Product Name

Stability

    Aqueous solutions react violently with active metals.Incompatible with strong oxidizing agents, strong bases.

Toxicology

    Highly toxic by inhalation, ingestion and through skin contact.May cau
  • Melting Point 195-198 °C
  • Formula C2H7 As O2
  • Boiling Point 253.1 °C at 760 mmHg
  • Molecular Weight 137.998
  • Flash Point 109.4 °C
  • Transport Information UN 1572 6
  • Appearance colorless or white crystalline powder
  • Safety Poison by an unspecified route. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. A skin and eye irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Used as an herbicide, defoliant, and silvicide. Hazardous when water solution is in contact with active metals, e.g., Fe, Al, Zn. When heated to decomposition it emits toxic fumes of As. See also ARSINE and ARSENIC COMPOUNDS.

    Analytical Methods:

       

    For occupational chemical analysis use NIOSH: Arsenic, Organo-, 5022.

  • Risk Codes 23/25-50/53
  • Molecular Structure Molecular Structure of 75-60-5 (CACODYLIC ACID)
  • Hazard Symbols ToxicTDangerousN
  • Synonyms Arsineoxide, hydroxydimethyl- (7CI,8CI); Arsinic acid, dimethyl- (9CI); Cacodylicacid (6CI); Ansar 138; Arsan; Dimethylarsenic acid; Dimethylarsinic acid;Hydroxydimethylarsine oxide; NSC 103115; NSC 71157; NSC 71158; Phytar; Silvisar510; Sylvicor
  • PSA 37.30000
  • LogP 0.11100

Synthetic route

trimethylarsine
593-88-4

trimethylarsine

A

trimethylarsine oxide
4964-14-1

trimethylarsine oxide

B

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Conditions
ConditionsYield
With air
With diethyl ether
Dimethylchloroarsine
557-89-1

Dimethylchloroarsine

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Conditions
ConditionsYield
With dihydrogen peroxide
tetramethyldiarsine
471-35-2

tetramethyldiarsine

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Conditions
ConditionsYield
bei der Oxydation;
bis-{dimethylarsenic}-oxide
503-80-0

bis-{dimethylarsenic}-oxide

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Conditions
ConditionsYield
Oxydiert sich an der Luft;
With air
With water; mercury(II) oxide
With water; oxygen
allyldimethylarsine
691-35-0

allyldimethylarsine

A

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

B

allyl-dimethyl-arsine oxide

allyl-dimethyl-arsine oxide

Conditions
ConditionsYield
With diethyl ether
sodium dimethylarsenide
13787-40-1

sodium dimethylarsenide

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Conditions
ConditionsYield
With oxygen In tetrahydrofuran
3,5-dinitrosalicylic acid
609-99-4

3,5-dinitrosalicylic acid

cacodylic acid anion
15132-04-4

cacodylic acid anion

A

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

B

3,5-dinitrosalicylic acid anion
52040-82-1

3,5-dinitrosalicylic acid anion

Conditions
ConditionsYield
at 25℃; Rate constant;
Conditions
ConditionsYield
With GLUTATHIONE; DL-dithiothreitol; magnesium chloride; monomethylarsonic acid methyltransferase from rabbit liver In various solvent(s) at 37℃; for 1.5h; Methylation; Enzymatic reaction;

A

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

B

methylarsonic Acid
124-58-3

methylarsonic Acid

Conditions
ConditionsYield
With trisodium arsenite; GLUTATHIONE; magnesium chloride; arsenite methyltransferase from rabbit liver In various solvent(s) at 37℃; for 1h; Methylation; Enzymatic reaction;
'Cadet's liquid'(cacodyl oxide mainly)

'Cadet's liquid'(cacodyl oxide mainly)

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Conditions
ConditionsYield
With sodium hypochlorite; water; oxygen Reagens 4: Aceton;
With iron(III) oxide; water
With sulfuric acid Electrolysis.an Platinelektroden;
tetramethyldiarsine
471-35-2

tetramethyldiarsine

sulfuric acid
7664-93-9

sulfuric acid

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

bis-{dimethylarsenic}-oxide
503-80-0

bis-{dimethylarsenic}-oxide

dihydrogen peroxide
7722-84-1

dihydrogen peroxide

acid

acid

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Dimethylchloroarsine
557-89-1

Dimethylchloroarsine

ammonium persulfate

ammonium persulfate

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

bis-{dimethylarsenic}-oxide
503-80-0

bis-{dimethylarsenic}-oxide

water
7732-18-5

water

dihydrogen peroxide
7722-84-1

dihydrogen peroxide

mercury oxide

mercury oxide

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

trichloro-dimethyl-arsorane
558-31-6

trichloro-dimethyl-arsorane

water
7732-18-5

water

A

hydrogenchloride
7647-01-0

hydrogenchloride

B

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

tetramethyldiarsine
471-35-2

tetramethyldiarsine

air

air

A

bis-{dimethylarsenic}-oxide
503-80-0

bis-{dimethylarsenic}-oxide

B

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

dimethylarsine
593-57-7

dimethylarsine

oxide of/the/ nitrogen

oxide of/the/ nitrogen

A

tetramethyldiarsine
471-35-2

tetramethyldiarsine

B

bis-{dimethylarsenic}-oxide
503-80-0

bis-{dimethylarsenic}-oxide

C

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

trimethylarsine
593-88-4

trimethylarsine

air

air

A

trimethylarsine oxide
4964-14-1

trimethylarsine oxide

B

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

dimethylarsine
593-57-7

dimethylarsine

liquid sulfur dioxide

liquid sulfur dioxide

A

methyl-arsenic sulfide
2533-82-6

methyl-arsenic sulfide

B

trimethylarsine sulphide
26386-93-6

trimethylarsine sulphide

C

dimethylarsino dimethyldithioarsinate
59840-68-5

dimethylarsino dimethyldithioarsinate

D

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

diethyl ether
60-29-7

diethyl ether

allyldimethylarsine
691-35-0

allyldimethylarsine

air

air

A

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

B

allyl-dimethyl-arsine oxide

allyl-dimethyl-arsine oxide

dimethylarsine
593-57-7

dimethylarsine

sulfuric acid
7664-93-9

sulfuric acid

A

cacodyl sulfide
591-10-6

cacodyl sulfide

B

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

C

dimethyl-arsine; sulfate

dimethyl-arsine; sulfate

bis-{dimethylarsenic}-oxide
503-80-0

bis-{dimethylarsenic}-oxide

dihydrogen peroxide
7722-84-1

dihydrogen peroxide

alkali

alkali

A

trimethylarsine
593-88-4

trimethylarsine

B

methylarsine oxide
593-58-8

methylarsine oxide

C

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

D

arsenous acid

arsenous acid

Conditions
ConditionsYield
Produkt 5: Trimethylarsinoxyd; Produkt 6: Methylarsinsaeure;
bis-{dimethylarsenic}-oxide
503-80-0

bis-{dimethylarsenic}-oxide

water
7732-18-5

water

oxygen

oxygen

alkali

alkali

A

trimethylarsine
593-88-4

trimethylarsine

B

methylarsine oxide
593-58-8

methylarsine oxide

C

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

D

arsenous acid

arsenous acid

Conditions
ConditionsYield
Produkt 5: Trimethylarsinoxyd; Produkt 6: Methylarsinsaeure;
Dimethylchloroarsine
557-89-1

Dimethylchloroarsine

water
7732-18-5

water

A

hydrogenchloride
7647-01-0

hydrogenchloride

B

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

C

mercury

mercury

Conditions
ConditionsYield
das erhaltene Produkt beim Kochen mit Wasser;
Dimethylchloroarsine
557-89-1

Dimethylchloroarsine

water
7732-18-5

water

mercury (II)-chloride

mercury (II)-chloride

A

hydrogenchloride
7647-01-0

hydrogenchloride

B

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

D

mercury

mercury

Conditions
ConditionsYield
das erhaltene Produkt zerfaellt beim Kochen mit Wasser;
dimethylarsinous acid
55094-22-9

dimethylarsinous acid

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Conditions
ConditionsYield
With oxygen In water-d2 at 24.3℃; pH=3.2; Kinetics; Further Variations:; pH-values;
dimethylarsine
593-57-7

dimethylarsine

Nitrogen dioxide
10102-44-0

Nitrogen dioxide

A

cacodyloxide
418758-51-7

cacodyloxide

B

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Conditions
ConditionsYield
byproducts: cacodyl; inflamation;
byproducts: cacodyl; inflamation;
methylcobalamin

methylcobalamin

arsenic(III) trioxide

arsenic(III) trioxide

A

monomethylarsinic acid

monomethylarsinic acid

B

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Conditions
ConditionsYield
With GLUTATHIONE; selenious acid In water at 37℃; for 360h; pH=3; Product distribution / selectivity; Tris-HCl buffer solution;
monomethylarsinic acid

monomethylarsinic acid

methylcobalamin

methylcobalamin

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Conditions
ConditionsYield
With GLUTATHIONE In water at 37℃; for 7h; pH=7.6; Product distribution / selectivity; Tris-HCl buffer solution;
bismuth (III) nitrate pentahydrate

bismuth (III) nitrate pentahydrate

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

bis(dimethylarsinato)bismuth nitrate monohydrate

bis(dimethylarsinato)bismuth nitrate monohydrate

Conditions
ConditionsYield
In acetone at 20℃; for 3h;100%
In acetone at 20℃; for 3h;96%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

antimony(III) chloride
10025-91-9

antimony(III) chloride

tris(dimethylarsinato)antimony

tris(dimethylarsinato)antimony

Conditions
ConditionsYield
In acetone at 20℃; for 5h;99%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

palladium diacetate
3375-31-3

palladium diacetate

bis(dimethylarsinato)palladium(II)

bis(dimethylarsinato)palladium(II)

Conditions
ConditionsYield
In acetone Pd acetate added to suspn. of cacodylic acid in acetone; stirred vigoroously for 48 h; centrifuged, washed with acetone; crude product extd. with CH2Cl2 by centrifugation; extract combined, evapd., dried in vacuo; elem. anal.;98%
aluminum (III) chloride
7446-70-0, 7784-13-6

aluminum (III) chloride

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

tris(dimethylphosphinato)aluminum

tris(dimethylphosphinato)aluminum

Conditions
ConditionsYield
In acetone at 20℃; for 24h;97%
iron(II) trifluoromethanesulfonate acetonitrile disolvate

iron(II) trifluoromethanesulfonate acetonitrile disolvate

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

sodium tetraphenyl borate
143-66-8

sodium tetraphenyl borate

N,N,N′,N′-tetrakis((1-ethylbenzimidazol-2-yl)methyl)-2-hydroxy-1,3-diaminopropane
79724-80-4

N,N,N′,N′-tetrakis((1-ethylbenzimidazol-2-yl)methyl)-2-hydroxy-1,3-diaminopropane

[Fe2(N,N,N',N'-tetrakis(2-benzimidazolylmethyl)-2-hydroxy-1,3-diaminopropane(-1H))(μ-O2AsMe2)](BPh4)(OTf)
1178891-43-4

[Fe2(N,N,N',N'-tetrakis(2-benzimidazolylmethyl)-2-hydroxy-1,3-diaminopropane(-1H))(μ-O2AsMe2)](BPh4)(OTf)

Conditions
ConditionsYield
With (C2H5)3N In methanol HOCH(CH2N(CH2C7H4N2C2H5)2)2 dissolved in MeOH along with (C2H5)3N, (CH3)2AsO2H added, Fe salt added, NaB(C6H5)4 added after 5 min; filtered, dried (vac.), recrystd. (MeCN and Et2O); elem. anal.;93%
gallium(III) trichloride

gallium(III) trichloride

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

tris(dimethylarsinato)gallium

tris(dimethylarsinato)gallium

Conditions
ConditionsYield
In methanol; diethyl ether at 20℃; for 2h;91%
indium(III) chloride

indium(III) chloride

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

tris(dimethylphosphinato)indium

tris(dimethylphosphinato)indium

Conditions
ConditionsYield
Stage #1: indium(III) chloride; Dimethylarsinic acid In acetone at 20℃; for 1h;
Stage #2: With triethylamine In acetone at 20℃; for 48h;
89%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

methylarsenic dibromide
676-70-0

methylarsenic dibromide

Conditions
ConditionsYield
With hydrogen bromide In water at 130℃; for 5h;84%
bismuth(III) chloride

bismuth(III) chloride

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

tris(dimethylarsinato)bismuth

tris(dimethylarsinato)bismuth

Conditions
ConditionsYield
In acetone at 20℃; for 5h;80%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

bismuth(III) chloride
7787-60-2

bismuth(III) chloride

tris(dimethylarsinato)bismuth

tris(dimethylarsinato)bismuth

Conditions
ConditionsYield
In acetone at 20℃; for 5h;80%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

dimethyliodoarsine
676-75-5

dimethyliodoarsine

Conditions
ConditionsYield
With sulfuric acid; sulfur dioxide; potassium iodide In water for 3h;76%
With sulfuric acid; sulfur dioxide; potassium iodide
With hydrogenchloride; sulfur dioxide; potassium iodide
Multistep reaction;
With sulfuric acid; sulfur dioxide; potassium iodide In water
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

18C2H3O2(1-)*8H2O*2H(1+)*Mn12O12(16+)

18C2H3O2(1-)*8H2O*2H(1+)*Mn12O12(16+)

6C2H6AsO2(1-)*Mn4O4(6+)

6C2H6AsO2(1-)*Mn4O4(6+)

Conditions
ConditionsYield
In acetonitrile75%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

zirconium(IV) tert-butoxide

zirconium(IV) tert-butoxide

Zr3(μ,μ'-O2AsMe2)2(μ2,μ'-O2AsMe2)(O-t-Bu)7(μ-O-t-Bu)2
606948-98-5

Zr3(μ,μ'-O2AsMe2)2(μ2,μ'-O2AsMe2)(O-t-Bu)7(μ-O-t-Bu)2

Conditions
ConditionsYield
In toluene under N2 atm. to Zr(O-t-Bu)4 in toluene was added cacodilic acid and heated with stirring at 70°C for 24 h; react. mixt. was cooled, solvent was removed in vac., residue was dissolved in hexane, filtered, and kept at -10°C; elem. anal.;69%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

di(n-butyl)tin oxide
818-08-6

di(n-butyl)tin oxide

Bu2Sn(O2AsMe2)2 C12H30As2O4Sn, orthorhombic

Bu2Sn(O2AsMe2)2 C12H30As2O4Sn, orthorhombic

Conditions
ConditionsYield
In methanol Bu2SnO, HO2AsMe2 mixed in MeOH; refluxed for 3 h; filtered off; set aside at ambient temp. in open flask; filtered off after 1 d; set aside in refrigerator in closed flask; filtered off after 3 d; recrystd. from MeOH; elem. anal.;64%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

dichlorodiethylstannane
866-55-7

dichlorodiethylstannane

(CH3CH2)2ClSnO2As(CH3)2

(CH3CH2)2ClSnO2As(CH3)2

Conditions
ConditionsYield
In methanol byproducts: HCl; 2 equiv. of As-compd. in MeOH was added to MeOH soln. of Sn-compd., keeping for 2 weeks at room temp.; soln. was concd. by partial evapn. of MeOH at room temp., crystals were filtered off, washed with small amt. of MeOH, dried in vac., elem. anal.;42%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

dimethyltin dichloride
753-73-1

dimethyltin dichloride

(CH3)2ClSnO2As(CH3)2

(CH3)2ClSnO2As(CH3)2

Conditions
ConditionsYield
In methanol byproducts: HCl; 2 equiv. of As-compd. in MeOH was added to MeOH soln. of Sn-compd., keeping for 2 months at room temp.; soln. was concd. by partial evapn. of MeOH at room temp., crystals were filtered off, washed with small amt. of MeOH, dried in vac., elem. anal.;33%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

6C5H9O2(1-)*3H2O*Cl(1-)*Fe3O(7+)

6C5H9O2(1-)*3H2O*Cl(1-)*Fe3O(7+)

acetonitrile
75-05-8

acetonitrile

8C5H9O2(1-)*3H2O*3Cl(1-)*15C2H3N*[(17O2As(CH3)2)(Fe12O4)](11+)

8C5H9O2(1-)*3H2O*3Cl(1-)*15C2H3N*[(17O2As(CH3)2)(Fe12O4)](11+)

Conditions
ConditionsYield
at 20℃;31%
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

Dimethylchloroarsine
557-89-1

Dimethylchloroarsine

Conditions
ConditionsYield
With hydrogenchloride; tin(ll) chloride In water at 5 - 20℃; Cooling with ice; Inert atmosphere;26%
With hydrogenchloride; sodium hypophosphite
With hydrogenchloride; tin(ll) chloride
methanol
67-56-1

methanol

Iron(III) nitrate nonahydrate

Iron(III) nitrate nonahydrate

8-quinolinol
148-24-3

8-quinolinol

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

NO3(1-)*2C9H6NO(1-)*4CH4O*[(6O2As(CH3)2)(AsHO2(CH3)2)(Fe3)](3+)

NO3(1-)*2C9H6NO(1-)*4CH4O*[(6O2As(CH3)2)(AsHO2(CH3)2)(Fe3)](3+)

Conditions
ConditionsYield
With triethylamine for 3h;26%
strontium perchlorate monohydrate

strontium perchlorate monohydrate

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

[Mn12O12(O2CPh)16(H2O)4]

[Mn12O12(O2CPh)16(H2O)4]

16Mn(3+)*4Sr(2+)*16C7H5O2(1-)*24C2H6AsO2(1-)*8O(2-)

16Mn(3+)*4Sr(2+)*16C7H5O2(1-)*24C2H6AsO2(1-)*8O(2-)

Conditions
ConditionsYield
In methanol; acetonitrile for 0.333333h;7%
calcium(II) nitrate tetrahydrate

calcium(II) nitrate tetrahydrate

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

[Mn12O12(O2CPh)16(H2O)4]

[Mn12O12(O2CPh)16(H2O)4]

16Mn(3+)*4Ca(2+)*16C7H5O2(1-)*24C2H6AsO2(1-)*8O(2-)

16Mn(3+)*4Ca(2+)*16C7H5O2(1-)*24C2H6AsO2(1-)*8O(2-)

Conditions
ConditionsYield
In methanol; acetonitrile for 0.333333h;5%
Thioglycolamide
758-08-7

Thioglycolamide

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

A

dimethylarsinomercapto-acetic acid amide
133401-89-5

dimethylarsinomercapto-acetic acid amide

B

NSC 28727
64057-55-2

NSC 28727

Conditions
ConditionsYield
With water
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

l-cysteine hydrochloride
52-89-1

l-cysteine hydrochloride

cysteinyldimethylthioarsenite
91919-78-7

cysteinyldimethylthioarsenite

Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

trichloro-dimethyl-arsorane
558-31-6

trichloro-dimethyl-arsorane

Conditions
ConditionsYield
With diethyl ether; phosphorus pentachloride
Dimethylarsinic acid
75-60-5

Dimethylarsinic acid

cacodyl sulfide
591-10-6

cacodyl sulfide

Conditions
ConditionsYield
With hydrogen sulfide; water

Cacodylic Acid Chemical Properties

Chemistry informtion about Cacodylic Acid (CAS NO.75-60-5) is:
IUPAC Name: Dimethylarsinic Acid
Synonyms: Ansar(R) ; Cacodylic Acid ; Cacodylie Acid ; Hydroxydimethylarsine Oxide ; Dimethylhydroxyarsine Oxide ; Dimethylarsinic Acid ; Dimethylarsonic Acid ; Silvisar(R)
MF: C2H7AsO2
MW: 138
EINECS: 200-883-4
Melting Point: 195-198 °C 
Flash Point: 109.4 °C
Boiling Point: 253.1 °C at 760 mmHg
Vapour Pressure: 0.00288 mmHg at 25°C 
Enthalpy of Vaporization: 56.98 kJ/mol
Storage temp.: Store at RT.
Sensitive: Hygroscopic
Merck: 14,1604
BRN: 1736965
Stability: Aqueous solutions react violently with active metals. Incompatible with strong oxidizing agents, strong bases.
Following is the molecular structure of  Cacodylic Acid (CAS NO.75-60-5) is:

Cacodylic Acid History

Significant early research into cacodyls was done by Robert Bunsen at the University of Marburg. Bunsen said of the compounds, "the smell of this body produces instantaneous tingling of the hands and feet, and even giddiness and insensibility...It is remarkable that when one is exposed to the smell of these compounds the tongue becomes covered with a black coating, even when no further evil effects are noticeable". His work in this field led to an increased understanding of the methyl radical.

Cacodylic Acid Uses

Derivatives of  Cacodylic Acid (CAS NO.75-60-5) , cacodylates , were frequently used as herbicides . For example, "Agent Blue," one of the chemicals used during the Vietnam War, is a mixture of cacodylic acid and sodium cacodylate. Sodium cacodylate is frequently used as a buffering agent in the preparation and fixation of biological samples for transmission electron microscopy.

Cacodylic Acid Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   National Technical Information Service. Vol. AD295-864,
mouse LD50 oral 1200mg/kg (1200mg/kg)   Journal of Agricultural and Food Chemistry. Vol. 45, Pg. 449, 1997.
mouse LD50 unreported 185mg/kg (185mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 393, 1971.
rat LCLo inhalation > 2600mg/m3/2H (2600mg/m3)   Toxicology and Applied Pharmacology. Vol. 37, Pg. 165, 1976.
rat LD50 oral 644mg/kg (644mg/kg)   Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986.

Cacodylic Acid Consensus Reports

IARC Cancer Review: Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 23 , 1980,p. 39.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Arsenic and its compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Cacodylic Acid Safety Profile

Poison by an unspecified route. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. A skin and eye irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Used as an herbicide, defoliant, and silvicide. Hazardous when water solution is in contact with active metals, e.g., Fe, Al, Zn. When heated to decomposition it emits toxic fumes of As. See also ARSINE and ARSENIC COMPOUNDS.
Hazard Codes:
T: Toxic 
N: Dangerous for the environment
Risk Statements:
R23/25: Toxic by inhalation and if swallowed.  
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
Safety Statements:
S20/21: When using, do not eat or drink and do not smoke. 
S28: After contact with skin, wash immediately with plenty of soap-suds.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S60: This material and its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 1572 6.1/PG 2
WGK Germany: 3
RTECS: CH7525000
F:
F 3: Hygroscopic.
F 10: Keep under argon.
HazardClass: 6.1
PackingGroup: II

Cacodylic Acid Standards and Recommendations

OSHA PEL: TWA 0.5 mg(As)/m3
ACGIH TLV: BEI: 35 µ (As)/L inorganic arsenic and methylated metabolites in urine
DOT Classification:  6.1; Label: Poison

Cacodylic Acid Analytical Methods

For occupational chemical analysis use NIOSH: Arsenic, Organo-, 5022.

Cacodylic Acid Specification

General description about Cacodylic Acid (CAS NO.75-60-5) , it is a colorless, odorless crystalline solid.Toxic by ingestion and irritating to skin and eyes.
Air & Water Reactions: Hygroscopic. Water soluble.
Reactivity Profile: It is a weak acid. Dissolves in water to yield solutions containing more hydrogen ions than pure water contains and so having a pH less than 7.0. Is neutralized exothermically by all bases to produce water plus a salt. Reacts (but usually slowly) with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for the solid acid but are quite slow if the solid acid remains dry. The solid may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers. Reacts with cyanide salts to generate gaseous hydrogen cyanide. Flammable and/or toxic gases and heat may be generated with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Also may react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still some heat. Can be oxidized exothermically by strong oxidizing agents and reduced by strong reducing agents; a wide variety of products is possible. May initiate polymerization reactions; may catalyze (increase the rate of) chemical reactions.
Health Hazard: Chemical is essentially non-irritating in contact with skin or eyes. Ingestion causes arsenic poisoning, but symptoms are delayed.
Fire Hazard: Behavior in Fire: May form toxic oxides of arsenic when heated.

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