Chloromethanesulfonyl chloride supplier

Name
Chloromethanesulfonyl chloride
EINECS 222-526-1
CAS No. 3518-65-8
Article Data33
CAS DataBase
Density 1.677 g/cm³
Solubility It is soluble in dichloromethane, pyridine, and most organic solvents. It is insoluble in water.
Melting Point
Formula CH₂Cl₂O₂S
Boiling Point 197.8 °C at 760 mmHg
Molecular Weight 148.998
Flash Point 73.4 °C
Transport Information UN 3265 8/PG 2
Appearance
Safety 26-36/37/39-45
Risk Codes 22-34
Molecular Structure
Hazard Symbols C, Xi
Synonyms Methanesulfonylchloride, chloro- (6CI,7CI,8CI,9CI);(Chloromethyl)sulfonyl chloride;
PSA 42.52000
LogP 1.83210

Synthetic route

: 4431-79-2
bis(benzylthio)methane

A: 3518-65-8
monochloromethanesulfonyl chloride

B: 140-11-4
Benzyl acetate

C: 100-44-7
benzyl chloride

Conditions

Conditions	Yield
With water; chlorine; acetic acid In water at 20 - 30℃; for 2h;	A 53.6% B 9.8% C 73.9%

...Expand

: 4431-79-2
bis(benzylthio)methane

A: 3518-65-8
monochloromethanesulfonyl chloride

B: 140-11-4
Benzyl acetate

C: 100-44-7
benzyl chloride

D: 1939-99-7
benzenesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine In acetic acid Product distribution; other methyl substituted bis(thiobenzyl) methane derivatives; other products;	A 53.6% B 9.8% C 73.9% D 38%

...Expand

: 291-21-4
[1,3,5]trithiane

: 3518-65-8
monochloromethanesulfonyl chloride

Conditions

Conditions	Yield
With potassium chlorate In hydrogenchloride for 5h; Ambient temperature;	62%
With chlorine; acetic acid
With hydrogenchloride; potassium chlorate

: 3970-13-6
benzyl chloromethyl sulfide

A: 3518-65-8
monochloromethanesulfonyl chloride

B: 140-11-4
Benzyl acetate

C: 100-44-7
benzyl chloride

D: 1939-99-7
benzenesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine; acetic acid at 20 - 30℃; for 2h;	A 54% B 16% C 38% D 9.4%

...Expand

: 3970-13-6
benzyl chloromethyl sulfide

: 64-19-7
acetic acid

A: 3518-65-8
monochloromethanesulfonyl chloride

B: 140-11-4
Benzyl acetate

C: 100-44-7
benzyl chloride

D: 1939-99-7
benzenesulfonyl chloride

Conditions

Conditions	Yield
With chlorine In water at 20 - 30℃; for 2h;	A 54% B 16% C 38% D 9.4%

...Expand

: 50-00-0
formaldehyd

: 3518-65-8
monochloromethanesulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; chlorine; sodium thiosulfate In water at -10℃; for 1.5h;	28%
With hydrogenchloride; formaldehyd; hydrogen sulfide 2.) glacial acetic acid, water, 30 deg C, 3-4 h; Yield given. Multistep reaction;
With hydrogenchloride; formaldehyd; hydrogen sulfide; water anschliessendes Behandeln bei -15grad mit Chlor;

: 26826-80-2
chloromethanesulfenyl chloride

: 3518-65-8
monochloromethanesulfonyl chloride

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid
With chlorine

: 34557-54-5
methane

: 3518-65-8
monochloromethanesulfonyl chloride

Conditions

Conditions	Yield
With sulfur dioxide; chlorine bei der Einwirkung von hochfrequenten elektrischen Entladungen;

: 10352-63-3
chloromethyl sodium sulfonate

: 3518-65-8
monochloromethanesulfonyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride; trichlorophosphate
With phosphorus pentachloride (heating);
Stage #1: sodium chloromethanesulfonate With phosphorus pentachloride at 130℃; for 1.25h; Cooling with ice; Stage #2: With water for 1h; Cooling with ice;

: 124-63-0
methanesulfonyl chloride

: 3518-65-8
monochloromethanesulfonyl chloride

Conditions

Conditions	Yield
With pyridine; sulfuryl dichloride In tetrachloromethane

: 7732-18-5
water

: 7782-50-5
chlorine

: 291-21-4
[1,3,5]trithiane

: 3518-65-8
monochloromethanesulfonyl chloride

...Expand

1.3.5-trithiane: 1.3.5-trithiane

: 3518-65-8
monochloromethanesulfonyl chloride

Conditions

Conditions	Yield
With water; chlorine unter Kuehlung;
With chlorine; acetic acid

: 26826-80-2
chloromethanesulfenyl chloride

: 7732-18-5
water

: 7782-50-5
chlorine

: 3518-65-8
monochloromethanesulfonyl chloride

...Expand

: 3518-65-8
monochloromethanesulfonyl chloride

: 878-47-7, 4242-00-6, 34996-06-0, 50302-16-4, 70191-02-5, 34996-05-9
(4aS,5S)-4,4a,5,6,7,8-hexahydro-5-hydroxy-4a-methylnaphthalen-2(3H)-one

: 182243-72-7
Chloro-methanesulfonic acid (1S,8aS)-8a-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl ester

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 0.333333h;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: 58-22-0
testosterone

: 182243-71-6
Chloro-methanesulfonic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 0.25h;	100%
With pyridine at 0℃; Substitution;

: 3518-65-8
monochloromethanesulfonyl chloride

: 516-95-0
epicholestanol

: Chloro-methanesulfonic acid (3R,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 0.75h;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: 80-97-7
Cholestanol

: 182243-57-8
Chloro-methanesulfonic acid (3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 0.0833333h;	100%
With pyridine at 0℃; Substitution;

: 3518-65-8
monochloromethanesulfonyl chloride

: 516-92-7
epicoprostanol

: Chloro-methanesulfonic acid (3R,5R,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions

Conditions	Yield
With pyridine at 0 - 30℃; for 0.166667h;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: 80-97-7, 360-68-9, 516-92-7, 516-95-0, 566-84-7, 14615-12-4, 16720-60-8, 17608-41-2, 18769-46-5, 27409-41-2, 56193-35-2, 57759-49-6, 73465-18-6, 103365-91-9, 105119-51-5
Coprostanol

: Chloro-methanesulfonic acid (3S,5R,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 1h;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: 182243-56-7
(2S,3R)-1-Benzyloxymethoxy-2,4-dimethyl-pentan-3-ol

: Chloro-methanesulfonic acid (1R,2S)-3-benzyloxymethoxy-1-isopropyl-2-methyl-propyl ester

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 0.166667h;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: 307315-82-8
(4R,5S,6S)-1-tert-butyldimethylsilyloxy-4,5,7-tribenzyloxy-2(E)-hepten-6-ol

: 307315-83-9
(4R,5S,6S)-1-tert-butyldimethylsilyloxy-6-[(chloro-methylsulfonyl)-oxy]-4,5,7-tribenzyloxy-2(E)-heptene

Conditions

Conditions	Yield
With pyridine at 20℃; for 0.5h; Substitution;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: 475641-71-5
[(2R,4S,5R)-2-Phenyl-5-((4R,5S)-2-phenyl-4-vinyl-[1,3,2]dioxaborinan-5-yloxy)-[1,3]dioxan-4-yl]-methanol

: 475641-81-7
Chloro-methanesulfonic acid (2R,4S,5R)-2-phenyl-5-((4R,5S)-2-phenyl-4-vinyl-[1,3,2]dioxaborinan-5-yloxy)-[1,3]dioxan-4-ylmethyl ester

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 21 - 23℃;	100%

: (3R*,8aS*)-3-(2-hydroxyethyl)-8a-methoxy-3,6,6,8,8-pentamethyl-8,8a-dihydro-3H-benzo[c][1,2]dioxine-5,7-dione

: 3518-65-8
monochloromethanesulfonyl chloride

: C17H25ClO8S

Conditions

Conditions	Yield
With lutidine In dichloromethane for 12h;	100%

: (R)-3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1-methyl-1-(3-methyl-butyl)-1H-naphthalen-2-one hydrochloride

: 3518-65-8
monochloromethanesulfonyl chloride

: 1-chloro-N-{3-[(4R)-1-hydroxy-4-methyl-4-(3-methylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide

Conditions

Conditions	Yield
Stage #1: (R)-3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1-methyl-1-(3-methyl-butyl)-1H-naphthalen-2-one hydrochloride; monochloromethanesulfonyl chloride With pyridine In acetone at 20℃; for 24h; Stage #2: With citric acid In water; ethyl acetate; acetone	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: 635678-99-8
2-azido-N,N-diethyl-4,5-O-isopropylidene-3-O-triisopropylsilyl-7-O-trityl-D-glycero-D-allo-heptonamide

: 934271-05-3
C43H61ClN4O8SSi

Conditions

Conditions	Yield
With pyridine at 0℃; for 0.75h;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: C17H22O7

: C18H23ClO9S

Conditions

Conditions	Yield
With pyridine at 0℃; for 0.166667h;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: 1-(tert-butyl) 2-methyl (2S,3S,4S)-3-allyl-4-hydroxypyrrolidine-1,2-dicarboxylate

: 1-(tert-butyl) 2-methyl (2S,3S,4S)-3-allyl-4-(((chloromethyl)sulfonyl)oxy)pyrrolidine-1,2-dicarboxylate

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
With 2,6-dimethylpyridine In dichloromethane at 0 - 20℃;

: 3518-65-8
monochloromethanesulfonyl chloride

: C14H20O3

: C15H21ClO5S

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 1h; Inert atmosphere;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: C17H34O5Si

: C18H35ClO7SSi

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 1h; Inert atmosphere;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: C17H30Br2O5Si

: C18H31Br2ClO7SSi

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 1.5h; Inert atmosphere;	100%

: 3518-65-8
monochloromethanesulfonyl chloride

: 1448328-64-0
(R)-4-benzyl-3-((2R,3S,6R)-6-((2R,5S)-5-((S)-((tert-butyldimethylsilyl)oxy)((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-((4-methoxybenzyl)oxy)-2-methyltetrahydrofuran-2-yl)methyl)tetrahydrofuran-2-yl)-6-hydroxy-2-methyl-3-((triethylsilyl)oxy)hexanoyl)oxazolidin-2-one

: 1448328-65-1
(1R,4S,5R)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-1-((2R,5S)-5-((S)-((tert-butyldimethylsilyl)oxy)((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-((4-methoxybenzyl)oxy)-2-methyltetrahydrofuran-2-yl)methyl)tetrahydrofuran-2-yl)-5-methyl-6-oxo-4-((triethylsilyl)oxy)hexyl chloromethanesulfonate

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 2.5h;	99%

: 3518-65-8
monochloromethanesulfonyl chloride

: 172986-75-3
(4R,5R,6R)-1-<(tert-butyldimethylsilyl)oxy>-4,5,7-tris(benzyloxy)-2(E)-hepten-6-ol

: 231618-84-1
(4R,5R,6R)-1-<(tert-butyldimethylsilyl)oxy>-6-<((chloromethyl)sulfonyl)oxy>-4,5,7-tris(benzyloxy)-2(E)-heptene

Conditions

Conditions	Yield
In pyridine for 0.5h; Ambient temperature;	98%
With pyridine at 20℃; for 0.5h;	98%
With pyridine for 0.5h; Ambient temperature;

: 3518-65-8
monochloromethanesulfonyl chloride

: 182243-64-7
Methanesulfonic acid (1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-propyl ester

: 182243-65-8
Chloro-methanesulfonic acid (1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-propyl ester

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 0.5h;	98%

: 3518-65-8
monochloromethanesulfonyl chloride

: 599-04-2
(R)-Pantolacton

: 182243-70-5
Chloro-methanesulfonic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 0.166667h;	98%

: 3518-65-8
monochloromethanesulfonyl chloride

: 475641-72-6
[(2R,4S,5R)-5-((4R,5S)-4-Allyl-2-phenyl-[1,3,2]dioxaborinan-5-yloxy)-2-phenyl-[1,3]dioxan-4-yl]-methanol

: 475641-82-8
Chloro-methanesulfonic acid (2R,4S,5R)-5-((4R,5S)-4-allyl-2-phenyl-[1,3,2]dioxaborinan-5-yloxy)-2-phenyl-[1,3]dioxan-4-ylmethyl ester

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 21 - 23℃;	98%

: N-[(1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl]-5-chloro-1H-indole-2-carboxamide trifluoroacetic acid salt

: 3518-65-8
monochloromethanesulfonyl chloride

: 5-chloro-N-((1R,2R)-1-([(chloromethyl)sulfonyl]amino)-2,3-dihydro-1H-inden-2-yl)-1H-indole-2-carboxamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 5 - 25℃; for 2h;	98%

: 3-(2,3-dihydro-1H-indol-5-yl)-5-vinyl-3H-imidazo[4,5-b]pyridine

: 3518-65-8
monochloromethanesulfonyl chloride

: 878389-72-1
3-{1-[(chloromethyl)sulfonyl]2,3-dihydro-1H-indol-5-yl}-5-vinyl-3H-imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.333333h;	98%

: 3518-65-8
monochloromethanesulfonyl chloride

: 119020-01-8
(S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1037297-36-1
C11H21ClN2O4S

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 17h;	98%

: 3518-65-8
monochloromethanesulfonyl chloride

: C31H46O10Si

: C19H27ClO12S

Conditions

Conditions	Yield
Stage #1: C31H46O10Si With pyridine; tetra-(n-butyl)ammonium iodide; pyridine hydrogenfluoride In dichloromethane at 0℃; Stage #2: monochloromethanesulfonyl chloride In dichloromethane at -30℃;	98%

: 3518-65-8
monochloromethanesulfonyl chloride

: C19H36O5Si

: C20H37ClO7SSi

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 0℃; for 1h; Inert atmosphere;	98%

: 3518-65-8
monochloromethanesulfonyl chloride

: 307315-79-3
(4R,5S,6R)-1-tert-butyldimethylsilyloxy-4,5,7-tribenzyloxy-2(E)-hepten-6-ol

: 307315-80-6
(4R,5S,6R)-1-tert-butyldimethylsilyloxy-6-[(chloromethylsulfonyl)-oxy]-4,5,7-tribenzyloxy-2(E)-heptene

Conditions

Conditions	Yield
With pyridine at 20℃; for 0.5h; Substitution;	97%

: 3518-65-8
monochloromethanesulfonyl chloride

: tert-butyl [(3S,5R)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-{[(3aR,6R,7R,7aS)-7-hydroxy-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-6-yl]methyl}-2-oxotetrahydrofuran-3-yl]carbamate

: (3aR,6R,7R,7aR)-6-{[(2R,4S)-4-[(tert-butoxycarbonyl)amino]-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-oxotetrahydrofuran-2-yl]methyl}-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-7-yl chloromethanesulfonate

Conditions

Conditions	Yield
With pyridine; dmap at 0 - 20℃; for 1.5h;	97%

: acetic acid 3-hydroxy-5-triisopropylsilanyloxy-2,4-divinyl-cyclopentyl ester

: 3518-65-8
monochloromethanesulfonyl chloride

: C21H37ClO6SSi

Conditions

Conditions	Yield
With pyridine at -10℃; for 4h;	95%

Chloromethanesulfonyl chloride Chemical Properties

Product Name: Chloromethanesulfonyl chloride (3518-65-8)
CAS: 3518-65-8
Synonyms: Chlorid kyseliny Chlormethansulfonove ; Chloridkyselinychlormethansulfonove ; Chlormethansulfochlorid ; Chlormethansulfonylchlorid ; chloro-methanesulfonylchlorid ; Methanesulfonyl chloride, chloro- ; Rarechem aw ha 0004 ; Cmsc

MF: CH₂Cl₂O₂S
MW: 149
Molecular Structure:
EINECS: 222-526-1
Product Categories:
Mol File: 3518-65-8.mol
BP: 80-81°C
Density 1.64 g/mL at 20 °C(lit.)
Refractive index : 1.488
Sensitive: Moisture Sensitive
Surface Tension: 46.5 dyne/cm
Density: 1.677 g/cm3
Flash Point: 73.4 °C
Enthalpy of Vaporization: 41.62 kJ/mol
Boiling Point: 197.8 °C at 760 mmHg
Vapour Pressure: 0.524 mmHg at 25°C

Chloromethanesulfonyl chloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	oral	372mg/kg (372mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1070, 1986.

Chloromethanesulfonyl chloride Safety Profile

Hazard Codes: C,Xi
Risk Statements : 22-34
22: Chloromethanesulfonyl chloride (3518-65-8) is harmful if swallowed
34: Chloromethanesulfonyl chloride (3518-65-8) causes burns
Safety Statements: 26-36/37/39-45
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Chloromethanesulfonyl chloride (3518-65-8) used,wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR: UN 3265 8/PG 2
WGK Germany : 3
RTECS: PB2800000
F: 10-21
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: I

Product Name

Chloromethanesulfonyl chloride

Synthetic route

Chloromethanesulfonyl chloride Chemical Properties

Chloromethanesulfonyl chloride Toxicity Data With Reference

Chloromethanesulfonyl chloride Safety Profile

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