Product Name

  • Name

    Azetidine

  • EINECS 207-963-8
  • CAS No. 503-29-7
  • Article Data38
  • CAS DataBase
  • Density 0.851 g/cm3
  • Solubility miscible in water
  • Melting Point -70°C
  • Formula C3H7N
  • Boiling Point 64.9 °C at 760 mmHg
  • Molecular Weight 57.0953
  • Flash Point ?5°F
  • Transport Information UN 2733 3/PG 2
  • Appearance clear colorless liquid
  • Safety 16-26-36/37/39-45
  • Risk Codes 11-34
  • Molecular Structure Molecular Structure of 503-29-7 (Azetidine)
  • Hazard Symbols FlammableF,CorrosiveC
  • Synonyms 1,3-Propylenimine;Azacyclobutane;Azete, tetrahydro-;Trimethylenimine;
  • PSA 12.03000
  • LogP 0.30850

Synthetic route

Conditions
ConditionsYield
With potassium hydroxide In water at 20 - 95℃; for 3h; Inert atmosphere;89%
With sodium hydroxide In dichloromethane; water
With sodium hydroxide In water at 20℃; for 1h;
With potassium hydroxide In water
With sodium hydroxide In water at 20℃; for 1h;18 g
potassium hydroxide

potassium hydroxide

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
In water at 90℃;85%
N-benzhydryl azetidine
107128-00-7

N-benzhydryl azetidine

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide; hydrogen; palladium on activated charcoal 1.) methanol, 60 deg C, 40 - 80 psi, 2 h, 2.) 100 deg C;83%
azetidine hydrogen perchlorate

azetidine hydrogen perchlorate

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
With sodium; ethylene glycol81%
1-methyl-1H-imidazole
616-47-7

1-methyl-1H-imidazole

3-chloropropylamine hydrochloride
6276-54-6

3-chloropropylamine hydrochloride

A

azetidine
503-29-7

azetidine

B

1-(3-aminopropyl)-3-methyl-1H-imidazol-3-ium chloride

1-(3-aminopropyl)-3-methyl-1H-imidazol-3-ium chloride

Conditions
ConditionsYield
With triethylamine at 170℃; for 0.025h; microwave irradiation;A n/a
B 65%
N-benzhydryl azetidine
107128-00-7

N-benzhydryl azetidine

A

azetidine
503-29-7

azetidine

B

N-γ-aminopropyltrimethyleneimine
54262-75-8

N-γ-aminopropyltrimethyleneimine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol other solvents;A 50%
B n/a
3-<(Triphenylphosphoranylidene)amino>-1-propanol
78064-88-7

3-<(Triphenylphosphoranylidene)amino>-1-propanol

A

azetidine
503-29-7

azetidine

B

benzene
71-43-2

benzene

Conditions
ConditionsYield
Heating;A 33%
B 15%
3-<(Triphenylphosphoranylidene)amino>-1-propanol
78064-88-7

3-<(Triphenylphosphoranylidene)amino>-1-propanol

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
at 190℃; for 1.5h;29%
3-aminopropyl hydrogen sulfate
1071-29-0

3-aminopropyl hydrogen sulfate

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
With sodium hydroxide
1-(toluene-4-sulfonyl)azetidine
7730-45-2

1-(toluene-4-sulfonyl)azetidine

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
With pentan-1-ol; sodium at 120℃;
With ammonia; sodium
Trimethylenediamine
109-76-2

Trimethylenediamine

A

azetidine
503-29-7

azetidine

B

3-Methylpyridine
108-99-6

3-Methylpyridine

Conditions
ConditionsYield
Destillation von salzsaurem Trimethylendiamin;
3-chloropropan-1-amine
14753-26-5

3-chloropropan-1-amine

A

azetidine
503-29-7

azetidine

B

3-(3-aminopropylamino)propan-1-ol
40226-15-1

3-(3-aminopropylamino)propan-1-ol

C

N-γ-aminopropyltrimethyleneimine
54262-75-8

N-γ-aminopropyltrimethyleneimine

D

N1-(3-Azetidin-1-yl-propyl)-propane-1,3-diamine
129157-76-2

N1-(3-Azetidin-1-yl-propyl)-propane-1,3-diamine

E

1-amino-2-propene
107-11-9

1-amino-2-propene

F

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

Conditions
ConditionsYield
With sodium hydroxide In water at 80℃; Product distribution;A n/a
B 6 % Chromat.
C 50 % Chromat.
D 25 % Chromat.
E n/a
F 15 % Chromat.
1-azetine
6788-85-8

1-azetine

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 0℃;
3-chloropropan-1-amine
14753-26-5

3-chloropropan-1-amine

ethylenediamine
107-15-3

ethylenediamine

A

azetidine
503-29-7

azetidine

B

N-(2-Aminoethyl)-1,3-propanediamine
13531-52-7

N-(2-Aminoethyl)-1,3-propanediamine

Conditions
ConditionsYield
With sodium hydroxide In water Product distribution; Heating;A 3 % Chromat.
B 96 % Chromat.
3-chloropropan-1-amine
14753-26-5

3-chloropropan-1-amine

ethylenediamine
107-15-3

ethylenediamine

A

azetidine
503-29-7

azetidine

B

3-(3-aminopropylamino)propan-1-ol
40226-15-1

3-(3-aminopropylamino)propan-1-ol

Conditions
ConditionsYield
With sodium hydroxide In water at 50℃; Kinetics; Mechanism; Thermodynamic data; other temperatures; ΔH(excit.), ΔS(excit.), Ea;
N-p-toluenesulfonyl-trimethyleneimine

N-p-toluenesulfonyl-trimethyleneimine

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
With pentan-1-ol; sodium
pentan-1-ol
71-41-0

pentan-1-ol

1-(toluene-4-sulfonyl)azetidine
7730-45-2

1-(toluene-4-sulfonyl)azetidine

sodium

sodium

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
Kochen;
trimethylenediamine, hydrochloride

trimethylenediamine, hydrochloride

A

azetidine
503-29-7

azetidine

B

3-Methylpyridine
108-99-6

3-Methylpyridine

Conditions
ConditionsYield
Trockene Destillation;
trimethylenediamine hydrochloride

trimethylenediamine hydrochloride

A

azetidine
503-29-7

azetidine

B

3-Methylpyridine
108-99-6

3-Methylpyridine

Conditions
ConditionsYield
bei der Destillation;
γ-bromo-propylamine hydrobromide

γ-bromo-propylamine hydrobromide

A

azetidine
503-29-7

azetidine

B

N-<γ-amino-propyl>-trimethyleneimine

N-<γ-amino-propyl>-trimethyleneimine

Conditions
ConditionsYield
With potassium hydroxide at 80℃;
(3-bromopropyl)amine
18370-81-5

(3-bromopropyl)amine

aqueous NaOH-solution

aqueous NaOH-solution

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
at 25.5 - 35.5℃; Kinetik der Umwandlung; Reaktion des Hydrobromids;
3-bromopropylamine hydrochloride
5003-71-4

3-bromopropylamine hydrochloride

KOH-solution

KOH-solution

azetidine
503-29-7

azetidine

zinc chloride trimethyleneimine complex

zinc chloride trimethyleneimine complex

sodium hydroxide
1310-73-2

sodium hydroxide

A

azetidine
503-29-7

azetidine

B

zinc(II) hydroxide

zinc(II) hydroxide

Conditions
ConditionsYield
byproducts: NaCl; 0-20 ° C;;
zinc chloride trimethyleneimine complex

zinc chloride trimethyleneimine complex

ammonia
7664-41-7

ammonia

A

azetidine
503-29-7

azetidine

B

zinc(II) chloride
7646-85-7

zinc(II) chloride

Conditions
ConditionsYield
0-20 ° C;;
propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

azetidine
503-29-7

azetidine

Conditions
ConditionsYield
With dodecacarbonyl-triangulo-triruthenium; water; N–phenyl–2–(dicyclohexylphosphino)pyrrole In cyclohexane at 140℃; for 21h; Reagent/catalyst; Inert atmosphere; Schlenk technique; Autoclave;
at 350℃; under 760.051 Torr; for 1h; Inert atmosphere; Flow reactor;
azetidine
503-29-7

azetidine

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
84358-13-4

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

4-(azetidine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester
957054-78-3

4-(azetidine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h;100%
Stage #1: N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In tetrahydrofuran at 20℃; for 1h;
Stage #2: azetidine With triethylamine In tetrahydrofuran for 14h;
100%
Stage #1: N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In tetrahydrofuran at 22℃; for 1h;
Stage #2: azetidine In tetrahydrofuran at 22℃;
azetidine
503-29-7

azetidine

2,4-dichloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine
1263868-24-1

2,4-dichloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

4-(azetidin-1-yl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine
1263868-28-5

4-(azetidin-1-yl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Conditions
ConditionsYield
In methanol at 20℃; for 0.5h;100%
In methanol at 20℃; for 0.5h;100%
azetidine
503-29-7

azetidine

1-methyl-5-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid
1380329-77-0

1-methyl-5-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid

4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)amide
1380329-78-1

4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)amide

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate at 70℃; for 2h;100%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate at 70℃; for 2h;100%
azetidine
503-29-7

azetidine

N-{1-[N-(benzyloxycarbonyl)-sulfamoyl]pyridin-4(1H)-ylidene}-N-methylmethanaminium chloride
1443432-71-0

N-{1-[N-(benzyloxycarbonyl)-sulfamoyl]pyridin-4(1H)-ylidene}-N-methylmethanaminium chloride

benzyl (azetidin-1-ylsulfonyl)carbamate
1271835-78-9

benzyl (azetidin-1-ylsulfonyl)carbamate

Conditions
ConditionsYield
In dichloromethane at 20℃;100%
In dichloromethane at 20℃;100%
azetidine
503-29-7

azetidine

3-chloro-5-(3-iodo-1H-pyrazol-1-yl)pyridazine
1616070-35-9

3-chloro-5-(3-iodo-1H-pyrazol-1-yl)pyridazine

3-(azetidin-1-yl)-5-(3-iodo-1H-pyrazol-1-yl)pyridazine
1621525-33-4

3-(azetidin-1-yl)-5-(3-iodo-1H-pyrazol-1-yl)pyridazine

Conditions
ConditionsYield
In 1,4-dioxane at 60℃; for 6h;100%
azetidine
503-29-7

azetidine

6-chloropyridine-2-carboxaldehyde
54087-03-5

6-chloropyridine-2-carboxaldehyde

6-(azetidin-1-yl)picolinaldehyde

6-(azetidin-1-yl)picolinaldehyde

Conditions
ConditionsYield
In dimethyl sulfoxide at 120℃; for 1h;100%
azetidine
503-29-7

azetidine

C69H116N6O29

C69H116N6O29

C75H126N8O27

C75H126N8O27

Conditions
ConditionsYield
Stage #1: C69H116N6O29 With N-ethyl-N,N-diisopropylamine; O‐(1H‐benzotriazol‐1‐yl)‐N,N,N′,N′‐tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 0 - 20℃; for 3h;
Stage #2: azetidine at 55℃; Sealed tube;
100%
Stage #1: C69H116N6O29 With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 3h;
Stage #2: azetidine In N,N-dimethyl-formamide at 55℃; Sealed tube;
100%
azetidine
503-29-7

azetidine

2,8-dibromo-4,6-difluoro-5-(4-methoxybenzyl)-10,10-dimethyl-5,10-dihydrodibenzo[b,e][1,4]azasiline

2,8-dibromo-4,6-difluoro-5-(4-methoxybenzyl)-10,10-dimethyl-5,10-dihydrodibenzo[b,e][1,4]azasiline

2,8-di(azetidin-l-yl)-4,6-difluoro-5-(4-methoxybenzyl)-10,10-dimethyl-5,10 dihydrodibenzo[b,e][1,4]azasiline

2,8-di(azetidin-l-yl)-4,6-difluoro-5-(4-methoxybenzyl)-10,10-dimethyl-5,10 dihydrodibenzo[b,e][1,4]azasiline

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 110℃; for 24h; Buchwald-Hartwig Coupling; Sealed tube; Inert atmosphere;100%
azetidine
503-29-7

azetidine

C9H11NO5

C9H11NO5

(4S,5R)-3-((R)-1,3-di(azetidin-1-yl)-1-oxopropan-2-yl)-4-hydroxy-5-methoxy-4,5-dimethyloxazolidin-2-one

(4S,5R)-3-((R)-1,3-di(azetidin-1-yl)-1-oxopropan-2-yl)-4-hydroxy-5-methoxy-4,5-dimethyloxazolidin-2-one

Conditions
ConditionsYield
In dichloromethane at 20℃; for 0.166667h;100%
azetidine
503-29-7

azetidine

(E)-O-methyl-4-nitrobenzohydroximoyl chloride
41071-36-7

(E)-O-methyl-4-nitrobenzohydroximoyl chloride

Azetidin-1-yl-(4-nitro-phenyl)-methanone O-methyl-oxime
142701-85-7

Azetidin-1-yl-(4-nitro-phenyl)-methanone O-methyl-oxime

Conditions
ConditionsYield
In benzene at 32℃;99.7%
In benzene at 32℃; Rate constant;
In acetonitrile at 32℃; Rate constant; different amine excess;
In acetonitrile at 32℃;
azetidine
503-29-7

azetidine

N-chloroazetidine
32115-53-0

N-chloroazetidine

Conditions
ConditionsYield
With N-chloro-succinimide at 20℃; under 0.1 Torr;99%
With N-chloro-succinimide under 0.001 Torr; for 3h; Ambient temperature;
With N-chloro-succinimide; chlorine at 600℃; quarz U-tube;
With N-chloro-succinimide
With N-chloro-succinimide at 46.9℃; under 0.008 - 0.08 Torr; Yield given;
azetidine
503-29-7

azetidine

5-bromomethyl-2,3-dimethoxy-7-nitro-quinoxaline
188699-17-4

5-bromomethyl-2,3-dimethoxy-7-nitro-quinoxaline

5-Azetidin-1-ylmethyl-2,3-dimethoxy-7-nitro-quinoxaline

5-Azetidin-1-ylmethyl-2,3-dimethoxy-7-nitro-quinoxaline

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydroxide In dichloromethane99%
azetidine
503-29-7

azetidine

6-(2-hydroxyethyl)-2-(methylthio)-4-pyrimidinyl 4-methyl-1-benzenesulfonate
920490-05-7

6-(2-hydroxyethyl)-2-(methylthio)-4-pyrimidinyl 4-methyl-1-benzenesulfonate

C10H15N3OS

C10H15N3OS

Conditions
ConditionsYield
In tetrahydrofuran at 70℃; for 48h;99%
azetidine
503-29-7

azetidine

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

1-(2-nitrophenyl)azetidine
90557-58-7

1-(2-nitrophenyl)azetidine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 90℃; for 3h; Inert atmosphere;99%
With PS-morpholine In chloroform at 50℃; for 2h;
azetidine
503-29-7

azetidine

5-(bromomethyl)-1-methyl-3-nitro-1H-pyrazole
1227210-47-0

5-(bromomethyl)-1-methyl-3-nitro-1H-pyrazole

5-(azetidin-1-ylmethyl)-1-methyl-3-nitro-1H-pyrazole
1227210-48-1

5-(azetidin-1-ylmethyl)-1-methyl-3-nitro-1H-pyrazole

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;99%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 24h;90%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 24h;90%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 24h;75.1%
azetidine
503-29-7

azetidine

5-(ethoxycarbonyl)-1-methyl-1H-pyrazole-4-carboxylic acid
1174886-97-5

5-(ethoxycarbonyl)-1-methyl-1H-pyrazole-4-carboxylic acid

4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester
1278407-69-4

4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With propylphosphonic anhydride; N-ethyl-N,N-diisopropylamine In ethyl acetate at 0 - 20℃;99%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate at 0 - 20℃;60.7%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 0 - 20℃;
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 20℃; for 3h; Cooling;
azetidine
503-29-7

azetidine

3-bromo-4-chloropyridine
36953-42-1

3-bromo-4-chloropyridine

4-(azetidin-1-yl)-3-bromopyridine
1289267-06-6

4-(azetidin-1-yl)-3-bromopyridine

Conditions
ConditionsYield
With caesium carbonate In 1,2-dimethoxyethane at 90℃; for 18h; Inert atmosphere; capped;99%
With caesium carbonate In 1,2-dimethoxyethane at 90℃; for 18h; Inert atmosphere;66%
azetidine
503-29-7

azetidine

(E)-2-{8-[(4-chloro-2-methyl-6-propylpyrimidin-5-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile
1421787-27-0

(E)-2-{8-[(4-chloro-2-methyl-6-propylpyrimidin-5-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile

(E)-2-(8-{[4-(azetidin-1-yl)-2-methyl-6-propylpyrimidin-5-yl]methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile
1421787-24-7

(E)-2-(8-{[4-(azetidin-1-yl)-2-methyl-6-propylpyrimidin-5-yl]methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile

Conditions
ConditionsYield
In ethanol at 50℃; for 2h;99%
azetidine
503-29-7

azetidine

C54H66ClF3O12

C54H66ClF3O12

C50H65ClF3NO11

C50H65ClF3NO11

Conditions
ConditionsYield
at 35℃; for 18h;99%
azetidine
503-29-7

azetidine

(x)C2HF3O2*C11H6BrClF3N3O4

(x)C2HF3O2*C11H6BrClF3N3O4

1-(2-(azetidin-1-yl)-2-oxoethyl)-6-bromo-7-chloro-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one trifluoroacetic acid

1-(2-(azetidin-1-yl)-2-oxoethyl)-6-bromo-7-chloro-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one trifluoroacetic acid

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide99%
azetidine
503-29-7

azetidine

3-bromo-1-methyl-4-(2,2,2-trifluoroethoxy)-1H-pyrazolo[3,4-d]pyrimidine

3-bromo-1-methyl-4-(2,2,2-trifluoroethoxy)-1H-pyrazolo[3,4-d]pyrimidine

4-(azetidin-1-yl)-3-bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

4-(azetidin-1-yl)-3-bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

Conditions
ConditionsYield
With triethylamine In dimethyl sulfoxide at 80℃; for 0.0833333h;99%
azetidine
503-29-7

azetidine

trityl chloride
76-83-5

trityl chloride

N-Tritylazetidine
133146-48-2

N-Tritylazetidine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran 1.) 0 deg C, 20 min, 2.) RT, 1 h;98%
azetidine
503-29-7

azetidine

geldanmycin
30562-34-6

geldanmycin

17-azetidin-1-yl-17-demethoxygeldanamycin
155630-40-3

17-azetidin-1-yl-17-demethoxygeldanamycin

Conditions
ConditionsYield
In dichloromethane for 0.666667h;98%
In dichloromethane for 0.666667h;98%
In dichloromethane for 1h;97%
azetidine
503-29-7

azetidine

5-chlorosulfonylisatin
132898-96-5

5-chlorosulfonylisatin

5-(azetidin-1-ylsulfonyl)indoline-2,3-dione

5-(azetidin-1-ylsulfonyl)indoline-2,3-dione

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; dichloromethane at 0 - 20℃; Inert atmosphere;98%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; chloroform at 0℃; for 0.333333h;
azetidine
503-29-7

azetidine

geldanamycin

geldanamycin

17-(1-azetidinyl)-17-demethoxygeldanamycin

17-(1-azetidinyl)-17-demethoxygeldanamycin

Conditions
ConditionsYield
In dichloromethane for 0.666667h;98%
azetidine
503-29-7

azetidine

cis-Cl2(Ph3P)Pd(CNC6H4-p-OMe)
38883-39-5

cis-Cl2(Ph3P)Pd(CNC6H4-p-OMe)

cis-{dichloro(triphenylphosphine)(C(NCH2CH2CH2)NHC6H4OCH3)}palladium(II)*0.7CH2Cl2

cis-{dichloro(triphenylphosphine)(C(NCH2CH2CH2)NHC6H4OCH3)}palladium(II)*0.7CH2Cl2

Conditions
ConditionsYield
In tetrahydrofuran To suspn. of Pd compd. is added azetidine, then react. mixture is stirred at 0°C, is allowed to warm to room temp., mixture is stirred at room temp. for 10 h (under N2).; monitored by IR, ppt. is filtered off, washed with n-hexane, dried under vacuum, recrystd. from CH2Cl2-n-hexane, elem. anal.;98%
azetidine
503-29-7

azetidine

cyclohexanedione monoethylene ketal
4746-97-8

cyclohexanedione monoethylene ketal

potassium cyanide
151-50-8

potassium cyanide

8-azetidin-1-yl-1,4-dioxaspiro[4,5]decane-8-carbonitrile
1002916-64-4

8-azetidin-1-yl-1,4-dioxaspiro[4,5]decane-8-carbonitrile

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 0 - 20℃; for 120h;98%
azetidine
503-29-7

azetidine

potassium cyanide

potassium cyanide

cyclohexanedione monoethylene ketal
4746-97-8

cyclohexanedione monoethylene ketal

8-azetidin-1-yl-1,4-dioxaspiro[4,5]decane-8-carbonitrile
1002916-64-4

8-azetidin-1-yl-1,4-dioxaspiro[4,5]decane-8-carbonitrile

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 20℃; for 120h; Cooling with ice;98%
azetidine
503-29-7

azetidine

5-phenylmethoxypyridin-2-carboxylic acid
74386-55-3

5-phenylmethoxypyridin-2-carboxylic acid

2-(azetidin-1-ylcarbonyl)-5-(benzyloxy)pyridine
1208536-50-8

2-(azetidin-1-ylcarbonyl)-5-(benzyloxy)pyridine

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;98%
azetidine
503-29-7

azetidine

C23H26BrClN6O4S
1353628-72-4

C23H26BrClN6O4S

C26H32BrN7O4S
1353623-63-8

C26H32BrN7O4S

Conditions
ConditionsYield
With triethylamine In methanol at 70℃; for 1h;98%

Azetidine Specification

The Azetidine, with the CAS registry number 503-29-7 and EINECS registry number 207-963-8,  is a heterocyclic organic compound. And the molecular formula of this chemical is C3H7N. It is a kind of clear colorless liquid, and belongs to the class of four membered rings and it contains a nitrogen atom. It is sensitive to moisture and air, and should be stored at 2-8°C with the shielding gas argon.

The physical properties of Azetidine are as following: (1)ACD/LogP: -0.20; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.3; (4)ACD/LogD (pH 7.4): -3.23; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 3.24 Å2; (13)Index of Refraction: 1.426; (14)Molar Refractivity: 17.18 cm3; (15)Molar Volume: 67 cm3; (16)Polarizability: 6.81×10-24cm3; (17)Surface Tension: 27.1 dyne/cm; (18)Density: 0.851 g/cm3; (19)Enthalpy of Vaporization: 30.69 kJ/mol; (20)Boiling Point: 64.9 °C at 760 mmHg; (21)Vapour Pressure: 162 mmHg at 25°C.

Uses of Azetidine: It can react with bis-(3-amino-propyl)-amine to produce N,N'-bis-(3-amino-propyl)-propanediyldiamine. This reaction will need catalyst palladium black. The reaction time is 12 hours with temperature of 120°C, and the yield is about 75%.

Azetidine can react with bis-(3-amino-propyl)-amine to produce N,N'-bis-(3-amino-propyl)-propanediyldiamine

You should be cautious while dealing with this chemical. It is a kind of highly flammale chemical which may cause burns. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; Keep away from sources of ignition - No smoking; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: N1CCC1
(2)InChI: InChI=1/C3H7N/c1-2-4-3-1/h4H,1-3H2
(3)InChIKey: HONIICLYMWZJFZ-UHFFFAOYAE

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