Carbobenzoxyhydrazide supplier

Name
Carbobenzoxyhydrazide
EINECS 226-230-3
CAS No. 5331-43-1
Article Data15
CAS DataBase
Density 1.202 g/cm³
Solubility Soluble in water (slightly), methanol and DMSO.
Melting Point 65-68 °C(lit.)
Formula C₈H₁₀N₂O₂
Boiling Point 351.292 °C at 760 mmHg
Molecular Weight 166.18
Flash Point 166.255 °C
Transport Information
Appearance light beige shiny flakes
Safety 26-36
Risk Codes 41
Molecular Structure
Hazard Symbols Xi
Synonyms Carbazicacid, benzyl ester (6CI,7CI,8CI);Benzylhydrazinecarboxylate;Benzyl hydrazinocarboxylate;Benzyloxycarbonyl hydrazide;Hydrazincarboxylic acid benzylester;NSC 2287;[(Benzyloxy)carbonyl]hydrazine;Carbazic acid, benzyl ester;
PSA 64.35000
LogP 1.87770

Synthetic route

: 202980-89-0
C11H11Cl3N2O4

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

Conditions

Conditions	Yield
With chloro-trimethyl-silane; mischmetal (50 percent Ce, 25 percent La, 16 percent Nd, 6 percent Pr) In tetrahydrofuran for 3h; Heating;	99%

: 501-53-1
benzyl chloroformate

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

Conditions

Conditions	Yield
With lithium carbonate; hydrazine hydrate In ethyl acetate at 30 - 120℃; for 2.75h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere;	95%
With potassium carbonate; hydrazine hydrate In tetrahydrofuran at -20℃; for 2h;	90%
With hydrazine hydrate In diethyl ether for 1h; Acylation;	82%
With chloroform; hydrazine hydrate
(i) N2H4*H2O, (ii) HCl; Multistep reaction;

: 22129-07-3
N-benzyloxycarbonylimidazole

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

Conditions

Conditions	Yield
With hydrazine hydrate In tetrahydrofuran at 20℃;	95%
With hydrazine hydrate In dichloromethane at 0 - 20℃; for 1.5h;	5.78 g

: 7803-57-8
hydrazine hydrate

: 501-53-1
benzyl chloroformate

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

Conditions

Conditions	Yield
In diethyl ether at -5 - 20℃; for 2h;	58%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 100-51-6
benzyl alcohol

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	39%

: 13795-24-9
benzyl 4-nitrophenyl carbonate

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

Conditions

Conditions	Yield
With hydrazine hydrate In dichloromethane at 0 - 20℃; Inert atmosphere;	24%

: 3459-92-5
DBC

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

Conditions

Conditions	Yield
With hydrazine hydrate at 110℃;
With hydrazine hydrate auf dem Dampfbad;
With hydrazine hydrate In isopropyl alcohol

: (5-Ethyl-3,7,8,10-tetramethyl-2,4-dioxo-3,4,5,10-tetrahydro-2H-benzo[g]pteridin-4a-yl)-carbamic acid benzyl ester

A: 5331-43-1
N-benzyloxycarbonyl-hydrazine

B: 5-ethyl-10-methyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridin-5-ium perchlorate

Conditions

Conditions	Yield
In acetonitrile at 25℃; Equilibrium constant;

: 100-44-7
benzyl chloride

sodium compound of α-naphthol: sodium compound of α-naphthol

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (i) Na, petroleum ether, (ii) /BRN= 471308/, KI, DMF 2: N2H4*H2O / propan-2-ol View Scheme

: 100-51-6
benzyl alcohol

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dichloromethane / 1 h / 20 °C 2: hydrazine hydrate / dichloromethane / 1.5 h / 0 - 20 °C View Scheme

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 407-25-0
trifluoroacetic anhydride

: benzyl 2-(trifluoroacetyl)hydrazinecarboxylate

Conditions

Conditions	Yield
In dichloromethane at 0℃;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	77%

: 127406-56-8
2-(4-formylphenyl)pyridine

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 1003888-34-3
C20H17N3O2

Conditions

Conditions	Yield
In isopropyl alcohol at 80℃; for 16h;	100%

: 1093214-91-5
1-(tert-butoxycarbonyl)-3-(ethoxycarbonyl)piperidine-3-carboxylic acid

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 1186019-61-3
1-tert-butyl 3-ethyl 3-({2-[(benzyloxy)carbonyl]hydrazino}carbonyl)piperidine-1,3-dicarboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 16h;	100%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: C11H15N3O3

Conditions

Conditions	Yield
With sodium hydroxide In ethyl acetate at 50℃; for 16h; Reagent/catalyst;	100%

: 175211-73-1
methyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-N-(2-oxoethyl)glycinate

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: C18H25N3O6

Conditions

Conditions	Yield
With sodium sulfate In methanol at 20℃; for 2h;	100%

: 55820-40-1, 34710-33-3, 97859-03-5
Pd(t-BuNC)2Cl2

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: C18H28Cl2N4O2Pd

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 5h;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 57699-88-4
1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine

Conditions

Conditions	Yield
With triethylamine In dichloromethane	99%
With dmap; triethylamine In dichloromethane for 24h;	90%
With triethylamine In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;	89%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 67-64-1
acetone

: 3057-26-9
2-(propan-2-yliden)hydrazinecarboxylic acid benzyl ester

Conditions

Conditions	Yield
In toluene at 20 - 60℃; for 26h;	99%
With triethylamine In methanol for 2h; Heating;	97%
In toluene a.) 50 degC, 30 min, b.) room temp., 12 h;	94%

: 4-[4-(tert-butyl)-1,3-thiazol-2-yl]benzaldehyde

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 1003888-35-4
C22H23N3O2S

Conditions

Conditions	Yield
In isopropyl alcohol at 80℃; for 18h;	99%

: 624-31-7
4-tolyl iodide

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 1197055-07-4
benzyl 1-p-tolylhydrazinecarboxylate

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In N,N-dimethyl-formamide at 20 - 80℃; Inert atmosphere;	99%

: 35779-04-5
1-tert-butyl-4-iodobenzene

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 1197055-09-6
benzyl 1-(4-tert-butylphenyl)hydrazinecarboxylate

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In N,N-dimethyl-formamide at 20 - 80℃; Inert atmosphere;	99%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 14763-00-9, 14865-30-6
4,5-diphenylocta-1,7-diyne-4,5-diol

: 1252032-33-9
benzyl (2,5-dimethyl-3a,6a-diphenylhexahydro-2,5-epiminofuro[3,2-b]furan-7-yl)carbamate

Conditions

Conditions	Yield
With (N'-(tbutyl)-N,N-diethylcarbamimidoyl)gold(I) chloride; silver(I) triflimide In acetonitrile at 20℃; for 16h; Inert atmosphere;	99%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 78-84-2
isobutyraldehyde

: 1451982-81-2
(2E)-(2-methylpropyliden)hydrazinecarboxylic acid benzyl ester

Conditions

Conditions	Yield
In toluene at 20 - 60℃; for 26h;	99%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 3934-87-0
5-hydroxyvanillin

: 1621252-64-9
(E)-benzyl 2-(3,4-dihydroxy-5-methoxybenzylidene)hydrazinecarboxylate

Conditions

Conditions	Yield
In ethanol Reflux;	99%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 121-33-5
vanillin

: 1621252-65-0
(E)-benzyl 2-(4-hydroxy-3-methoxybenzylidene)hydrazinecarboxylate

Conditions

Conditions	Yield
In ethanol Reflux;	99%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1621252-66-1
(E)-benzyl 2-(3,4-dihydroxybenzylidene)hydrazinecarboxylate

Conditions

Conditions	Yield
In ethanol Reflux;	99%

: 51061-83-7
2,4-dihydroxy-5-methoxybenzaldehyde

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 1621252-68-3
(E)-benzyl 2-(2,4-Dihydroxy-5-methoxybenzylidene)hydrazinecarboxylate

Conditions

Conditions	Yield
In ethanol Reflux;	99%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 98-86-2
acetophenone

: N'-(1-phenyl-ethylidene)-hydrazinecarboxylic acid benzyl ester

Conditions

Conditions	Yield
In methanol at 20℃;	98%
In hexane for 8h; Heating;	79%
In methanol at 65℃;

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 96-22-0
pentan-3-one

: N'-(1-ethyl-propylidene)-hydrazinecarboxylic acid benzyl ester

Conditions

Conditions	Yield
In hexane for 8h; Heating;	98%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 97297-40-0
N'-((DL)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-hydrazine carboxylic acid benzyl ester

Conditions

Conditions	Yield
Stage #1: 2-(tert-butoxycarbonylamino)-3-phenylpropionic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h; Stage #2: N-benzyloxycarbonyl-hydrazine In dichloromethane at 20℃;	98%

: 766-85-8
3-methoxy-1-iodobenzene

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 1197055-14-3
benzyl 1-(3-methoxyphenyl)hydrazinecarboxylate

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In N,N-dimethyl-formamide at 20 - 80℃; Inert atmosphere;	98%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 1621252-63-8
(E)-benzyl 2-(3,4,5-trimethoxybenzylidene)hydrazinecarboxylate

Conditions

Conditions	Yield
In ethanol Reflux;	98%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: [5-(2-ethoxy-2-oxoethyl)-1H-tetrazol-1-yl]acetic acid

: benzyl 2-{[5-(2-ethoxy-2-oxoethyl)-1H-tetrazol-1-yl]acetyl}hydrazinecarboxylate

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25 - 30℃; for 16h;	98%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 61771-76-4
1-(but-3-enyl)-2-oxocyclohexanecarboxylic acid ethyl ester

: C21H28N2O4

Conditions

Conditions	Yield
In ethanol	98%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: methyl 1-(pent-4-en-1-yl)-2,5-dioxocyclohexanecarboxylate 5-monoethylene ketal

: C23H30N2O6

Conditions

Conditions	Yield
In ethanol	98%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 298-12-4
Glyoxilic acid

: C10H10N2O4

Conditions

Conditions	Yield
In ethanol; water at 80℃; for 4h;	98%

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 90-02-8
salicylaldehyde

: 1621252-67-2
benzyl (E)-2-(2-hydroxybenzylidene)hydrazine-1-carboxylate

Conditions

Conditions	Yield
In ethanol at 20℃; for 0.666667h;	97.8%
In ethanol Reflux;	91.5%

: 696-62-8
para-iodoanisole

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 40093-52-5
benzyl 1-(4-methoxyphenyl)hydrazinecarboxylate

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In N,N-dimethyl-formamide at 20 - 80℃; Inert atmosphere;	97%
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In N,N-dimethyl-formamide at 80℃; for 1h; Inert atmosphere;	51%

: 3188-00-9
2-methyltetrahydrofuran-3-one

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: benzyl 2-(2-methyldihydrofuran-3(2H)-ylidene)hydrazine-1-carboxylate

Conditions

Conditions	Yield
at 15℃; for 16h;	97%

Carbobenzoxyhydrazide Specification

The Carbobenzoxyhydrazide, with the CAS registry number 5331-43-1, is also known as Carbazic acid, benzyl ester. It belongs to the product category of Phosgene Derivatives. Its EINECS number is 226-230-3. This chemical's molecular formula is C₈H₁₀N₂O₂ and molecular weight is 166.18. What's more, its systematic name is Benzyl hydrazinecarboxylate. This chemical is stable at common pressure and temperature, and it should be sealed and stored in a cool and dry place. Moreover, it should be protected from light. It is used to synthetize peptide.

Physical properties of Carbobenzoxyhydrazide are: (1)ACD/LogP: 0.777; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.78; (4)ACD/LogD (pH 7.4): 0.78; (5)ACD/BCF (pH 5.5): 2.29; (6)ACD/BCF (pH 7.4): 2.29; (7)ACD/KOC (pH 5.5): 62.81; (8)ACD/KOC (pH 7.4): 63.00; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 64.35 Å²; (13)Index of Refraction: 1.56; (14)Molar Refractivity: 44.707 cm³; (15)Molar Volume: 138.226 cm³; (16)Polarizability: 17.723 10^-24cm³; (17)Surface Tension: 48.9 dyne/cm; (18)Density: 1.202 g/cm³; (19)Flash Point: 166.255 °C; (20)Enthalpy of Vaporization: 59.598 kJ/mol; (21)Boiling Point: 351.292 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

Preparation: this chemical can be prepared by carbonochloridic acid benzyl ester. This reaction will need reagent hydrazine monohydrate and solvent diethyl ether with the reaction time of 1 hour. The yield is about 82%.

Carbobenzoxyhydrazide can be prepared by carbonochloridic acid benzyl ester

Uses of Carbobenzoxyhydrazide: it can be used to produce N-Methylenbenzylcarbazat by heating. It will need reagent triethylamine and solvent methanol with the reaction time of 2 hours. The yield is about 95%.

Carbobenzoxyhydrazide can be used to produce N-Methylenbenzylcarbazat by heating

When you are using this chemical, please be cautious about it as the following:
This chemical has a risk of serious damage to eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OCc1ccccc1)NN
(2)Std. InChI: InChI=1S/C8H10N2O2/c9-10-8(11)12-6-7-4-2-1-3-5-7/h1-5H,6,9H2,(H,10,11)
(3)Std. InChIKey: RXUBZLMIGSAPEJ-UHFFFAOYSA-N

Product Name

Carbobenzoxyhydrazide

Synthetic route

Carbobenzoxyhydrazide Specification

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