1,2,3-thiadiazol-5-ylamine
Conditions | Yield |
---|---|
Stage #1: methyl 2-chloroethylhydrazinoformate With thionyl chloride; sodium hydroxide In chloroform at 30℃; pH=10; Cooling with ice; Stage #2: With ammonia for 4h; Cooling with ice; | 97.1% |
diazoacetonitrile
1,2,3-thiadiazol-5-ylamine
Conditions | Yield |
---|---|
With hydrogen sulfide; triethylamine In tetrachloromethane; dichloromethane at -10℃; for 0.75h; | 73% |
With triethylamine In hexane; dichloromethane | |
With triethylamine In hexane; dichloromethane | |
With sodium hydrogensulfide In ethanol | |
With sodium methylate In methanol |
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol |
Conditions | Yield |
---|---|
With magnesium oxide In water; acetone Heating; |
Conditions | Yield |
---|---|
In dichloromethane |
diazoacetonitrile
1,2,3-thiadiazol-5-ylamine
Conditions | Yield |
---|---|
In dichloromethane |
Conditions | Yield |
---|---|
With ammonia |
Conditions | Yield |
---|---|
In tetrahydrofuran at -10 - 30℃; for 0.666667h; | 95% |
carbon monoxide
p-toluidine
1,2,3-thiadiazol-5-ylamine
1-[1,2,3]thiadiazol-5-yl-3-p-tolyl-urea
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 74% |
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 74% |
carbon monoxide
aniline
1,2,3-thiadiazol-5-ylamine
thidiazuron
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; | 70% |
1,2,3-thiadiazol-5-ylamine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; XPhos In 1,4-dioxane at 100℃; for 4h; Inert atmosphere; Sealed tube; | 66% |
carbon monoxide
1,2,3-thiadiazol-5-ylamine
1-amino-3-methylbenzene
1-[1,2,3]thiadiazol-5-yl-3-m-tolyl-urea
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 60% |
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 54% |
carbon monoxide
1,2,3-thiadiazol-5-ylamine
o-toluidine
1-(2-methylphenyl)-3-(1,2,3-thiadiazole-5-yl)-urea
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 50% |
carbon monoxide
1,2,3-thiadiazol-5-ylamine
3-chloro-aniline
1-(3-chloro-phenyl)-3-[1,2,3]thiadiazol-5-yl-urea
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 49% |
2-aminopyridine
carbon monoxide
1,2,3-thiadiazol-5-ylamine
N-2-pyridyl-N'-1,2,3-thiadiazol-5-yl urea
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 46% |
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 42% |
carbon monoxide
4-chloro-aniline
1,2,3-thiadiazol-5-ylamine
1-(4-chloro-phenyl)-3-[1,2,3]thiadiazol-5-yl-urea
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 41% |
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 40% |
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 36% |
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 33% |
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 32% |
carbon monoxide
cyclohexylamine
1,2,3-thiadiazol-5-ylamine
1-cyclohexyl-3-[1,2,3]thiadiazol-5-yl-urea
Conditions | Yield |
---|---|
With selenium; oxygen; triethylamine In N,N-dimethyl-formamide at 100℃; for 8h; | 28% |
chloroformic acid ethyl ester
1,2,3-thiadiazol-5-ylamine
μ-[1,2,3]thiadiazol-5-yl-μ-imido-dicarbonic acid diethyl ester
Conditions | Yield |
---|---|
With triethylamine In diethyl ether |
4-methoxy-benzaldehyde
1,2,3-thiadiazol-5-ylamine
(4-methoxy-benzylidene)-[1,2,3]thiadiazol-5-yl-amine
Conditions | Yield |
---|---|
In ethanol |
chloroacetyl chloride
1,2,3-thiadiazol-5-ylamine
2-chloro-N-[1,2,3]thiadiazol-5-yl-acetamide
Conditions | Yield |
---|---|
In diethyl ether |
Conditions | Yield |
---|---|
In ethyl acetate |
dichloroacethyl chloride
1,2,3-thiadiazol-5-ylamine
2,2-dichloro-N-[1,2,3]thiadiazol-5-yl-acetamide
Conditions | Yield |
---|---|
In diethyl ether |
4-hydroxy-2-methoxybenzaldehyde
1,2,3-thiadiazol-5-ylamine
Conditions | Yield |
---|---|
In ethanol |
1,2,3-thiadiazol-5-ylamine
β-naphthol
1-[1,2,3]thiadiazol-5-ylazo-naphthalen-2-ol
Conditions | Yield |
---|---|
(i) NaNO2, H3PO4, (ii) /BRN= 742134/, MeOH; Multistep reaction; |
1,2,3-thiadiazol-5-ylamine
p-acetylaminobenzenesulfonyl chloride
4-acetylamino-N-[1,2,3]thiadiazol-5-yl-benzenesulfonamide
Conditions | Yield |
---|---|
With pyridine |
The 5-Amino-1,2,3-thiadiazole, with the CAS registry number 4100-41-8 and EINECS registry number 223-868-4, is also known as 5-Amino-1,2,3-thiadiazole. It is a kind of white to light yellow crystal powder, and the molecular formula of this chemical is C2H3N3S.
The physical properties of 5-Amino-1,2,3-thiadiazole are as following: (1)ACD/LogP: -0.49; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.49; (4)ACD/LogD (pH 7.4): -0.49; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 12.85; (8)ACD/KOC (pH 7.4): 12.85; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 57.26 Å2; (13)Index of Refraction: 1.662; (14)Molar Refractivity: 25.05 cm3; (15)Molar Volume: 67.6 cm3; (16)Polarizability: 9.93×10-24cm3; (17)Surface Tension: 83.6 dyne/cm; (18)Density: 1.495 g/cm3; (19)Flash Point: 98.9 °C; (20)Enthalpy of Vaporization: 47.68 kJ/mol; (21)Boiling Point: 239.8 °C at 760 mmHg; (22)Vapour Pressure: 0.0392 mmHg at 25°C.
Preparation of 5-Amino-1,2,3-thiadiazole: This chemical can be prepared by diazoacetonitrile. The reaction will need reagents hydrogen sulfide and triethylamine, and the solvents CH2Cl2 and CCl4. The reaction time is 45 minutes with temperature of -10°C, and the yield is about 73%.
You can still convert the following datas into molecular structure:
(1)SMILES: n1nsc(N)c1
(2)InChI: InChI=1/C2H3N3S/c3-2-1-4-5-6-2/h1H,3H2
(3)InChIKey: PVGHNTXQMCYYGF-UHFFFAOYAK
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