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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

D-(-)-Pantolactone

Cas:599-04-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply α-hydroxy-β,β-dimethyl-γ-butyrolactone

Cas:599-04-2

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

D-(-)-Pantolactone

Cas:599-04-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Factory price D-(-)-PANTOLACTONE CAS 599-04-2 in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediates (Fluorene,Carb

Factory price D-(-)-PANTOLACTONE CAS 599-04-2 in stock

Cas:599-04-2

Min.Order:1 Gram

FOB Price: $50.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 599-04-2 with best quality

Cas:599-04-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 599-04-2 D-Pantolactone

Cas:599-04-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

599-04-2/2,4-DIHYDROXY-3,3-DIMETHYLBUTYRIC ACID GAMMA-LACTONE

Cas:599-04-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

D-(-)-PANTOLACTONECAS NO.:599-04-2

Cas:599-04-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

D-(-)-PANTOLACTONE

Cas:599-04-2

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (3R)- 599-04-2

Cas:599-04-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

D-(-)-PANTOLACTONE /CAS:599-04-2

Cas:599-04-2

Min.Order:1 Kilogram

FOB Price: $70.0 / 80.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

D-(-)-PANTOLACTONE CAS:599-04-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermed

D-(-)-PANTOLACTONE CAS:599-04-2

Cas:599-04-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (3R)-

Cas:599-04-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Biggest Factory Manufacturer Supply D-Pantolactone CAS 599-04-2

Cas:599-04-2

Min.Order:100 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

D-(-)-PANTOLACTONE

Cas:599-04-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

1) For products exported we can offer COA Certificate and official PI. 2) We are manufacturer with own lab and factory, can provide high quality products with factory price. 3) Products can be sent out in 24 hours after payment. Tracking number avai

D-(-)-PANTOLACTONE CAS 599-04-2 with best price

Cas:599-04-2

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

D-(-)-PANTOLACTONE

Cas:599-04-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

D-(-)-PANTOLACTONE

Cas:599-04-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

D-(-)-pantolactone

Cas:599-04-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

D-(-)-Pantolactone

Cas:599-04-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2(3H)-Furanone,dihydro-3-hydroxy-4,4-dimethyl-, (3R)-

Cas:599-04-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

D-(-)-PANTOLACTONE

Cas:599-04-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality D-(-)-Pantolactone

Cas:599-04-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Factory supply D-Pantolactone/599-04-2

Cas:599-04-2

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

D-(-)-PANTOLACTONE

Cas:599-04-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

D-(-)-Pantolactone

Cas:599-04-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Factory supply D-Pantolactone/599-04-2

Cas:599-04-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: D-Pantolactone CAS No.:599-04-2 Molecule Formula:C6H10O3 Molecule Weight:130.14 Purity: 98.0% Package: 25kg/drum Description:White solid Manufacture Standards:Enterprise Standard Testing Index

Lower Price D-Pantolactone

Cas:599-04-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

D-(-)-PANTOLACTONE

Cas:599-04-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Factory supply D-Pantolactone/599-04-2

Cas:599-04-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

ketopantolactone
13031-04-4

ketopantolactone

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With chiral Rh complex derived from N,O-bis(dicyclopentylphosphinyl)-(S)-2-hydroxymethylindoline; hydrogen In toluene at 20℃; under 750.06 Torr; for 0.17h;100%
With (R)-N-dicyclohexylphosphino-N-methyl-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; hydrogen; bis(cycloocta-1,5-diene)rhodium(I) trifluoromethanesulfonate In ethyl acetate at 25℃; under 15514.4 Torr; for 1.25h;99%
With D-glucose; Rhodotorula minuta IFO 0920 at 28℃; for 36h;80.3%
D-potassium pantoate

D-potassium pantoate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 0.5h; pH=1 - 2; Reagent/catalyst;96.9%
(R)-2,4-dihydroxy-N-<(1R)-2-endo-hydroxy-3-endo-bornyl>-3,3-dimethylbutyramide
107730-03-0

(R)-2,4-dihydroxy-N-<(1R)-2-endo-hydroxy-3-endo-bornyl>-3,3-dimethylbutyramide

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 40℃; for 1h;96.8%
ketopantolactone
13031-04-4

ketopantolactone

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (2S,4S)-N-butoxycarbonyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidine In toluene at 50℃; under 37503 Torr; for 45h; Yields of byproduct given. Title compound not separated from byproducts;A n/a
B 95%
With hydrogen; (S)-Cp-isoAlaNOP - 2 In toluene at 20℃; under 760 Torr; for 0.5h; Title compound not separated from byproducts;
With magnesium(II) perchlorate; (S)-3-(N,N-dimethylcarbamoyl)-1,2,4-trimethyl-1,4-dihydropyridine In [D3]acetonitrile -25 degC to r.t, 1 h;
D-sodium pantoate
60979-68-2

D-sodium pantoate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 0.5h; pH=1 - 2; Reagent/catalyst;94.7%
3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one
133094-78-7

3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With phosphomolybdic acid hydrate; silica gel In tetrahydrofuran at 20℃; for 12h;94%
With iron(III) p-toluenesulfonate hexahydrate In methanol for 27.5833h; Reflux; chemoselective reaction;84%
(R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on
20374-33-8

(R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol optical yield given as %ee;93%
2(R)-hydroxy-3,3-dimethyl-4-oxo-butxyric acid ethyl ester
1196498-52-8

2(R)-hydroxy-3,3-dimethyl-4-oxo-butxyric acid ethyl ester

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0℃;93%
With sodium cyanoborohydride In methanol Reagent/catalyst; Solvent; Cooling with ice;93%
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / diethyl ether / 20 °C
1.2: Saturated solution
2.1: toluene-4-sulfonic acid / diethyl ether / 20 °C
View Scheme
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; (R)-N-(2-hydroxyethyl)pyrrolidine-2-carboxamide; sodium formate In water; tert-butyl alcohol at 40℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere;
(R)-4-Chloro-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-4-Chloro-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h;88%
methyl 2-hydroxy-3,3-dimethyl-4-oxobutanoate

methyl 2-hydroxy-3,3-dimethyl-4-oxobutanoate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol Cooling with ice;87%
D-pantoic acid
1112-33-0

D-pantoic acid

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
at 90 - 95℃;85%
(R)-2-Hydroxy-4-methoxy-3,3-dimethyl-butyronitrile

(R)-2-Hydroxy-4-methoxy-3,3-dimethyl-butyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h;78%
(R)-acetic acid 4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl ester
28227-36-3

(R)-acetic acid 4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl ester

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With sodium methylate In methanol for 0.5h; Ambient temperature;76.6%
(R)-4-Bromo-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-4-Bromo-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h;65%
(R)-2,4-Dihydroxy-3,3-dimethylbutyronitrile
134929-92-3

(R)-2,4-Dihydroxy-3,3-dimethylbutyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride for 8.5h; Ambient temperature;62%
With hydrogenchloride In methanol; water at 20℃; Reflux;
(R)-4-Allyloxy-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-4-Allyloxy-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h;62%
(R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-3,3-dimethyl-butyric acid
158045-18-2

(R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-3,3-dimethyl-butyric acid

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With toluene-4-sulfonic acid In chloroform60%
methanol
67-56-1

methanol

C13H18O6
861855-32-5

C13H18O6

A

C8H12O4
861855-40-5

C8H12O4

B

methyl-2,3-dideoxy-4,6-O-methylene-D-erythro-hex-2-enopyranoside

methyl-2,3-dideoxy-4,6-O-methylene-D-erythro-hex-2-enopyranoside

C

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
lanthanum(lll) triflate In acetonitrile at 20℃; for 15h; Product distribution / selectivity;A n/a
B n/a
C 60%
erbium(III) triflate In acetonitrile Product distribution / selectivity;
scandium tris(trifluoromethanesulfonate) In acetonitrile Product distribution / selectivity;
iron(III) chloride In acetonitrile Product distribution / selectivity;
(R)-4-Ethoxy-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-4-Ethoxy-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h;55%
methanol
67-56-1

methanol

C13H18O6
861855-32-5

C13H18O6

A

methyl-2,3-dideoxy-4,6-O-methylene-D-erythro-hex-2-enopyranoside

methyl-2,3-dideoxy-4,6-O-methylene-D-erythro-hex-2-enopyranoside

B

C9H16O5
1222471-59-1

C9H16O5

C

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With 10M acid-treated K10 Montmorillonite at 40℃; for 8h; optical yield given as %ee;A 18%
B 13%
C 35%
(RS)-2-acetoxy-3,3-dimethyl-γ-butyrolactone
28227-35-2

(RS)-2-acetoxy-3,3-dimethyl-γ-butyrolactone

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With yeast lipase; butan-1-ol In di-isopropyl ether at 30℃; for 336h; Title compound not separated from byproducts;
With sodium phosphate buffer; esterase B from Candida antarctica In water at 37℃; for 1h; pH=7.3; Product distribution;
pantothenic acid
79-83-4

pantothenic acid

A

(R)-Pantolacton
599-04-2

(R)-Pantolacton

B

3-amino propanoic acid
107-95-9

3-amino propanoic acid

Conditions
ConditionsYield
With pantothenase UK-1 at 25℃; Equilibrium constant;
DL-sodium pantoate
1902-01-8

DL-sodium pantoate

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With (+)-10-camphorsulfonic acid In various solvent(s) in 99.5 percent EtOH; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With (1S)-(+)-camphorsulfonic acid monohydrate In various solvent(s) at -78℃; Product distribution; 99.5 percent EtOH;
C22H38N2O8
144762-89-0

C22H38N2O8

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 90℃; for 12h;
Acetic acid (R)-3-cyano-3-hydroxy-2,2-dimethyl-propyl ester

Acetic acid (R)-3-cyano-3-hydroxy-2,2-dimethyl-propyl ester

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
(R)-4-Benzyloxy-2-hydroxy-3,3-dimethyl-butyronitrile

(R)-4-Benzyloxy-2-hydroxy-3,3-dimethyl-butyronitrile

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogenchloride at 115℃; for 5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
(R)-4,4-Dimethyl-3-((S)-1-phenyl-ethoxy)-dihydro-furan-2-one

(R)-4,4-Dimethyl-3-((S)-1-phenyl-ethoxy)-dihydro-furan-2-one

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol
R(-)pantoyllactone-β-D-glucopyranoside
171884-77-8

R(-)pantoyllactone-β-D-glucopyranoside

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With ammonium sulfate; potassium phosphate buffer In water Ambient temperature; β-glucosidase presence;
(R)-(1-naphthyl)-glycyl-(R)-phenylglycine
160289-70-3

(R)-(1-naphthyl)-glycyl-(R)-phenylglycine

pantolactone
79-50-5

pantolactone

A

(R)-Pantolacton
599-04-2

(R)-Pantolacton

B

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (S)-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (S)-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one

C

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (R)-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (R)-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one

Conditions
ConditionsYield
In methanol Ambient temperature; Yield given; Title compound not separated from byproducts;
3-diphenylsilanyloxy-4,4-dimethyl-dihydro-furan-2-one

3-diphenylsilanyloxy-4,4-dimethyl-dihydro-furan-2-one

B

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol Hydrolysis; Title compound not separated from byproducts;
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl trifluoromethanesulfonate
157717-57-2

(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl trifluoromethanesulfonate

Conditions
ConditionsYield
With pyridine In dichloromethane at -78 - 23℃; for 3.5h; Inert atmosphere;100%
With pyridine In dichloromethane at 20℃; for 19.0667h; Inert atmosphere; Cooling with acetone-dry ice;98%
In pyridine; dichloromethane at -78 - 20℃; for 1.16667h; Inert atmosphere;96%
benzoyl chloride
98-88-4

benzoyl chloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-benzoic acid 4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl ester

(R)-benzoic acid 4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl ester

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0℃; for 0.5h;100%
With dmap; triethylamine In dichloromethane at 0 - 5℃;90.59%
ethylenediamine
107-15-3

ethylenediamine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(2R)-N-(2-aminoethyl)-2,4-dihydroxy-3,3-dimethylbutyramide
616235-99-5

(2R)-N-(2-aminoethyl)-2,4-dihydroxy-3,3-dimethylbutyramide

Conditions
ConditionsYield
at 55℃;100%
In ethanol at 120℃; for 2h; Microwave irradiation;37%
at 55℃;
methylamine
74-89-5

methylamine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-2,4-dihydroxy-N-3,3-trimethylbutanamide
88308-84-3

(R)-2,4-dihydroxy-N-3,3-trimethylbutanamide

Conditions
ConditionsYield
In methanol; water at 25℃; for 3h; Inert atmosphere;100%
In methanol at 20℃; for 3h; Inert atmosphere;97%
4-methoxybenzyl-2,2,2-trichloroacetimidate

4-methoxybenzyl-2,2,2-trichloroacetimidate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(3R)-3-(4-methoxybenzyloxy)-4,4-dimethyltetrahydrofuran-2-one

(3R)-3-(4-methoxybenzyloxy)-4,4-dimethyltetrahydrofuran-2-one

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In diethyl ether at 0 - 20℃; for 1h; Inert atmosphere;100%
triisopropylsilyl trifluoromethanesulfonate
80522-42-5

triisopropylsilyl trifluoromethanesulfonate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-4,4-dimethyl-3-((triisopropylsilyl)oxy)dihydrofuran-2(3H)-one

(R)-4,4-dimethyl-3-((triisopropylsilyl)oxy)dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 20℃; for 96h; Inert atmosphere;100%
(R)-Pantolacton
599-04-2

(R)-Pantolacton

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

hopantenic acid
18679-90-8

hopantenic acid

Conditions
ConditionsYield
Stage #1: 4-amino-n-butyric acid With sodium hydroxide In water
Stage #2: (R)-Pantolacton at 130℃; for 17h; Inert atmosphere;
99%
With triethylamine In methanol at 65℃; for 24h; Inert atmosphere;89%
With diethylamine In methanol at 60℃;53%
With sodium methylate
With diethylamine In methanol
(R)-Pantolacton
599-04-2

(R)-Pantolacton

6-aminohexanoic acid
60-32-2

6-aminohexanoic acid

N-((R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-6-aminohexanoic acid

N-((R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-6-aminohexanoic acid

Conditions
ConditionsYield
With N,N,N',N'-tetramethylguanidine In methanol at 26℃; for 40h;99%
With diethylamine In methanol
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one
133094-78-7

3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 2.5h;99%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 3h;99%
With 1H-imidazole In tetrahydrofuran at 20℃; for 24h; Substitution;97%
(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-2,4-Dihydroxy-3,3-dimethylbutyramide
27778-35-4

(R)-2,4-Dihydroxy-3,3-dimethylbutyramide

Conditions
ConditionsYield
With ammonia Inert atmosphere;99%
With ammonia In methanol at 20℃; for 24h;99%
at 20 - 60℃; for 6h;95%
O-benzyl 2,2,2-trichloroacetimidate
81927-55-1

O-benzyl 2,2,2-trichloroacetimidate

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on
20374-33-8

(R)-(+)-3-(Benzyloxy)-4,5-dihydro-4,4-dimethyl-furan-2(3H)-on

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 15h;98%
With trifluorormethanesulfonic acid In hexane; dichloromethane for 1h;83%
With trifluorormethanesulfonic acid In dichloromethane benzylation;
dimethyl amine
124-40-3

dimethyl amine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

D(-)2R,4-dihydroxy-3,3-dimethyl-N,N-dimethyl-butyramide

D(-)2R,4-dihydroxy-3,3-dimethyl-N,N-dimethyl-butyramide

Conditions
ConditionsYield
In ethanol for 72h;98%
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

Chloro-methanesulfonic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester
182243-70-5

Chloro-methanesulfonic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 0.166667h;98%
(R)-Pantolacton
599-04-2

(R)-Pantolacton

(2R)-(-)-3,3-dimethylbutane-1,2,4-triol
60856-63-5

(2R)-(-)-3,3-dimethylbutane-1,2,4-triol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;97%
Stage #1: (R)-Pantolacton With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 4h;
Stage #2: With sulfuric acid; sodium sulfate In tetrahydrofuran; water pH=Ca. 3;
88%
Stage #1: (R)-Pantolacton With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;
Stage #2: With sodium hydroxide; water In tetrahydrofuran at 0℃;
82%
(S)-1-phenyl-ethylamine
2627-86-3

(S)-1-phenyl-ethylamine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-2,4-Dihydroxy-3,3-dimethyl-N-((S)-1-phenyl-ethyl)-butyramide

(R)-2,4-Dihydroxy-3,3-dimethyl-N-((S)-1-phenyl-ethyl)-butyramide

Conditions
ConditionsYield
With triethylamine In ethanol for 7h; Heating;97%
methyl 3-aminopropanoate hydrochloride
3196-73-4

methyl 3-aminopropanoate hydrochloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

C8H15NO5

C8H15NO5

Conditions
ConditionsYield
Stage #1: methyl 3-aminopropanoate hydrochloride With diethylamine In methanol at 0℃; for 0.25h; Inert atmosphere;
Stage #2: (R)-Pantolacton In methanol at 60℃; for 20h; Inert atmosphere;
97%
(1R,2R,3S,4S)-3-Amino-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol
29900-93-4

(1R,2R,3S,4S)-3-Amino-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-2,4-dihydroxy-N-<(1R)-2-endo-hydroxy-3-endo-bornyl>-3,3-dimethylbutyramide
107730-03-0

(R)-2,4-dihydroxy-N-<(1R)-2-endo-hydroxy-3-endo-bornyl>-3,3-dimethylbutyramide

Conditions
ConditionsYield
In ethanol at 78℃; for 3h;96.2%
4-methyleneoxetan-2-one
674-82-8

4-methyleneoxetan-2-one

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 3-oxobutanoate
186899-17-2

(R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 3-oxobutanoate

Conditions
ConditionsYield
With sodium acetate In acetonitrile for 2h; Heating;96%
chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

(R)-Pantolacton
599-04-2

(R)-Pantolacton

3R-(-)-dihydro-4,4-dimethyl-3-<(methoxymethyl)oxy>-2(3H)-furanone
165450-30-6

3R-(-)-dihydro-4,4-dimethyl-3-<(methoxymethyl)oxy>-2(3H)-furanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 40℃; for 20h;96%
With N-ethyl-N,N-diisopropylamine In dichloromethane; toluene at 0℃; for 24h; Reflux;95%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 48h; Inert atmosphere;90%
With sodium hydride In tetrahydrofuran for 1h; Ambient temperature;89%
With lithium diisopropyl amide In dichloromethane Ambient temperature;75%
cyanomethylene triphenylphosphorane
16640-68-9

cyanomethylene triphenylphosphorane

(R)-Pantolacton
599-04-2

(R)-Pantolacton

[(R)-3-Hydroxy-4,4-dimethyl-dihydro-furan-(2E)-ylidene]-acetonitrile

[(R)-3-Hydroxy-4,4-dimethyl-dihydro-furan-(2E)-ylidene]-acetonitrile

Conditions
ConditionsYield
In toluene for 0.0666667h; Condensation; Irradiation;96%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(R)-Pantolacton
599-04-2

(R)-Pantolacton

O-(toluene-4-sulfonyl)-D-pantolactone
20374-31-6

O-(toluene-4-sulfonyl)-D-pantolactone

Conditions
ConditionsYield
dmap In pyridine Ambient temperature;95%
With pyridine
propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

pantothenol
81-13-0

pantothenol

Conditions
ConditionsYield
With triethylamine In ethanol at 160℃; for 3h; Microwave irradiation;95%
With methanol
at 60℃; for 5h;
n-Dodecylamine
124-22-1

n-Dodecylamine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(2R)-N-Dodecyl-2,4-dihydroxy-3,3-dimethylbutanamid
117801-01-1

(2R)-N-Dodecyl-2,4-dihydroxy-3,3-dimethylbutanamid

Conditions
ConditionsYield
at 115℃; for 3h;95%
(E)-2-oxo-4-phenyl-3-butenoic acid
1914-59-6

(E)-2-oxo-4-phenyl-3-butenoic acid

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(E)-2-Oxo-4-phenyl-but-3-enoic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

(E)-2-Oxo-4-phenyl-but-3-enoic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃;95%
(R)-Pantolacton
599-04-2

(R)-Pantolacton

6,8-dimethoxy-3-(1-methyl-2-oxo-vinyl)-isochromen-1-one
447407-66-1

6,8-dimethoxy-3-(1-methyl-2-oxo-vinyl)-isochromen-1-one

(R)-2-(6,8-Dimethoxy-1-oxo-1H-isochromen-3-yl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester
447407-65-0

(R)-2-(6,8-Dimethoxy-1-oxo-1H-isochromen-3-yl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Conditions
ConditionsYield
at -40℃; for 1.66667h;95%
4-(methylthio)benzylamine
83171-39-5

4-(methylthio)benzylamine

(R)-Pantolacton
599-04-2

(R)-Pantolacton

(R)-(+)-2,4-dihydroxy-3,3-dimethyl-N-(4-methyl-sulfanyl-benzyl)butyramide
1227380-62-2

(R)-(+)-2,4-dihydroxy-3,3-dimethyl-N-(4-methyl-sulfanyl-benzyl)butyramide

Conditions
ConditionsYield
In toluene at 65℃; Inert atmosphere;95%
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