pyridyl) phenyl-acetate

Conditions

Conditions	Yield
With potassium hydrogencarbonate In acetonitrile at 20℃;

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Chemical Properties

Following is the structure of Thieno[3,2-c]pyridin-2(4H)-one,5,6,7,7a-tetrahydro-, hydrochloride (1:1) (CAS NO.115473-15-9):

Empirical Formula: C₇H₁₀ClNOS
Molecular Weight: 191.6784
Melting point: 2100 °C
Flash Point: 174.1 °C
Enthalpy of Vaporization: 62.25 kJ/mol
Boiling Point: 364.3 °C at 760 mmHg
Vapour Pressure: 1.17E-05 mmHg at 25 °C
Appearance of Thieno[3,2-c]pyridin-2(4H)-one,5,6,7,7a-tetrahydro-, hydrochloride (1:1) (CAS NO.115473-15-9): Cream Solid
Product Categories of Thieno[3,2-c]pyridin-2(4H)-one,5,6,7,7a-tetrahydro-, hydrochloride (1:1) (CAS NO.115473-15-9): Heterocyclic Compounds; Heterocycles; Sulfur & Selenium Compounds
SMILES: Cl.O=C1/C=C2/CNCCC2S1
InChI: InChI=1/C7H9NOS.ClH/c9-7-3-5-4-8-2-1-6(5)10-7;/h3,6,8H,1-2,4H2;1H
InChIKey: PUQKTVAKLPDUAW-UHFFFAOYAV

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Specification

Thieno[3,2-c]pyridin-2(4H)-one,5,6,7,7a-tetrahydro-, hydrochloride (1:1) , its cas register number 115473-15-9. It also can be called 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride .

Product Name

Prasugrel

Synthetic route

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Chemical Properties

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride Specification

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