Product Name

  • Name

    Diethyl oxalate

  • EINECS 202-464-1
  • CAS No. 95-92-1
  • Article Data118
  • CAS DataBase
  • Density 1.086 g/cm3
  • Solubility may decompose in water
  • Melting Point -41 °C(lit.)
  • Formula C6H10O4
  • Boiling Point 185.4 °C at 760 mmHg
  • Molecular Weight 146.143
  • Flash Point 75.6 °C
  • Transport Information UN 2525 6.1/PG 3
  • Appearance colourless liquid
  • Safety 23
  • Risk Codes 22-36
  • Molecular Structure Molecular Structure of 95-92-1 (Diethyl oxalate)
  • Hazard Symbols HarmfulXn
  • Synonyms Ethanedioicacid, diethyl ester (9CI);Oxalic acid, diethyl ester (6CI,8CI);Diethylethanedioate;Ethyl oxalate;NSC 8851;Ethanedioicacid, 1,2-diethyl ester;
  • PSA 52.60000
  • LogP 0.11260

Synthetic route

ethanol
64-17-5

ethanol

oxalic acid
144-62-7

oxalic acid

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
With enriched hydroxylated graphene oxide In benzene at 120 - 140℃;99.3%
With sulfuric acid for 1h; Reflux;93%
With Fe(SO4)3 * xH2O In toluene for 1.2h; Heating;90%
ethanol
64-17-5

ethanol

N,N'-diacetyl-oxalamide
40227-15-4

N,N'-diacetyl-oxalamide

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
With sodium methylate95%
diacetyloxamide

diacetyloxamide

ethanol
64-17-5

ethanol

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
With sodium methylate95%
diethyl malonate
105-53-3

diethyl malonate

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
With aluminum (III) chloride; Oxone In water at 20℃; for 0.166667h;95%
ethanol
64-17-5

ethanol

1,1'-oxalyldiimidazole
18637-83-7

1,1'-oxalyldiimidazole

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
87%
oxalyl dichloride
79-37-8

oxalyl dichloride

ethanol
64-17-5

ethanol

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethanol
64-17-5

ethanol

ethanedinitrile
460-19-5

ethanedinitrile

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
With hydrogenchloride
ethanol
64-17-5

ethanol

dichloro-(2-chloro-ethoxy)-acetyl chloride
98020-30-5

dichloro-(2-chloro-ethoxy)-acetyl chloride

A

chloroethane
75-00-3

chloroethane

B

1,2-dichloro-ethane
107-06-2

1,2-dichloro-ethane

C

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
zuletzt in der Siedehitze; reagiert analog mit Methanol und Isopropylalkohol;
ethanol
64-17-5

ethanol

bis(trichloromethyl) oxalate
98020-90-7

bis(trichloromethyl) oxalate

A

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

B

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethanol
64-17-5

ethanol

phenol; compound with oxalic acid
66775-86-8

phenol; compound with oxalic acid

A

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

B

phenol
108-95-2

phenol

oxalic acid monoethyl ester
617-37-8

oxalic acid monoethyl ester

A

oxalic acid
144-62-7

oxalic acid

B

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
im Einschlussrohr;
beim Aufbewahren;
oxalic acid monoethyl ester
617-37-8

oxalic acid monoethyl ester

A

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

B

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

C

formic acid ethyl ester
109-94-4

formic acid ethyl ester

Conditions
ConditionsYield
bei der Destillation unter gewoehnlichem Druck;
(3-carbamoyl-phenyl)-oxalamic acid ethyl ester

(3-carbamoyl-phenyl)-oxalamic acid ethyl ester

A

N,N'-bis-(3-carbamoyl-phenyl)-oxalamide

N,N'-bis-(3-carbamoyl-phenyl)-oxalamide

B

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
beim Erhitzen ueber den Schmelzpunkt;
3-ethoxyoxalylamino-benzoic acid
90681-11-1

3-ethoxyoxalylamino-benzoic acid

A

3,3'-oxalyldiamino-di-benzoic acid
155049-63-1

3,3'-oxalyldiamino-di-benzoic acid

B

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
at 225℃;
5-acetoxy-6-ethoxyoxalyloxy-2-methyl-benzofuran-3-carboxylic acid ethyl ester
110029-67-9

5-acetoxy-6-ethoxyoxalyloxy-2-methyl-benzofuran-3-carboxylic acid ethyl ester

A

ethyl 5,6-dihydroxy-2-methyl-1-benzofuran-3-carboxylate
83634-11-1

ethyl 5,6-dihydroxy-2-methyl-1-benzofuran-3-carboxylate

B

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
With hydrogenchloride; ethanol
potassium monoethyl oxalate
1906-57-6

potassium monoethyl oxalate

A

ethanol
64-17-5

ethanol

B

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
beim Gluehen;
ethanol
64-17-5

ethanol

oxalic acid
144-62-7

oxalic acid

A

oxalic acid monoethyl ester
617-37-8

oxalic acid monoethyl ester

B

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
at 40 - 50℃; bei mehrwoechigem Stehen der gesaettigen Loesung;
With 20 molpercent molybdenum oxide nanoparticle supported on mesoporous silica at 75℃; for 8h; Time;
ethanol
64-17-5

ethanol

oxalic acid
144-62-7

oxalic acid

A

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

B

formic acid ethyl ester
109-94-4

formic acid ethyl ester

Conditions
ConditionsYield
durch Erhitzen; Nebenprod.2:Kohlensaeurediaethylester;
oxalic acid
144-62-7

oxalic acid

chloroacetaldehyde diethyl acetal
621-62-5

chloroacetaldehyde diethyl acetal

A

2-chloroethanal
107-20-0

2-chloroethanal

B

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Conditions
ConditionsYield
at 100 - 150℃;
monoorthooxalic acid-1,1,2-triethyl ester; sodium salt

monoorthooxalic acid-1,1,2-triethyl ester; sodium salt

acetic acid
64-19-7

acetic acid

A

ethanol
64-17-5

ethanol

B

sodium oxalate
62-76-0

sodium oxalate

C

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

para-chloroacetophenone
99-91-2

para-chloroacetophenone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 4-chlorobenzoylpyruvate
5814-38-0

ethyl 4-chlorobenzoylpyruvate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 1h; Claisen Condensation; Reflux;100%
With sodium In ethanol for 16h; Cooling with ice;97%
With sodium ethanolate In toluene at 50 - 60℃; for 4h;90%
3-methyl-butan-2-one
563-80-4

3-methyl-butan-2-one

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 2,4-dioxo-5-methylhexanoate
64195-85-3

ethyl 2,4-dioxo-5-methylhexanoate

Conditions
ConditionsYield
With sodium In ethanol at 0 - 80℃; for 2h;100%
Stage #1: 3-methyl-butan-2-one; oxalic acid diethyl ester With sodium In ethanol at 0 - 80℃; for 1.75h;
Stage #2: With sulfuric acid In ethanol; water at 15 - 25℃; pH=2;
90%
With sodium In ethanol at 20 - 80℃; for 76.25h; Reflux; Inert atmosphere;89.7%
biphenyl-4-acetaldehyde
92-91-1

biphenyl-4-acetaldehyde

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 3-(4-phenylbenzoyl)-2-ketopropionate
41350-17-8

ethyl 3-(4-phenylbenzoyl)-2-ketopropionate

Conditions
ConditionsYield
Stage #1: biphenyl-4-acetaldehyde With lithium hexamethyldisilazane In tetrahydrofuran; dichloromethane at -78℃; for 0.75h;
Stage #2: oxalic acid diethyl ester In tetrahydrofuran; dichloromethane at 0 - 20℃; for 16h;
Stage #3: With water; ammonium chloride In tetrahydrofuran; dichloromethane
100%
With sodium ethanolate In benzene for 4.5h; Ambient temperature;70%
With sodium
Stage #1: oxalic acid diethyl ester With sodium ethanolate In toluene for 0.166667h; Cooling with ice;
Stage #2: biphenyl-4-acetaldehyde In toluene for 4h; Cooling with ice;
With sodium In diethyl ether at 20 - 40℃;
oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

N,N'-bis[tris(hydroxymethyl)methyl]ethanediamide
5714-31-8

N,N'-bis[tris(hydroxymethyl)methyl]ethanediamide

Conditions
ConditionsYield
at 140℃; for 1h;100%
In ethylene glycol at 100 - 105℃; for 6h; Conversion of starting material;92%
oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

1-(4-methoxyphenyl)ethanone
100-06-1

1-(4-methoxyphenyl)ethanone

ethyl 3-(4-methoxybenzoyl)pyruvate
35322-20-4

ethyl 3-(4-methoxybenzoyl)pyruvate

Conditions
ConditionsYield
Stage #1: 1-(4-methoxyphenyl)ethanone With sodium In ethanol at 20℃; for 0.5h;
Stage #2: oxalic acid diethyl ester at 20 - 80℃; for 3h;
100%
With sodium hydride In N,N-dimethyl-formamide at 0 - 100℃;100%
Stage #1: oxalic acid diethyl ester With sodium methylate In diethyl ether at 20℃; Inert atmosphere;
Stage #2: 1-(4-methoxyphenyl)ethanone In diethyl ether at 20℃; for 12h;
92%
oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

naphthalene-1,8-diamine
479-27-6

naphthalene-1,8-diamine

ethyl 1H-perimidine-2-carboxylate
109735-80-0

ethyl 1H-perimidine-2-carboxylate

Conditions
ConditionsYield
at 135 - 140℃; for 1.5h;100%
acetophenone
98-86-2

acetophenone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 2,4-dioxo-4-phenylbutyrate
6296-54-4

ethyl 2,4-dioxo-4-phenylbutyrate

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 0 - 20℃; for 20h; Condensation;100%
Stage #1: acetophenone; oxalic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide at 20 - 50℃; for 0.833333h;
Stage #2: With hydrogenchloride In water
100%
With sodium hydride In tetrahydrofuran for 1h; Claisen Condensation; Reflux;100%
2-Acetylthiophene
88-15-3

2-Acetylthiophene

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 2,4-dioxo-4-(thiophen-2-yl)butanoate
36983-36-5

ethyl 2,4-dioxo-4-(thiophen-2-yl)butanoate

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 0 - 20℃; for 20h; Condensation;100%
With sodium methylate for 0.333333h;82%
With sodium methylate for 0.333333h; Heating;82%
2,3-dihydro-4H-[1]benzothiopyran-4-one
3528-17-4

2,3-dihydro-4H-[1]benzothiopyran-4-one

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

3-ethoxalyl-2,3-dihydro-1-benzothiopyran-4-one
56876-58-5

3-ethoxalyl-2,3-dihydro-1-benzothiopyran-4-one

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 40℃; for 2h;100%
With sodium In ethanol Claisen Condensation;
para-chloroacetophenone
99-91-2

para-chloroacetophenone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

4-(4-chlorophenyl)-2-hydroxy-4-oxobut-2-enoic acid ethyl ester lithium salt

4-(4-chlorophenyl)-2-hydroxy-4-oxobut-2-enoic acid ethyl ester lithium salt

Conditions
ConditionsYield
With lithium hexamethyldisilazane In diethyl ether at -78 - 20℃;100%
Stage #1: para-chloroacetophenone With lithium hexamethyldisilazane In tetrahydrofuran; tert-butyl methyl ether at -75 - -70℃; for 1h;
Stage #2: oxalic acid diethyl ester at -70 - 20℃; for 19h;
94%
Stage #1: para-chloroacetophenone With lithium hexamethyldisilazane In tetrahydrofuran; diethyl ether at -78℃; for 0.666667h;
Stage #2: oxalic acid diethyl ester In tetrahydrofuran; diethyl ether at -78 - 20℃;
92%
With lithium hexamethyldisilazane 1.) ether, -78 deg C, 30 min, 2.) room temperature, 2 h; Yield given. Multistep reaction;
1-(benzyloxy)-3-methyl-2-nitrobenzene
61535-21-5

1-(benzyloxy)-3-methyl-2-nitrobenzene

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 3-(3-benzyloxy-2-nitrophenyl)-pyruvate, potassium salt
96564-49-7

ethyl 3-(3-benzyloxy-2-nitrophenyl)-pyruvate, potassium salt

Conditions
ConditionsYield
With potassium ethoxide In diethyl ether for 20h; Heating;100%
With potassium tert-butylate In tetrahydrofuran; tert-butyl methyl ether at 20℃; Heating / reflux;74%
With potassium tert-butylate In tetrahydrofuran; diethyl ether at 20℃; Heating / reflux;
n-hexylmagnesium bromide
3761-92-0

n-hexylmagnesium bromide

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 2-oxooctanoate
67873-26-1

ethyl 2-oxooctanoate

Conditions
ConditionsYield
Stage #1: n-hexylmagnesium bromide; oxalic acid diethyl ester In tetrahydrofuran; diethyl ether at -58 - 0℃; for 0.5h;
Stage #2: With sulfuric acid; water In tetrahydrofuran; diethyl ether
100%
In tetrahydrofuran; diethyl ether at -60℃;88%
In tetrahydrofuran at -10℃; for 1h;43%
In diethyl ether at -78℃; for 1.66667h; Inert atmosphere;
In tetrahydrofuran at -78 - 20℃; for 1h; Inert atmosphere;
isopropenylmagnesium bromide
13291-18-4

isopropenylmagnesium bromide

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 3-methyl-2-oxobut-3-enoate
50331-71-0

ethyl 3-methyl-2-oxobut-3-enoate

Conditions
ConditionsYield
In tetrahydrofuran; diethyl ether at -70℃; for 0.333333h;100%
In tetrahydrofuran; diethyl ether at -60℃;87%
In tetrahydrofuran; diethyl ether at -78℃; for 1.83333h; Inert atmosphere;80%
In tetrahydrofuran; diethyl ether at -80℃;3.75 g
In tetrahydrofuran; diethyl ether at -78℃;
2-amino-4,5-difluoroaniline
76179-40-3

2-amino-4,5-difluoroaniline

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

6,7-difluoro-1,4-dihydro-2,3-quinoxalinedione
91895-29-3

6,7-difluoro-1,4-dihydro-2,3-quinoxalinedione

Conditions
ConditionsYield
for 16h; Heating;100%
oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

1,2-Bis-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-ethane-1,2-dione
85351-62-8

1,2-Bis-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-ethane-1,2-dione

Conditions
ConditionsYield
0 degC-room temp, 2 h, room temp;100%
4'-chloropropiophenone
6285-05-8

4'-chloropropiophenone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester
169544-41-6

4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester

Conditions
ConditionsYield
With sodium In ethanol at 20℃; for 18h; Claisen Condensation;100%
With lithium tert-butoxide In tetrahydrofuran at 0 - 20℃; for 4h; Claisen Condensation; Inert atmosphere;82%
Stage #1: oxalic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: 4'-chloropropiophenone In ethanol at 20℃; for 24h;
76.9%
oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

[5-(4-amino-2,6-dimethyl-phenoxy)-2-hydroxy-phenyl]-(4-fluoro-phenyl)-methanone
156740-88-4

[5-(4-amino-2,6-dimethyl-phenoxy)-2-hydroxy-phenyl]-(4-fluoro-phenyl)-methanone

ethyl N-<4-<3-(4-fluorobenzoyl)-4-hydroxyphenoxy>-3,5-dimethylphenyl>oxamate
156740-56-6

ethyl N-<4-<3-(4-fluorobenzoyl)-4-hydroxyphenoxy>-3,5-dimethylphenyl>oxamate

Conditions
ConditionsYield
at 100℃; for 1h;100%
In n-heptane
1-amino-3-(dimethylamino)propane
109-55-7

1-amino-3-(dimethylamino)propane

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

N,N'-bis(3-dimethylaminopropyl)oxalamide
25148-90-7

N,N'-bis(3-dimethylaminopropyl)oxalamide

Conditions
ConditionsYield
In ethanol Inert atmosphere; Flow reactor;100%
In tetrahydrofuran at 65℃; for 24h;90%
para-bromoacetophenone
99-90-1

para-bromoacetophenone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 4-(4-bromophenyl)-2,4-dioxobutanoate
40155-54-2

ethyl 4-(4-bromophenyl)-2,4-dioxobutanoate

Conditions
ConditionsYield
Stage #1: para-bromoacetophenone With sodium In ethanol at 0 - 10℃; for 1h;
Stage #2: oxalic acid diethyl ester In ethanol for 1.5h;
100%
With sodium ethanolate In ethanol at 20℃; for 12h;85%
Stage #1: oxalic acid diethyl ester With sodium ethanolate In benzene at 0℃; Inert atmosphere;
Stage #2: para-bromoacetophenone In benzene at 0 - 20℃; for 14.5h; Inert atmosphere;
75%
(3-acetylphenyl)(phenyl)methanone
66067-44-5

(3-acetylphenyl)(phenyl)methanone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

(Z)-4-(3-Benzoyl-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester

(Z)-4-(3-Benzoyl-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In toluene at 60℃;100%
oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

3-(azidophenyl) methyl ketone
70334-60-0

3-(azidophenyl) methyl ketone

(Z)-4-(3-Azido-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester

(Z)-4-(3-Azido-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In toluene at 60℃;100%
oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

1-[3-(4-benzoyl-benzyloxy)-phenyl]-ethanone
682360-15-2

1-[3-(4-benzoyl-benzyloxy)-phenyl]-ethanone

(Z)-4-[3-(4-Benzoyl-benzyloxy)-phenyl]-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester

(Z)-4-[3-(4-Benzoyl-benzyloxy)-phenyl]-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In toluene at 60℃;100%
o-hydroxyacetophenone
118-93-4

o-hydroxyacetophenone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 2-hydroxy-4-(2-hydroxyphenyl)-4-oxobut-2-enoate

ethyl 2-hydroxy-4-(2-hydroxyphenyl)-4-oxobut-2-enoate

Conditions
ConditionsYield
With sodium ethanolate In tetrahydrofuran at 25℃; for 0.00277778h; microwave irradiation;100%
3-Hydroxyacetophenone
121-71-1

3-Hydroxyacetophenone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

(Z)-ethyl 2-hydroxy-4-(3-hydroxyphenyl)-4-oxobut-2-enoate

(Z)-ethyl 2-hydroxy-4-(3-hydroxyphenyl)-4-oxobut-2-enoate

Conditions
ConditionsYield
With sodium ethanolate In tetrahydrofuran at 25℃; for 0.00277778h; microwave irradiation;100%
With potassium tert-butylate In tetrahydrofuran at 20℃; Claisen Condensation;88%
1-(2-chlorophenyl)ethanone
2142-68-9

1-(2-chlorophenyl)ethanone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

Lithium; (Z)-3-(2-chloro-phenyl)-1-ethoxycarbonyl-3-oxo-propen-1-olate

Lithium; (Z)-3-(2-chloro-phenyl)-1-ethoxycarbonyl-3-oxo-propen-1-olate

Conditions
ConditionsYield
With lithium hexamethyldisilazane In diethyl ether at -78 - 20℃;100%
oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

2-bromo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one
169192-93-2

2-bromo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

ethyl γ-(7-bromo-1-oxo-2,3,4,5-tetrahydrobenzocyclohepten-2-yl)-α-oxoacetate
870679-54-2

ethyl γ-(7-bromo-1-oxo-2,3,4,5-tetrahydrobenzocyclohepten-2-yl)-α-oxoacetate

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 20℃; Inert atmosphere;100%
With sodium ethanolate In ethanol at 20℃; for 9h;90%
oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

acetone
67-64-1

acetone

2-hydroxy-4-oxopent-2-enoic acid ethyl ester
53120-38-0

2-hydroxy-4-oxopent-2-enoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: oxalic acid diethyl ester; acetone With sodium ethanolate In ethanol at 20℃; for 2h;
Stage #2: With sulfuric acid In water at 0 - 20℃;
100%
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 16h;47%
With sodium ethanolate In ethanol at 20℃; for 2h; aldol condensation;
3,6-diacetyl-4(1H)-quinolinone
883107-05-9

3,6-diacetyl-4(1H)-quinolinone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

(Z)-4-[6-((Z)-3-Ethoxycarbonyl-3-hydroxy-acryloyl)-4-oxo-1,4-dihydro-quinolin-3-yl]-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester

(Z)-4-[6-((Z)-3-Ethoxycarbonyl-3-hydroxy-acryloyl)-4-oxo-1,4-dihydro-quinolin-3-yl]-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester

Conditions
ConditionsYield
With sodium ethanolate In tetrahydrofuran at 20℃; for 2h; Claisen condensation;100%
3,4-diamino-2'-methoxy-biphenyl-2-carbonitrile

3,4-diamino-2'-methoxy-biphenyl-2-carbonitrile

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

6-(2-methoxy-phenyl)-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-5-carbonitrile
951630-17-4

6-(2-methoxy-phenyl)-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-5-carbonitrile

Conditions
ConditionsYield
for 5h; Heating / reflux;100%
3-acetyl-5-methoxy-1-(4-(trifluoromethyl)benzyl)-1H-indole
947589-65-3

3-acetyl-5-methoxy-1-(4-(trifluoromethyl)benzyl)-1H-indole

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl (Z)-4-[5-methoxy-1-(4-(trifluoromethyl)benzyl)-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

ethyl (Z)-4-[5-methoxy-1-(4-(trifluoromethyl)benzyl)-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

Conditions
ConditionsYield
With sodium methylate In tetrahydrofuran at 50℃; under 15514.9 Torr; for 0.0666667h; microwave irradiation;100%

Diethyl oxalate Consensus Reports

Diethyl oxalate ( 95-92-1) Market Research Report 2009

Diethyl oxalate Specification

The Diethyl oxalate, with the CAS registry number 95-92-1, is also known as Ethanedioicacid, 1,2-diethyl ester. It belongs to the product categories of Pharmaceutical Intermediates; Organics; Analytical Chemistry; Solvents for HPLC & Spectrophotometry; Solvents for Spectrophotometry; C6 to C7; Carbonyl Compounds; Esters; Esters Chromatography; Alpha Sort; Chemical Class; DAlphabetic; DID - DIN Analytical Standards; Food & Beverage Standards; Organic Acids; Volatiles/ Semivolatiles. Its EINECS number is 202-464-1. This chemical's molecular formula is C6H10O4 and molecular weight is 146.14. What's more, its systematic name is diethyl ethanedioate. Its classification code is Skin / Eye Irritant. It is mainly used as an intermediate for phenobarbital, azathioprine, sulfadoxine-pyrimethamine and so on in the pharmaceutical industry. It is also used as a plastic promoter, dyes intermediates and as solvent of cellulose esters, spices. It should be sealed and stored in a cool, ventilated and dry place. Moreover, it should be protected from oxides, acids, bases, heat and fire.

Physical properties of Diethyl oxalate are: (1)ACD/LogP: 0.73; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.73; (4)ACD/LogD (pH 7.4): 0.73; (5)ACD/BCF (pH 5.5): 2.1; (6)ACD/BCF (pH 7.4): 2.1; (7)ACD/KOC (pH 5.5): 59.17; (8)ACD/KOC (pH 7.4): 59.17; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 52.6 Å2; (13)Index of Refraction: 1.41; (14)Molar Refractivity: 33.39 cm3; (15)Molar Volume: 134.5 cm3; (16)Polarizability: 13.23×10-24cm3; (17)Surface Tension: 32.1 dyne/cm; (18)Density: 1.086 g/cm3; (19)Flash Point: 75.6 °C; (20)Enthalpy of Vaporization: 42.16 kJ/mol; (21)Boiling Point: 185.4 °C at 760 mmHg; (22)Vapour Pressure: 0.698 mmHg at 25°C.

Preparation: this chemical can be prepared by oxalic acid and ethanol by heating. This reaction will need reagent Fe(SO4)3 ·xH2O and solvent toluene with the reaction time of 1.2 hours. The yield is about 96%.

Diethyl oxalate can be prepared by oxalic acid and ethanol by heating

Uses of Diethyl oxalate: it can be used to produce oxo-(2-oxo-tetrahydro-furan-3-yl)-acetic acid ethyl ester at the temperature of 0 - 20 °C. It will need reagent sodium ethoxide and solvent ethanol. The yield is about 96%.

Diethyl oxalate can be used to produce oxo-(2-oxo-tetrahydro-furan-3-yl)-acetic acid ethyl ester at the temperature of 0 - 20 °C

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed. It is irritating to the eyes. You should not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer).

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1S/C6H10O4/c1-3-9-5(7)6(8)10-4-2/h3-4H2,1-2H3
(2)InChIKey: WYACBZDAHNBPPB-UHFFFAOYSA-N
(3)Canonical SMILES: CCOC(=O)C(=O)OCC

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ANTIPSYCHOTIC
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(5), Pg. 87, 1981.

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