Product Name

  • Name

    D-Tyrosine

  • EINECS 209-112-6
  • CAS No. 556-02-5
  • Article Data152
  • CAS DataBase
  • Density 1.333 g/cm3
  • Solubility soluble in water
  • Melting Point >300 °C(lit.)
  • Formula C9H11NO3
  • Boiling Point 385.2 °C at 760 mmHg
  • Molecular Weight 181.191
  • Flash Point 186.7 °C
  • Transport Information
  • Appearance white to off-white powder
  • Safety 26-36-24/25
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 556-02-5 (D-Tyrosine)
  • Hazard Symbols HarmfulXn
  • Synonyms (R)-3-(p-Hydroxyphenyl)alanine;D-Tyrosin;(R)-2-Amino-3-(p-hydroxyphenyl)propionic acid;H-D-Tyr-OH;D-Tyrosine(556-02-5);
  • PSA 83.55000
  • LogP 1.04690

Synthetic route

(RS)-tyrosinamide hydrochloride
117888-80-9

(RS)-tyrosinamide hydrochloride

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
With pyridoxal 5'-phosphate monohydrate In aq. buffer at 40℃; for 6h; pH=8.0; Enzymatic reaction;99%
C15H15N3*C16H13Cl2NO4

C15H15N3*C16H13Cl2NO4

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
Stage #1: C15H15N3*C16H13Cl2NO4 With hydrogenchloride In acetonitrile at 20℃; for 1h;
Stage #2: With triethylamine In water at 20℃; for 1h;
90%
tyrosine methyl ester hydrochloride
3417-91-2, 3728-20-9, 68697-61-0

tyrosine methyl ester hydrochloride

A

tyrosine
556-02-5

tyrosine

B

D-tyrosine methyl ester
3410-66-0

D-tyrosine methyl ester

C

L-tyrosine
60-18-4

L-tyrosine

Conditions
ConditionsYield
at 30℃; for 0.333333h; enzyme alcalase from Bacillus licheniforms; pH 8.0; Yields of byproduct given;A n/a
B 86%
C n/a
at 30℃; for 0.333333h; enzyme alcalase from Bacillus licheniforms; pH 8.0; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
4-hydroxyphenylpropionic acid
501-97-3

4-hydroxyphenylpropionic acid

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
With D-Alanine; meso-diaminopimelate dehydrogenase; pyridoxal 5'-phosphate; alcohol dehydrogenases from Bacillus stearothermophilus; alcohol dehydrogenases from Thermoanaerobacter brockii; NADH In isopropyl alcohol at 35℃; for 12h; pH=8; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;62.3%
Conditions
ConditionsYield
With sodium hydroxide; oxygen; 2-amino-2-hydroxymethyl-1,3-propanediol In water at 30℃; for 1h; pH=7.3; Resolution of racemate; Enzymatic reaction; enantioselective reaction;47%
durch Einw. von wachsender Hefe in Gegenwart von Malzextrakt oder Hefeautolysat;
With oidium lactis
N-formyl-DL-tyrosine
41516-11-4

N-formyl-DL-tyrosine

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
With water; brucine
D-tyrosine amide; hydrochloride
117888-79-6

D-tyrosine amide; hydrochloride

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
With hydrogenchloride
D-(R)-phenylalanine
673-06-3

D-(R)-phenylalanine

A

tyrosine
556-02-5

tyrosine

B

(2R)-2-amino-3-(2-hydroxyphenyl)propanoic acid
24008-77-3

(2R)-2-amino-3-(2-hydroxyphenyl)propanoic acid

C

m-hydroxy-D-phenylalanine
32140-49-1

m-hydroxy-D-phenylalanine

Conditions
ConditionsYield
With sulfuric acid; 5-ethyl-10-methyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridin-5-ium perchlorate at 20 - 50℃; Product distribution; various acid concentration; anaerob condition;
With air; 5-ethyl-10-methyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridin-5-ium perchlorate In sulfuric acid at 20℃; Product distribution; Mechanism; hydroxylating ability of the system; other temperatures and acid; other oxidant or without them;
kistamicin A

kistamicin A

A

tyrosine
556-02-5

tyrosine

B

2-amino-2-(3,5-dihydroxyphenyl)acetic acid
146255-66-5

2-amino-2-(3,5-dihydroxyphenyl)acetic acid

C

Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid
155435-50-0

Amino-{3-[4-(amino-carboxy-methyl)-2-chloro-phenoxy]-4-hydroxy-phenyl}-acetic acid

D

2-Amino-3-{6-[3-[4-(2-amino-2-carboxy-ethyl)-phenoxy]-5-(amino-carboxy-methyl)-2-hydroxy-phenyl]-1H-indol-3-yl}-propionic acid

2-Amino-3-{6-[3-[4-(2-amino-2-carboxy-ethyl)-phenoxy]-5-(amino-carboxy-methyl)-2-hydroxy-phenyl]-1H-indol-3-yl}-propionic acid

Conditions
ConditionsYield
With hydrogenchloride; mercaptoacetic acid at 110℃; for 24h;A n/a
B n/a
C n/a
D 39 mg
N-carbamyl-D-tyrosine
54896-58-1

N-carbamyl-D-tyrosine

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h;
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h; pH 7.5; enzymatic reaction;
D,L-Tyr-OPron
125511-37-7

D,L-Tyr-OPron

A

tyrosine
556-02-5

tyrosine

B

L-tyrosine
60-18-4

L-tyrosine

Conditions
ConditionsYield
With pyridoxal 5'-phosphate In water; tert-butyl alcohol at 40℃; for 4h; alcalase, pH=8.5; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
benzyl tyrosinate
137838-07-4

benzyl tyrosinate

A

tyrosine
556-02-5

tyrosine

B

L-tyrosine
60-18-4

L-tyrosine

Conditions
ConditionsYield
With pyridoxal 5'-phosphate In water; tert-butyl alcohol at 40℃; for 3h; alcalase, pH=8.5; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
4-Hydroxyphenylpyruvic acid
156-39-8

4-Hydroxyphenylpyruvic acid

A

tyrosine
556-02-5

tyrosine

B

L-tyrosine
60-18-4

L-tyrosine

Conditions
ConditionsYield
With sodium chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid In water at 37℃; adipocyte lipid binding protein containing 5-(2-pyridylthio)pyridoxamine cofactor; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With pyridoxal 5'-phosphate; ethylenediaminetetraacetic acid; sodium diphenylglycine In aq. buffer at 50℃; pH=8; Overall yield = 9 %; enantioselective reaction;A n/a
B n/a
tyrosine methyl ester
1080-06-4, 3410-66-0, 18869-47-1

tyrosine methyl ester

A

tyrosine
556-02-5

tyrosine

B

L-tyrosine
60-18-4

L-tyrosine

Conditions
ConditionsYield
With Phen60*Cu(II); PIPES buffer; water at 25℃; for 24h; Title compound not separated from byproducts;
D-tyrosine methyl ester
3410-66-0

D-tyrosine methyl ester

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
With water In tert-butyl alcohol pH=11.5; Hydrolysis;
With Streptomyces spp. 82F2 D-aminopeptidase In dimethyl sulfoxide at 20℃; for 0.0833333h; pH=6.5; aq. buffer; Enzymatic reaction;
bacterium proteus vulgaris

bacterium proteus vulgaris

A

tyrosine
556-02-5

tyrosine

B

2-hydroxy-3-(4-hydroxyphenyl)propanoic acid
6482-98-0, 23508-35-2, 89919-57-3, 306-23-0

2-hydroxy-3-(4-hydroxyphenyl)propanoic acid

bacterium subtilis

bacterium subtilis

A

tyrosine
556-02-5

tyrosine

B

2-hydroxy-3-(4-hydroxyphenyl)propanoic acid
6482-98-0, 23508-35-2, 89919-57-3, 306-23-0

2-hydroxy-3-(4-hydroxyphenyl)propanoic acid

oidium lactis

oidium lactis

A

tyrosine
556-02-5

tyrosine

B

2-hydroxy-3-(4-hydroxyphenyl)propanoic acid
6482-98-0, 23508-35-2, 89919-57-3, 306-23-0

2-hydroxy-3-(4-hydroxyphenyl)propanoic acid

L-arginine
74-79-3

L-arginine

2-methyl-4-<4-acetoxy-benzyliden>-oxazolone-(5)

2-methyl-4-<4-acetoxy-benzyliden>-oxazolone-(5)

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
With acetone man hydriert das Reaktionsprodukt mit Palladium in Eisessig und verseift das Produkt mit Salzsaeure;
cinchonine salt of N-benzoyl-d-tyrosine

cinchonine salt of N-benzoyl-d-tyrosine

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
With potassium hydroxide Erhitzen mit Salzsaeure im Druckrohr auf 100grad;
D-tyrosine ethyl ester hydrochloride

D-tyrosine ethyl ester hydrochloride

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
With hydrogenchloride
N-acetyl-dl-tyrosine

N-acetyl-dl-tyrosine

tyrosine
556-02-5

tyrosine

hydrogenchloride
7647-01-0

hydrogenchloride

Nα-(N,O-diacetyl-tyrosyl)-arginine

Nα-(N,O-diacetyl-tyrosyl)-arginine

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
Hydrolysis; -;
tyrosine ethyl ester
34081-17-9

tyrosine ethyl ester

A

tyrosine
556-02-5

tyrosine

B

L-tyrosine
60-18-4

L-tyrosine

Conditions
ConditionsYield
With aminoacylase I from Aspergillus melleus; Tris buffer In water at 25℃; for 5.5h; pH=6.5; Title compound not separated from byproducts;
C64H84N4O20*C9H11NO3*H(1+)

C64H84N4O20*C9H11NO3*H(1+)

(S)-2-aminobutane
513-49-5

(S)-2-aminobutane

A

C64H84N4O20*C4H11N*H(1+)

C64H84N4O20*C4H11N*H(1+)

B

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
at 20℃; under 0 Torr; Kinetics;
C64H84N4O20*C9H11NO3*H(1+)

C64H84N4O20*C9H11NO3*H(1+)

(S)-2-aminobutane
513-49-5

(S)-2-aminobutane

A

C64H84N4O20*C4H11N*H(1+)

C64H84N4O20*C4H11N*H(1+)

B

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
at 20℃; under 0 Torr; Kinetics;
C64H84N4O20*C9H11NO3*H(1+)

C64H84N4O20*C9H11NO3*H(1+)

(R)-sec-butylamine
13250-12-9

(R)-sec-butylamine

A

C64H84N4O20*C4H11N*H(1+)

C64H84N4O20*C4H11N*H(1+)

B

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
at 20℃; under 0 Torr; Kinetics;
C64H84N4O20*C9H11NO3*H(1+)

C64H84N4O20*C9H11NO3*H(1+)

(R)-sec-butylamine
13250-12-9

(R)-sec-butylamine

A

C64H84N4O20*C4H11N*H(1+)

C64H84N4O20*C4H11N*H(1+)

B

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
at 20℃; under 0 Torr; Kinetics;
4-Hydroxyphenylpyruvic acid
156-39-8

4-Hydroxyphenylpyruvic acid

tyrosine
556-02-5

tyrosine

Conditions
ConditionsYield
With meso-2,6-D-diaminopimelic acid dehydrogenase mutant BC621; ammonium chloride; NADPH In various solvent(s) for 24h;
With L-glutamic acid; recombinant Pseudomonas stutzeri ST-201 D-phenylglycine aminotransferase; sodium chloride In aq. buffer at 37℃; pH=9.5; Enzymatic reaction; enantioselective reaction;n/a
methanol
67-56-1

methanol

tyrosine
556-02-5

tyrosine

D-tyrosine methyl ester
3410-66-0

D-tyrosine methyl ester

Conditions
ConditionsYield
With thionyl chloride Reflux;100%
With thionyl chloride at 0 - 25℃; for 12h;95%
With thionyl chloride at 0 - 10℃; for 0.5h;
methanol
67-56-1

methanol

tyrosine
556-02-5

tyrosine

D-tyrosine methylester hydrochloride
3728-20-9

D-tyrosine methylester hydrochloride

Conditions
ConditionsYield
With acetyl chloride100%
With acetyl chloride for 3h; Heating;100%
With thionyl chloride at 0℃; for 16h;100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tyrosine
556-02-5

tyrosine

N,O-bis(tert-butoxycarbonyl)-D-tyrosine
1241677-97-3

N,O-bis(tert-butoxycarbonyl)-D-tyrosine

Conditions
ConditionsYield
With sodium hydroxide In water; isopropyl alcohol at 37℃; pH=11.5 - 12;100%
With sodium hydroxide In water; isopropyl alcohol at 37℃; pH=11.5 - 12;
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

tyrosine
556-02-5

tyrosine

N-TFA-D-tyrosine

N-TFA-D-tyrosine

Conditions
ConditionsYield
With triethylamine In methanol at 20℃; for 168h;100%
tyrosine
556-02-5

tyrosine

D-tyrosine methylester hydrochloride
3728-20-9

D-tyrosine methylester hydrochloride

Conditions
ConditionsYield
With thionyl chloride In methanol for 5h; Reflux;99.7%
tyrosine
556-02-5

tyrosine

3',5'-dibromo-D-tyrosine hydrobromide
1031685-35-4

3',5'-dibromo-D-tyrosine hydrobromide

Conditions
ConditionsYield
With bromine; acetic acid at 20℃; for 4h;98%
tyrosine
556-02-5

tyrosine

(1R)-1-carboxy-2-(3-chloro-4-hydroxy-phenyl)-ethyl-ammonium chloride

(1R)-1-carboxy-2-(3-chloro-4-hydroxy-phenyl)-ethyl-ammonium chloride

Conditions
ConditionsYield
With thionyl chloride; acetic acid at 20℃; for 3h;97.5%
With sulfuryl dichloride; acetic acid at 20℃; for 2h;94%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tyrosine
556-02-5

tyrosine

N-(tert-butoxycarbonyl)-D-tyrosine
70642-86-3

N-(tert-butoxycarbonyl)-D-tyrosine

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 20℃;97%
With sodium hydroxide In 1,4-dioxane at 20℃; for 0.5h;
With sodium hydroxide In 1,4-dioxane at 20℃;
tyrosine
556-02-5

tyrosine

(R)-3,5-bromotyrosine bromate
50299-42-8

(R)-3,5-bromotyrosine bromate

Conditions
ConditionsYield
With bromine In acetic acid at 80℃; for 2h;92%
With bromine; acetic acid at 70℃; for 0.5h;92%
ferrocenecarboxaldehyde
12093-10-6

ferrocenecarboxaldehyde

tyrosine
556-02-5

tyrosine

C10H9FeCHNCH(COOH)CH2C6H4OH

C10H9FeCHNCH(COOH)CH2C6H4OH

Conditions
ConditionsYield
With sodium carbonate In ethanol boiling;90%
C17H17N3O4
632365-25-4

C17H17N3O4

tyrosine
556-02-5

tyrosine

C26H26N4O6

C26H26N4O6

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 2h;90%
tyrosine
556-02-5

tyrosine

hexan-1-ol
111-27-3

hexan-1-ol

hexyl D-tyrosinate hydrochloride
1322097-54-0

hexyl D-tyrosinate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 95℃; for 12h;90%
tyrosine
556-02-5

tyrosine

N-(tert-butoxycarbonyl)-D-tyrosine
70642-86-3

N-(tert-butoxycarbonyl)-D-tyrosine

Conditions
ConditionsYield
88%
Multi-step reaction with 3 steps
1: HCl
2: 95 percent / triethylamine; pyridine / CHCl3; tetrahydrofuran / 10 - 20 °C
3: lithium hydroxide / methanol; H2O / 20 °C
View Scheme
tyrosine
556-02-5

tyrosine

(1S,3E)-5-<(2,5-dioxo-1-pyrrolidinyl)oxy>-1-<(1R,2E)-1-methyl-3-phenyl-2-propenyl>-5-oxo-3-pentenyl-(2S)-<3-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-dimethyl-1-oxopropoxy>-4-methylpentanoate
188346-51-2

(1S,3E)-5-<(2,5-dioxo-1-pyrrolidinyl)oxy>-1-<(1R,2E)-1-methyl-3-phenyl-2-propenyl>-5-oxo-3-pentenyl-(2S)-<3-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-dimethyl-1-oxopropoxy>-4-methylpentanoate

N-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl-D-tyrosine
240428-56-2

N-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-(methylpentanoyl)-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoyl-D-tyrosine

Conditions
ConditionsYield
With N,O-bis-(trimethylsilyl)-acetamide In N,N-dimethyl-formamide at 55 - 60℃;87%
tyrosine
556-02-5

tyrosine

3-chloro-D-tyrosine
162599-96-4

3-chloro-D-tyrosine

Conditions
ConditionsYield
With sulfuryl dichloride; acetic acid at 20℃;86%
tyrosine
556-02-5

tyrosine

benzoyl chloride
98-88-4

benzoyl chloride

C23H19NO5

C23H19NO5

Conditions
ConditionsYield
With sodium hydroxide In water at 0 - 20℃; for 8h;85%
With sodium hydroxide In water at 2℃; for 1h;
tyrosine
556-02-5

tyrosine

(R)-2-amino-3-(4-(phosphonooxy)phenyl)propanoic acid

(R)-2-amino-3-(4-(phosphonooxy)phenyl)propanoic acid

Conditions
ConditionsYield
With phosphorus pentoxide; phosphoric acid at 80℃; for 24h;85%
With phosphorus pentoxide; phosphoric acid In water at 80℃; for 24h; Inert atmosphere;81%
With phosphorus pentoxide; phosphoric acid at 80℃; Inert atmosphere;16%
With phosphorus pentoxide; phosphoric acid at 80℃; for 24h;
lithium perchlorate trihydrate

lithium perchlorate trihydrate

[(-CH2C6H2(S)(tert-butyl)CH2N(methyl)C2H4N(methyl)C2H4N(methyl)CH2C6H2(S)(tert-butyl)CH2N(methyl)C2H4N(methyl)C2H4N(methyl)-)Ni2(μ-Cl)](perchlorate)
366804-74-2

[(-CH2C6H2(S)(tert-butyl)CH2N(methyl)C2H4N(methyl)C2H4N(methyl)CH2C6H2(S)(tert-butyl)CH2N(methyl)C2H4N(methyl)C2H4N(methyl)-)Ni2(μ-Cl)](perchlorate)

tyrosine
556-02-5

tyrosine

[(-CH2C6H2(S)(tert-butyl)CH2N(methyl)C2H4N(methyl)C2H4N(methyl)CH2C6H2(S)(tert-butyl)CH2N(methyl)C2H4N(methyl)C2H4N(methyl)-)Ni2(μ-(D)-tyrosinato)](perchlorate) monohydrate

[(-CH2C6H2(S)(tert-butyl)CH2N(methyl)C2H4N(methyl)C2H4N(methyl)CH2C6H2(S)(tert-butyl)CH2N(methyl)C2H4N(methyl)C2H4N(methyl)-)Ni2(μ-(D)-tyrosinato)](perchlorate) monohydrate

Conditions
ConditionsYield
Stage #1: [(-CH2C6H2(S)(tert-butyl)CH2N(methyl)C2H4N(methyl)C2H4N(methyl)CH2C6H2(S)(tert-butyl)CH2N(methyl)C2H4N(methyl)C2H4N(methyl)-)Ni2(μ-Cl)](perchlorate); tyrosine With triethylamine In methanol; acetonitrile for 4h; Inert atmosphere; Schlenk technique;
Stage #2: lithium perchlorate trihydrate In methanol; ethanol; acetonitrile at 40℃; for 6h; Inert atmosphere; Schlenk technique;
84%
tyrosine
556-02-5

tyrosine

[(Cp)Ru(η6-naphthalene)]CF3SO3

[(Cp)Ru(η6-naphthalene)]CF3SO3

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

[Fmoc-D-tyrosine(Ru(cyclopentadienyl))-OH]trifluoroacetate

[Fmoc-D-tyrosine(Ru(cyclopentadienyl))-OH]trifluoroacetate

Conditions
ConditionsYield
Stage #1: tyrosine; [(Cp)Ru(η6-naphthalene)]CF3SO3 With hydrogenchloride In water for 15h; Irradiation;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide With sodium carbonate In 1,4-dioxane at 0 - 23℃; for 15h;
84%
tyrosine
556-02-5

tyrosine

[(Cp)Ru(η6-naphthalene)]CF3SO3

[(Cp)Ru(η6-naphthalene)]CF3SO3

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

trifluoroacetic acid
76-05-1

trifluoroacetic acid

[Fmoc-D-tyrosine(Ru(cyclopentadienyl))-OH]trifluoroacetate

[Fmoc-D-tyrosine(Ru(cyclopentadienyl))-OH]trifluoroacetate

Conditions
ConditionsYield
Stage #1: tyrosine; [(Cp)Ru(η6-naphthalene)]CF3SO3 With hydrogenchloride In water for 15h; Irradiation;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide With sodium carbonate In 1,4-dioxane; water at 0 - 23℃; for 15h;
Stage #3: trifluoroacetic acid In water pH=3;
84%
tyrosine
556-02-5

tyrosine

(R)-2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid

(R)-2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid

Conditions
ConditionsYield
With sulfuryl dichloride In acetic acid for 5h; Ambient temperature;80%
With sulfuryl dichloride; acetic acid at 20℃; for 5h; Inert atmosphere;
With sulfuryl dichloride; acetic acid at 20℃; for 24h; Inert atmosphere;
With sulfuryl dichloride In acetic acid at 20℃; for 16h;
1,3-dimethoxy propane
17081-21-9

1,3-dimethoxy propane

tyrosine
556-02-5

tyrosine

D-tyrosine methyl ester
3410-66-0

D-tyrosine methyl ester

Conditions
ConditionsYield
With hydrogenchloride at 20℃;80%
tyrosine
556-02-5

tyrosine

benzyl chloroformate
501-53-1

benzyl chloroformate

N-benzyloxycarbonyl-(O-benzyloxycarbonyl)-(R)-tyrosine
57228-57-6

N-benzyloxycarbonyl-(O-benzyloxycarbonyl)-(R)-tyrosine

Conditions
ConditionsYield
In tetrahydrofuran78%
With sodium hydroxide
tyrosine
556-02-5

tyrosine

benzyl chloride
100-44-7

benzyl chloride

(R)-2-amino-3-(4-(benzyloxy)phenyl)propanoic acid
65733-15-5

(R)-2-amino-3-(4-(benzyloxy)phenyl)propanoic acid

Conditions
ConditionsYield
Stage #1: tyrosine With potassium hydroxide; copper(II) sulfate In water at 15 - 65℃; for 1h;
Stage #2: benzyl chloride In water; N,N-dimethyl-formamide at 20 - 60℃; for 2h;
Stage #3: With hydrogenchloride; ammonia more than 3 stages;
77%
tyrosine
556-02-5

tyrosine

C18H16N2O2
18019-55-1

C18H16N2O2

C20H18N2O5

C20H18N2O5

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 60 - 80℃; for 1.5h;74.5%
tyrosine
556-02-5

tyrosine

3-trifluoromethylphenyl propargyl sulfide

3-trifluoromethylphenyl propargyl sulfide

(R)-1-[1-carboxy-2-(4-hydroxyphenyl)ethyl]-4-[3-(trifluoromethyl)phenylthiomethyl]-1H-1,2,3-triazole

(R)-1-[1-carboxy-2-(4-hydroxyphenyl)ethyl]-4-[3-(trifluoromethyl)phenylthiomethyl]-1H-1,2,3-triazole

Conditions
ConditionsYield
Stage #1: tyrosine With copper(ll) sulfate pentahydrate; 3-azidosulfonyl-3H-imidazole-1-ium hydrogen sulfate; potassium carbonate In methanol; water at 20℃; for 5h;
Stage #2: 3-trifluoromethylphenyl propargyl sulfide With sodium acetate; copper (I) acetate; sodium L-ascorbate In methanol at 30℃; for 16h;
73%
cis-[RuCl2(dppe)2]

cis-[RuCl2(dppe)2]

tyrosine
556-02-5

tyrosine

[Ru(Tyr-)(1,2-bis(diphenylphosphino)ethan)2]Cl

[Ru(Tyr-)(1,2-bis(diphenylphosphino)ethan)2]Cl

Conditions
ConditionsYield
In methanol; water for 24h; Inert atmosphere; Reflux;69%

D-Tyrosine Chemical Properties

Molecular Structure:

Molecular Formula: C9H11NO3
Molecular Weight: 181.1885
IUPAC Name: (2R)-2-Amino-3-(4-hydroxyphenyl)propanoic acid
Synonyms of D-Tyrosine (CAS NO.556-02-5): EINECS 209-112-6 ; (R)-(+)-Tyrosine;rarechem ab pp 1343 ; (R)-(+)-3-(4-Hydroxyphenyl)-d-alanine ; (R)-2-Amino-3-(4-hydroxyphenyl)propionic acid;TYROSINE, D- ; 3-(4-Hydroxyphenyl)-d-alanine ; D-3-(4-Hydroxyphenyl)alanine;d(+)-tyrosine
CAS NO: 556-02-5
Product Categories: Amino Acids Derivatives ; AMINO ACIDS ; Tyrosine [Tyr, Y] ; Amino Acids and Derivatives ; alpha-Amino Acids ; Biochemistry ; Amino Acids and Derivatives
Melting point: >300 °C
Index of Refraction: 1.614
Molar Refractivity: 47.37 cm3
Molar Volume: 135.8 cm3
Surface Tension: 65.7 dyne/cm
Density: 1.333 g/cm3
Flash Point: 186.7 °C
Enthalpy of Vaporization: 66.87 kJ/mol
Boiling Point: 385.2 °C at 760 mmHg
Vapour Pressure: 1.27E-06 mmHg at 25°C

D-Tyrosine Uses

 D-Tyrosine (CAS NO.556-02-5) is an amino acid synthesized in the body from the essential amino acid phenylalanine. And it has been used to treat sleep disorders, enhance cognitive function, and alleviate symptoms of ADD.

D-Tyrosine Safety Profile

Hazard Codes of D-Tyrosine (CAS NO.556-02-5): IrritantXi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing. 
S24/25: Avoid contact with skin and eyes.
WGK Germany: 3

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