Acrylic anhydride supplier | CasNO.2051-76-5

Name
Acrylic anhydride
EINECS 218-128-2
CAS No. 2051-76-5
Article Data57
CAS DataBase
Density 1.065 g/cm³
Solubility
Melting Point -20 °C
Formula C₆H₆O₃
Boiling Point 203.839 °C at 760 mmHg
Molecular Weight 126.112
Flash Point 85.705 °C
Transport Information
Appearance
Safety 26-36/37/39-45
Risk Codes 14-20/21/22-34
Molecular Structure
Hazard Symbols
Synonyms 2-Propenoic acid,anhydride (9CI);Acrylic anhydride (6CI,7CI,8CI);Acrylic acid anhydride;NSC32616;
PSA 43.37000
LogP 0.42820

Synthetic route

: 79-10-7
acrylic acid

: 2051-76-5
acrylic acid anhydride

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; acetic anhydride at 100℃;	95%
With triethylamine; benzenesulfonyl chloride; Santonox R; 2-(2-hydroxy-3-tert-butyl-5-methylbenzyl)-4-methyl-6-tert-butylphenyl acrylate; pentaerythritol tetrakis(β-dodecylmercapto)propionate In dichloromethane at 5 - 30℃; for 3h;	91%
With methanesulfonyl chloride; triethylamine; Santonox R; 2-(2-hydroxy-3-tert-butyl-5-methylbenzyl)-4-methyl-6-tert-butylphenyl acrylate; pentaerythritol tetrakis(β-dodecylmercapto)propionate In dichloromethane at 5 - 30℃; for 3h;	79%

: 10192-85-5
potassium acrylate

: 2051-76-5
acrylic acid anhydride

Conditions

Conditions	Yield
With 10H-phenothiazine; methanesulfonyl chloride; 4-methoxy-phenol In acetone for 0.5h; Reagent/catalyst; Cooling with ice;	93.3%

: 79-10-7
acrylic acid

: 814-68-6
acryloyl chloride

: 2051-76-5
acrylic acid anhydride

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 16.0833h; Inert atmosphere; Cooling with ice;	80%
With triethylamine In tetrahydrofuran at 20℃; for 16h; Cooling with ice; Inert atmosphere;	80%
With triethylamine In tetrahydrofuran at 20℃; for 16h;	75%

: 108-24-7
acetic anhydride

: 79-10-7
acrylic acid

: 2051-76-5
acrylic acid anhydride

Conditions

Conditions	Yield
With phosphorus oic acid
With 10H-phenothiazine; cupric dibutyldithiocarbamate at 90℃; under 18 - 160 Torr; Product distribution / selectivity; Air atmosphere;

: 7446-81-3
sodium 2-propenoate

: 814-68-6
acryloyl chloride

: 2051-76-5
acrylic acid anhydride

: 814-68-6
acryloyl chloride

: 13270-28-5
Lithium acrylate

: 2051-76-5
acrylic acid anhydride

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h;

: 814-68-6
acryloyl chloride

acrylacidic sodium: acrylacidic sodium

: 2051-76-5
acrylic acid anhydride

: 79-10-7
acrylic acid

: 74-86-2
acetylene

carbon monoxide: carbon monoxide

: 2051-76-5
acrylic acid anhydride

Conditions

Conditions	Yield
With 1,2-dichloro-ethane; tetracarbonyl nickel
With 1,4-dioxane; tetracarbonyl nickel
With 1,4-dioxane; tetracarbonyl nickel
With 1,2-dichloro-ethane; tetracarbonyl nickel

...Expand

: 79-10-7
acrylic acid

: 74-86-2
acetylene

tetracarbonyl nickel: tetracarbonyl nickel

: 2051-76-5
acrylic acid anhydride

Conditions

Conditions	Yield
With 1,4-dioxane
With 1,2-dichloro-ethane
With 1,4-dioxane
With 1,2-dichloro-ethane

...Expand

: 74-86-2
acetylene

carbon monoxide: carbon monoxide

A: 2051-76-5
acrylic acid anhydride

B: 79-10-7
acrylic acid

Conditions

Conditions	Yield
With water; acetonitrile; nickel dibromide at 90℃; under 14710.2 Torr;

...Expand

: 121-44-8
triethylamine

: 79-10-7
acrylic acid

: 814-68-6
acryloyl chloride

: 2051-76-5
acrylic acid anhydride

Conditions

Conditions	Yield
In tetrahydrofuran

...Expand

: 7446-81-3
sodium 2-propenoate

: 98-88-4
benzoyl chloride

: 2051-76-5
acrylic acid anhydride

: 2051-76-5
acrylic acid anhydride

: 160732-12-7
acide 2-bromo-3-hydroxy propanoique

: C6H7BrO4

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; 2-hydroxyresorcinol at 25℃; for 12h; Darkness;	99.8%

: 2051-76-5
acrylic acid anhydride

: N,N-bis(2-hydroxyethyl)octadeca-9,11,13-trienamide

: C28H43NO5

Conditions

Conditions	Yield
With dmap In dichloromethane at 0 - 30℃; for 19h;	99%

: 2051-76-5
acrylic acid anhydride

: (1R,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hexane-2-ol

: isobornyl acrylate

Conditions

Conditions	Yield
With sulfuric acid In toluene at 60 - 80℃; for 4.5h; Solvent;	98.9%

: 2051-76-5
acrylic acid anhydride

: tert-butyl (5R)-5-[[7-(3-hydroxy-1-naphthyl)-4-piperazin-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]oxymethyl]-2,2-dimethylpyrrolidine-1-carboxylate

: tert-butyl (5R)-5-[[7-(3-hydroxy-1-naphthyl)-4-(4-prop-2-enoylpiperazin-1-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]oxymethyl]-2,2-dimethyl-pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at -40℃; for 1h; Inert atmosphere;	98.6%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -40℃; for 1h; Inert atmosphere;	98.6%

: 2051-76-5
acrylic acid anhydride

: 78-81-9
isobutylamine

: 471-25-0
Propiolic acid

: 1-isobutyl-2-oxo-1,2,3,4-tetrahydro-5-pyridinecarboxylic acid

Conditions

Conditions	Yield
Stage #1: acrylic acid anhydride; isobutylamine; Propiolic acid Solid phase reaction; Stage #2: With 3percent TFA In dichloromethane at 20℃; for 2h; Hydrolysis; Further stages.;	98%

...Expand

: 2051-76-5
acrylic acid anhydride

: 75-31-0
isopropylamine

: 471-25-0
Propiolic acid

: 1-isopropyl-2-oxo-1,2,3,4-tetrahydro-5-pyridinecarboxylic acid

Conditions

Conditions	Yield
Stage #1: acrylic acid anhydride; isopropylamine; Propiolic acid Solid phase reaction; Stage #2: With 3percent TFA In dichloromethane at 20℃; for 2h; Hydrolysis; Further stages.;	98%

...Expand

: 2051-76-5
acrylic acid anhydride

N-tert-butyloxycarbonyl-β-tert-butyl-L-aspartyl-D-alaninol: N-tert-butyloxycarbonyl-β-tert-butyl-L-aspartyl-D-alaninol

: 79-10-7
acrylic acid

Conditions

Conditions	Yield
In pyridine; ethyl acetate; benzene	97.8%

: 2051-76-5
acrylic acid anhydride

: 100-52-7
benzaldehyde

: phenylmethylene diacrylate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃; for 12h;	97%
With toluene-4-sulfonic acid at 20℃; for 12h;	97%
With sulfuric acid; copper

: 2051-76-5
acrylic acid anhydride

: 768-95-6
1-adamanthanol

: 121601-93-2
1-acryloyloxy-adamantane

Conditions

Conditions	Yield
Acidic catalyst In cyclohexane Heating;	95%

: 2051-76-5
acrylic acid anhydride

: 707-37-9
1,3-dimethyl-5-adamantanol

: 23743-72-8
3,5-Dimethyl-1-adamantyl acrylate

Conditions

Conditions	Yield
Acidic catalyst In cyclohexane Heating;	95%

: 2051-76-5
acrylic acid anhydride

: 78-81-9
isobutylamine

: 471-25-0
Propiolic acid

: 1-isobutyl-2-oxo-1,2,3,4-tetrahydro-5-pyridinecarboxamide

Conditions

Conditions	Yield
Stage #1: acrylic acid anhydride; isobutylamine; Propiolic acid Solid phase reaction; Stage #2: With 3percent TFA In dichloromethane at 20℃; for 2h; Hydrolysis; Further stages.;	95%

...Expand

: 2051-76-5
acrylic acid anhydride

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 141-97-9
ethyl acetoacetate

: ethyl 1-carbamoylmethyl-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyridinecarboxylate

Conditions

Conditions	Yield
Stage #1: acrylic acid anhydride; N-(fluoren-9-ylmethoxycarbonyl)glycine; ethyl acetoacetate Solid phase reaction; Stage #2: With 3percent TFA In dichloromethane at 20℃; for 2h; Hydrolysis; Further stages.;	95%

...Expand

: 2051-76-5
acrylic acid anhydride

: 75-31-0
isopropylamine

: 471-25-0
Propiolic acid

: 1-isopropyl-2-oxo-1,2,3,4-tetrahydro-5-pyridinecarboxamide

Conditions

Conditions	Yield
Stage #1: acrylic acid anhydride; isopropylamine; Propiolic acid Solid phase reaction; Stage #2: With 3percent TFA In dichloromethane at 20℃; for 2h; Hydrolysis; Further stages.;	95%

...Expand

: 2051-76-5
acrylic acid anhydride

: 35453-19-1
2,4,6-triiodo-5-aminoisophthalic acid

: 783279-02-7
2,4,6-triiodo-5-(prop-2-enamido)benzene-1,3-dicarboxylic acid

Conditions

Conditions	Yield
With sulfuric acid In acetonitrile at 80℃;	95%

: 2051-76-5
acrylic acid anhydride

: 4081-00-9
spiro(fluorene-9,9′-xanthene)-3',6'-diol

: spiro[9H-fluorene-9,9'-xanthene]-3',6'-diacrylate

Conditions

Conditions	Yield
Stage #1: spiro[fuoroline-9,9'-(2',7'-dihydroxyxanthone)] With dmap; triethylamine In dichloromethane at 0℃; for 0.5h; Stage #2: acrylic acid anhydride In dichloromethane at 0℃; for 5h;	94.7%

: 110-91-8
morpholine

: 2051-76-5
acrylic acid anhydride

: 5117-12-4
N-Acryloylmorpholine

Conditions

Conditions	Yield
With 10H-phenothiazine; sulfuric acid for 2h; Reagent/catalyst; Heating;	93.12%

: 2051-76-5
acrylic acid anhydride

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 529-34-0
3,4-dihydronaphthalene-1(2H)-one

: 2-(3-oxo-1,2,3,4,5,6-hexahydrobenzo[f]quinolin-4-yl)acetamide

Conditions

Conditions	Yield
Stage #1: acrylic acid anhydride; N-(fluoren-9-ylmethoxycarbonyl)glycine; 3,4-dihydronaphthalene-1(2H)-one Solid phase reaction; Stage #2: With 3percent TFA In dichloromethane at 20℃; for 2h; Hydrolysis; Further stages.;	92%

...Expand

: 2051-76-5
acrylic acid anhydride

: 5,12-di-tert-pentyl-7,16-di-tert-butyl-8,15-diisopropyl-4,13-dihydroxy[2,2]paracyclophane

: C43H66O3

Conditions

Conditions	Yield
With n-butyllithium In acetone at 15 - 60℃; for 2h; Inert atmosphere;	91%

: 2051-76-5
acrylic acid anhydride

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 90719-27-0
(S)-3-acryloyl-4-benzyloxazolidin-2-one

Conditions

Conditions	Yield
With lithium chloride In tetrahydrofuran at 20℃; for 8h;	90%
With lithium chloride In tetrahydrofuran Ambient temperature; Yield given;
With lithium chloride In tetrahydrofuran at -20 - 20℃; for 24h;	2.914 g

: 2051-76-5
acrylic acid anhydride

: 170659-85-5
1-Morpholino-4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-2-undecanol

: 1-Morpholinomethyl-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl acrylate

Conditions

Conditions	Yield
In dichloromethane for 5h; Heating;	90%

: 2051-76-5
acrylic acid anhydride

: 128-39-2
2,6-di-tert-butylphenol

: 1-(3,5-di-tert-butyl-4-hydroxyphenyl)vinyl ketone

Conditions

Conditions	Yield
With perchloric acid for 1h; Ambient temperature;	90%

: 2051-76-5
acrylic acid anhydride

: C10H11NO5

: C16H15NO7

Conditions

Conditions	Yield
With dmap In methanol; chloroform at 50℃; for 1h; Inert atmosphere;	89%

: 4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-(piperazin-1-yl)-1,3,5-triazin-2-yl)morpholine

: 2051-76-5
acrylic acid anhydride

: 1345988-62-6
1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h;	88%

: 2051-76-5
acrylic acid anhydride

: 364385-54-6
(1S,2R)-2-tert-Butoxycarbonylamino-cyclohexylamine

: tert-butyl ((1R,2S)-2-acrylamidocyclohexyl)carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h; Temperature; Concentration; Cooling with ice; Inert atmosphere;	87%
With triethylamine In dichloromethane at 20℃; for 1h; Cooling with ice; Inert atmosphere;	74%
Stage #1: acrylic acid anhydride; (1S,2R)-2-tert-Butoxycarbonylamino-cyclohexylamine With triethylamine In dichloromethane at 20℃; for 0.5h; Cooling with ice; Inert atmosphere; Stage #2: With methanesulfonic acid In dichloromethane at 20℃; for 5h; Inert atmosphere;

: 2051-76-5
acrylic acid anhydride

: 2-(2-hydroxyethyl)-4-(hydroxymethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

: C17H17NO7

Conditions

Conditions	Yield
With pyridine In methanol; dichloromethane at 30℃; for 2.5h; Inert atmosphere;	87%

: 2051-76-5
acrylic acid anhydride

: 721395-15-9
(1S,2R)-2-(N-t-butyloxycarbonylamino)-1-aminocyclopentane

: tert-butyl ((1R,2S)-2-acrylamidocyclopentyl)carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h; Cooling with ice; Inert atmosphere;	87%

: 1462-10-8
4-methyl-1,4-pentanediol

: 2051-76-5
acrylic acid anhydride

: 4-(4-methylpentane-1,4-diyl)diacrylate

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine at 60℃;	86%

Acrylic anhydride Specification

The IUPAC name of Acrylic anhydride is prop-2-enoyl prop-2-enoate. With the CAS registry number 2051-76-5, it is also named as 2-Propenoic acid, anhydride. The product's categories are Monomer; Organic acids. It is colorless liquid with strong irritating odor that reacts violently with water and is miscible with ethanol and ether. Additionally, this chemical should be sealed in the container and stored in the cool and dry place.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.72; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.71; (4)ACD/LogD (pH 7.4): 0.71; (5)ACD/BCF (pH 5.5): 2.06; (6)ACD/BCF (pH 7.4): 2.06; (7)ACD/KOC (pH 5.5): 58.33; (8)ACD/KOC (pH 7.4): 58.33; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.438; (13)Molar Refractivity: 31.1 cm³; (14)Molar Volume: 118.3 cm³; (15)Polarizability: 12.32×10^-24cm³; (16)Surface Tension: 30.7 dyne/cm; (17)Enthalpy of Vaporization: 44.01 kJ/mol; (18)Vapour Pressure: 0.272 mmHg at 25°C; (19)Rotatable Bond Count: 4; (20)Exact Mass: 126.031694; (21)MonoIsotopic Mass: 126.031694; (22)Topological Polar Surface Area: 43.4; (23)Heavy Atom Count: 9; (24)Complexity: 140.

Preparation of Acrylic anhydride: It can be obtained by acrylic acid. This reaction needs reagents copper acetate and diketene.

Uses of Acrylic anhydride: It is used in the preparation of acrylic resin. And it is also used in organic synthesis. For example: it can react with adamantan-1-ol to get acrylic acid adamantan-1-yl ester. This reaction needs catalytic agent acidic catalyst and solvent cyclohexane by heating. The yield is 95%.

When you are using this chemical, please be cautious about it as the following:
It is harmful by inhalation, in contact with skin and if swallowed. And it can cause burns. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
1. SMILES:O=C(OC(=O)\C=C)\C=C
2. InChI:InChI=1/C6H6O3/c1-3-5(7)9-6(8)4-2/h3-4H,1-2H2
3. InChIKey:ARJOQCYCJMAIFR-UHFFFAOYAS

Product Name

Acrylic anhydride

Synthetic route

Acrylic anhydride Specification

Related Products

Hot Products