Chloroacetamide supplier

Name
Chloroacetamide
EINECS 201-174-2
CAS No. 79-07-2
Article Data108
CAS DataBase
Density 1.268 g/cm³
Solubility Soluble in water(90g/L).
Melting Point 116-118 °C(lit.)
Formula C₂H₄ClNO
Boiling Point 256 °C at 760 mmHg
Molecular Weight 93.5129
Flash Point 108.6 °C
Transport Information UN 2811 6.1/PG 3
Appearance White crystal
Safety 22-36/37-45
Risk Codes 25-43-62
Molecular Structure
Hazard Symbols T
Synonyms Acetamide, a-chloro- (4CI);2-Chloroacetamide;Chloracetamide;KM 101;KM 101 (fungicide);Mergal AF;Microcide;NSC 54286;NSC 8408;a-Chloroacetamide;
PSA 43.09000
LogP 0.41080

Synthetic route

: 112-41-4
1-dodecene

: 35070-77-0
N-chloro-alpha-chloroacetamide

A: 35077-34-0
2-Chloro-N-(2-chloro-dodecyl)-acetamide

B: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; Irradiation;	A 95% B 3%

...Expand

: 120158-03-4
tert-butyl (2-chloroacetyl)carbamate

: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane for 1h; Ambient temperature;	94%

: 35070-77-0
N-chloro-alpha-chloroacetamide

: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With n-octyne In dichloromethane at 15 - 20℃; Irradiation;	93%

: 107-14-2
chloroacetonitrile

: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With Amberlyst A-26 (OH- form); dihydrogen peroxide In methanol at 20℃; for 2h; Hydrolysis;	93%
With [RuCl2(η6-p-cymene)(P(4-C6H4F)2Cl)]; water at 40℃; for 1h; Sealed tube; Inert atmosphere;	93%
With C19H23Cl2N6PRuS3*3ClH; water at 100℃; for 1h; Inert atmosphere; Schlenk technique;	88%

: 35077-11-3
α-chloro-N-bromoacetamide

: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With 1,2-dimethylcyclohexene In dichloromethane at 15 - 20℃; Irradiation;	92%
With perchloric acid; water; potassium hydrogen phthalate; potassium nitrate; potassium bromide at 25℃; for 1h; Equilibrium constant;

: 591-49-1
1-methylcyclohex-1-ene

: 35070-77-0
N-chloro-alpha-chloroacetamide

: 35077-36-2, 64226-98-8
2-Chloro-N-((1S,2R)-2-chloro-2-methyl-cyclohexyl)-acetamide

B: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; Irradiation;	A 88% B 7%

...Expand

: 67-56-1
methanol

: 70737-12-1
methyl 2-chloroacetimidate hydrochloride

A: 74974-54-2
2-chloro-1,1,1-trimethoxyethane

B: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
at 20℃; for 24h;	A 65% B n/a

...Expand

: 112-41-4
1-dodecene

: 35077-11-3
α-chloro-N-bromoacetamide

A: 35077-35-1
N-(2-Bromo-dodecyl)-2-chloro-acetamide

B: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; Irradiation;	A 62% B 30%

...Expand

: 35070-77-0
N-chloro-alpha-chloroacetamide

: 930-66-5
1-chlorocyclohexene

A: 78174-21-7
2-Chloro-N-(2,2-dichloro-cyclohexyl)-acetamide

B: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; Irradiation;	A 35% B 59%

...Expand

: 35070-77-0
N-chloro-alpha-chloroacetamide

: 932-66-1
1-cyclohexenyl methyl ketone

: 35077-39-5, 35077-40-8
N-((1S,2R)-2-Acetyl-2-chloro-cyclohexyl)-2-chloro-acetamide

: 35077-39-5, 35077-40-8
N-((1R,2R)-2-Acetyl-2-chloro-cyclohexyl)-2-chloro-acetamide

C: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; Irradiation;	A 16% B 54% C 30%

...Expand

: 591-49-1
1-methylcyclohex-1-ene

: 35077-11-3
α-chloro-N-bromoacetamide

: 35077-37-3, 35077-38-4
N-((1S,2R)-2-Bromo-2-methyl-cyclohexyl)-2-chloro-acetamide

: 35077-37-3, 35077-38-4
N-((1R,2R)-2-Bromo-2-methyl-cyclohexyl)-2-chloro-acetamide

C: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; Irradiation;	A 48% B 14% C 35%

...Expand

: 35077-11-3
α-chloro-N-bromoacetamide

: 110-83-8
cyclohexene

: 35077-28-2, 35077-29-3
N-((1S,2R)-2-Bromo-cyclohexyl)-2-chloro-acetamide

: 35077-28-2, 35077-29-3
N-(trans-2-bromocyclohexyl)chloroacetamide

C: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; for 1.5h; Irradiation; Yield given. Yields of byproduct given;	A n/a B n/a C 37%

...Expand

: 67-56-1
methanol

: 110-83-8
cyclohexene

: trans-3-bromomethoxycyclohexane

: 35077-28-2, 35077-29-3
N-((1S,2R)-2-Bromo-cyclohexyl)-2-chloro-acetamide

: 35077-28-2, 35077-29-3
N-(trans-2-bromocyclohexyl)chloroacetamide

D: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With α-chloro-N-bromoacetamide at -70℃; for 17h; Irradiation; Yields of byproduct given;	A 27% B n/a C n/a D 31%

...Expand

: 498-66-8
norborn-2-ene

: 35077-11-3
α-chloro-N-bromoacetamide

: 64227-10-7, 64312-52-3
N-((1R,2S,3S,4S)-3-Bromo-bicyclo[2.2.1]hept-2-yl)-2-chloro-acetamide

: 64227-10-7, 64312-52-3
N-((1R,2S,3R,4S)-3-Bromo-bicyclo[2.2.1]hept-2-yl)-2-chloro-acetamide

C: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; Irradiation; Yield given. Yields of byproduct given;	A n/a B n/a C 30%

...Expand

: 35070-77-0
N-chloro-alpha-chloroacetamide

: 110-83-8
cyclohexene

: 24281-07-0, 33092-85-2, 35077-14-6, 53297-75-9
N-(trans-2-chlorocyclohexyl)acetamide

: 35077-18-0, 35077-19-1
2-Chloro-N-((1S,2R)-2-chloro-cyclohexyl)-acetamide

: 35077-18-0, 35077-19-1
2-Chloro-N-((1S,2S)-2-chloro-cyclohexyl)-acetamide

D: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In acetonitrile at 15 - 20℃; Irradiation; Yields of byproduct given;	A 18% B n/a C n/a D 12%

...Expand

: 498-66-8
norborn-2-ene

: 35070-77-0
N-chloro-alpha-chloroacetamide

: 64227-07-2, 64281-95-4
2-Chloro-N-((1R,2S,3S,4S)-3-chloro-bicyclo[2.2.1]hept-2-yl)-acetamide

: 64227-07-2, 64281-95-4
2-Chloro-N-((1R,2S,3R,4S)-3-chloro-bicyclo[2.2.1]hept-2-yl)-acetamide

C: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; Irradiation; Yield given. Yields of byproduct given;	A n/a B n/a C 10%

...Expand

: 35070-77-0
N-chloro-alpha-chloroacetamide

: 110-83-8
cyclohexene

: 35077-18-0, 35077-19-1
2-Chloro-N-((1S,2R)-2-chloro-cyclohexyl)-acetamide

: 35077-18-0, 35077-19-1
2-Chloro-N-((1S,2S)-2-chloro-cyclohexyl)-acetamide

C: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; for 2.5h; Irradiation; Yield given;	A n/a B n/a C 9%

...Expand

: 463-51-4
Ketene

: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With nitrogen trichloride; diethyl ether at -60℃; unter Ausschluss von Feuchtigkeit;

: 64-17-5
ethanol

: 4960-82-1
dichlorodiacetamide

A: 105-39-5
chloroacetic acid ethyl ester

B: 79-07-2
Chloroacetamide

...Expand

: 96-34-4
methyl chloroacetate

: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With ammonia; water
sodium methylate In methanol
sodium methylate In methanol

: 105-39-5
chloroacetic acid ethyl ester

: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With ammonia
With ammonium hydroxide
With ammonium hydroxide
With ammonium hydroxide at 0℃;
With ammonium hydroxide at 0℃; for 0.25h; Temperature;

: 79-11-8
chloroacetic acid

: 57-13-6
urea

: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
at 160 - 170℃;

: 79-04-9
chloroacetyl chloride

: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With ammonia
With sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane 1.) CH2Cl2, room temp., 2.) CH3OH; Yield given. Multistep reaction;
With ammonia; triethylamine In chloroform at 20℃; for 2h; Substitution;

: 504-29-0
2-aminopyridine

: 2-Chloro-N-(1λ5-pyrrolidin-1-ylidenemethyl)-acetamide

A: N-(2-Pyridino)-N,N'-tetramethylenformamidin

B: 79-07-2
Chloroacetamide

...Expand

: 35070-77-0
N-chloro-alpha-chloroacetamide

: 78174-28-4
2-Chloro-N-(2,2-dimethoxy-cyclohexyl)-acetamide

A: 35077-41-9
α-chloroacetamidocyclohexanone

B: 822-87-7
2-Chlorocyclohexanone

C: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With water -70 degC, then allowed to warm to r.t.; Yield given. Yields of byproduct given;

...Expand

: 931-57-7
1-methoxy-cyclohex-1-ene

A: 1056477-06-5
2-bromocyclohexanone

B: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
Yield given. Multistep reaction. Yields of byproduct given;

: 26473-57-4
(1-methoxyethylidene)cyclohexane

A: 1004-55-3
1-(1-chlorocyclohexyl)ethanone

B: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With N-chloro-alpha-chloroacetamide; water 1.) irradiation, CH2Cl2; Yield given. Multistep reaction. Yields of byproduct given;

: 36709-55-4
chloro-acetic acid benzhydrylidenamide

A: 119-61-9
benzophenone

B: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With water at 25℃; Rate constant; effect of pH on the rate constants;

: 29422-34-2
potassium cyanamide salt

: 79-07-2
Chloroacetamide

: C6H9N3O2S

Conditions

Conditions	Yield
In acetone for 1h; Ambient temperature;	100%

: 889656-79-5
6-mercapto-3,3-dimethyl-8-dimethylamino-3,4-dihydro-1H-pyrano[3,4-c]-pyridine-5-carbonitrile

: 79-07-2
Chloroacetamide

: 889656-80-8
1-amino-5-dimethylamino-8,8-dimethyl-8,9-dihydro-6H-pyrano[4,3-d]thieno[2,3-b]pyridine-2-carboxamide

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 20℃; for 5h; Heating / reflux;	100%
With potassium carbonate In ethanol for 4h; Reflux; Inert atmosphere;

: 890023-58-2
1-(benzylmethylamino)-3-mercapto-6,6-dimethyl-5,6,7,8-tetrahydro-isoquinoline-4-carbonitrile

: 79-07-2
Chloroacetamide

: 890023-59-3
C22H26N4OS

Conditions

Conditions	Yield
With potassium carbonate In ethanol Heating / reflux;	100%
With potassium carbonate In ethanol for 4h; Reflux; Inert atmosphere;

: 924-44-7
glyoxylic acid ethyl ester

: 79-07-2
Chloroacetamide

: 1198115-96-6
ethyl 2-(2-chloroacetamido)-2-hydroxyacetate

Conditions

Conditions	Yield
In tetrahydrofuran; toluene at 80℃; Inert atmosphere;	100%

: 2075-46-9
4-nitro-1H-pyrazole

: 79-07-2
Chloroacetamide

: 32407-64-0
2-(4-nitro-1H-pyrazol-1-yl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 60℃;	100%

: 552-89-6
2-nitro-benzaldehyde

: 79-07-2
Chloroacetamide

: 109287-33-4
trans-3-(2-nitrophenyl)oxirane-2-carboxamide

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at 20℃; for 7h; Darzens Condensation; stereoselective reaction;	100%
With sodium ethanolate In ethanol at 20℃; for 5h;	100%

: 603-35-0
triphenylphosphine

: 79-07-2
Chloroacetamide

: 25361-54-0
(2-amino-2-oxo-ethyl)triphenyl-phosphonium chloride

Conditions

Conditions	Yield
In nitromethane at 105℃; for 19h; Schlenk technique;	99%
In nitromethane at 105℃; for 19h; Inert atmosphere;	98%
In acetonitrile for 11h; Heating; Inert atmosphere;	96%
In various solvent(s) at 100℃; for 16h;	84%

: 123-08-0
4-hydroxy-benzaldehyde

: 79-07-2
Chloroacetamide

: 135857-20-4
2-(4-formyl-phenoxy)-acetamide

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetone for 48h; Reflux;	99%
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 2h;
With potassium carbonate In acetonitrile Reflux;
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20℃; for 5h;

: 890023-03-7
3-mercapto-1-dimethylamino-6,6-dimethyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

: 79-07-2
Chloroacetamide

: 890023-04-8
1-amino-5-dimethylamino-8,8-dimethyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide

Conditions

Conditions	Yield
With potassium carbonate In ethanol Heating / reflux;	99%

: 890023-33-3
1-dimethylamino-3-mercapto-6,6-dimethyl-6,7-dihydro-5H-[2]pyridin-4-carbonitrile

: 79-07-2
Chloroacetamide

: 890023-34-4
1-amino-5-dimethylamino-7,7-dimethyl-6H-7,8-dihydrocycIopenta[d]thieno[2,3-b]pyridin-2-carboxamide

Conditions

Conditions	Yield
With potassium carbonate In ethanol Heating / reflux;	99%

: 942302-89-8
[2-[3-(3-fluoro-benzyloxy)-phenyl]-ethyl]-(furan-2-ylmethyl)amine

: 79-07-2
Chloroacetamide

: 2-[[2-[3-(3-fluoro-benzyloxy)-phenyl]-ethyl]-(furan-2-ylmethyl)amino]-acetamide

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 120℃; for 2h; microwave irradiation;	99%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 79-07-2
Chloroacetamide

: 2,3-epoxy-3-(4-trifluoromethylphenyl)propionamide

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at 20℃; for 5h;	99%

: 6640-27-3
2-chloro-p-cresol

: 79-07-2
Chloroacetamide

: 1248651-95-7
2-(2-chloro-4-methylphenoxy)acetamide

Conditions

Conditions	Yield
With potassium carbonate at 82℃; for 0.166667h; Solvent; Microwave irradiation;	98.7%

: 611-20-1
salicylonitrile

: 79-07-2
Chloroacetamide

: 54802-12-9
2-(2-cyanophenoxy)acetamide

Conditions

Conditions	Yield
With potassium carbonate In acetone at 56℃;	98.5%
Stage #1: salicylonitrile With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 1h; Stage #2: Chloroacetamide In N,N-dimethyl-formamide at 80℃; for 3h;
With potassium carbonate In N,N-dimethyl-formamide at 80℃;

: 5-chloro-7-methoxy-1H-pyrazolo[4,3-d]pyrimidine

: 79-07-2
Chloroacetamide

A: 2-(5-chloro-7-methoxy-1H-pyrazolo[4,3-d]pyrimidin-1-yl)acetamide

B: 2-(5-chloro-7-methoxypyrazolo[4,3-d]pyrimidin-2-yl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 10h;	A 98.21% B n/a

...Expand

: 108-89-4
picoline

: 79-07-2
Chloroacetamide

: 78572-45-9
1-(2-amino-2-oxoethyl)-4-methylpyridinium chloride

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 48h;	98%
In acetone at 25℃; for 72h;	75%
In toluene for 5h; Reflux;	52%

: 147381-62-2
6-(4-chlorophenyl)-3-cyano-4-trifluoromethyl-2(1H)-pyridone

: 79-07-2
Chloroacetamide

: 155635-60-2
2-[6-(4-Chloro-phenyl)-3-cyano-4-trifluoromethyl-pyridin-2-yloxy]-acetamide

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetone at 60℃; for 6h;	98%

: 121221-00-9
N-(O,O'-diisopropylthiophosphoryl)thioacetamide

: 79-07-2
Chloroacetamide

: aminocarbonylmethyl N-isopropoxythiophosphorylacetimidothioate

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 3h; Heating;	98%

: 2-amino-6-sulfanyl-4-(thiophen-2-yl)pyridine-3,5-dicarbonitrile

: 79-07-2
Chloroacetamide

: 136633-82-4
2-(6-amino-3,5-dicyano-4-thiophen-2-yl-pyridin-2-ylsulfanyl)-acetamide

Conditions

Conditions	Yield
With triethylamine In acetone at 20℃; for 5h;	98%

: potassium trifluoro[(1E)-3-methoxyprop-1-en-1-yl]borate

: 79-07-2
Chloroacetamide

: 1238357-72-6
2-chloro-trans-N-(3-methoxy-propenyl)-acetamide

Conditions

Conditions	Yield
With oxygen; copper diacetate In dichloromethane; dimethyl sulfoxide at 40℃; for 20h; Molecular sieve; diastereoselective reaction;	98%

: 1352948-27-6
3-((8-(tert-butoxycarbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid

: 79-07-2
Chloroacetamide

: 1352948-59-4
tert-butyl 3-(3-((2-amino-2-oxoethoxy)carbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 65℃; for 18h;	98%

: 90-00-6
o-Hydroxyethylbenzene

: 79-07-2
Chloroacetamide

: 35368-61-7
2-(2-ethylphenoxy)acetamide

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In butanone for 48h; Reflux; Inert atmosphere;	98%

: 342597-54-0
5-(4-methoxybenzyl)-4-phenyl-4H-1,2,4-triazole-3-thiol

: 79-07-2
Chloroacetamide

: 874798-09-1
2-[5-(4-methoxybenzyl)-4-phenyl-4H-1,2,4-triazol-3-ylsulfanyl]acetamide

Conditions

Conditions	Yield
Stage #1: 5-(4-methoxybenzyl)-4-phenyl-4H-1,2,4-triazole-3-thiol With potassium hydroxide In ethanol Reflux; Stage #2: Chloroacetamide In ethanol Reflux;	98%

: 6-hydroxy-2-pentyl-4-phenylquinoline-3-carbonitrile

: 79-07-2
Chloroacetamide

: 2-((3-cyano-2-pentyl-4-phenylquinolin-6-yl)oxy)acetamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 12h;	98%

: 5,5'-(octane-1,8-diyl)bis(4-allyl-4H-1,2,4-triazole-3-thiol)

: 79-07-2
Chloroacetamide

: 2,2'-{octane-1,8-diylbis[(4-allyl-4H-1,2,4-triazole-3,5-diyl)sulfanediyl]}diacetamide

Conditions

Conditions	Yield
Heating;	98%

: 90-99-3
diphenylchloromethane

: 79-07-2
Chloroacetamide

: 68524-30-1
2-(diphenylmethylthio)acetamide

Conditions

Conditions	Yield
Stage #1: diphenylchloromethane With thiourea; potassium iodide In water at 70 - 75℃; for 1.5h; Stage #2: With sodium hydroxide In water at 15 - 24℃; Stage #3: Chloroacetamide With triethylamine more than 3 stages;	97.9%
Stage #1: diphenylchloromethane With thiourea In isopropyl alcohol at 100℃; for 2h; Sealed tube; Stage #2: Chloroacetamide With potassium hydroxide In methanol; isopropyl alcohol at 60℃; for 2h; Sonication;

: 79-07-2
Chloroacetamide

: 35077-11-3
α-chloro-N-bromoacetamide

Conditions

Conditions	Yield
With dibromoisocyanuric acid In dichloromethane for 5h; Bromination; Heating;	97%
With perchloric acid; water; potassium hydrogen phthalate; potassium nitrate; potassium bromide at 25℃; for 1h; Equilibrium constant;
With bromine; trifluoroacetic acid; silver(l) oxide
With dibromoisocyanuric acid In dichloromethane
With sodium hypobromide

: 70182-88-6
7-Amino<1,2,4>triazolo<1,5-c>pyrimidine-5(6H)-thione

: 79-07-2
Chloroacetamide

: 143212-81-1
(7-amino-s-triazole<1,5-c>pyrimidyl-5)thioacetic acid amide

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 3h; Heating;	97%

: 79-07-2
Chloroacetamide

: 60-35-5
acetamide

Conditions

Conditions	Yield
With borohydride exchange resin; nickel diacetate In methanol for 1h; Ambient temperature;	97%

: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

: 79-07-2
Chloroacetamide

: 1-Carbamoylmethyl-4-aza-1-azonia-bicyclo[2.2.2]octane; chloride

Conditions

Conditions	Yield
In acetonitrile at 20 - 25℃;	97%
With diisopropylamine In acetonitrile at 20℃; for 16h;	86%

Chloroacetamide Specification

The CAS registry number of Chloroacetamide is 79-07-2. The IUPAC name is 2-chloroacetamide. Its EINECS registry number is 201-174-2. It is also called Acetamide, 2-chloro-. In addition, the molecular formula is C₂H₄ClNO and the molecular weight is 93.51. It is a colorless or yellow crystalline substance with characteristic smell, readily soluble in water. What's more, it belongs to the classes of Amides; Carbonyl Compounds; Organic Building Blocks. It should be stored in a airtight, cool and dry place.

Physical properties about this chemical are: (1)ACD/LogP: -0.85; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.85; (4)ACD/LogD (pH 7.4): -0.85; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 8.18; (8)ACD/KOC (pH 7.4): 8.18; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 20.31 Å²; (13)Index of Refraction: 1.447; (14)Molar Refractivity: 19.72 cm³; (15)Molar Volume: 73.7 cm³; (16)Polarizability: 7.82 ×10^-24cm³; (17)Surface Tension: 39 dyne/cm; (18)Density: 1.268 g/cm³; (19)Flash Point: 108.6 °C; (20)Enthalpy of Vaporization: 49.35 kJ/mol; (21)Boiling Point: 256 °C at 760 mmHg; (22)Vapour Pressure: 0.0158 mmHg at 25°C.

Preparation of Chloroacetamide: it can be prepared by ethyl chloroacetate and ammonia. At first, cool the ethyl chloroacetate to 10 °C, slowly add ammonia (relative density is 0.9) with stirring. After finish adding ammonia, continue to stir for 1 hour, filter and crystal the product, use ammonia to wash chloride, drained the product as far as possible, use ethanol for recrystallization at last.

Uses of Chloroacetamide: it can be used in organic synthesis, pharmaceutical intermediates. It can produce organic compounds such as chloroacetonitrile, sulfanilyl-3-methoxypyrazine and sulfanilylmethylpyrazine. In addition, it can be used as preservative of shampoo, cutting oils, plastics, coatings slab and shower gel. What's more, it can react with 1-phenyl-piperazine to get (4-phenyl-piperazino)-acetic acid amide. This reaction will need reagent K₂CO₃ and solvent toluene. The yield is about 75% by heating.

Chloroacetamide can react with 1-phenyl-piperazine to get (4-phenyl-piperazino)-acetic acid amide

When you are using this chemical, please be cautious about it as the following:
It is toxic if swallowed and may cause sensitization by skin contact. And it has risk of impaired fertility. During using it, do not breathe dust and wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.).

You can still convert the following datas into molecular structure:
(1)SMILES: ClCC(=O)N
(2)InChI: InChI=1/C2H4ClNO/c3-1-2(4)5/h1H2,(H2,4,5)
(3)InChIKey: VXIVSQZSERGHQP-UHFFFAOYAM

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	31mg/kg (31mg/kg)		Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 58, Pg. 462, 1978.
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03764,
mouse	LD50	oral	155mg/kg (155mg/kg)		Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 58, Pg. 462, 1978.
rabbit	LD50	oral	122mg/kg (122mg/kg)		Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 58, Pg. 462, 1978.
rat	LD50	oral	138mg/kg (138mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Technical Information Service. Vol. OTS0536947,
rat	LD50	unreported	70mg/kg (70mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1073, 1969.

Product Name

Chloroacetamide

Synthetic route

Chloroacetamide Specification

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