Product Name

  • Name

    Bromoacetaldehyde dimethyl acetal

  • EINECS 230-669-6
  • CAS No. 7252-83-7
  • Article Data16
  • CAS DataBase
  • Density 1.43 g/cm3
  • Solubility insoluble in water
  • Melting Point
  • Formula C4H9BrO2
  • Boiling Point 150.8 °C at 760 mmHg
  • Molecular Weight 169.018
  • Flash Point 53.9 °C
  • Transport Information UN 1989 3/PG 3
  • Appearance clear colourless to light yellow liquid
  • Safety 26-36/39-28-16
  • Risk Codes 10-36-36/37/38
  • Molecular Structure Molecular Structure of 7252-83-7 (Bromoacetaldehyde dimethyl acetal)
  • Hazard Symbols IrritantXi
  • Synonyms Acetaldehyde,bromo-, dimethyl acetal (7CI,8CI);1,1-Dimethoxy-2-bromoethane;1-Bromo-2,2-dimethoxyethane;2,2-Dimethoxy-1-bromoethane;2,2-Dimethoxybromoethane;2,2-Dimethoxyethyl bromide;2-Bromo-1,1-dimethoxyethane;2-Bromoacetaldehydedimethyl acetal;NSC 73700;
  • PSA 18.46000
  • LogP 1.00020

Synthetic route

methanol
67-56-1

methanol

vinyl acetate
108-05-4

vinyl acetate

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

Conditions
ConditionsYield
With bromine at 20℃; Cooling;77%
With bromine for 48h; Ambient temperature;55%
With chloroform; bromine at -40℃;
With chloroform; bromine at -40℃;
methanol
67-56-1

methanol

methoxyethene
107-25-5

methoxyethene

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

Conditions
ConditionsYield
With bromine at -60 - -50℃;
methanol
67-56-1

methanol

1,2-dibromoethyl ethyl ether
2983-26-8

1,2-dibromoethyl ethyl ether

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

Conditions
ConditionsYield
With potassium hydroxide
vinyl acetate
108-05-4

vinyl acetate

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

Conditions
ConditionsYield
With tetrachloromethane Bromierung und Eintragen des Reaktionsgemisches in Methanol unter Kuehlung;
1,1-dimethoxyethane
534-15-6

1,1-dimethoxyethane

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

Conditions
ConditionsYield
With bromine
paracetaldehyde
123-63-7

paracetaldehyde

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

Conditions
ConditionsYield
at -10 - -5℃; Bromieren und Behandeln des Reaktionsproduktes mit absol.Methylalkohol;
methanol
67-56-1

methanol

methoxyethene
107-25-5

methoxyethene

bromine
7726-95-6

bromine

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

Conditions
ConditionsYield
at -60 - -50℃;
...Expand
1,2-dibromoethyl ethyl ether
2983-26-8

1,2-dibromoethyl ethyl ether

methanolic KOH

methanolic KOH

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

potassium phtalimide
1074-82-4

potassium phtalimide

2-(2,2-dimethoxyethyl)-1H-isoindole-1,3(2H)-dione
27328-34-3

2-(2,2-dimethoxyethyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With acetamide; potassium iodide at 110 - 140℃; for 3.41667h;100%
In N,N-dimethyl-formamide at 130 - 135℃; for 20h;56%
With acetamide at 170℃;
With acetamide; potassium iodide at 130℃; for 5h;
chloraminophenamide
121-30-2

chloraminophenamide

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

3-bromomethyl-6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide
7181-60-4

3-bromomethyl-6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

Conditions
ConditionsYield
With hydrogen bromide In 1,4-dioxane; water at 100 - 120℃; for 0.333333h;100%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

4-bromo-N-(3-bromo-4-hydroxyphenethyl)thiophene-2-carboxamide
1174651-00-3

4-bromo-N-(3-bromo-4-hydroxyphenethyl)thiophene-2-carboxamide

4-bromo-N-(3-bromo-4-(2,2-dimethoxyethoxy)phenethyl)thiophene-2-carboxamide
1174651-01-4

4-bromo-N-(3-bromo-4-(2,2-dimethoxyethoxy)phenethyl)thiophene-2-carboxamide

Conditions
ConditionsYield
With caesium carbonate; potassium iodide In N,N-dimethyl-formamide at 120℃; under 760.051 Torr; for 1h; Inert atmosphere; Microwave irradiation;100%
With caesium carbonate; potassium iodide In N,N-dimethyl-formamide Reflux;70%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

2-(3,4-dimethoxyphenyl)-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-8-methoxy-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

2-(3,4-dimethoxyphenyl)-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-8-methoxy-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

3-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl)-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-8-methoxy-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

3-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl)-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-8-methoxy-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 110℃; for 14h; Inert atmosphere;100%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

tert-Butyl-((R)-4-[1,3]dithian-2-yl-2,2-dimethyl-pentyloxy)-diphenyl-silane
159751-66-3

tert-Butyl-((R)-4-[1,3]dithian-2-yl-2,2-dimethyl-pentyloxy)-diphenyl-silane

tert-Butyl-{(R)-4-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-2,2-dimethyl-pentyloxy}-diphenyl-silane
159751-67-4

tert-Butyl-{(R)-4-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-2,2-dimethyl-pentyloxy}-diphenyl-silane

Conditions
ConditionsYield
With tert.-butyl lithium In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide99%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide
128019-40-9, 149510-73-6, 136465-81-1

(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide

N-tert-butyl-2-(2,2-dimethoxyethyl)decahydro-3-isoquinoline carboxamide

N-tert-butyl-2-(2,2-dimethoxyethyl)decahydro-3-isoquinoline carboxamide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Heating;99%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

2-amino-3,5-dibromopyrazine
24241-18-7

2-amino-3,5-dibromopyrazine

6,8-dibromoimidazo[1,2-a]pyrazine
63744-22-9

6,8-dibromoimidazo[1,2-a]pyrazine

Conditions
ConditionsYield
Stage #1: 1-bromo-2,2-dimethoxyethane; 2-amino-3,5-dibromopyrazine In water at 20℃; for 2h; Reflux;
Stage #2: With sodium hydrogencarbonate In water for 0.25h;		99%
Stage #1: 1-bromo-2,2-dimethoxyethane; 2-amino-3,5-dibromopyrazine With hydrogen bromide In ethanol; water at 20℃; for 21h; Heating / reflux;
Stage #2: With sodium carbonate In dichloromethane; water		95%
In water at 100℃; for 2h;91%
Stage #1: 1-bromo-2,2-dimethoxyethane With hydrogen bromide In water at 120℃; for 1h; Inert atmosphere;
Stage #2: With sodium hydrogencarbonate In water; isopropyl alcohol for 0.5h; Inert atmosphere;
Stage #3: 2-amino-3,5-dibromopyrazine In water; isopropyl alcohol for 16h; Inert atmosphere; Reflux;		30 g
Stage #1: 1-bromo-2,2-dimethoxyethane With hydrogen bromide In water at 55℃; for 2h;
Stage #2: 2-amino-3,5-dibromopyrazine In isopropyl alcohol at 78℃; for 16h;		12.0 g
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

3,4-methylenedioxyphenylethylamine
1484-85-1

3,4-methylenedioxyphenylethylamine

C13H19NO4
1160948-79-7

C13H19NO4

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 12h;99%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

1-carbomethoxy-3,5-dihydroxybenzene
2150-44-9

1-carbomethoxy-3,5-dihydroxybenzene

C13H18O6

C13H18O6

Conditions
ConditionsYield
With caesium carbonate In acetonitrile for 40h; Reflux;99%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

3-hydroxy-5-methoxy-benzoic acid methyl ester
19520-74-2

3-hydroxy-5-methoxy-benzoic acid methyl ester

C13H18O6

C13H18O6

Conditions
ConditionsYield
With caesium carbonate In acetonitrile for 40h; Reflux;99%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

2-Iodophenol
533-58-4

2-Iodophenol

1-(2,2-dimethoxyethoxy)-2-iodobenzene

1-(2,2-dimethoxyethoxy)-2-iodobenzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Reflux;99%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

triphenylphosphine
603-35-0

triphenylphosphine

2-triphenylphosphoniumacetaldehyde dimethyl acetal bromide

2-triphenylphosphoniumacetaldehyde dimethyl acetal bromide

Conditions
ConditionsYield
In acetonitrile at 60 - 65℃; for 3h; Solvent; Inert atmosphere; Green chemistry;98.9%
In toluene at 120℃; for 24h;54%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

4-bromo-2-hydroxyphenylthioamide

4-bromo-2-hydroxyphenylthioamide

5-bromo-2-(2-thiazolyl)phenol

5-bromo-2-(2-thiazolyl)phenol

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethanol; water at 100℃; for 12h;98.2%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

thiophenol
108-98-5

thiophenol

2-(phenylthio)acetaldehyde dimethyl acetal
99172-76-6

2-(phenylthio)acetaldehyde dimethyl acetal

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 20℃; for 72h;98%
With 1-pentyl-3-methylimidazolium bromide at 25 - 30℃; for 0.2h;95%
With sodium hydride In tetrahydrofuran at 0 - 20℃;84%
With ethanol; sodium ethanolate; sodium iodide
With sodium hydroxide In methanol at 20℃; for 18h; Product distribution / selectivity; Inert atmosphere;
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

phenylmethanethiol
100-53-8

phenylmethanethiol

benzylmercaptoacetaldehyde dimethyl acetal
6304-94-5

benzylmercaptoacetaldehyde dimethyl acetal

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 20℃;98%
With ethanol; sodium ethanolate
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

2-Naphthalenethiol
91-60-1

2-Naphthalenethiol

[2]naphthylsulfanyl-acetaldehyde dimethylacetal

[2]naphthylsulfanyl-acetaldehyde dimethylacetal

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 20℃;98%
With sodium ethanolate; sodium iodide
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

benzylamine
100-46-9

benzylamine

N-benzyl-2,2-dimethoxyethylamine
54879-88-8

N-benzyl-2,2-dimethoxyethylamine

Conditions
ConditionsYield
at 80℃; for 18h; Inert atmosphere; sealed tube;98%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

potassium (2-phenylethynyl)trifluoroborate

potassium (2-phenylethynyl)trifluoroborate

(4-bromo-3-methoxybut-1-ynyl)benzene
1201652-07-4

(4-bromo-3-methoxybut-1-ynyl)benzene

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In acetonitrile at 0 - 23℃; Inert atmosphere;98%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

ethyl 3-(2-bromo-4,5-dimethoxyphenyl)-4,5-bis(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylate

ethyl 3-(2-bromo-4,5-dimethoxyphenyl)-4,5-bis(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylate

C35H40BrNO10

C35H40BrNO10

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 110℃; for 16h; Schlenk technique; Sealed tube;98%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

6-bromoguaiacol
28165-49-3

6-bromoguaiacol

1-bromo-2-(2,2-dimethoxyethoxy)-3-methoxybenzene

1-bromo-2-(2,2-dimethoxyethoxy)-3-methoxybenzene

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 8h;98%
With caesium carbonate In N,N-dimethyl-formamide at 80℃;98%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

2‐bromo‐1‐fluoro‐3‐methoxybenzene
446-59-3

2‐bromo‐1‐fluoro‐3‐methoxybenzene

2-bromo-1-(2,2-dimethoxyethoxy)-3-methoxybenzene

2-bromo-1-(2,2-dimethoxyethoxy)-3-methoxybenzene

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 120℃; for 16h; Inert atmosphere;98%
Thiophene-2-thiol
7774-74-5

Thiophene-2-thiol

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

2-(2,2-dimethoxy-ethylsulfanyl)-thiophene
98558-44-2

2-(2,2-dimethoxy-ethylsulfanyl)-thiophene

Conditions
ConditionsYield
With potassium carbonate In acetone97%
With ethanol; sodium ethanolate
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

(1S,2R)-1,2-diphenylethane-1,2-diol
579-43-1

(1S,2R)-1,2-diphenylethane-1,2-diol

2ξ-bromomethyl-4r,5c-diphenyl-[1,3]dioxolane
5436-03-3, 138922-97-1, 138923-00-9

2ξ-bromomethyl-4r,5c-diphenyl-[1,3]dioxolane

Conditions
ConditionsYield
With Dowex-x8 (H+) resin97%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

3,4-difluorophenol
2713-33-9

3,4-difluorophenol

4-(2,2-Dimethoxyethoxy)-1,2-difluorobenzene
342435-26-1

4-(2,2-Dimethoxyethoxy)-1,2-difluorobenzene

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 120℃; for 4h;97%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

3,4-dimethoxyphenol
2033-89-8

3,4-dimethoxyphenol

C12H18O5

C12H18O5

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 16h;97%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

methyl 5-amino-6-bromopyrazine-2-carboxylate
1076198-49-6

methyl 5-amino-6-bromopyrazine-2-carboxylate

methyl 8-bromoimidazo[1,2-a]pyrazine-6-carboxylate

methyl 8-bromoimidazo[1,2-a]pyrazine-6-carboxylate

Conditions
ConditionsYield
In acetonitrile at 150℃; for 2h; Concentration; Microwave irradiation; Sealed tube;97%
In acetonitrile at 150℃; for 2h; Microwave irradiation; Sealed tube;9%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

isopropylamine
75-31-0

isopropylamine

2-(isopropyl)acetaldehyde dimethyl acetal
60912-32-5

2-(isopropyl)acetaldehyde dimethyl acetal

Conditions
ConditionsYield
at 80℃; for 18h; Inert atmosphere; sealed tube;96%
In neat (no solvent) at 80℃; Sealed tube;92%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

2,5-Dimethyl-1,4-benzenedithiol
104014-86-0

2,5-Dimethyl-1,4-benzenedithiol

1,4-Bis(2,2-dimethoxyethylthio)-2,5-dimethylbenzene
104014-87-1

1,4-Bis(2,2-dimethoxyethylthio)-2,5-dimethylbenzene

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 3h; Heating;96%
6-hydroxyquinoline
580-16-5

6-hydroxyquinoline

1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

6-(2,2-dimethoxyethoxy)quinoline
1029714-98-4

6-(2,2-dimethoxyethoxy)quinoline

Conditions
ConditionsYield
Stage #1: 6-hydroxyquinoline With sodium hexamethyldisilazane In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: 1-bromo-2,2-dimethoxyethane In tetrahydrofuran; N,N-dimethyl-formamide for 6h; Heating / reflux;		96%
1-bromo-2,2-dimethoxyethane
7252-83-7

1-bromo-2,2-dimethoxyethane

3-Trifluoromethylphenol
98-17-9

3-Trifluoromethylphenol

C11H13F3O3
1190883-14-7

C11H13F3O3

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 140 - 150℃;96%

Bromoacetaldehyde dimethyl acetal Specification

The Bromoacetaldehyde dimethyl acetal, with the CAS registry number 7252-83-7, is also known as Bromoacetal. It belongs to the product categories of Pharmaceutical Intermediates; Aromatic Aldehydes & Derivatives (substituted). Its EINECS registry number is 230-669-6. This chemical's molecular formula is C4H9BrO2 and molecular weight is 169.02. Its IUPAC name is called 2-bromo-1,1-dimethoxyethane. This chemical is clear colourless to light yellow liquid. It should be sealed in a cool dry place. It is mainly used for synthesis of antibiotics, such as erythromycin, cephalosporins.

Physical properties of Bromoacetaldehyde dimethyl acetal: (1)ACD/LogP: 1.11; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.11; (4)ACD/LogD (pH 7.4): 1.11; (5)#H bond acceptors: 2; (6)#H bond donors: 0; (7)#Freely Rotating Bonds: 3; (8)Index of Refraction: 1.438; (9)Molar Refractivity: 31.76 cm3; (10)Molar Volume: 120.8 cm3; (11)Surface Tension: 28.8 dyne/cm; (12)Density: 1.398 g/cm3; (13)Flash Point: 53.9 °C; (14)Enthalpy of Vaporization: 37.17 kJ/mol; (15)Boiling Point: 150.8 °C at 760 mmHg; (16)Vapour Pressure: 4.81 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is flammable and is irritating to eyes, respiratory system and skin. You should keep away from sources of ignition - No smoking. Whenever you will contact it, please wear suitable protective clothing and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: COC(CBr)OC
(2)InChI: InChI=1S/C4H9BrO2/c1-6-4(3-5)7-2/h4H,3H2,1-2H3
(3)InChIKey: FUSFWUFSEJXMRQ-UHFFFAOYSA-N

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