Bethanechol supplier | CasNO.590-63-6

Name
Bethanechol
EINECS 209-686-8
CAS No. 590-63-6
Density
Solubility
Melting Point 187-190oC
Formula C₇H₁₇N₂O₂^.Cl
Boiling Point
Molecular Weight 196.677
Flash Point
Transport Information
Appearance white crystalline
Safety 36
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms (2-Hydroxypropyl)trimethylammoniumchloride carbamate (6CI);1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-,chloride (9CI);Ammonium, (2-hydroxypropyl)trimethyl-, chloride, carbamate(8CI);Besacholine;Bethanechol chloride;Carbamylmethylcholine chloride;Mechotane;Mechothane;Mecothane;Mictone;Myocholine;Myotonachol;Myotonine chloride;NSC 30783;Trimethyl(2-carbamoyloxypropyl)ammonium chloride;Urecholine;Urecholinechloride;Uro-Carb;b-Methyl carbachol chloride;b-Methylcholine chloride urethan;
PSA 52.32000
LogP -2.11930

Synthetic route

: 75-44-5
phosgene

: 2382-43-6
(+/-)-(2-hydroxy-propyl)-trimethyl-ammonium; chloride

: 590-63-6
bethanechol chloride

Conditions

Conditions	Yield
With chloroform folgende Einwirkung von NH3;
With 1,2-dichloro-ethane; 2,3-Dimethylaniline folgende Einwirkung von NH3;

: 590-63-6
bethanechol chloride

: 1200-22-2
(R)-1,2-dithiolane-3-pentanoic acid

: 2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium (R)-5-(1,2-dithiolan-3-yl)pentanoate

Conditions

Conditions	Yield
Stage #1: bethanechol chloride With sodium hydrogencarbonate In methanol at 20℃; for 0.0833333h; Stage #2: (R)-1,2-dithiolane-3-pentanoic acid In methanol at 20℃; for 16h;	97.6%

Bethanechol Chemical Properties

Chemical Name: Bethanechol
IUPAC NAME: 2-Carbamoyloxypropyl(trimethyl)azanium chloride
CAS No.: 590-63-6
EINECS: 209-686-8
RTECS: BR5425000
Molecular Formula: C₇H₁₇ClN₂O₂
Molecular Weight: 196.68 g/mol
Storage temp.: 2-8°C
Following is the structure of (2-Hydroxypropyl)trimethylammonium chloride carbamate (590-63-6):

Product Categories about (2-Hydroxypropyl)trimethylammonium chloride carbamate (590-63-6) is Acetylcholine receptor
The chemical synonymous of (2-Hydroxypropyl)trimethylammonium chloride carbamate (590-63-6) are (2-Hydroxypropyl)trimethylammoniumchloridecarbamate ; 2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propanaminiuchloride ; 2-[(Aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminiuchloride ; Ammonium,(2-hydroxypropyl)trimethyl-,chloride,carbamate ; Beta-Methylcholinechlorideurethan ; Bethainecholinechloride ; Carbaminoyl,Beta-Methylcholinechloride ; Carbamyl-B-methylcholinechloride*crystalline

Bethanechol Uses

(2-Hydroxypropyl)trimethylammonium chloride carbamate (590-63-6) is used as an anticholinergic drugs and it has a strong excitatory effect on smooth muscle.

Bethanechol Toxicity Data With Reference

1.	scu-hmn TDLo:130 mg/kg:SKN	34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,130.
2.	scu-man TDLo:1071 µg/kg/3D-I:SKN	ARDEAC Archives of Dermatology. 95 (1967),499.
3.	orl-rat LD50:1500 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 58 (1936),337.
4.	scu-rat LD50:175 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 58 (1936),337.
5.	ivn-rat LD50:21 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 58 (1936),337.
6.	ims-rat LD50:220 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),139.
7.	orl-mus LD50:250 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 58 (1936),337.
8.	scu-mus LD50:120 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 58 (1936),337.
9.	ivn-mus LD50:10 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 58 (1936),337.
10.	ims-mus LD50:192

Bethanechol Consensus Reports

Reported in EPA TSCA Inventory.

Bethanechol Safety Profile

Poison by ingestion, subcutaneous, intramuscular and intravenous routes. Human systemic effects by subcutaneous route: allergic dermatitis and sweating. Used as a synthetic cholinergic drug. When heated to decomposition it emits very toxic fumes of NH₃, NO_x, and Cl⁻. See also CARBAMATES.
Hazard Codes:
Xn: Harmful
Risk Statements about (2-Hydroxypropyl)trimethylammonium chloride carbamate (590-63-6):
R22 Harmful if swallowed.
Safety Statements about (2-Hydroxypropyl)trimethylammonium chloride carbamate (590-63-6):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Name

Bethanechol