5-Bromopyridine-2-carboxylic acid supplier

Name
5-Bromopyridine-2-carboxylic acid
EINECS -0
CAS No. 30766-11-1
Article Data31
CAS DataBase
Density 1.813 g/cm³
Solubility
Melting Point 173-175 °C
Formula C₆H₄BrNO₂
Boiling Point 319.5 °C at 760 mmHg
Molecular Weight 202.007
Flash Point 147 °C
Transport Information
Appearance white cryst.
Safety 24/25-36-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Picolinic acid, 5-bromo- (6CI,8CI);5-Bromo-2-picolinicacid;5-Bromo-2-pyridinecarboxylic acid;5-Bromopicolinic acid;
PSA 50.19000
LogP 1.54230

Synthetic route

: 845306-08-3
tert-butyl 5-bromopyridine-2-carboxylate

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
In hexafluoropropan-2-ol at 100℃; for 3h; Microwave irradiation;	95%

: 29682-15-3
methyl 5-bromopicolinate

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran at 0 - 20℃; for 15h;	90%
With lithium hydroxide monohydrate In tetrahydrofuran; water at 20℃;
With sodium hydroxide In water at 20℃; for 12h;

: 624-28-2
2,5-dibromopyridine

: 124-38-9
carbon dioxide

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
With n-butyllithium In hexane; toluene at -75℃; for 2h;	64%
Stage #1: 2,5-dibromopyridine With n-butyllithium In toluene at -78℃; for 2h; Stage #2: carbon dioxide In toluene at -78℃; for 1h; Stage #3: With hydrogenchloride In water; toluene	47%
Stage #1: 2,5-dibromopyridine With n-butyllithium In toluene at -78℃; for 2h; Stage #2: carbon dioxide In toluene at -78℃; for 1h;	47%

: 97483-77-7
2-Cyano-5-bromopyridine

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
With hydrogenchloride In water Reflux;	64%
With hydrogenchloride for 24h; Heating;
Stage #1: 2-Cyano-5-bromopyridine With potassium hydroxide; ethanol; water at 80℃; for 24h; Stage #2: With hydrogenchloride; water pH=4;

: 3430-13-5
5-bromo-2-methylpyridine

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
With potassium permanganate In water at 80℃;	39%
With potassium permanganate
With potassium permanganate; water at 100℃; for 6h;
With potassium permanganate Heating;

: 24242-20-4
5-amino-pyridine-2-carboxylic acid

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
With hydrogen sulfide; hydrogen bromide; urea; copper(I) bromide; sodium nitrite 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux; Yield given. Multistep reaction;

: 4214-76-0
5-nitro-pyridin-2-ylamine

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 1.) 48 percent HBr, Br2; 2.) NaNO2 / 1) 30-40 deg C; 2) -5 deg C, H2O; 10-15 Deg C, 90 min.; 3) 40 deg C. 15 min 2: dimethylsulfoxide / 0.08 h / 180 °C 3: 54 percent / HCl / 1.5 h / Heating 4: 70 percent / H2S, 25 percent NH3 5: 1) 24 percent HBr, NaNO2, urea; 2) CuBr, 48 percent HBr, H2S / 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux View Scheme

Yield

Multi-step reaction with 5 steps
1: 1.) 48 percent HBr, Br2; 2.) NaNO2 / 1) 30-40 deg C; 2) -5 deg C, H2O; 10-15 Deg C, 90 min.; 3) 40 deg C. 15 min
2: dimethylsulfoxide / 0.08 h / 180 °C
3: 54 percent / HCl / 1.5 h / Heating
4: 70 percent / H2S, 25 percent NH3
5: 1) 24 percent HBr, NaNO2, urea; 2) CuBr, 48 percent HBr, H2S / 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux
View Scheme

: 4487-59-6
2-bromo-5-nitropyridine

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: dimethylsulfoxide / 0.08 h / 180 °C 2: 54 percent / HCl / 1.5 h / Heating 3: 70 percent / H2S, 25 percent NH3 4: 1) 24 percent HBr, NaNO2, urea; 2) CuBr, 48 percent HBr, H2S / 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux View Scheme

: 100367-55-3
5-nitropyridine-2-carbonitrile

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 54 percent / HCl / 1.5 h / Heating 2: 70 percent / H2S, 25 percent NH3 3: 1) 24 percent HBr, NaNO2, urea; 2) CuBr, 48 percent HBr, H2S / 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux View Scheme

: 30651-24-2
5-nitropicolinic acid

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 70 percent / H2S, 25 percent NH3 2: 1) 24 percent HBr, NaNO2, urea; 2) CuBr, 48 percent HBr, H2S / 1) H2O, 0 deg C, 5 min; 0 deg C, 10 min; 2) 0 deg C, 10 min; reflux View Scheme

: 80287-53-2, 3430-14-6
5-Amino-2-methylpyridine

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 2: aqueous KMnO4 View Scheme

: 6960-22-1
6-methylnicotinamide

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NaOCl; aqueous KOH 2: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 3: aqueous KMnO4 View Scheme

: 21684-59-3
ethyl 6-methylnicotinate

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: aqueous NH3 2: NaOCl; aqueous KOH 3: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 4: aqueous KMnO4 View Scheme
Multi-step reaction with 6 steps 1: N2H4+H2O 2: KNO2; aqueous HCl 4: aqueous KOH 5: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 6: aqueous KMnO4 View Scheme

: 197079-25-7
6-methylpyridine-3-carbohydrazide

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: KNO2; aqueous HCl 3: aqueous KOH 4: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 5: aqueous KMnO4 View Scheme

: 64038-04-6
6-methyl-nicotinoyl azide

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 2: aqueous KOH 3: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 4: aqueous KMnO4 View Scheme

: 247077-42-5
(6-methyl-[3]pyridyl)-carbamic acid ethyl ester

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aqueous KOH 2: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 3: aqueous KMnO4 View Scheme

: 858844-85-6
1,3-bis(6-methylpyridin-3-yl)urea

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: concentrated aqueous HCl / 130 °C 2: aqueous sulfuric acid; potassium nitrite / anschliessend Behandeln mit Kupfer(I)-bromid 3: aqueous KMnO4 View Scheme

: 108885-80-9
C6H3BrNO2(1-)*Na(1+)

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
With water; acetic acid at 25℃; for 16h;

: 31181-90-5
5-bromo-pyridine-2-carbaldehyde

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Stage #1: 5-bromo-pyridine-2-carbaldehyde With potassium permanganate; sodium carbonate In water at 10 - 20℃; Stage #2: With hydrogenchloride In water pH=2 - 4;
With 1,4-dithio-D,L-threitol; recombinant aldehyde dehydrogenase from Escherichia coli; water‐forming NADH oxidase from Streptococcus mutans; NAD In aq. phosphate buffer at 40℃; for 4h; pH=8.5; Reagent/catalyst; Green chemistry; Enzymatic reaction; chemoselective reaction;

: 624-28-2
2,5-dibromopyridine

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: trimethylsilylmethyllithium / toluene / 0.5 h / -78 - 0 °C 1.2: 3 h 1.3: 18 h / 20 °C 2.1: sodium hydroxide / tetrahydrofuran / 15 h / 0 - 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: trimethylsilylmethyllithium / toluene / 0.5 h / -78 - 0 °C 1.2: 3 h 1.3: 18 h / 20 °C 2.1: sodium hydroxide / tetrahydrofuran / 15 h / 0 - 20 °C View Scheme

: 77199-09-8
5-bromo-pyridine-2-carboxylic acid ethyl ester

: 30766-11-1
5-bromoisonicotinic acid

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran at 0 - 20℃; for 15h;

: 30766-11-1
5-bromoisonicotinic acid

: 64-17-5
ethanol

: 77199-09-8
5-bromo-pyridine-2-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With thionyl chloride at 20℃; for 18h;	100%
With sulfuric acid at 75℃; for 2h;	86%
Stage #1: 5-bromoisonicotinic acid With thionyl chloride for 2h; Heating / reflux; Stage #2: ethanol In toluene Heating / reflux; Stage #3: With sodium carbonate In water; toluene pH=8;	28%

: 30766-11-1
5-bromoisonicotinic acid

: 137178-88-2
5-bromopyridine-2-carbonyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h;	100%
With thionyl chloride; N,N-dimethyl-formamide at 80℃; for 2h;	99%
With thionyl chloride for 2h; Inert atmosphere; Reflux;	93%

: 30766-11-1
5-bromoisonicotinic acid

: 959741-37-8
5-bromo-2-carboxypyridin-1-ium-1-olate

Conditions

Conditions	Yield
Stage #1: 5-bromoisonicotinic acid With urea hydrogen peroxide adduct; trifluoroacetic anhydride In acetonitrile at 0℃; for 4.5h; Stage #2: With sodium thiosulfate In water; acetonitrile at 0℃; for 0.166667h;	100%
Stage #1: 5-bromoisonicotinic acid With urea hydrogen peroxide adduct; trifluoroacetic anhydride In acetonitrile at 0℃; for 4.5h; Stage #2: With sodium thiosulfate In water; acetonitrile for 0.166667h;
With dihydrogen peroxide; urea; trifluoroacetic anhydride In acetonitrile at 0℃; for 0.5h;	19.6 g
With dihydrogen peroxide; urea; trifluoroacetic anhydride In acetonitrile at 0℃; for 0.5h;	19.6 g
Stage #1: 5-bromoisonicotinic acid With urea hydrogen peroxide adduct In acetonitrile at 0℃; for 0.333333h; Stage #2: With trifluoroacetic anhydride In acetonitrile at 20℃;

: 30766-11-1
5-bromoisonicotinic acid

: 1200575-98-9
tert-butyl 4-[6-(dimethoxyboryl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate

: 1200575-99-0
5-{2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-4H-1,3-benzodioxin-6-yl}pyridine-2-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In water; acetonitrile at 160℃; for 0.333333h; Irradiation;	100%

: 30766-11-1
5-bromoisonicotinic acid

: caudatin

: C34H44BrNO8

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere;	100%

: 30766-11-1
5-bromoisonicotinic acid

: ethyl 2-(furan-2-yl)-5-(trifluoromethyl)piperidine-3-carboxylate

: ethyl 1-(5-bromopyridine-2-carbonyl)-2-(furan-2-yl)-5-(trifluoromethyl)piperidine-3-carboxylate

Conditions

Conditions	Yield
Stage #1: 5-bromoisonicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: ethyl 2-(furan-2-yl)-5-(trifluoromethyl)piperidine-3-carboxylate With triethylamine In dichloromethane at 0 - 20℃;	99%

: 30766-11-1
5-bromoisonicotinic acid

: 771-61-9
2,3,4,5,6-pentafluorophenol

: (2,3,4,5,6-pentafluorophenyl)-5-bromopyridine-2-carboxylate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h;	98%

: 30766-11-1
5-bromoisonicotinic acid

: 43041-12-9
methyl (2R)-pyrrolidine-2-carboxylate

: C12H13BrN2O3

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h;	96%

: 30766-11-1
5-bromoisonicotinic acid

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: C12H13BrN2O3

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h;	96%

: 67-56-1
methanol

: 30766-11-1
5-bromoisonicotinic acid

: 950848-56-3
C7H6BrNO2*ClH

Conditions

Conditions	Yield
With thionyl chloride at -78 - 20℃; for 16.1667h;	95%

: 30766-11-1
5-bromoisonicotinic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: tert-butyl 4-(5-bromopicolinoyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With 4-methyl-morpholine; HATU In N,N-dimethyl-formamide at 20℃;	95%

: 30766-11-1
5-bromoisonicotinic acid

: rac-tert-butyl ((2R*,5R*)-5-(5-amino-2-fluorophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-yl)carbamate

: rac-tert-butyl ((2R*,5R*)-5-(5-(5-bromopicolinamido)-2-fluorophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-yl)carbamate

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 25h; Inert atmosphere;	95%

: 30766-11-1
5-bromoisonicotinic acid

: 7486-35-3
tri-n-butyl(vinyl)tin

: 45946-64-3
5-vinylpyridine-2-carboxylic acid

Conditions

Conditions	Yield
bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 20 - 100℃; Inert atmosphere;	94.5%

: 30766-11-1
5-bromoisonicotinic acid

: 2561-17-3
1-ethynyl-3-fluoro-benzene

: 1403771-21-0
5-(3-fluoro-phenylethynyl)-pyridine-2-carboxylic acid

Conditions

Conditions	Yield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diethylamine In N,N-dimethyl-formamide at 90℃; for 0.75h; Sonogashira Cross-Coupling; Microwave irradiation;	94%
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diethylamine In N,N-dimethyl-formamide at 90℃; for 0.75h; Microwave irradiation;	71%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine In N,N-dimethyl-formamide at 90℃; for 0.75h; Sonogashira Cross-Coupling; Inert atmosphere;	65%

: 30766-11-1
5-bromoisonicotinic acid

: caudatin

: 1377496-40-6
3-O-(5-bromopyridine-2-carbonyl)caudatin

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;	93.3%

: 30766-11-1
5-bromoisonicotinic acid

: 109-85-3
2-methoxyethylamine

: 5-bromo-N-(2-methoxyethyl)picolinamide

Conditions

Conditions	Yield
Stage #1: 5-bromoisonicotinic acid; 2-methoxyethylamine With pyridine In dichloromethane at 0℃; for 0.166667h; Stage #2: With trichlorophosphate In dichloromethane at 0 - 20℃; for 1h;	93%

: 30766-11-1
5-bromoisonicotinic acid

: 753-90-2
trifluoroethylamine

: 1496144-72-9
C8H6BrF3N2O

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 4h; Inert atmosphere;	93%

: 30766-11-1
5-bromoisonicotinic acid

: (R)-[5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]carbamic acid tert-butyl ester

: (R)-tert-butyl (5-(3-(5-bromopicolinamido)phenyl)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-yl)carbamate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 22℃; for 17h; Inert atmosphere;	93%

: 30766-11-1
5-bromoisonicotinic acid

: 90145-48-5
5-bromo-2-pyridinecarboxamide

Conditions

Conditions	Yield
Stage #1: 5-bromoisonicotinic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 80℃; for 1h; Stage #2: With ammonium hydroxide In dichloromethane at 20℃; for 1.5h;	92.4%
With ammonium hydroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h;	73%
Stage #1: 5-bromoisonicotinic acid With thionyl chloride; N,N-dimethyl-formamide In tetrahydrofuran at 0 - 23℃; for 1h; Stage #2: With ammonia In tetrahydrofuran; water at 0℃; for 0.5h;	50%
Stage #1: 5-bromoisonicotinic acid With thionyl chloride for 3h; Reflux; Stage #2: With ammonia In tetrahydrofuran; water at 20℃; Cooling with ice;
Stage #1: 5-bromoisonicotinic acid With thionyl chloride for 3h; Reflux; Stage #2: With ammonia In tetrahydrofuran; water Cooling with ice;	43 g

: 67-56-1
methanol

: 30766-11-1
5-bromoisonicotinic acid

: 29682-15-3
methyl 5-bromopicolinate

Conditions

Conditions	Yield
With sulfuric acid at 0 - 70℃; for 6h;	92%
Stage #1: methanol; 5-bromoisonicotinic acid With thionyl chloride at 20℃; for 3h; Reflux; Stage #2: With sodium hydrogencarbonate pH=7;	86.9%
With sulfuric acid for 117h; Reflux;	86%

: 30766-11-1
5-bromoisonicotinic acid

: 75-64-9
tert-butylamine

: 5-bromo-pyridine-2-carboxylic acid tert-butylamide

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 16h;	92%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 16h;	92%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 16h;	92%

: 30766-11-1
5-bromoisonicotinic acid

: 124-40-3
dimethyl amine

: 845305-86-4
5-bromo-2-(N,N-dimethylaminocarbonyl)pyridine

Conditions

Conditions	Yield
Stage #1: 5-bromoisonicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: dimethyl amine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; dichloromethane at 20℃; for 3h;	91.7%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 18h;
With oxalyl dichloride In dichloromethane at 0 - 40℃; for 1h;
Stage #1: 5-bromoisonicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 16h; Stage #2: dimethyl amine In dichloromethane at 0 - 20℃; for 3h;
Stage #1: 5-bromoisonicotinic acid With oxalyl dichloride In dichloromethane at 40℃; for 1h; Stage #2: dimethyl amine With N-ethyl-N,N-diisopropylamine In dichloromethane for 1h;

: 30766-11-1
5-bromoisonicotinic acid

: 616-34-2
methoxycarbonylmethylamine

: 915394-66-0
methyl (5-bromopyridine-2-carbonyl)glycinate

Conditions

Conditions	Yield
With thionyl chloride; N-ethyl-N,N-diisopropylamine	90%

: 30766-11-1
5-bromoisonicotinic acid

: 100-36-7
N,N-diethylethylenediamine

: 1285446-04-9
5-bromo-N-(2-(diethylamino)ethyl)picolinamide

Conditions

Conditions	Yield
Stage #1: 5-bromoisonicotinic acid With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 3h; Stage #2: N,N-diethylethylenediamine In N,N-dimethyl-formamide at 20℃; for 2h;	90%

: 5308-25-8
4-ethylpiperazine

: 30766-11-1
5-bromoisonicotinic acid

: (5-bromopyridin-2-yl)(4-ethylpiperazin-1-yl)methanone

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h;	89%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 30766-11-1
5-bromoisonicotinic acid

: 910903-54-7
(5-bromopyridin-2-yl)(4-hydroxyethylpiperazin-1-yl)methanone

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h;	88%
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	65%

: 30766-11-1
5-bromoisonicotinic acid

: 2516-34-9
cyclobutylamine

: 890928-69-5
5-bromo-N-cyclobutylpicolinamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 4h;	88%

5-Bromopyridine-2-carboxylic acid Chemical Properties

Molecular structure of 5-Bromopyridine-2-carboxylic acid (CAS NO.30766-11-1) is:

IUPAC Name: 5-bromopyridine-2-carboxylic acid
Molecular Weight: 202.00546 [g/mol]
Molecular Formula: C₆H₄BrNO₂
XLogP3-AA: 1.4
H-Bond Donor: 1
H-Bond Acceptor: 3
Melting Point: 173-175 °C
Index of Refraction: 1.616
Molar Refractivity: 38.96 cm³
Molar Volume: 111.3 cm³
Surface Tension: 63.2 dyne/cm
Density: 1.813 g/cm³
Flash Point: 147 °C
Enthalpy of Vaporization: 59.23 kJ/mol
Boiling Point: 319.5 °C at 760 mmHg
Vapour Pressure: 0.000141 mmHg at 25°C
Product Categories: blocks;Bromides; Carboxes; Pyridines; Pyridine;Pyridines, Pyrimidines, Purines and Pteredines; pharmacetical; Carboxylic Acids; Pyridine Series; Carboxy; Organohalides; Bromopyridines; Halopyridines; Carboxylic Acids

5-Bromopyridine-2-carboxylic acid Safety Profile

Safty information about 5-Bromopyridine-2-carboxylic acid (CAS NO.30766-11-1) is:
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Hazard Note: Irritant
HazardClass: IRRITANT

5-Bromopyridine-2-carboxylic acid Specification

5-Bromopyridine-2-carboxylic acid , its cas register number is 30766-11-1. It also can be called Picolinic acid, 5-bromo- (6CI,8CI) ; 5-Bromo-2-picolinicacid ; 5-Bromo-2-pyridinecarboxylic acid ; 5-Bromopicolinic acid ; 5-Bromopyridine-2-carboxylic acid ; 5-bromo-2-pyridine carboxlic acid .It is a white cryst.

Product Name

5-Bromopyridine-2-carboxylic acid

Synthetic route

5-Bromopyridine-2-carboxylic acid Chemical Properties

5-Bromopyridine-2-carboxylic acid Safety Profile

5-Bromopyridine-2-carboxylic acid Specification

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