Conditions | Yield |
---|---|
With 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine In dichloromethane at 20℃; for 18h; Acylation; | 96% |
With dicyclohexyl-carbodiimide |
Conditions | Yield |
---|---|
With 1,4-dioxane at 70 - 80℃; folgendes Destillieren des Reaktionsgemisches; |
Conditions | Yield |
---|---|
With acetic anhydride |
Conditions | Yield |
---|---|
With dichloromethane; mercury(II) oxide |
crotonyl chloride
triethylamine
benzene
trans-crotonic anhydride
diethyl ether
(E)-but-2-enoic acid
1-ethoxyacetylene
trans-crotonic anhydride
Conditions | Yield |
---|---|
With diethyl ether |
Conditions | Yield |
---|---|
With oxygen; cobalt(II) acetate; acetic acid at 30℃; unter leichtem Ueberdruck; | |
With oxygen; copper (I) acetate; acetic acid at 30℃; unter leichtem Ueberdruck; | |
With oxygen; manganese(II) acetate; acetic acid at 30℃; unter leichtem Ueberdruck; | |
With oxygen; acetic acid at 30℃; in Gegenwart einer Mischung von Wismut-,Kobalt- und Kupferpulver; |
trans-chrotonyl chloride
trans-crotonic anhydride
trans-crotonic anhydride
Conditions | Yield |
---|---|
With thionyl chloride; Petroleum ether |
trans-crotonic anhydride
methyl 2-O-benzyl-4,6-di-O-methyl-α-D-mannopyranoside
methyl 2-O-benzyl-3-O-crotonyl-4,6-di-O-methyl-α-D-mannopyranoside
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 16h; | 100% |
trans-crotonic anhydride
polymer, product of radical polymerization, loading of chiral auxiliary 2.42 mmol/g, Mn=5800, Mw=7000 (GPC, polystyrene standards); monomer(S): styrene; (4S)-4-{4-[(4-vinylbenzyl)oxy]benzyl}-1,3-oxazolidin-2-one
polymer, loading of chiral auxiliary 2.42 mmol/g, Mn=7500, Mw=10000 (GPC, polystyrene standards); monomer(s): styrene; (4S)-4-{4-[(4-vinylbenzyl)oxy]benzyl}-1,3-oxazolidin-2-one; trans-crotonic anhydride
Conditions | Yield |
---|---|
With dmap; triethylamine In tetrahydrofuran at 70℃; for 48h; | 100% |
methyl 6-deoxy-2,3-bis-O-(phenylmethyl)-α-D-glucopyranoside
trans-crotonic anhydride
methyl 2,3-di-O-benzyl-4-O-crotonyl-6-deoxy-α-D-glucopyranoside
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 20.5h; | 99% |
trans-crotonic anhydride
methyl 2,4,6-tri-O-benzyl-α-D-galactopyranoside
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 120h; | 98% |
trans-crotonic anhydride
methyl-2,3-di-O-benzyl-6-O-(4-toluenesulfonyl)-α-D-glucopyranoside
methyl 2,3-di-O-benzyl-4-O-crotonyl-6-O-p-toluenesulfonyl-α-D-glucopyranoside
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 23h; | 98% |
trans-crotonic anhydride
methyl 2,3-di-O-pivaloyl-6-O-p-toluenesulfonyl-α-D-glucopyranoside
methyl 4-O-crotonyl-2,3-di-O-pivaloyl-6-O-p-toluenesulfonyl-α-D-glucopyranoside
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 23h; | 98% |
trans-crotonic anhydride
(S)-4-Benzyl-2-oxazolidinone
(4S)-3-((E)-2-butenoyl)-4-benzyl-2-oxazolidinone
Conditions | Yield |
---|---|
With triethylamine; lithium chloride In tetrahydrofuran at -15 - 20℃; for 12h; | 97% |
With triethylamine; lithium chloride In tetrahydrofuran for 4h; Ambient temperature; | 88% |
methyl O-2,3,6-tri-O-benzyl-α-D-glucopyranoside
trans-crotonic anhydride
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 21h; | 97% |
Conditions | Yield |
---|---|
With ytterbium(III) chloride In tetrahydrofuran | 97% |
trans-crotonic anhydride
5-(2-((4S,6R)-6-((2S,3S)-3-(benzyloxy)-2-hydroxybutyl)-2,2-diisopropyl-1,3,2-dioxasilinan-4-yl)propan-2-yl)furan-2-carbaldehyde
(E)-((2S,3S)-3-(benzyloxy)-1-((4R,6S)-6-(2-(5-formylfuran-2-yl)propan-2-yl)-2,2-diisopropyl-1,3,2-dioxasilinan-4-yl)butan-2-yl) but-2-enoate
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 0℃; for 4h; Inert atmosphere; | 97% |
2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]propan-1-ol
trans-crotonic anhydride
but-2-enoic acid 2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]propyl ester
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 0℃; for 4h; | 96% |
Conditions | Yield |
---|---|
Acidic catalyst In cyclohexane Heating; | 95% |
trans-crotonic anhydride
1,3-dimethyl-5-adamantanol
3,5-Dimethyl-1-adamantyl crotonate
Conditions | Yield |
---|---|
Acidic catalyst In cyclohexane Heating; | 95% |
trans-crotonic anhydride
(1R,2R,3S,4R)-3-O-tert-Butyldimethylsilyl-1,2-O-cyclohexylidene-5-hydroxymethyl-5-cyclohexen-1,2,3,4-tetraol
(1R,2R,3S,4R)-3-O-tert-Butyldimethylsilyl-5-crotonyloxymethyl-1,2-O-cyclohexylidene-5-cyclohexen-1,2,3,4-tetraol
Conditions | Yield |
---|---|
With pyridine; dmap In dichloromethane | 95% |
With pyridine; dmap In dichloromethane for 12h; Ambient temperature; | 95% |
trans-crotonic anhydride
methyl 6-deoxy-2,3-di-O-methyl-α-D-glucopyranoside
methyl 4-O-crotonyl-6-deoxy-2,3-di-O-methyl-α-D-glucopyranoside
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 13h; | 95% |
trans-crotonic anhydride
(S)-4-benzyl-5,5-dimethyloxazolidin-2-one
(S)-3-((E)-but-2-enoyl)-4-benzyl-5,5-dimethyloxazolidin-2-one
Conditions | Yield |
---|---|
With triethylamine; lithium chloride In tetrahydrofuran at -78 - 20℃; for 12h; | 94% |
trans-crotonic anhydride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20 - 30℃; for 1h; | 94% |
trans-crotonic anhydride
methyl 6-deoxy-2,3-di-O-pivaloyl-α-D-glucopyranoside
methyl 4-O-crotonyl-6-deoxy-2,3-di-O-pivaloyl-α-D-glucopyranoside
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 19h; | 93% |
methyl 2,3,4-tri-O-benzyl-D-glucopyranoside
trans-crotonic anhydride
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 18h; | 92% |
trans-crotonic anhydride
methyl 2,3-di-O-benzyl-6-O-pivaloyl-α-D-glucopyranoside
methyl 2,3-di-O-benzyl-4-O-crotonyl-6-O-pivaloyl-α-D-glucopyranoside
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 7h; | 92% |
dimethylenecyclourethane
trans-crotonic anhydride
3-((E)-but-2-enoyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With triethylamine; lithium chloride In tetrahydrofuran | 92% |
10-Deacetylbaccatine III
trans-crotonic anhydride
Conditions | Yield |
---|---|
With cerium(III) chloride In tetrahydrofuran at 25℃; for 20h; Under N2; | 91% |
cerium(III) chloride In tetrahydrofuran at 25℃; for 20h; | 91% |
trans-crotonic anhydride
Conditions | Yield |
---|---|
Stage #1: (E)-N-(4-(3-hydroxyhexa-1,5-dien-1-yl)phenyl)nicotinamide With dmap; triethylamine In dichloromethane at 0℃; Stage #2: trans-crotonic anhydride In dichloromethane at 0 - 20℃; for 3h; | 90% |
Conditions | Yield |
---|---|
Stage #1: trimethylsilyl cyanide; benzaldehyde; iron(III) chloride In nitromethane at 0℃; for 0.5h; Stage #2: trans-crotonic anhydride In nitromethane at 20℃; for 3h; | 89% |
trans-crotonic anhydride
carbon monoxide
2-bromoaniline
(E)-2-(prop-1-en-1-yl)-4H-benzo[d][1,3]oxazin-4-one
Conditions | Yield |
---|---|
With potassium tetrachloropalladate(II); N-ethyl-N,N-diisopropylamine; catacxium A In toluene at 100℃; under 1500.15 Torr; for 16h; Autoclave; | 88% |
trans-crotonic anhydride
Conditions | Yield |
---|---|
With dmap In pyridine at 20℃; for 5h; | 88% |
trans-crotonic anhydride
(2R)-bornane-10,2-sultam
(1S)-N-crotyl-2,10-camphorsultam
Conditions | Yield |
---|---|
With triethylamine; lithium chloride In tetrahydrofuran for 4h; Ambient temperature; | 87% |
(4S,5R)-4-benzyl-5-(1'H,1'H,2'H,2'H-perfluorooctyl)-oxazolidin-2-one
trans-crotonic anhydride
(E)-(4S,5R)-4-benzyl-3-(2'-butenoyl)-5-(1'H,1'H,2'H,2'H-perfluorooctyl)-2-oxazolidinone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; lithium chloride In tetrahydrofuran for 24h; Heating; | 87% |
Chemistry informtion about Crotonic Anhydride (CAS NO.623-68-7) is:
IUPAC Name: [(E)-But-2-Enoyl] (E)-But-2-Enoate
Synonyms: 2-Butenoicacid,Anhydride ; Anhydridkyselinykrotonove ; Crotonicacidanhydride ; Crotonic Anhydride ; 2-Butenoic Anhydride ; Trans-2-Butenoic Anhydride ; 2-Butensureanhydrid ; Crotonsaeureanhydrid
Product Categories: Pharmaceutical Intermediates
MF: C8H10O3
MW: 154.16
EINECS: 210-807-1
Density: 1.038 g/cm3
Flash Point: 106.1 °C
Boiling Point: 247 °C at 760 mmHg
Vapour Pressure: 0.0263 mmHg at 25°C
Enthalpy of Vaporization: 48.41 kJ/mol
Refractive Index: n20/D 1.473(lit.)
Following is the molecular structure of Crotonic Anhydride (CAS NO.623-68-7) is:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rat | LD50 | oral | 2830mg/kg (2830mg/kg) | American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962. |
Reported in EPA TSCA Inventory.
Moderately toxic by ingestion. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
C
Risk Statements:
R34:Causes burns.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3265 8/PG 3
WGK Germany: 3
RTECS: GQ6125000
HazardClass: 8
PackingGroup III
To protect yourself, you can put on faceshields, full-face respirator (US), gloves, goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter.
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