Diethanolamine supplier | CasNO.111-42-2

Name
Diethanolamine
EINECS 203-868-0
CAS No. 111-42-2
Article Data84
CAS DataBase
Density 1.096 g/cm³
Solubility miscible with water
Melting Point 28 °C(lit.)
Formula C₄H₁₁NO₂
Boiling Point 268.389 °C at 760 mmHg
Molecular Weight 105.137
Flash Point 137.778 °C
Transport Information UN 1760
Appearance solid or viscous liquid
Safety 26-36/37/39-46
Risk Codes 22-38-41-48/22
Molecular Structure
Hazard Symbols Xn
Synonyms 2,2-Iminodi-1-ethanol;2,2-Dihydroxydiethylamine;bis(2-hydroxyethyl)azanium;N,N-Diethanolamine;Diethanolamine (NF);Iminodiethanol;Bis(2-hydroxyethyl)amine;Diethylolamine;2-(2-hydroxyethylamino)ethanol;Di(2-hydroxyethyl)amine;Purified Isophthalic Acid;Diethanolamin 98%;Diethanolamin min. 85%;2,2'-iminodiethanol;Ethanol, 2,2-iminodi-;Diethanolamine (DEA);Diethylamine, 2,2-dihydroxy-;DEA;2, 2-Iminobis[ethanol];Ethanol, 2,2-iminobis-;2,2-Iminodiethanol;2-[(2-Hydroxyethyl)amino]ethanol;Ethanol,2,2'-iminobis-;
PSA 52.49000
LogP -1.04850

Synthetic route

: 75-21-8
oxirane

: 141-43-5
ethanolamine

A: 102-71-6
triethanolamine

B: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With ammonia; ZSM-5 type zeolite ion exchange with lanthanum at 45℃; under 75007.5 Torr; Industry scale; Adiabatic conditions;	A 91.1% B 7.6%
With ammonia In water Continous process;	A 85.3% B 9.3%
With ammonia; ZSM-5 type zeolite ion exchange with lanthanum at 45℃; under 75007.5 Torr; Adiabatic conditions; Industry scale;	A 76.6% B 9.9%
In water Industry scale;
With ammonia; La/zeolites(ZSM-5) at 45℃; under 75007.5 Torr;

...Expand

: 1586805-11-9
C9H19NO2

A: 584-02-1
2-pentanol

B: 1-(2-hydroxyethyl)-2-ethyl-3-methylpyrrole

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With potassium hydroxide Reflux;	A n/a B 81% C n/a

...Expand

: 91322-91-7
2,2-hexamethylene-3-(2-hydroxyethyl)oxazolidine

A: 502-41-0
cycloheptanol

B: 91322-87-1
1-(2-hydroxyethyl)-5,6,7,8-tetrahydrocyclohepta(b)pyrrole

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With potassium hydroxide Reflux;	A n/a B 76% C n/a

...Expand

: 2359-11-7
2-Spirocyclohexyl-3-(β-hydroxyethyl)oxazolidine

A: 51265-34-0
1-(2-hydroxyethyl)-4,5,6,7-tetrahydro-1H-indole

B: 111-42-2
2,2'-iminobis[ethanol]

C: 108-93-0
cyclohexanol

Conditions

Conditions	Yield
With potassium hydroxide for 4h; Product distribution; Heating; alcoholates(C1-C4) of K, Na, Li, Ba, Ba, Al as reagents;	A 73% B n/a C n/a
With potassium hydroxide for 4h; Heating; CH3ONa as reagent;	A 73% B n/a C n/a

...Expand

: 91322-93-9
2,2-dipropyl-3-(2-hydroxyethyl)oxazolidine

A: 589-55-9
heptan-4-ol

B: 91322-89-3
1-(2-hydroxyethyl)-2-propyl-3-ethylpyrrole

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With potassium hydroxide Reflux;	A n/a B 64% C n/a

...Expand

: 106345-17-9
2-(6-Methyl-1-oxa-4-aza-spiro[4.5]dec-4-yl)-ethanol

A: 583-59-5
2-Methylcyclohexanol

B: 106345-21-5
2-(7-Methyl-4,5,6,7-tetrahydro-indol-1-yl)-ethanol

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With potassium hydroxide Heating; CH3ONa as reagent;	A n/a B 59% C n/a

...Expand

: 1586805-13-1
C13H27NO2

A: 623-93-8
5-nonanol

B: 1586805-19-7
2-butyl-1-(2-hydroxyethyl)-3-propylpyrrole

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With potassium hydroxide Reflux;	A n/a B 53% C n/a

...Expand

: 69470-38-8
C14H29NO2

A: 112-30-1
1-Decanol

B: 1586805-20-0
1-(2-hydroxyethyl)-3-octylpyrrole

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With potassium hydroxide Reflux;	A n/a B 53% C n/a

...Expand

: 75-21-8
oxirane

: 7664-41-7
ammonia

A: 102-71-6
triethanolamine

B: 141-43-5
ethanolamine

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
water at 48.84 - 76.84℃; under 12751.3 Torr; for 0.25h;	A 7.7% B 52.1% C 40.2%

...Expand

: 107-21-1
ethylene glycol

A: 110-85-0
piperazine

B: 141-43-5
ethanolamine

C: 111-41-1
2-(2-Aminoethylamino)ethanol

D: 107-15-3
ethylenediamine

E: 111-40-0
1,5-diamino-3-azapentane

F: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
Stage #1: ethylene glycol With ammonia; hydrogen at 150℃; under 150015 Torr; Stage #2: copper oxide; graphite; molybdenum oxide; nickel oxide; zirconium dioxide; mixture of at 170℃; under 150015 Torr;	A 6.8% B 29% C 5.7% D 49.5% E 3.9% F 1.7%
With ammonia; hydrogen at 170 - 180℃; under 150015 Torr; Conversion of starting material;
With ammonia; water; hydrogen at 180℃; under 150015 Torr; Conversion of starting material;
With ammonia; hydrogen at 150 - 170℃; under 150015 Torr; Conversion of starting material;
With ammonia; hydrogen at 200℃; under 150015 Torr; Conversion of starting material;

...Expand

: 495419-32-4
C12H17NO2

A: 1-(2-hydroxyethyl)-2-phenylpyrrole

B: 98-85-1, 13323-81-4
1-Phenylethanol

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With potassium hydroxide Reflux;	A 34% B n/a C n/a

...Expand

: C9H19NO2

A: 123-51-3
i-Amyl alcohol

B: 1-(2-hydroxyethyl)-3-isopropylpyrrole

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With potassium hydroxide Reflux;	A n/a B 30% C n/a

...Expand

: 80136-05-6
2-(2,2-dimethyl-oxazolidin-3-yl)-ethanol

A: 104803-80-7
N-hydroxy-2 ethyl-1 methyl-2 pyrrole

B: 111-42-2
2,2'-iminobis[ethanol]

C: 67-63-0
isopropyl alcohol

Conditions

Conditions	Yield
With potassium hydroxide Reflux;	A 20% B n/a C n/a

...Expand

: 75-21-8
oxirane

A: 141-43-5
ethanolamine

B: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With ammonia at 79.84℃; under 60006 Torr;
With ammonia at 130℃; under 82376.9 Torr;
With ammonia at 110℃; Temperature; Reagent/catalyst;

: 75-21-8
oxirane

: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With ammonia; water at 100℃; under 44130.5 - 58840.6 Torr;
With ammonia

: 75-21-8
oxirane

A: 102-71-6
triethanolamine

B: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With ammonia; water; ethanolamine at 15℃;
With ammonia In water
With ammonia; water; ethanolamine at 15℃;

: 110-86-1
pyridine

: 102-71-6
triethanolamine

: 94-36-0
dibenzoyl peroxide

A: 141-46-8
Glycolaldehyde

B: 111-42-2
2,2'-iminobis[ethanol]

...Expand

: 95073-63-5
N,N-bis-(2-hydroxy-ethyl)-hydroxylamine

: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With hydrogenchloride; zinc at 0℃;

: 7529-23-9
tris(2-hydroxyethyl)amine-N-oxide

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 102-71-6
triethanolamine

B: 111-42-2
2,2'-iminobis[ethanol]

...Expand

: 7529-23-9
tris(2-hydroxyethyl)amine-N-oxide

A: 102-71-6
triethanolamine

B: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With sodium hydroxide
With water; zinc beim Erhitzen mit Natronlauge;

: 107-16-4
glycolonitrile

: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With methanol; nickel at 100℃; Hydrogenation;

: 107-07-3
2-chloro-ethanol

: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With ammonia

: 75-21-8
oxirane

A: 102-71-6
triethanolamine

B: 141-43-5
ethanolamine

C: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With ammonia; wofatit KPS at 80℃; under 44253.5 Torr; for 0.25h; Product distribution; 10 - 30 min, water as a catalyst;	A 10.8 % Chromat. B 55.5 % Chromat. C 33.7 % Chromat.
With ammonia In water at 60℃;
With ammonia In water under 90009 - 105011 Torr; Heating;

...Expand

: 102-71-6
triethanolamine

A: 75-07-0
acetaldehyde

B: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
In water Mechanism; Rate constant; radiolysis;

: 116849-46-8
bis(2-hydroxyethyl)carbamate

A: 124-38-9
carbon dioxide

B: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
In water at 25℃; Thermodynamic data; Equilibrium constant; ΔH,ΔG, ΔS;

: sodium diethanolamine carbamate

: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With sodium hydroxide; sodium perchlorate; sodium hydrogencarbonate at 29.9 - 57.9℃; Equilibrium constant;

: 111-42-2
2,2'-iminobis[ethanol]

: 112-89-0
1-Bromooctadecane

: 10213-78-2
N,N-diethanolstearylamine

Conditions

Conditions	Yield
In acetonitrile Heating;	100%
With potassium carbonate; potassium iodide In acetonitrile	100%
With potassium hydrogencarbonate; potassium iodide In acetonitrile for 3h; Heating / reflux;	100%
With 2-pentanol das Hydrobromid ensteht;

: 100-39-0
benzyl bromide

: 111-42-2
2,2'-iminobis[ethanol]

: 101-32-6
N-benzyl-diethanolamine

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	100%
With potassium carbonate In acetone for 8h; Heating;	97%
With potassium carbonate In acetone for 8h; Heating / reflux;	97%

: 103-71-9
phenyl isocyanate

: 111-42-2
2,2'-iminobis[ethanol]

: 20074-78-6
1,1-[Di-(2-hydroxyethyl)]-3-phenylurea

Conditions

Conditions	Yield
In dichloromethane	100%
In benzene
In dichloromethane; toluene at 20℃;
In dichloromethane at 20℃; for 0.0166667h; Inert atmosphere;	1.14 g

: 111-42-2
2,2'-iminobis[ethanol]

: 3890-99-1
bis(2-bromoethyl)amine

Conditions

Conditions	Yield
With hydrogen bromide Reflux;	100%
With hydrogen bromide

: 112-26-5
1,2-bis(2-chloroethoxy)ethane

: 111-42-2
2,2'-iminobis[ethanol]

: 78995-84-3
3,12-Bis(2-hydroxyethyl)-6,9-dioxa-3,12-diaza-1,14-tetradecanediol

Conditions

Conditions	Yield
With sodium carbonate In xylene for 48h; Heating;	100%
With sodium carbonate In xylene Yield given;

: 16801-19-7
2-[2-(vinyloxy)ethoxymethyl]oxirane

: 111-42-2
2,2'-iminobis[ethanol]

: 122278-65-3
N-<2-hydroxy-2-(2-vinyloxyethoxymethyl)ethyl>-bis(2-hydroxyethyl)amine

Conditions

Conditions	Yield
at 55 - 60℃; under 760 Torr; for 2h;	100%
at 20 - 60℃; for 1.5h;	80%

: 24424-99-5
di-tert-butyl dicarbonate

: 111-42-2
2,2'-iminobis[ethanol]

: 103898-11-9
N,N-bis(2-hydroxyethyl)-O-tert-butylcarbamate

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 24h;	100%
In tetrahydrofuran for 24h; Ambient temperature;	100%
In tetrahydrofuran at 20℃; for 24h;	100%

: 59565-09-2
2-(vinyloxy)ethyl isothiocyanate

: 111-42-2
2,2'-iminobis[ethanol]

: 121612-58-6
1,1-Bis-(2-hydroxy-ethyl)-3-(2-vinyloxy-ethyl)-thiourea

Conditions

Conditions	Yield
	100%

: 111-42-2
2,2'-iminobis[ethanol]

: 762-04-9
phosphonic acid diethyl ester

: 2359-07-1
bis-(2-hydroxy-ethyl)-amidophosphoric acid diethyl ester

Conditions

Conditions	Yield
With potassium carbonate; potassium hydrogencarbonate; tetrabutylammomium bromide In tetrachloromethane; dichloromethane at 15 - 20℃; for 2h;	100%
With tetrachloromethane; triethylamine In chloroform at 10 - 20℃;
With tetrabutylammomium bromide; potassium carbonate; potassium hydrogencarbonate In tetrahydrofuran; tetrachloromethane for 1h; Ambient temperature; Yield given;

: 201230-82-2
carbon monoxide

: 111-42-2
2,2'-iminobis[ethanol]

: 2043-61-0
cyclohexanecarbaldehyde

: 55135-29-0
2-(2-cyclohexyl-oxazolidin-3-yl)-ethanol

Conditions

Conditions	Yield
With 1-Methylpyrrolidine; water; 3>PF6 at 140℃; under 51714.8 Torr; for 6h;	100%

...Expand

: 350-30-1
3-chloro-4-fluoronitrobenzene

: 111-42-2
2,2'-iminobis[ethanol]

: 65976-57-0
2-[(2-Chloro-4-nitro-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol

Conditions

Conditions	Yield
at 130℃; for 2h;	100%
In dimethyl sulfoxide	64%

: 111-42-2
2,2'-iminobis[ethanol]

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In 1,2-dichloro-ethane at 50℃; for 3h;	100%
With thionyl chloride In dichloromethane for 24h;	100%
With thionyl chloride In chloroform at 50℃; for 4h; Temperature;	98.8%

: 111-42-2
2,2'-iminobis[ethanol]

: 58479-61-1
tert-butylchlorodiphenylsilane

: 189279-33-2
N,N-[bis(2-tert-butyldiphenylsilyloxyethyl)]amine

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 0.5h;	100%
With triethylamine; dmap In dichloromethane at 0 - 20℃; for 20h; Product distribution / selectivity;	90%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 20h;	90%
With dmap; triethylamine In methanol; dichloromethane	2.53 g (2.13 mmol, 29%)
With dmap; triethylamine In methanol; dichloromethane	2.53 g (2.13 mmol, 29%)

: 111-42-2
2,2'-iminobis[ethanol]

: 464188-90-7
(4R,5R)-2-thioxo-4,5-bis(tert-butyloxycarbonyl)-1,3-dioxolane

: (2R,3R)-di-tert-butyl 2-[bis(2-hydroxyethyl)]thiocarbamoyloxy-3-hydroxysuccinate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 0.5h;	100%

: 2156-97-0
lauryl acrylate

: 111-42-2
2,2'-iminobis[ethanol]

: 3-[bis-(2-hydroxy-ethyl)-amino]-propionic acid dodecyl ester

Conditions

Conditions	Yield
at 50℃; Michael addition;	100%

: 111-42-2
2,2'-iminobis[ethanol]

: C50H98O25

: C54H109NO27

Conditions

Conditions	Yield
at 50℃; Michael addition;	100%

: 587880-74-8
[4-(4-Benzyloxycarbonylaminobutyl)phenoxy]acetic acid ethyl ester

: 111-42-2
2,2'-iminobis[ethanol]

: 847201-08-5
[4-(4-{[N,N-bis-(2-hydroxyethyl)carbamoyl]methoxy}phenyl)butyl]carbamic acid benzyl ester

Conditions

Conditions	Yield
With ethanol at 70℃; for 72h;	100%

: 111-42-2
2,2'-iminobis[ethanol]

: 308795-79-1
DTP2

: 467222-19-1
C4H11NO2*C20H30O2

Conditions

Conditions	Yield
In tetrahydrofuran; methanol for 1h;	100%

: 111-42-2
2,2'-iminobis[ethanol]

: 112-82-3
hexadecanyl bromide

: 18924-67-9
2,2'-(hexadecylazanediyl)diethanol

Conditions

Conditions	Yield
With potassium hydrogencarbonate; potassium iodide In acetonitrile for 3h; Reflux;	100%
With potassium carbonate; potassium iodide In acetonitrile for 12h; Inert atmosphere; Reflux;	96.1%
With potassium carbonate; potassium iodide In acetonitrile
With N-ethyl-N,N-diisopropylamine In methanol for 96h; Reflux;

: 945892-54-6
1-[6-fluoro-8-methoxy-3-({[2-methyl-4-(trifluoromethoxy)benzyl]amino}carbonyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylic acid

: 111-42-2
2,2'-iminobis[ethanol]

: 945892-80-8
1-[6-fluoro-8-methoxy-3-({[2-methyl-4-(trifluoromethoxy)benzyl]amino}carbonyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylic acid diethanolamine salt

Conditions

Conditions	Yield
In water; acetonitrile at 20℃;	100%

: 1067884-35-8
(2′Z-3′E)-6-bromoindirubin-3′-[O-(2-bromoethyl)oxime]

: 111-42-2
2,2'-iminobis[ethanol]

: 1067884-43-8
(2'Z-3'E)-6-bromoindirubin-3'-[O-(2-(N,N-(2-hydroxyethyl)amino)ethyl)oxime]

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃;	100%

: 1159105-82-4
4-methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylboronic acid

: 111-42-2
2,2'-iminobis[ethanol]

: 1159105-98-2
2-(4-methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,6,2-dioxazaborocane

Conditions

Conditions	Yield
In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;	100%

: 1159105-85-7
4-ethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylboronic acid

: 111-42-2
2,2'-iminobis[ethanol]

: 1159106-01-0
2-(4-ethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,6,2-dioxazaborocane

Conditions

Conditions	Yield
In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;	100%

: 245435-17-0
4-propoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylboronic acid

: 111-42-2
2,2'-iminobis[ethanol]

: 1159106-04-3
2-(4-propoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,6,2-dioxazaborocane

Conditions

Conditions	Yield
In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;	100%

: 1159105-89-1
4-butoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylboronic acid

: 111-42-2
2,2'-iminobis[ethanol]

: 1159106-07-6
2-(4-butoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,6,2-dioxazaborocane

Conditions

Conditions	Yield
In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;	100%

: 1159105-92-6
4-pentyloxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylboronic acid

: 111-42-2
2,2'-iminobis[ethanol]

: 1159106-10-1
2-(4-pentyloxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,6,2-dioxazaborocane

Conditions

Conditions	Yield
In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;	100%

: 1159105-95-9
4-hexyloxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylboronic acid

: 111-42-2
2,2'-iminobis[ethanol]

: 1159106-14-5
2-(4-hexyloxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,6,2-dioxazaborocane

Conditions

Conditions	Yield
In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;	100%

: 1112459-57-0
C28H20ClN5O5S2

: 111-42-2
2,2'-iminobis[ethanol]

: 1112459-39-8
2-Hydroxy-N-(2-hydroxyethyl)ethanaminium 3-(2-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]phenoxy}ethoxy)-3-oxopropanoate

Conditions

Conditions	Yield
In 1,4-dioxane; water at 20℃;	100%

: 1072833-77-2
Ixazomib

: 111-42-2
2,2'-iminobis[ethanol]

: 2,5-dichloro-N-[(2-((1R)-3-methyl-1-[1,3,6,2]-dioxaborolan-2-yl)-butylamino)-2-oxyethyl]benzamide

Conditions

Conditions	Yield
In ethyl acetate at 20℃; for 2h; Product distribution / selectivity;	100%

: 3-(2,6-dichloropyridin-4-yl)-4-methylaniline

: 111-42-2
2,2'-iminobis[ethanol]

: 2,2'-((4-(5-amino-2-methylphenyi)-6-chloropyridin-2-yl)azanediyl)diethanol

Conditions

Conditions	Yield
at 105℃;	100%

Diethanolamine Chemical Properties

Molecular Structure of Diethanolamine (CAS No.111-42-2):

Molecular Formula: C₄H₁₁NO₂
Molecular Weight: 105.14
IUPAC Name: 2-(2-Hydroxyethylamino)ethanol
CAS No: 111-42-2
EINECS: 203-868-0
H bond acceptors: 3
H bond donors: 3
Freely Rotating Bonds: 6
Polar Surface Area: 52.49 Å²
Index of Refraction: 1.465
Molar Refractivity: 27.24 cm³
Molar Volume: 98.3 cm³
Surface Tension: 43.5 dyne/cm
Density: 1.068 g/cm³
Flash Point: 137.8 °C
Melting Point: 28 °C(lit.)
Enthalpy of Vaporization: 58.81 kJ/mol
Boiling Point: 268.4 °C at 760 mmHg
Vapour Pressure: 0.00104 mmHg at 25°C
Melting Point: 27-30 ºC
Refractive Index: 1.475-1.479
Water Solubility: Miscible
Sensitive: Hygroscopic
Classification Code: Drug / Therapeutic Agent;Pharmaceutic aid [alkalizing agent];Reproductive Effect;Skin / Eye Irritant;TSCA Flag T [Subject to the Section 4 test rule under TSCA];Tumor data
Product Categories: Pharmaceutical Intermediates;Thanolamine Series;Analytical Chemistry;Mass Spectrometry;Matrix Materials (FABMS liquid SIMS)

Diethanolamine Uses

As surfactant and corrosion inhibitor, Diethanolamine (CAS No.111-42-2) is used to remove hydrogen sulfide and carbon dioxide from natural gas.

Diethanolamine Production

The reaction of Ethylene oxide with aqueous ammonia first produces Ethanolamine:
C₂H₄O + NH₃ → H₂NCH₂CH₂OH
which reacts with a second and third equivalent of Ethylene oxide to give Diethanolamine and Triethanolamine:
C₂H₄O + H₂NCH₂CH₂OH → HN(CH₂CH₂OH)₂
C₂H₄O + HN(CH₂CH₂OH)₂ → N(CH₂CH₂OH)₃
About 300M kg are produced annually in this way. The ratio of the products can be controlled by changing the stoichiometry of the reactants.

Diethanolamine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	2gm/kg (2000mg/kg)		"Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986Vol. 5, Pg. 197, 1986.
guinea pig	LD50	skin	11900uL/kg (11.9mL/kg)		National Technical Information Service. Vol. OTS0516742,
mammal (species unspecified)	LDLo	oral	3gm/kg (3000mg/kg)		National Technical Information Service. Vol. OTS0520710,
mouse	LD50	intraperitoneal	210mg/kg (210mg/kg)		National Technical Information Service. Vol. OTS0516742,
mouse	LD50	oral	3300mg/kg (3300mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(11), Pg. 25, 1964.
rabbit	LD50	oral	2200mg/kg (2200mg/kg)		Environmental Space Science. English Translation of Kosmicheskaya Biologiya Meditsina. 1967-70.Vol. 2, Pg. 289, 1968.
rabbit	LD50	skin	7640uL/kg (7.64mL/kg)	BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" MUSCULOSKELETAL: OTHER CHANGES	National Technical Information Service. Vol. OTS0516797,
rat	LD50	intramuscular	1500mg/kg (1500mg/kg)		Environmental Space Science. English Translation of Kosmicheskaya Biologiya Meditsina. 1967-70.Vol. 2, Pg. 289, 1968.
rat	LD50	intraperitoneal	120mg/kg (120mg/kg)		Environmental Space Science. English Translation of Kosmicheskaya Biologiya Meditsina. 1967-70.Vol. 2, Pg. 289, 1968.
rat	LD50	intravenous	778mg/kg (778mg/kg)		Environmental Space Science. English Translation of Kosmicheskaya Biologiya Meditsina. 1967-70.Vol. 2, Pg. 289, 1968.
rat	LD50	oral	620uL/kg (0.62mL/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR SKIN AND APPENDAGES (SKIN): HAIR: OTHER	National Technical Information Service. Vol. OTS0516797,
rat	LD50	subcutaneous	2200mg/kg (2200mg/kg)		Environmental Space Science. English Translation of Kosmicheskaya Biologiya Meditsina. 1967-70.Vol. 2, Pg. 289, 1968.

Diethanolamine Consensus Reports

Community Right-To-Know List. Reported in EPA TSCA Inventory.

Diethanolamine Safety Profile

Safety Information of Diethanolamine (CAS No.111-42-2):
Hazard Codes: Harmful Xn
Risk Statements: 22-38-41-48/22
R22:Harmful if swallowed.
R38:Irritating to skin.
R41:Risk of serious damage to the eyes.
R48/22:Harmful: danger of serious damage to health by prolonged exposure if swallowed.
Safety Statements: 26-36/37/39-46
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S46:If swallowed, seek medical advice immediately and show this container or label.
RIDADR: 3267
WGK Germany: 1
RTECS: KL2975000
F: 3
PackingGroup: II
Hazardous Substances Data: 111-42-2(Hazardous Substances Data)

Diethanolamine Standards and Recommendations

OSHA PEL: TWA 3 ppm
ACGIH TLV: TWA 0.46 ppm (skin)

Diethanolamine Analytical Methods

For occupational chemical analysis use NIOSH: Aminoethanol Compounds II 3509.

Diethanolamine Specification

Diethanolamine (CAS No.111-42-2), it also can be called 2,2'-Dihydroxydiethylamine ; 2,2'-Iminodiethanol ; Bis(2-hydroxyethyl)amine ; DEA .It is solid or viscous liquid with an amine odour.

Product Name

Diethanolamine

Synthetic route

Diethanolamine Chemical Properties

Diethanolamine Uses

Diethanolamine Production

Diethanolamine Toxicity Data With Reference

Diethanolamine Consensus Reports

Diethanolamine Safety Profile

Diethanolamine Standards and Recommendations

Diethanolamine Analytical Methods

Diethanolamine Specification

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