Product Name

  • Name

    Cycloleucine

  • EINECS 200-144-6
  • CAS No. 52-52-8
  • Article Data18
  • CAS DataBase
  • Density 1.207 g/cm3
  • Solubility 5 g/100 mL in waier
  • Melting Point 320 °C (dec.)(lit.)
  • Formula C6H11NO2
  • Boiling Point 256.1 °C at 760 mmHg
  • Molecular Weight 129.159
  • Flash Point 108.7 °C
  • Transport Information UN 2811 6.1/PG 3
  • Appearance white to beige crystalline flakes or powder
  • Safety 22-24/25
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 52-52-8 (Cycloleucine)
  • Hazard Symbols IrritantXi, HarmfulXn
  • Synonyms 1-Amino-1-carboxycyclopentane;1-Aminocyclopentane-1-carboxylic acid;1-Aminocyclopentanecarboxylic acid;ACPC;Cycloleucin;NSC 1026;NSC 112194;NSC 112195;NSC 112197;WR 14997;
  • PSA 63.32000
  • LogP 1.04280

Synthetic route

1-amino-1-cyanocyclopentane
49830-37-7

1-amino-1-cyanocyclopentane

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With hydrogenchloride; water In 1,4-dioxane for 8h; Inert atmosphere; Reflux;99%
With hydrogenchloride
1,3-diazaspiro[4.4]nonane-2,4-dione
699-51-4

1,3-diazaspiro[4.4]nonane-2,4-dione

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide Heating;75%
With barium dihydroxide In water for 3h; Heating;71%
With barium hydroxide octahydrate; water In water at 160℃; for 2h; Autoclave;70%
1-hydroxyamino-cyclopentanecarboxylic acid
2627-43-2

1-hydroxyamino-cyclopentanecarboxylic acid

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With ammonium hydroxide; palladium Hydrogenation;
potassium cyanide
151-50-8

potassium cyanide

cyclopentanone
120-92-3

cyclopentanone

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With ethanol; ammonium chloride Verseifen des Nitrils durch Erhitzen mit Salzsaeure;
1-<(Diphenylmethylene)-amino>-1-cyclopentanecarbonitrile
89985-89-7

1-<(Diphenylmethylene)-amino>-1-cyclopentanecarbonitrile

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With hydrogenchloride 1.) ether, 12 h, room temp., 2.) reflux; Yield given. Multistep reaction;
1,3-diaza-spiro<4,4>nonanedione-(2,4)

1,3-diaza-spiro<4,4>nonanedione-(2,4)

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sulfuric acid at 140℃;
cyclopentanone
120-92-3

cyclopentanone

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / (NH4)2CO3 / ethanol; H2O / 2 h / 58 - 60 °C
2: 71 percent / Ba(OH)2*8H2O / H2O / 3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: H2O; NH2OH+HCl
2: aqueous HCl
3: palladium; aqueous NH3 / Hydrogenation
View Scheme
Multi-step reaction with 2 steps
1: ammonium chloride; ammonium hydroxide / isopropyl alcohol / 20 °C / Inert atmosphere
2: hydrogenchloride; water / 1,4-dioxane / 8 h / Inert atmosphere; Reflux
View Scheme
cyclopentanone
120-92-3

cyclopentanone

furan(?)

furan(?)

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol; H2O / Heating
2: 60percent H2SO4 / 10 h / 140 °C
View Scheme
cyclopentanone
120-92-3

cyclopentanone

diluted alcoholic KOH

diluted alcoholic KOH

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 73 percent / ethanol; H2O / 6 h / Heating
2: 75 percent / 3 N aq. NaOH / Heating
View Scheme
Cyclopentanone oxime
1192-28-5

Cyclopentanone oxime

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aqueous NaHSO3
2: aqueous HCl
3: palladium; aqueous NH3 / Hydrogenation
View Scheme
1-hydroxyamino-cyclopentanecarbonitrile
99848-19-8

1-hydroxyamino-cyclopentanecarbonitrile

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous HCl
2: palladium; aqueous NH3 / Hydrogenation
View Scheme
C17H26N2O6

C17H26N2O6

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With water; potassium hydroxide In tetrahydrofuran at 20℃; for 6h;0.77 g
methanol
67-56-1

methanol

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

cycloleucine methyl ester hydrochloride
60421-23-0

cycloleucine methyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride In methanol at -15 - 20℃;100%
With thionyl chloride at 20℃; for 3h; Cooling with ice;98%
With thionyl chloride at 20℃; for 3h; Inert atmosphere;98%
1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

cycloleucine methyl ester hydrochloride
60421-23-0

cycloleucine methyl ester hydrochloride

Conditions
ConditionsYield
100%
In methanol
formic acid
64-18-6

formic acid

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-formamidocyclopentane-1-carboxylic acid
15026-77-4

1-formamidocyclopentane-1-carboxylic acid

Conditions
ConditionsYield
With acetic anhydride at 50℃; for 4h;98%
thiourea
17356-08-0

thiourea

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

cyclopentanespiro-5-(2-thiohydantoin) {cyclopentanespiro-5-(2-thioxoimidazolidin-4-one)}
14109-98-9

cyclopentanespiro-5-(2-thiohydantoin) {cyclopentanespiro-5-(2-thioxoimidazolidin-4-one)}

Conditions
ConditionsYield
at 225 - 230℃;96%
methanol
67-56-1

methanol

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

cycloleucine methyl ester
78388-61-1

cycloleucine methyl ester

Conditions
ConditionsYield
With thionyl chloride at 0℃; for 3h; Reflux;93.5%
With thionyl chloride at 0 - 20℃; Inert atmosphere;67%
With hydrogenchloride Heating;
With thionyl chloride r.t., 15 h, reflux, 1 h;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid
35264-09-6

1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water; acetone Inert atmosphere;90%
With tetramethyl ammoniumhydroxide In acetonitrile for 72h; Ambient temperature;88%
With sodium hydroxide In tetrahydrofuran; water at 55℃; for 18h; Inert atmosphere;85%
1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

(1-aminocyclopentyl)methanol
10316-79-7

(1-aminocyclopentyl)methanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 1h;89%
With sodium tetrahydroborate; sulfuric acid In tetrahydrofuran; diethyl ether at 20℃; for 15h;75%
Multi-step reaction with 2 steps
1: thionyl chloride / 0 - 20 °C / Inert atmosphere
2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 0 - 110 °C / Inert atmosphere
View Scheme
benzoyl chloride
98-88-4

benzoyl chloride

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-benzoylamino-cyclopentanecarboxylic acid
6306-10-1

1-benzoylamino-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 0 - 10℃; for 2h;89%
With sodium hydroxide In water at 0 - 20℃; for 5h;
1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

benzyl alcohol
100-51-6

benzyl alcohol

benzyl 1-amino-1-cyclopentanoate hydrochloride

benzyl 1-amino-1-cyclopentanoate hydrochloride

Conditions
ConditionsYield
Stage #1: 1-amino-1-cyclopentanecarboxylic acid; benzyl alcohol With toluene-4-sulfonic acid In toluene for 24h; Heating / reflux;
Stage #2: With hydrogenchloride In water; acetone		88.5%
butyryl chloride
141-75-3

butyryl chloride

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-butyrylamino-cyclopentanecarboxylic acid
945267-44-7

1-butyrylamino-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 0 - 10℃; for 2h;87%
ethanol
64-17-5

ethanol

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

ethyl 1-aminocyclopentanecarboxylate
1664-35-3

ethyl 1-aminocyclopentanecarboxylate

Conditions
ConditionsYield
With hydrogenchloride86.5%
With hydrogenchloride Destillieren des Hydrochlorids nach Zusatz von Bleihydroxyd unter vermindertem Druck;
With hydrogenchloride Heating;
Stage #1: ethanol; 1-amino-1-cyclopentanecarboxylic acid With sulfuric acid at 0℃; for 24h; Heating / reflux;
Stage #2: With sodium hydrogencarbonate In water
propionyl chloride
79-03-8

propionyl chloride

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-propionylamino-cyclopentanecarboxylic acid
945267-43-6

1-propionylamino-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 0 - 10℃; for 2h;85%
benzothiophene-2-carboxylic acid chloride
39827-11-7

benzothiophene-2-carboxylic acid chloride

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-[(benzo[b]thiophene-2-carbonyl)amino]cyclopentanecarboxylic acid

1-[(benzo[b]thiophene-2-carbonyl)amino]cyclopentanecarboxylic acid

Conditions
ConditionsYield
Stage #1: 1-amino-1-cyclopentanecarboxylic acid With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane for 1.5h;
Stage #2: benzothiophene-2-carboxylic acid chloride In dichloromethane at 20℃; Further stages.;		85%
Stage #1: 1-amino-1-cyclopentanecarboxylic acid With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 20℃; Inert atmosphere;
Stage #2: benzothiophene-2-carboxylic acid chloride In dichloromethane at 20℃; Inert atmosphere;
Hexanoyl chloride
142-61-0

Hexanoyl chloride

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-hexanoylamino-cyclopentanecarboxylic acid
945267-45-8

1-hexanoylamino-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 0 - 10℃; for 2h;84%
ethanol
64-17-5

ethanol

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-amino-cyclopentanecarboxylic acid ethyl ester hydrochloride
22649-37-2

1-amino-cyclopentanecarboxylic acid ethyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride for 4h; Heating;83%
With hydrogenchloride at 23℃; for 48h;6.57 g
n-valeryl chloride
638-29-9

n-valeryl chloride

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

N-pentanoylaminocyclopentane-1-carboxylic acid
15026-80-9

N-pentanoylaminocyclopentane-1-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 0 - 10℃; for 2h;82%
Stage #1: n-valeryl chloride; 1-amino-1-cyclopentanecarboxylic acid With sodium hydroxide In water; toluene at 0 - 10℃; for 2 - 3h;
Stage #2: With hydrogenchloride In water for 0.25h; pH=2.0 - 2.5;
[(2'-cyanobiphenyl-4-yl)methyl]amine
133690-92-3

[(2'-cyanobiphenyl-4-yl)methyl]amine

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-aminocyclopentanecarboxylic acid (2'-cyanobiphenyl-4-ylmethyl)amide

1-aminocyclopentanecarboxylic acid (2'-cyanobiphenyl-4-ylmethyl)amide

Conditions
ConditionsYield
Stage #1: 1-amino-1-cyclopentanecarboxylic acid With phosphorus pentachloride In chloroform at 55 - 60℃; for 1h;
Stage #2: [(2'-cyanobiphenyl-4-yl)methyl]amine In chloroform at 60℃; Further stages.;		82%
2-Nitrobenzenesulfonyl chloride
1694-92-4

2-Nitrobenzenesulfonyl chloride

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-(2-nitrobenzenesulfonylamino)cyclopentanecarboxylic acid

1-(2-nitrobenzenesulfonylamino)cyclopentanecarboxylic acid

Conditions
ConditionsYield
Stage #1: 1-amino-1-cyclopentanecarboxylic acid With chloro-trimethyl-silane; N,O-bis-(trimethylsilyl)-acetamide In dichloromethane for 1h;
Stage #2: 2-Nitrobenzenesulfonyl chloride In dichloromethane Further stages.;		81%
benzyl chloroformate
501-53-1

benzyl chloroformate

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-{[(benzyloxy)carbonyl]amino}cyclopentanecarboxylic acid
17191-44-5

1-{[(benzyloxy)carbonyl]amino}cyclopentanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In tert-butyl methyl ether; water at 23℃; for 3h; pH=10.5 - 11.5; Inert atmosphere;80%
Stage #1: benzyl chloroformate; 1-amino-1-cyclopentanecarboxylic acid With sodium carbonate In 1,4-dioxane; water at 20℃;
Stage #2: With lithium hydroxide In tetrahydrofuran; water at 20℃;
Stage #3: In tetrahydrofuran; diethyl ether pH=2; Acidic conditions;		78%
Stage #1: benzyl chloroformate; 1-amino-1-cyclopentanecarboxylic acid With sodium carbonate In 1,4-dioxane; water at 20℃;
Stage #2: With hydrogenchloride In 1,4-dioxane; water pH=2;		78%
2-hydroxy-5-methylbenzaldehyde
613-84-3

2-hydroxy-5-methylbenzaldehyde

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-[(2-hydroxy-5-methyl-benzyl)amino]cyclopentane-1-carboxylic acid
929602-66-4

1-[(2-hydroxy-5-methyl-benzyl)amino]cyclopentane-1-carboxylic acid

Conditions
ConditionsYield
76%
formaldehyd
50-00-0

formaldehyd

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-(dimethylamino)cyclopentane-1-carboxylic acid
933690-12-1

1-(dimethylamino)cyclopentane-1-carboxylic acid

Conditions
ConditionsYield
With formic acid In water at 80℃; for 2.5h;75%
n-valeryl chloride
638-29-9

n-valeryl chloride

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

2-butyl-3-oxa-1-aza-spiro[4.4]non-1-en-4-one
15026-81-0

2-butyl-3-oxa-1-aza-spiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
With triethylamine In toluene at 80℃; for 5h;74.4%
copper(II) choride dihydrate

copper(II) choride dihydrate

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

[CuII(ACPC)2].H2O

[CuII(ACPC)2].H2O

Conditions
ConditionsYield
With triethylamine In methanol; water74%
Bicyclo<4.4.0>deca-3,8-dien-1,6-dicarbonsaeureanhydrid
3642-06-6

Bicyclo<4.4.0>deca-3,8-dien-1,6-dicarbonsaeureanhydrid

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

1-(11,13-Dioxo-12-aza-tricyclo[4.4.3.01,6]trideca-3,8-dien-12-yl)-cyclopentanecarboxylic acid
78388-62-2

1-(11,13-Dioxo-12-aza-tricyclo[4.4.3.01,6]trideca-3,8-dien-12-yl)-cyclopentanecarboxylic acid

Conditions
ConditionsYield
With pyridine In neat (no solvent) at 250℃;73%
1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

5-chlorosalicyclaldehyde
635-93-8

5-chlorosalicyclaldehyde

1-[(2-hydroxy-5-chloro-benzyl)amino]cyclopentane-1-carboxylic acid
929602-63-1

1-[(2-hydroxy-5-chloro-benzyl)amino]cyclopentane-1-carboxylic acid

Conditions
ConditionsYield
73%
[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

copper(II) perchlorate hexahydrate

copper(II) perchlorate hexahydrate

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

[CuII(bpy)(ACPC)]ClO4·H2O
1628897-39-1

[CuII(bpy)(ACPC)]ClO4·H2O

Conditions
ConditionsYield
With triethylamine In methanol at 20℃; for 1h;73%
...Expand
[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

copper(II) perchlorate hexahydrate

copper(II) perchlorate hexahydrate

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

[CuII(2,2'-bipyridine)(1-aminocyclopentane-1-carboxylic acid(H-))]ClO4*H2O

[CuII(2,2'-bipyridine)(1-aminocyclopentane-1-carboxylic acid(H-))]ClO4*H2O

Conditions
ConditionsYield
With triethylamine In methanol at 20℃; for 1h; Inert atmosphere;73%
...Expand
N-phenyl-maleimide
941-69-5

N-phenyl-maleimide

pyridoxal hydrochloride
65-22-5

pyridoxal hydrochloride

1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

4'-(3-hydroxy-5-hydroxymethyl-2-methylpyridin-4-yl)-6',8'-dioxo-7'-phenylspiro(cyclopentane-1,2'-<3',7'>diazabicyclo<3.3.0>octane)
117088-34-3

4'-(3-hydroxy-5-hydroxymethyl-2-methylpyridin-4-yl)-6',8'-dioxo-7'-phenylspiro(cyclopentane-1,2'-<3',7'>diazabicyclo<3.3.0>octane)

Conditions
ConditionsYield
With sodium acetate In water; acetonitrile for 3h; Heating;70%
...Expand

Cycloleucine Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Cycloleucine Specification

The IUPAC name of Cycloleucine is 1-aminocyclopentane-1-carboxylic acid. With the CAS registry number 52-52-8, it is also named as Cyclopentanecarboxylic acid, 1-amino-, L-. The product's categories are Pharmacetical; Amino Acids; Amino Acids; Amino Acids & Derivatives; Cycloalkanes, and the other registry number is 15313-85-6. Besides, it is white to beige crystalline flakes or powder, which should be stored in sealed, cool and dry place at room temperature. In addition, its molecular formula is C6H11NO2 and molecular weight is 129.16.

The other characteristics of this product can be summarized as: (1)EINECS: 200-144-6; (2)ACD/LogP: -0.05; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -2.55; (5)ACD/LogD (pH 7.4): -2.55; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 3; (11)#H bond donors: 3; (12)#Freely Rotating Bonds: 2; (13)Index of Refraction: 1.522; (14)Molar Refractivity: 32.62 cm3; (15)Molar Volume: 106.9 cm3; (16)Surface Tension: 53.2 dyne/cm; (17)Density: 1.207 g/cm3; (18)Flash Point: 108.7 °C; (19)Melting point: 320 °C; (20)Water solubility: 5 g/100 mL; (21)Enthalpy of Vaporization: 54.35 kJ/mol; (22)Boiling Point: 256.1 °C at 760 mmHg; (23)Vapour Pressure: 0.00481 mmHg at 25 °C.

Preparation of Cycloleucine: this chemical can be prepared by 1,3-Diaza-spiro[4.4]nonane-2,4-dione.



This reaction needs 3 N aq. NaOH by heating. The yield is 75 %.

Uses of Cycloleucine:  this chemical is a non-metabolisable amino acid. It is a specific and reversible inhibitor of nucleic acid methylation. It is widely used in biochemical experiments. Additionally, it can react with Ethanol to get 1-Amino-cyclopentanecarboxylic acid ethyl ester.



This reaction needs HCl. The yield is 86.5 %.

When you are using this chemical, please be cautious about it as the following: it is harmful if swallowed. Please do not breathe dust. And you should avoid contact with skin and eyes.

People can use the following data to convert to the molecule structure.
(1)SMILES: O=C(O)C1(N)CCCC1
(2)InChI: InChI=1/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
(3)InChIKey: NILQLFBWTXNUOE-UHFFFAOYAN
(4)Std. InChI: InChI=1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
(5)Std. InChIKey: NILQLFBWTXNUOE-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 4gm/kg (4000mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 469, 1971.
dog LD50 intravenous 300mg/kg (300mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 1, 1961.
dog LD50 oral 300mg/kg (300mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 1, 1961.
guinea pig LD50 oral 140mg/kg (140mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 1, 1961.
human TDLo oral 60mg/kg (60mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

GASTROINTESTINAL: NAUSEA OR VOMITING		 Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 1, 1961.
mouse LD50 intraperitoneal 119mg/kg (119mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 oral 309mg/kg (309mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 1, 1961.
mouse LD50 subcutaneous 375mg/kg (375mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
quail LD50 oral > 316mg/kg (316mg/kg)   Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
rat LD50 intravenous 340mg/kg (340mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 1, 1961.
rat LD50 oral 290mg/kg (290mg/kg)   Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 1, 1961.
 

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