Conditions | Yield |
---|---|
In dimethyl sulfoxide at 110℃; for 5h; Inert atmosphere; | 82% |
cyclopropylacetaldehyde oxime
2-cyclopropylacetonitrile
Conditions | Yield |
---|---|
With acetic anhydride In ethyl acetate at 25℃; for 3.5h; Heating / reflux; | 76.7% |
Conditions | Yield |
---|---|
phase transfer; | 75% |
In dimethyl sulfoxide at 120℃; | 41% |
In dimethyl sulfoxide for 3h; |
Conditions | Yield |
---|---|
In dimethyl sulfoxide Heating; | 50% |
potassium cyanide
cyclopropylcarbinyl bromide
2-cyclopropylacetonitrile
Conditions | Yield |
---|---|
With ethanol |
Conditions | Yield |
---|---|
(i) PBr3, (ii) NaCN, aq. EtOH; Multistep reaction; |
Conditions | Yield |
---|---|
With palladium diacetate In diethyl ether for 0.166667h; Yield given; |
2-cyclopropylacetonitrile
2-(cyclopropyl)ethylamine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; sulfuric acid In diethyl ether for 2h; Heating; | 99% |
With lithium aluminium tetrahydride; sulfuric acid In diethyl ether at 20℃; for 2h; Heating / reflux; | 70% |
With lithium aluminium tetrahydride; sulfuric acid In diethyl ether for 2h; Heating / reflux; | 70% |
Conditions | Yield |
---|---|
With water; silver trifluoromethanesulfonate at 0℃; for 1h; Ritter Amidation; chemoselective reaction; | 97% |
Conditions | Yield |
---|---|
With water; potassium hydroxide In ethanol at 90℃; for 18h; | 96% |
With dihydrogen peroxide; sodium hydroxide In water at 0℃; for 48h; Reflux; Inert atmosphere; | 83% |
With dihydrogen peroxide; sodium hydroxide In water Reflux; | 81% |
2-cyclopropylacetonitrile
4-t-butoxy-3-methyl-2,5-difluoropyridine
2-(4-tert-butoxy-5-fluoro-3-methyl-2-pyridinyl)-2-cyclopropylacetonitrile
Conditions | Yield |
---|---|
Stage #1: 4-t-butoxy-3-methyl-2,5-difluoropyridine With lithium diisopropyl amide In tetrahydrofuran; hexane at -51 - 17℃; Metallation; Stage #2: 2-cyclopropylacetonitrile In tetrahydrofuran; hexane at -51 - 17℃; Methylation; | 93% |
With lithium diisopropyl amide 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 1 h, b) 0 deg C, 1 h; Yield given. Multistep reaction; | |
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexanes at -78℃; for 0.5h; Stage #2: 2-cyclopropylacetonitrile; 4-t-butoxy-3-methyl-2,5-difluoropyridine In tetrahydrofuran; hexanes at -78 - 20℃; for 2h; |
2-cyclopropylacetonitrile
4-tert-butoxy-2,5-difluoro-3-methoxypyridine
(4-tert-butoxy-5-fluoro-3-methoxypyridin-2-yl)cyclopropylacetonitrile
Conditions | Yield |
---|---|
With lithium diisopropyl amide | 93% |
With lithium diisopropyl amide 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 1 h, b) 0 deg C, 1 h; Multistep reaction; | |
With n-butyllithium; ammonium chloride; diisopropylamine In tetrahydrofuran |
2-cyclopropylacetonitrile
N-cyclohexenyl-N-(4-methoxybenzyl)furan-2-carboxamide
4-(cyclopropylmethyl)-2-(furan-2-yl)-5,6,7,8-tetrahydroquinazoline
Conditions | Yield |
---|---|
With 2-chloropyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78 - 25℃; Inert atmosphere; | 91% |
Conditions | Yield |
---|---|
90% | |
(i) Et2O, (ii) H2O; Multistep reaction; |
Conditions | Yield |
---|---|
With 2-chloropyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78 - 25℃; Inert atmosphere; | 90% |
2-cyclopropylacetonitrile
benzoic acid tert-butyl ester
N-(tert-butyl)cyclopropanecarboxamide
Conditions | Yield |
---|---|
With zinc perchlorate In neat (no solvent) at 50℃; for 5h; Ritter Amidation; | 90% |
2-cyclopropylacetonitrile
phenylmagnesium bromide
2-cyclopropyl-1-phenylethanone
Conditions | Yield |
---|---|
Stage #1: 2-cyclopropylacetonitrile; phenylmagnesium bromide In diethyl ether at 0 - 20℃; Stage #2: With hydrogenchloride; water In tetrahydrofuran; diethyl ether for 12h; | 89% |
Stage #1: 2-cyclopropylacetonitrile; phenylmagnesium bromide In diethyl ether at 0℃; for 2h; Stage #2: With hydrogenchloride In diethyl ether; water for 12h; | 70% |
Stage #1: 2-cyclopropylacetonitrile; phenylmagnesium bromide In diethyl ether at 0 - 20℃; Stage #2: With hydrogenchloride In diethyl ether; water for 12h; | 70% |
2-cyclopropylacetonitrile
methyl 2-amino-4,5-dimethoxybenzoate
2-(cyclopropylmethyl)-6,7-dimethoxyquinazolin-4-ol
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 100℃; for 15h; Inert atmosphere; | 85% |
Conditions | Yield |
---|---|
Stage #1: bromobenzene With magnesium In tetrahydrofuran for 1h; Inert atmosphere; Reflux; Stage #2: 2-cyclopropylacetonitrile In tetrahydrofuran at 20℃; Inert atmosphere; Stage #3: With sulfuric acid for 2h; Reflux; | 85% |
2-cyclopropylacetonitrile
Conditions | Yield |
---|---|
With hydroxylamine In ethanol for 1h; Reflux; | 85% |
With hydroxylamine In ethanol for 1h; Reflux; | 85% |
Conditions | Yield |
---|---|
With 1,4-di(diphenylphosphino)-butane; cobalt(II) iodide; zinc In N,N-dimethyl acetamide at 80℃; for 24h; Inert atmosphere; | 85% |
Conditions | Yield |
---|---|
at 100℃; for 46h; | 83.5% |
2-cyclopropylacetonitrile
Conditions | Yield |
---|---|
With fac-[(CO)3Mn(iPr2P(CH2)2PiPr2)(triflato)]; potassium tert-butylate; hydrogen In iso-butanol at 110℃; under 5171.62 Torr; for 0.25h; Catalytic behavior; Glovebox; Schlenk technique; Inert atmosphere; Autoclave; | 83% |
Multi-step reaction with 2 steps 1.1: BH3 / tetrahydrofuran / 14 h / Heating 1.2: MeOH / 2 h / Heating 1.3: CH2Cl2 / 14 h / 20 °C 2.1: HCl / dioxane; CH2Cl2 / 14 h / 20 °C View Scheme | |
With hydrogenchloride; borane In tetrahydrofuran; 1,4-dioxane; dichloromethane |
Conditions | Yield |
---|---|
With 2-chloropyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78 - 25℃; Inert atmosphere; | 83% |
ethanol
2-cyclopropylacetonitrile
2-cyclopropyl-1-ethoxy-1-ethanimine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether at 0℃; for 24h; | 82% |
With hydrogenchloride at 0℃; |
tert-Butoxybis(dimethylamino)methane
2-cyclopropylacetonitrile
2-cyclopropyl-3-dimethylaminoacrylonitrile
Conditions | Yield |
---|---|
at 100℃; for 46h; | 81% |
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical
2-cyclopropylacetonitrile
2-cyclopropyl-2-(2,2,6,6-tetramethylpiperidin-1-yloxy)acetonitrile
Conditions | Yield |
---|---|
Stage #1: 2-cyclopropylacetonitrile With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical With ferrocenium hexafluorophosphate In tetrahydrofuran; hexane at -78℃; Inert atmosphere; | 80% |
Conditions | Yield |
---|---|
With 2-chloropyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78 - 25℃; Inert atmosphere; | 79% |
Conditions | Yield |
---|---|
With tert.-butyl lithium In tetrahydrofuran; n-heptane at -78℃; for 0.5h; | 78% |
2-cyclopropylacetonitrile
acetic anhydride
2-cyclopropyl-3-oxobutanenitrile
Conditions | Yield |
---|---|
Stage #1: 2-cyclopropylacetonitrile With lithium diisopropyl amide In tetrahydrofuran; cyclohexane for 0.166667h; cooling; Stage #2: acetic anhydride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; | 78% |
Stage #1: 2-cyclopropylacetonitrile With lithium diisopropyl amide In tetrahydrofuran; cyclohexane for 0.166667h; cooling; Stage #2: acetic anhydride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Further stages.; | 78% |
Stage #1: 2-cyclopropylacetonitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; Stage #2: acetic anhydride In tetrahydrofuran at -78 - 15℃; for 1h; | |
Stage #1: 2-cyclopropylacetonitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.666667h; Stage #2: acetic anhydride In tetrahydrofuran at -78℃; for 0.333333h; | 0.98 g |
tert-butylisonitrile
2-cyclopropylacetonitrile
dibromamine-T
Conditions | Yield |
---|---|
With potassium carbonate In water at 20℃; for 0.5h; | 78% |
2-cyclopropylacetonitrile
Diethyl carbonate
ethyl 2-cyano-2-cyclopropylacetate
Conditions | Yield |
---|---|
With sodium hydride In toluene for 2h; Heating; | 77% |
With sodium hydride In toluene; mineral oil for 2.67h; Reflux; | 50 g |
With sodium hydride In toluene for 2.5h; Inert atmosphere; Reflux; | |
With potassium tert-butylate In N,N-dimethyl-formamide at 50℃; | 130 g |
Stage #1: 2-cyclopropylacetonitrile; Diethyl carbonate With sodium hydride In toluene for 2.5h; Inert atmosphere; Reflux; Stage #2: With acetic acid In toluene at 0℃; |
Conditions | Yield |
---|---|
With 2-chloropyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78 - 25℃; Inert atmosphere; | 77% |
2-cyclopropylacetonitrile
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water at 80℃; for 12h; | 77% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 48h; Inert atmosphere; | 76% |
This chemical is called Cyclopropaneacetonitrile, and its CAS registry number is 6542-60-5. With the molecular formula of C5H7N, its molecular weight is 81.12. Additionally, its product categories are C1 to C5; Cyanides / Nitriles; Nitrogen Compounds.
Other characteristics of the Cyclopropaneacetonitrile can be summarised as followings: (1)ACD/LogP: 0.45; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.45; (4)ACD/LogD (pH 7.4): 0.45; (5)ACD/BCF (pH 5.5): 1.3; (6)ACD/BCF (pH 7.4): 1.3; (7)ACD/KOC (pH 5.5): 41.91; (8)ACD/KOC (pH 7.4): 41.91; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 23.79 Å2; (13)Index of Refraction: 1.46; (14)Molar Refractivity: 23.07 cm3; (15)Molar Volume: 84.1 cm3; (16)Polarizability: 9.14×10-24cm3; (17)Surface Tension: 40.6 dyne/cm; (18)Density: 0.963 g/cm3; (19)Flash Point: 57.4 °C; (20)Enthalpy of Vaporization: 39.64 kJ/mol; (21)Boiling Point: 159.8 °C at 760 mmHg; (22)Vapour Pressure: 2.46 mmHg at 25°C.
Production method of this chemical: The Cyclopropaneacetonitrile could be obtained by the reactants of bromomethyl-cyclopropane and hydrocyanic acid; sodium salt. The yield is 75 %.
Uses of this chemical: The could react with phenylmagnesium bromide, and obtain the cyclopropyl-2 acetophenone. The yield is 90 %.
When you are using this chemical, please be cautious about it as the following: This chemical is flammable. Keep it away from the sources of ignition. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1.SMILES: N#CCC1CC1
2.InChI: InChI=1/C5H7N/c6-4-3-5-1-2-5/h5H,1-3H2
3.InChIKey: FAUQRRGKJKMEIW-UHFFFAOYAZ
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