6-Chloro-2-hexanone supplier | CasNO.10226-30-9

Name
6-Chloro-2-hexanone
EINECS 233-546-5
CAS No. 10226-30-9
Article Data37
CAS DataBase
Density 0.989 g/cm³
Solubility Insoluble in water, soluble in chloroform (chloroform, carbon), n-heptane, ethanol, butanol, etc.
Melting Point
Formula C₆H₁₁ Cl O
Boiling Point 207.6 °C at 760 mmHg
Molecular Weight 134.606
Flash Point 91.6 °C
Transport Information
Appearance Clear yellow to brown liquid
Safety S26;S37/39
Risk Codes R36/37/38
Molecular Structure
Hazard Symbols
Synonyms 1-Chlorohexan-5-one;4-Chlorobutyl methyl ketone; 5-Oxohexyl chloride; 6-Chloro-2-hexanone
PSA 17.07000
LogP 1.98450

Synthetic route

: 1462-03-9
1-methylcyclopentanol

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With sodium hydrogencarbonate; iron(II) sulfate In tetrachloromethane Ambient temperature; in the dark;	100%
With lead(IV) acetate; lithium chloride at 20 - 35℃; for 4h; Oxidation; oxidative decyclization; mechanical activation;	51%
(i) aq. NaOCl, (ii) AgNO3, NaOH, aq. NH3; Multistep reaction;

: 928-89-2
6-chlorohexene

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With copper(l) iodide; oxygen; palladium dichloride In water; N,N-dimethyl-formamide for 48h;	99%

: 10297-06-0
1-chloro-5-hexyne

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With (cyclohexylisocyanide)gold(I) chloride; water; potassium tetrakis(pentafluorophenyl)borate In methanol at 20℃; for 24h; Reagent/catalyst;	99%
With methanol; [Co((dimethylglyoximate)BF2)2•2H2O] at 65℃; for 2.5h; Sealed tube; Neutral conditions; regioselective reaction;	98%
With silver hexafluoroantimonate; SPGS-550-M; NOK; C35H47O3PAu(1+)Cl(1-); trifluoroacetic acid In water; toluene at 20℃; for 24h; Green chemistry;	90%

: 57987-84-5
2-methyl-5,6-dihydro-4H-pyran-3-carboxylic acid methyl ester

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With hydrogenchloride at 50℃; for 3h;	93%

: 33694-90-5
1-methylcyclopentyl hypochlorite

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
In tetrachloromethane at 70℃; for 6h; Irradiation;	90%
at 40℃;

: 6-chloro-2-methoxy-1-hexene

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran for 0.5h; Heating;	85%

: 876384-79-1
N'-[5-Chloro-1-methyl-pent-(Z)-ylidene]-N,N-dimethyl-hydrazine

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With water; copper dichloride In tetrahydrofuran; phosphoric acid	84%
With boron trifluoride diethyl etherate In water; acetone	64%

: 77570-29-7
5-(1-Amino-5-chloro-pentylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With hydrogenchloride Heating;	73%

: 1462-03-9
1-methylcyclopentanol

A: 1-methyl-1,4-epoxycyclopentane

B: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With pyridine; lead(IV) acetate; lithium chloride In benzene at 80℃; for 5h;	A 15% B 70%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 138344-21-5
4-Chloro-N,O-dimethylbutyric acid amide

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at -15℃; Stage #2: 4-Chloro-N,O-dimethylbutyric acid amide In tetrahydrofuran; hexane at -78 - 20℃; Wittig reaction; Stage #3: With hydrogenchloride In tetrahydrofuran; diethyl ether; hexane at 20℃;	68%

: 18804-33-6
6-chloro-2-hexanol

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With C44H66O8P4Pd2; methyl vinyl ketone In water; toluene at 105℃; for 16h; Inert atmosphere; chemoselective reaction;	65%
With pyridinium chlorochromate

: 76-09-5
2,3-dimethyl-2,3-butane diol

: 928-89-2
6-chlorohexene

A: 10226-30-9
6-chloro-2-hexanone

B: 2-(5-chloropentyl)-4,4,5,5-tetramethyl-1,3-dioxolane

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); oxygen; 2-Methyl-1,4-benzoquinone; copper(l) chloride; tert-butyl alcohol at 40℃; under 760.051 Torr; for 3h;	A 8 %Spectr. B 60%

...Expand

: 928-89-2
6-chlorohexene

A: 10226-30-9
6-chloro-2-hexanone

B: 18804-33-6
6-chloro-2-hexanol

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); 1-hydroxytetraphenyl-cyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); water; p-benzoquinone In methanol; isopropyl alcohol at 85℃; for 48h; Inert atmosphere; Glovebox; regioselective reaction;	A 40% B 9 %Spectr.

: 21856-89-3
6-hydroxy-2-hexanone

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With hydrogenchloride; water

: 27115-55-5
1-methyl-cyclopentyl hydroperoxide

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With hydrogenchloride; iron(II) sulfate In water

: 6407-36-9
N-isopropyliden-cyclohexyl amine

: 109-70-6
1,3-chlorobromopropane

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
(i) LiNEt2, THF, (ii) /BRN= 605278/, (iii) aq. HCl; Multistep reaction;
With n-butyllithium 1.) THF; Yield given. Multistep reaction;

: 38049-07-9
1,3-Dioxolan-2-buttersaeure-ethylester

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With hydrogenchloride; lithium aluminium tetrahydride 1) ether, 4 h, room temp.; 30 min., reflux; 2) 2 h, reflux; Yield given. Multistep reaction;

: 194920-91-7
5-chloro-2-(1-methylethenyl)pentanoic acid

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
With pyridine; dimethylsulfide; ozone 1.) dichloromethane, -70 deg C, 2.) dichloromethane, room temperature, 15 h; Yield given. Multistep reaction;

: 194920-91-7
5-chloro-2-(1-methylethenyl)pentanoic acid

A: 10226-30-9
6-chloro-2-hexanone

B: 89118-09-2
6-chloro-3-methylene-2-hexanone

Conditions

Conditions	Yield
With ozone; triethylamine 1.) dichloromethane, -70 deg C, 2.) dichloromethane, room temperature; Yield given. Multistep reaction. Yields of byproduct given;

: 194920-99-5
6-chloro-2-(1-methylethenyl)hexanoic acid

A: 10226-30-9
6-chloro-2-hexanone

B: 4630-77-7
7-chloroheptan-2-one

Conditions

Conditions	Yield
With pyridine; dimethylsulfide; ozone 1.) dichloromethane, -70 deg C, 2.) dichloromethane, room temperature, 15 h; Yield given. Multistep reaction. Yields of byproduct given;

: 7-chloro-2-(1-methylethenyl)heptanoic acid

A: 10226-30-9
6-chloro-2-hexanone

B: 72978-95-1
8-chloro-octan-2-one

Conditions

Conditions	Yield
With pyridine; dimethylsulfide; ozone 1.) dichloromethane, -70 deg C, 2.) dichloromethane, room temperature, 15 h; Yield given. Multistep reaction. Yields of byproduct given;

: 1575-61-7
5-Chlorovaleroyl chloride

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 70 percent / tetrahydrofuran / -78 °C 2.1: n-BuLi / tetrahydrofuran; hexane / -15 °C 2.2: tetrahydrofuran; hexane / -78 - 20 °C 2.3: 68 percent / aq. HCl / tetrahydrofuran; hexane; diethyl ether / 20 °C View Scheme

: 20074-80-0
5-chloro-pentanal

: 10226-30-9
6-chloro-2-hexanone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: pyridinium chlorochromate View Scheme

: 107-10-8
propylamine

: 10226-30-9
6-chloro-2-hexanone

: 75-20-7
calcium carbide

: 2-ethynyl-2-methyl-1-propylpiperidine

Conditions

Conditions	Yield
Stage #1: propylamine; 6-chloro-2-hexanone; calcium carbide With copper(l) iodide; triethylamine In water; acetonitrile at 60℃; for 24h; Stage #2: In water; acetonitrile for 2h; Reagent/catalyst; Solvent;	99%

...Expand

: 10226-30-9
6-chloro-2-hexanone

: 4367-98-0
1-iodo-5-hexanone

Conditions

Conditions	Yield
With sodium iodide In acetone at 60℃; for 12h; Sealed tube;	97%
With sodium iodide In acetone at 60℃;	87%
With sodium iodide In acetone
With sodium iodide In acetone Heating;

: 96-54-8
N-Methylpyrrole

: 10226-30-9
6-chloro-2-hexanone

: 1152705-89-9
3-(5-chloro-1-methylpentyl)-1-methyl-1H-pyrrole

Conditions

Conditions	Yield
With triethylsilane; indium(III) tris[bis(trifluoromethanesulfonyl)amide] In 1,4-dioxane at 85℃; for 5h; Schlenk technique; Inert atmosphere; regioselective reaction;	97%
With triethylsilane; bis(trifluoromethanesulfonyl)amide In 1,4-dioxane at 100℃; for 10h; Schlenk technique; Inert atmosphere; regioselective reaction;	86%

: 10226-30-9
6-chloro-2-hexanone

: 75-20-7
calcium carbide

: 64-04-0
phenethylamine

: 2-ethynyl-2-methyl-1-phenethylpiperidine

Conditions

Conditions	Yield
Stage #1: 6-chloro-2-hexanone; calcium carbide; phenethylamine With copper(l) iodide; triethylamine In water; acetonitrile at 60℃; for 24h; Stage #2: In water; acetonitrile for 2h; Reagent/catalyst;	96%

...Expand

: 10226-30-9
6-chloro-2-hexanone

: 2-amino-N'-(2,4-dichlorophenyl)benzohydrazide

: 2-(4-chlorobutyl)-3-((2,4-dichlorophenyl)amino)-2-methyl-2,3-dihydroquinazolin-4(1H)-one

Conditions

Conditions	Yield
With iodine; 1-n-butyl-3-methylimidazolim bromide at 80℃; for 15h; Reagent/catalyst; Temperature; Ionic liquid; Green chemistry; chemoselective reaction;	93%

: 10226-30-9
6-chloro-2-hexanone

: 84702-77-2
6-azido-2-hexanone

Conditions

Conditions	Yield
With sodium azide; sodium iodide In dimethyl sulfoxide at 55℃; for 18h;	92%
With sodium azide; sodium iodide In N,N-dimethyl-formamide at 80℃; for 5h; Inert atmosphere;	81%
With sodium azide; sodium iodide In N,N-dimethyl-formamide at 80℃;	67%
With sodium azide; sodium iodide In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;	59%

: 10226-30-9
6-chloro-2-hexanone

: 111562-32-4
5-(2-aminophenyl)-1H-pyrazole

: C15H17N3

Conditions

Conditions	Yield
With acetic acid for 4h; Reflux;	92%

: 10226-30-9
6-chloro-2-hexanone

: C13H11Cl2N3O

: 6-chloro-2-(4-chlorobutyl)-3-((4-chlorophenyl)amino)-2-methyl-2,3-dihydroquinazolin-4(1H)-one

Conditions

Conditions	Yield
With iodine; 1-n-butyl-3-methylimidazolim bromide at 80℃; for 14h; Ionic liquid; Green chemistry; chemoselective reaction;	92%

: 10226-30-9
6-chloro-2-hexanone

: 131598-86-2
7-Ethyl-3,8-dimethyl-3,7-dihydro-purine-2,6-dione

: 7-Ethyl-3,8-dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione

Conditions

Conditions	Yield
With sodium ethanolate In N,N-dimethyl-formamide at 125℃; for 4h;	91%

: 136918-14-4
phthalimide

: 10226-30-9
6-chloro-2-hexanone

: 71510-41-3
2-(5-oxohexyl)-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 100℃; for 12h;	91%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 100℃; for 18h;	73.2%

: 10226-30-9
6-chloro-2-hexanone

: 30086-49-8
2-amino-N'-phenylbenzohydrazide

: 2-(4-chlorobutyl)-2-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one

Conditions

Conditions	Yield
With iodine; 1-n-butyl-3-methylimidazolim bromide at 80℃; for 15h; Ionic liquid; Green chemistry; chemoselective reaction;	91%

: 10226-30-9
6-chloro-2-hexanone

: 216311-70-5
C13H12ClN3O

: 7-chloro-2-(4-chlorobutyl)-2-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one

Conditions

Conditions	Yield
With iodine; 1-n-butyl-3-methylimidazolim bromide at 80℃; for 13h; Ionic liquid; Green chemistry; chemoselective reaction;	91%

: 10226-30-9
6-chloro-2-hexanone

: 107-05-1
3-chloroprop-1-ene

: C9H17ClO

Conditions

Conditions	Yield
With manganese; TiCpCl2 In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;	91%

: 10226-30-9
6-chloro-2-hexanone

: 56025-86-6
7-benzyl-3-methylxanthine

: 7-benzyl-3-methyl-1-(5-oxohexyl)-xanthine

Conditions

Conditions	Yield
	90.4%

: 10226-30-9
6-chloro-2-hexanone

: 20878-54-0
2-amino-N-(4-methoxyphenyl)benzamide

: 5-(4-methoxyphenyl)-4a-methyl-3,4,4a,5-tetrahydro-1H-pyrido[1,2-a]quinazolin-6(2H)-one

Conditions

Conditions	Yield
With iodine at 80℃; for 8h; Ionic liquid;	90%

: 10226-30-9
6-chloro-2-hexanone

: C14H14ClN3O

: 2-(4-chlorobutyl)-3-((3-chlorophenyl)amino)-2,8-dimethyl-2,3-dihydroquinazolin-4(1H)-one

Conditions

Conditions	Yield
With iodine; 1-n-butyl-3-methylimidazolim bromide at 80℃; for 11h; Ionic liquid; Green chemistry; chemoselective reaction;	90%

: 10226-30-9
6-chloro-2-hexanone

: C14H11N3O2

: 9a-methyl-7,8,9,9a-tetrahydro-6H-benzo[4,5]imidazo[1,2-c][1,3]dioxolo[4,5-g]pyrido[1,2-a]quinazoline

Conditions

Conditions	Yield
With iodine at 80℃; for 9h; Ionic liquid;	90%

: 10226-30-9
6-chloro-2-hexanone

: 131598-99-7
3-Ethyl-7,8-dimethyl-3,7-dihydro-purine-2,6-dione

: 3-Ethyl-7,8-dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione

Conditions

Conditions	Yield
With sodium ethanolate In N,N-dimethyl-formamide at 125℃; for 4h;	89%

: 10226-30-9
6-chloro-2-hexanone

: 221539-30-6
2-amino-N-(p-methoxybenzyl)benzamide

: 5-(4-methoxybenzyl)-4a-methyl-3,4,4a,5-tetrahydro-1H-pyrido[1,2-a]quinazolin-6(2H)-one

Conditions

Conditions	Yield
With iodine at 80℃; for 8h; Ionic liquid;	89%

: 10226-30-9
6-chloro-2-hexanone

: 18852-01-2
2-Amino-5-chlor-N2-phenyl-benzoesaeure-hydrazid

: 6-chloro-2-(4-chlorobutyl)-2-methyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one

Conditions

Conditions	Yield
With iodine; 1-n-butyl-3-methylimidazolim bromide at 80℃; for 11h; Ionic liquid; Green chemistry; chemoselective reaction;	89%

: 10226-30-9
6-chloro-2-hexanone

: 5805-39-0
2-(aminophenyl)benzimidazole

: 9a-methyl-7,8,9,9a-tetrahydro-6H-benzo[4,5]imidazo[1,2-c]pyrido[1,2-a]quinazoline

Conditions

Conditions	Yield
With iodine at 80℃; for 11h; Ionic liquid;	89%

: 107-10-8
propylamine

: 10226-30-9
6-chloro-2-hexanone

: 536-74-3
phenylacetylene

: C17H23N

Conditions

Conditions	Yield
With copper(I) oxide In acetonitrile at 90℃; for 24h; Inert atmosphere;	88%

...Expand

: 10226-30-9
6-chloro-2-hexanone

: 565171-47-3
2-amino-N-[2-(4-methoxyphenyl)ethyl]benzamide

: 5-(4-methoxyphenylethyl)-4a-methyl-3,4,4a,5-tetrahydro-1H-pyrido[1,2-a]quinazolin-6(2H)-one

Conditions

Conditions	Yield
With iodine at 80℃; for 8h; Ionic liquid;	87%

: 95-20-5
2-methyl-1H-indole

: 10226-30-9
6-chloro-2-hexanone

: 3-(5-chloro-1-methylpentyl)-2-methyl-1H-indole

Conditions

Conditions	Yield
With indium(III) tris[bis(trifluoromethanesulfonyl)amide]; methyldiphenylsilane In 1,4-dioxane at 50℃; for 24h; Inert atmosphere; Schlenk technique;	87%

: 10226-30-9
6-chloro-2-hexanone

: 2-amino-5-methyl-N'-phenylbenzohydrazide

: 2-(4-chlorobutyl)-2,6-dimethyl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one

Conditions

Conditions	Yield
With iodine; 1-n-butyl-3-methylimidazolim bromide at 80℃; for 10h; Ionic liquid; Green chemistry; chemoselective reaction;	87%

6-Chloro-2-hexanone Chemical Properties

Empirical Formula: C₆H₁₁ClO
Molecular Weight: 134.6039 g/mol
EINECS: 233-546-5
Index of Refraction: 1.424
Density: 0.989 g/cm³
Flash Point: 91.6 °C
Enthalpy of Vaporization: 44.38 kJ/mol
Boiling Point: 207.6 °C at 760 mmHg
Vapour Pressure: 0.224 mmHg at 25 °C
Storage tempreture: Freezer
Appearance: Clear yellow to brown liquid
Structure of 6-Chloro-2-hexanone (CAS NO.10226-30-9):

IUPAC Name: 6-Chlorohexan-2-one
Product Category of 6-Chloro-2-hexanone (CAS NO.10226-30-9): Pharmaceutical Intermediates;Carbonyl Compounds;Ketones;Pentoxifylline

6-Chloro-2-hexanone Uses

6-Chloro-2-hexanone (CAS NO.10226-30-9) has been used as ntermediate for pentoxifylline .

6-Chloro-2-hexanone Toxicity Data With Reference

6-Chloro-2-hexanone (CAS NO.10226-30-9) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated.

6-Chloro-2-hexanone Safety Profile

Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 37/39-26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.

6-Chloro-2-hexanone Specification

6-Chloro-2-hexanone , its cas register number is 10226-30-9. It also can be called 2-Hexanone, 6-chloro- . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, 6-Chloro-2-hexanone (CAS NO.10226-30-9) is not compatible with strong oxidizing agents, acids, acid chlorides, carbon dioxide, acid anhydrides, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide.

Product Name

6-Chloro-2-hexanone

Synthetic route

6-Chloro-2-hexanone Chemical Properties

6-Chloro-2-hexanone Uses

6-Chloro-2-hexanone Toxicity Data With Reference

6-Chloro-2-hexanone Safety Profile

6-Chloro-2-hexanone Specification

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