4α-ethylthio-5α-androstane-3,6,17-trione
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In ethyl acetate for 9h; Ambient temperature; | 90% |
Conditions | Yield |
---|---|
With Montmorillonite K10; pyridinium chlorochromate In 1,4-dioxane for 0.75h; Irradiation; | 89% |
With chromium(VI) oxide; sulfuric acid In acetone at 0℃; modified Jones oxidation; | 85% |
With Jones reagent | 83% |
5α-hydroxyandrostane-3,6,17-trione
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With sulfuric acid; water In ethanol for 3.5h; Reflux; | 89% |
80% | |
With hydrogenchloride; chloroform |
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With sulfuric acid In ethanol for 5h; Concentration; Reflux; | 87% |
3-tetrahydropyran-2-yloxy-androst-5-en-17-one
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With 3 A molecular sieve; pyridinium chlorochromate In benzene for 5h; Heating; | 86% |
6α-hydroxy-androst-4-ene-3,17-dione
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With potassium hydroxide; tetrazolium blue In ethanol Heating; | 85% |
With potassium hydroxide; tetrazolium blue In ethanol at 25 - 50℃; Rate constant; rate constants for enolisation and oxidation; |
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; Rh2(cap)4 In 1,2-dichloro-ethane at 40℃; for 16h; Product distribution / selectivity; Allylic oxidation; | 80% |
With tert.-butylhydroperoxide; [Rh2(cap)4*2CH3CN] In water; 1,2-dichloro-ethane at 40℃; for 40h; | 80% |
With tert.-butylhydroperoxide; Rh2(cap)4 In water at 40℃; for 16h; Product distribution / selectivity; Allylic oxidation; | 62% |
6-methoxy-4,6-androstadiene-3,17-dione
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With hydrogenchloride In dichloromethane for 72h; Ambient temperature; | 73% |
Conditions | Yield |
---|---|
With N-hydroxyphthalimide; 2,2’-azobis(4-methoxy-2,4-dimethyl)valeronitrile; oxygen In acetonitrile at 30℃; under 760 Torr; for 48h; | A 56% B 12% |
3-hydroxy-5-androsten-17-one
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With pyridinium chlorochromate In dichloromethane for 96h; | 53% |
Conditions | Yield |
---|---|
With potassium hydroxide; tetrazolium blue In ethanol Heating; | 32% |
With potassium hydroxide; tetrazolium blue at 25 - 50℃; Rate constant; rate constants for enolisation and oxidation; |
testosterone
A
Androstenedione
B
17β-hydroxy-4-androstene-3,6-dione
C
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; Rh2(cap)4 In 1,2-dichloro-ethane at 40℃; for 16h; Product distribution / selectivity; Allylic oxidation; | A n/a B 28% C n/a |
With tert.-butylhydroperoxide; Rh2(cap)4 In water at 40℃; for 16h; Product distribution / selectivity; Allylic oxidation; | A n/a B 23% C n/a |
With tert.-butylhydroperoxide; [Rh2(cap)4*2CH3CN] In water; 1,2-dichloro-ethane at 40℃; for 16h; | A n/a B 23% C n/a |
dehydroepiandrosterone
A
androst-4-ene-3,6,17-trione
B
6β-hydroxy-4-androstene-3,17-dione
Conditions | Yield |
---|---|
With jones reagent In diethyl ether for 0.25h; Heating; | A 24% B 8% |
Androstenedione
A
androst-4-ene-3,6,17-trione
B
4-hydroxy-androsta-4,6-diene-3,17-dione
Conditions | Yield |
---|---|
With potassium tert-butylate In tert-butyl alcohol for 20h; | A n/a B 15% |
Androsta-1,4-diene-3,17-dione
A
androst-4-ene-3,6,17-trione
B
4-hydroxy-1,4,6-androstatriene-3,17-dione
Conditions | Yield |
---|---|
With potassium tert-butylate In tert-butyl alcohol for 20h; | A n/a B 6% |
dehydroepiandrosterone
A
androst-4-ene-3,6,17-trione
B
5α-hydroxyandrostane-3,6,17-trione
Conditions | Yield |
---|---|
With chromium(VI) oxide; water; acetic acid |
6β-hydroxytestosterone
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With sodium dichromate |
Conditions | Yield |
---|---|
With chromium(VI) oxide |
3β,6β-dihydroxyandrost-4-en-17-one
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With manganese(IV) oxide |
Conditions | Yield |
---|---|
With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide In dichloromethane at 25℃; ultrasonic irradiation; Yield given; |
6α-nitro-androst-4-ene-3,17-dione
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With aluminum oxide |
3-methoxyandrosta-3,5-dien-17-one
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With (tBuO)2CrO2 In tetrachloromethane |
6β-Methoxy-7α-hydroxy-androsten-(4)-dion-(3,17)
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid |
6-Chloro-3-ethoxyandrosta-3,5-dien-17-on
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid |
17-β-hydroxyandrosta-4,6-diene
A
androst-4-ene-3,6,17-trione
B
androst-5-ene-4,7,17-trione
Conditions | Yield |
---|---|
With chromium(VI) oxide In acetone for 0.166667h; Ambient temperature; | A 60 mg B 500 mg |
Conditions | Yield |
---|---|
With chromic acid In acetone at 0 - 20℃; Oxidation; | 190 mg |
dehydroepiandrosterone
acetic acid
A
androst-4-ene-3,6,17-trione
B
5α-hydroxyandrostane-3,6,17-trione
hydrogenchloride
chloroform
5α-hydroxyandrostane-3,6,17-trione
androst-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
With chromium(VI) oxide; sulfuric acid In acetone at 0 - 20℃; |
androst-4-ene-3,6,17-trione
androst-4-ene-3β,6α,17β-triol
Conditions | Yield |
---|---|
With sodium tetrahydroborate; cerium(III) chloride | 95% |
androst-4-ene-3,6,17-trione
ethane-1,2-dithiol
3α,4α-ethylenedithio-3β-hydroxy-5α-androstane-6,17-dione
Conditions | Yield |
---|---|
In methanol for 48h; Ambient temperature; | 88% |
androst-4-ene-3,6,17-trione
ethane-1,2-dithiol
A
3,3:6,6-bis(ethylenedithio)-4-androsten-17-one
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In methanol for 24h; Ambient temperature; | A 84% B 6% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In methanol at 20℃; for 1h; Concentration; | 81% |
Stage #1: androst-4-ene-3,6,17-trione With sodium tetrahydroborate; nickel(II) Stage #2: With pyridinium chlorochromate | 78% |
With acetic acid; zinc |
Conditions | Yield |
---|---|
In methanol for 28h; Ambient temperature; | 80% |
androst-4-ene-3,6,17-trione
ethanethiol
4α-ethylthio-5α-androstane-3,6,17-trione
Conditions | Yield |
---|---|
With methanol; sodium hydrogencarbonate for 10h; Ambient temperature; | 80% |
androst-4-ene-3,6,17-trione
5α-androst-3β,6β,17β-triol
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel dichloride | 73% |
androst-4-ene-3,6,17-trione
lead(IV) tetraacetate
7α-acetoxyandrost-4-ene-3,6,17-trione
Conditions | Yield |
---|---|
In acetic anhydride; acetic acid for 72h; Ambient temperature; | 72% |
androst-4-ene-3,6,17-trione
ethane-1,2-dithiol
A
3,3-ethylenedithio-4-androstene-6,17-dione
B
3,3:6,6-bis(ethylenedithio)-4-androsten-17-one
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In methanol for 7h; Ambient temperature; | A 60% B 4% |
(ethylthio)trimethylsilane
androst-4-ene-3,6,17-trione
A
5α-androst-3,6,17-trione
B
3,3-diethylthio-5α-androstane-6,17-dione
Conditions | Yield |
---|---|
With zinc(II) iodide In chloroform for 48h; Ambient temperature; | A 30% B 46% |
androst-4-ene-3,6,17-trione
A
5α-androst-3,6,17-trione
B
3,3-diethylthio-5α-androstane-6,17-dione
Conditions | Yield |
---|---|
With (ethylthio)trimethylsilane; zinc(II) iodide In chloroform for 48h; Ambient temperature; | A 30% B 46% |
androst-4-ene-3,6,17-trione
ethanethiol
A
3-ethylthio-2,4-androstadiene-6,17-dione
B
3,3-diethylthio-4-androstene-6,17-dione
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 6h; Heating; | A 35% B 2% |
androst-4-ene-3,6,17-trione
ethanethiol
A
6-methoxy-4,6-androstadiene-3,17-dione
B
3,3-diethylthio-4-androstene-6,17-dione
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In methanol for 8h; Ambient temperature; | A 10% B 26% |
methanol
androst-4-ene-3,6,17-trione
A
5α-androst-3,6,17-trione
B
6-methoxy-4,6-androstadiene-3,17-dione
C
4α-ethylthio-5α-androstane-3,6,17-trione
D
3,3-diethylthio-4-androstene-6,17-dione
Conditions | Yield |
---|---|
With ethanethiol In methanol for 24h; Ambient temperature; | A 4% B 10% C 20% D 2% |
Conditions | Yield |
---|---|
With methanol for 96h; Ambient temperature; | A 2% B 20% |
Conditions | Yield |
---|---|
In methanol for 96h; Ambient temperature; | A 8% B n/a |
The Androst-4-ene-3,6,17-trione with the cas number 2243-06-3 is also called (8R,9S,10R,13S,14S)-10,13-dimethyl-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,6,17-trione. Its molecular formula is C19H24O3. This chemical belongs to the following product categories: (1)Steroids & Hormones - 13C & 2H; (2)Steroids. It is an aromatase inhibitor.
You can still convert the following datas into molecular structure:
(1)SMILES: C1(CC[C@@]2([C@H]3CC[C@@]4(C(CC[C@@H]4[C@@H]3CC(C2=C1)=O)=O)C)C)=O
(2)InChI: InChI=1/C19H24O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14H,3-8,10H2,1-2H3/t12-,13-,14-,18+,19-/m0/s1
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