Diethyl phosphoric acid supplier

Name
DIETHYL PHOSPHATE
EINECS
CAS No. 598-02-7
Article Data208
CAS DataBase
Density 1.195g/cm³
Solubility
Melting Point 6 °C
Formula C4H11 O4 P
Boiling Point 203 °C
Molecular Weight 154.103
Flash Point 74.9°C
Transport Information
Appearance
Safety A poison by ingestion. When heated to decomposition it emits toxic vapors of PO_x.
Risk Codes R36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Ethylphosphate ((C2H5O)2(HO)PO) (6CI); DEP; Diethyl acid phosphate; Diethyl hydrogenphosphate; Diethyl phosphate; Diethyl phosphoric acid; NSC 97178; O,O-Diethylhydrogen phosphate
PSA 65.57000
LogP 1.15980

Synthetic route

: 150943-28-5
diethyl pyren-1-ylmethyl phosphate

: 598-02-7
Diethyl phosphate

Conditions

Conditions	Yield
In methanol; benzene for 2h; Product distribution; Quantum yield; Irradiation; other phosphates; var. solvents;	100%

: C13H19NO3P(1-)*Li(1+)

: 100-52-7
benzaldehyde

A: 598-02-7
Diethyl phosphate

B: 113237-57-3
α-methyltrans-cinnamyl N-phenylimine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 25℃; for 3h;	A n/a B 98%

...Expand

: 814-49-3
diethyl chlorophosphate

: 598-02-7
Diethyl phosphate

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran for 0.5h;	95%
With sodium hydroxide In tetrahydrofuran; water at 0℃;	92%
With sodium hydroxide at 30 - 40℃;	90%

: 1108208-57-6
tetrachlorobis[4-(dimethylamino)pyridine]phosphorus(V) chloride

: 64-17-5
ethanol

: 598-02-7
Diethyl phosphate

Conditions

Conditions	Yield
at 60℃; for 4.5h;	95%

: 1108208-58-7
cis-tetrachlorobis(1-methylimidazole)phosphorus(V) chloride

: 64-17-5
ethanol

: 598-02-7
Diethyl phosphate

Conditions

Conditions	Yield
at 60℃; for 4.5h;	95%

: 133323-03-2
Diethyl 2-(methylsulfonylamino)phenyl phosphate

A: 598-02-7
Diethyl phosphate

B: 19299-40-2
N-cyclohexylmethanesulfonamide

Conditions

Conditions	Yield
With hydrogen; acetic acid; trifluoroacetic acid; platinum(IV) oxide at 20℃; under 750.06 Torr; for 20h;	A 93% B 73%

: 884-90-2
benzyl diethyl phosphate

: 598-02-7
Diethyl phosphate

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In benzene at 80℃; for 4h; Inert atmosphere;	93%
With trifluorormethanesulfonic acid In toluene at 120℃; for 24h; Sealed tube; Schlenk technique; Inert atmosphere;	93%

: 30094-32-7
(diethoxy phosphoryl) fluoroacetic acid

: 100-52-7
benzaldehyde

A: 598-02-7
Diethyl phosphate

B: 20397-61-9
(Z)-2-fluoro-3-phenylacrylic acid

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane 1.) -78 deg C, 1 h; 2.) 15 h room temperature;	A n/a B 91%

...Expand

: 30094-32-7
(diethoxy phosphoryl) fluoroacetic acid

: 123-11-5
4-methoxy-benzaldehyde

A: 598-02-7
Diethyl phosphate

B: 26928-12-1
(Z)-2-fluoro-3-(4-methoxyphenyl)-2-propenoic acid

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane 1.) -78 deg C, 1 h; 2.) 15 h room temperature;	A n/a B 90%

...Expand

: 762-04-9
phosphonic acid diethyl ester

A: 598-02-7
Diethyl phosphate

B: 107-49-3
Tetraethyl pyrophosphate

Conditions

Conditions	Yield
With iodosylbenzene In tetrahydrofuran for 48h; Heating;	A 90% B 5%
With iodosylbenzene In benzene for 0.5h; Product distribution; Further Variations:; Solvents; Heating;	A 11% B 77%
With iodosylbenzene In benzene for 0.5h; Heating;	A 11% B 77%

: 64-17-5
ethanol

A: 598-02-7
Diethyl phosphate

B: 15845-66-6
Ethylphosphorige Saeure

Conditions

Conditions	Yield
With oxygen; hypophosphorous acid; copper dichloride at 70℃; for 6h;	A 89% B 4%

: 64-17-5
ethanol

: 762-04-9
phosphonic acid diethyl ester

A: 598-02-7
Diethyl phosphate

B: 78-40-0
triethyl phosphate

Conditions

Conditions	Yield
With tetraethylammonium iodide; water In acetonitrile at 25℃; Product distribution; var. ethanol:H2O ratios; electrosynthesis;	A 12.5% B 86.1%

...Expand

: 762-04-9
phosphonic acid diethyl ester

A: 598-02-7
Diethyl phosphate

B: 78-40-0
triethyl phosphate

Conditions

Conditions	Yield
With tetraethylammonium iodide; water In ethanol; acetonitrile at 25℃;	A 12.5% B 86.1%

: 88418-70-6
N,N'-di-(2,2,6,6-tetramethyl-1-oxyl-piperidin-4-yl)-N-diethylphosphorylurea

A: 598-02-7
Diethyl phosphate

B: 78140-61-1
di-(2,2,6,6-tetramethyl-1-oxyl-piperidin-4-yl)carbodiimide

Conditions

Conditions	Yield
With sodium hydride In 1,2-dimethoxyethane 1. ) 20 deg C, 6 h, 2.) reflux, 2 h;	A n/a B 86%

: 113680-16-3
diethyl (2-(4-methoxyphenyl)-2-oxoethyl) phosphate

A: 598-02-7
Diethyl phosphate

B: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With 1,4-dioxane; triethylamine at -20℃; for 8h; Mechanism; Product distribution; Irradiation;	A 86% B 84%

: 156661-88-0
Phosphoric acid 2-chloro-6-methanesulfonylamino-phenyl ester diethyl ester

A: 598-02-7
Diethyl phosphate

B: N-(3-Chloro-cyclohexyl)-methanesulfonamide

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In acetic acid; trifluoroacetic acid at 20℃; under 750.06 Torr; for 20h;	A 85% B 70%

: 156661-89-1
Phosphoric acid 2,4-dichloro-6-methanesulfonylamino-phenyl ester diethyl ester

A: 598-02-7
Diethyl phosphate

B: N-(3,5-Dichloro-cyclohexyl)-methanesulfonamide

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In acetic acid; trifluoroacetic acid at 20℃; under 750.06 Torr; for 20h;	A 85% B 70%

: 64-17-5
ethanol

A: 1623-14-9
ethyl phosphate

B: 598-02-7
Diethyl phosphate

C: 78-40-0
triethyl phosphate

Conditions

Conditions	Yield
With phosphorus; tetraethylammonium iodide In water; acetonitrile electrolysis;	A n/a B n/a C 84%

...Expand

: 2942-58-7
diethyl cyanophosphonate

: 7732-18-5
water

: 598-02-7
Diethyl phosphate

Conditions

Conditions	Yield
With HKUST-1 metal organic framework In chloroform at 20℃; Kinetics;	83%

: 762-04-9
phosphonic acid diethyl ester

: 598-02-7
Diethyl phosphate

Conditions

Conditions	Yield
With di-iodine pentaoxide In acetonitrile at 80℃; for 12h;	82%
With oxygen; silver nitrate In toluene at 60℃; for 1h;	37%
With iodosylbenzene In acetonitrile at 20℃; for 180h;	29%
With iodide; iodine; carbonate(2-) at 25℃; Rate constant; various catalysts, reagent and catalyst concentration, isotope effect;

: 65345-03-1
bromo-1 hydroxy-2 ethyl phosphonate de diethyle

A: 20030-44-8
epoxy-1,2 ethyl phosphonate de diethyle

B: 598-02-7
Diethyl phosphate

C: 38318-52-4
α-bromovinylphosphonic acid diethyl ester

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 2h; Ambient temperature;	A 82% B 5% C n/a

...Expand

: 126-68-1
O,O,O-triethyl phosphorothioate

A: 598-02-7
Diethyl phosphate

B: 78-38-6
ethylphosphonic acid diethyl ester

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With magnesium monoperoxyphthalate hexahydrate In water at 25℃; for 24h;	A 10% B 81% C 9%

...Expand

: 206666-54-8
[2-(4,5-Dimethyl-2-piperidin-1-yl-[1,3]dithiol-2-yl)-benzo[1,3]dithiol-2-yl]-phosphonic acid diethyl ester

A: 618-42-8
1-piperidin-1-yl-ethanone

B: 65220-59-9
dimethyl benzotetrathiafulvalene

C: 598-02-7
Diethyl phosphate

D: 4540-33-4
piperdinium acetate

Conditions

Conditions	Yield
With acetic acid Ambient temperature; AcOH : Educt ratio = 10;	A n/a B 80% C n/a D n/a
With acetic acid Ambient temperature; AcOH : Educt ratio = 10; Yield given;

...Expand

: 2942-58-7
diethyl cyanophosphonate

: 598-02-7
Diethyl phosphate

Conditions

Conditions	Yield
With HKUST-1 metal organic framework In chloroform at 20℃; Kinetics;	78%
With 7,7'-carbonylbis(azanediyl)bis(N-butyl-1H-indole-2-carboxamide) In water; acetone at 25℃;
With K12(Ti2O2)(GeNb12O40)*19H2O; water In N,N-dimethyl-formamide at 20℃; for 0.5h; Reagent/catalyst;

: O-(diethoxyphosphinyl)-1,2-naphthoquinone oxime

A: 598-02-7
Diethyl phosphate

B: 2886-29-5
trans-3-(2-cyanophenyl)propenoic acid

Conditions

Conditions	Yield
With hydrogenchloride In acetone -5 deg C, 1 h then 20 deg C, 2 h;	A n/a B 77%

: C13H19NO3P(1-)*Li(1+)

: 100-52-7
benzaldehyde

A: 598-02-7
Diethyl phosphate

B: 15174-47-7
α-methyl-trans-cinnamaldehyde

Conditions

Conditions	Yield
Product distribution; multistep reaction, var. aldehydes.;	A n/a B 71%
With hydrogenchloride 1.) THF, 0 to 20 deg C, 3 h, 2.) ether; Yield given. Multistep reaction;

...Expand

: 2465-65-8
Thiophosphorsaeure-O,O-diethylester

A: 598-02-7
Diethyl phosphate

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With magnesium monoperoxyphthalate hexahydrate In water at 25℃; for 24h;	A 70% B 30%

: 5131-24-8
O,O-diethyl phthalimido-phosphonothioate

A: 598-02-7
Diethyl phosphate

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With magnesium monoperoxyphthalate hexahydrate In water at 25℃; for 24h;	A 27% B 70%

: C15H23NO3P(1-)*Li(1+)

: 100-52-7
benzaldehyde

A: 598-02-7
Diethyl phosphate

B: 75101-98-3
(2E)-3-phenyl-2-propylprop-2-enal

Conditions

Conditions	Yield
Product distribution; multistep reaction, var. aldehydes.;	A n/a B 66%
With hydrogenchloride 1.) THF, 0 to 25 deg C, 3 h, 2.) ether; Yield given. Multistep reaction;

...Expand

: 100-52-7
benzaldehyde

: 146064-45-1
diethyl (α-thiocyanatomethyl)phosphonate

A: 598-02-7
Diethyl phosphate

B: 61807-26-9
(E)-(2-thiocyanatovinyl)-benzene

C: 25362-01-0
(Z)-diethyl styrylphosphonate

D: 20408-33-7
diethyl (E)-(2-phenylethenyl)phosphonate

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at -70℃; for 2h;	A n/a B n/a C 60% D n/a

...Expand

: 598-02-7
Diethyl phosphate

: {2-[2-(2-tert-butoxycarbonylamino-acetylamino)-acetylamino]-acetylamino}-thioacetic acid S-ethyl ester

: [2-{2-[2-(2-tert-butoxycarbonylamino-acetylamino)-acetylamino]-acetylamino}-1-(diethoxy-phosphoryloxy)-ethyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 0.25h;	98%

: 598-02-7
Diethyl phosphate

: C14H22N2

: [(2-ethylhexylamino)pyridin-4-ylmethyl]phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 80℃; for 5h;	96.3%

: 598-02-7
Diethyl phosphate

: 524684-52-4
prinaberel

: 1178586-90-7
diethyl 2-fluoro-4-(5-hydroxy-7-vinylbenzo[d]oxazol-2-yl)phenyl phosphate

Conditions

Conditions	Yield
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; tetrachloromethane; acetonitrile at 20℃; for 24h;	93%

: 3-[3-amino-4-chlorophenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

: 598-02-7
Diethyl phosphate

: 555-16-8
4-nitrobenzaldehdye

: C23H23ClF3N4O7P

Conditions

Conditions	Yield
With magnesium(II) perchlorate In acetonitrile at 70 - 80℃; Kabachnik-Fields Reaction;	93%

...Expand

: 598-02-7
Diethyl phosphate

: 1428527-64-3
tert-butyl 2-(6-(4-bromophenyl)pyridin-3-yl)propan-2-ylcarbamate

: 1436433-27-0
tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine In toluene for 8h; Inert atmosphere; Reflux;	92.4%

: 3385-94-2
hexamethyldisilathiane

: 598-02-7
Diethyl phosphate

: 18306-68-8
diethyltrimethylsilyl phosphate

Conditions

Conditions	Yield
at 50℃; for 0.5h;	92%

: 598-02-7
Diethyl phosphate

: 108128-31-0
2-diazo-1-(4-hydroxy-3-methoxyphenyl)ethanone

: 1292298-90-8
diethyl (2-(4-hydroxy-3-methoxyphenyl)-2-oxoethyl) phosphate

Conditions

Conditions	Yield
In benzene at 60℃; for 24h;	92%

: 3-(5-amino-2,4-dichlorophenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione

: 598-02-7
Diethyl phosphate

: 104-88-1
4-chlorobenzaldehyde

: C23H22Cl3F3N3O5P

Conditions

Conditions	Yield
With magnesium(II) perchlorate In acetonitrile at 70 - 80℃; Kabachnik-Fields Reaction;	92%

...Expand

: 598-02-7
Diethyl phosphate

: C8H20O8P2*Br2Sn

Conditions

Conditions	Yield
With stannic bromide	91%

: 598-02-7
Diethyl phosphate

: 98-88-4
benzoyl chloride

: 7334-48-7
benzoic (diethyl phosphoric) anhydride

Conditions

Conditions	Yield
With silver(l) oxide In acetonitrile at 20℃; for 5h;	91%

: 598-02-7
Diethyl phosphate

: 100-46-9
benzylamine

: 53640-96-3
diethyl N-benzylphosphoramidate

Conditions

Conditions	Yield
With triethylamine; hexamethyltriaminodibromophosphorane In dichloromethane for 2h; Ambient temperature;	91%

: 598-02-7
Diethyl phosphate

: 1369964-75-9
2-diazomethyl-3-phenyl-4H-sulfonylchromen

: 1187758-97-9
(1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl diethyl phosphate

Conditions

Conditions	Yield
With hydrogenchloride In chloroform; water at 60℃; for 3h; pH=4; Inert atmosphere;	91%

: 598-02-7
Diethyl phosphate

: 123-11-5
4-methoxy-benzaldehyde

: 110470-34-3, 110548-53-3, 110548-54-4, 112564-56-4
diethyl [1-amine(4-methoxyphenyl)methyl]phosphonate

Conditions

Conditions	Yield
With ammonium acetate at 20 - 60℃; for 44h; Molecular sieve;	91%

: 598-02-7
Diethyl phosphate

: 107-49-3
Tetraethyl pyrophosphate

Conditions

Conditions	Yield
With N,N,N',N'-tetramethylchlorformamidinium chloride; triethylamine In dichloromethane at 0 - 20℃; for 2h;	90%

: 598-02-7
Diethyl phosphate

: 292150-92-6
(S)-S-ethyl 2-((tert-butoxycarbonyl)amino)propanethioate

: [2-tert-butoxycarbonylamino-1-(diethoxy-phosphoryloxy)-propyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With potassium tert-butylate In toluene at 20℃; for 0.25h;	90%

: 598-02-7
Diethyl phosphate

: 2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-thiopropionic acid S-ethyl ester

: [2-tert-butoxycarbonylamino-1-(diethoxy-phosphoryloxy)-3-(1H-indol-3-yl)-propyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With potassium tert-butylate In toluene at 20℃; for 0.25h;	90%

: 854172-02-4
N-(cyclobutylidene)-2-methyl-2-propanamine

: 598-02-7
Diethyl phosphate

: diethyl (1-(tert-butylamino)cyclobutyl)phosphonate

Conditions

Conditions	Yield
With titanium tetrachloride In neat liquid at 0℃; for 24h;	90%

Diethyl phosphoric acid Chemical Properties

Product Name: Diethyl phosphoric acid (CAS NO.598-02-7)

Molecular Formula: C₄H₁₁O₄P
Molecular Weight: 154.1g/mol
Mol File: 598-02-7.mol
Einecs: 209-912-5
Appearance: Clear colorless to light yellow-orange liquid
Melting Point: 6 °C
Boiling point: 200.3 °C at 760 mmHg
Flash Point: 74.9 °C
Density: 1.195 g/cm³
Surface Tension: 37.6 dyne/cm
Enthalpy of Vaporization: 48.11 kJ/mol
Vapour Pressure: 0.137 mmHg at 25°C
XLogP3-AA: -0.3
H-Bond Donor: 1
H-Bond Acceptor: 4
Structure Descriptors of Diethyl phosphoric acid (CAS NO.598-02-7):
IUPAC Name: diethyl hydrogen phosphate
Canonical SMILES: CCOP(=O)(O)OCC
InChI: InChI=1S/C4H11O4P/c1-3-7-9(5,6)8-4-2/h3-4H2,1-2H3,(H,5,6)
InChIKey: UCQFCFPECQILOL-UHFFFAOYSA-N
Product Categories: Alphabetic; D; DID - DINEnvironmental Standards; Metabolites; Pesticides&Metabolites

Diethyl phosphoric acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LDLo	oral	> 250mg/kg (250mg/kg)		National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 37, 1953.

Diethyl phosphoric acid Consensus Reports

Reported in EPA TSCA Inventory.

Diethyl phosphoric acid Safety Profile

A poison by ingestion. When heated to decomposition it emits toxic vapors of PO_x.
Safety Information of Diethyl phosphoric acid (CAS NO.598-02-7):
Hazard Codes: Xi Irritant
Risk Statements: 36/37/38
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 37/39-26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection

Diethyl phosphoric acid Specification

Diethyl phosphoric acid ,its CAS NO. is 598-02-7,the synonyms is Diethyl acid phosphate ; Diethyl hydrogen phosphate ; Diethyl phosphate ; EINECS 209-912-5 ; Ethyl phosphate, (ETO)₂(HO)PO ; Ethyl phosphate, di- ; NSC 97178 ; O,O-Diethyl hydrogen phosphate ; Phosphoric acid, diethyl ester .

Product Name

DIETHYL PHOSPHATE

Synthetic route

Diethyl phosphoric acid Chemical Properties

Diethyl phosphoric acid Toxicity Data With Reference

Diethyl phosphoric acid Consensus Reports

Diethyl phosphoric acid Safety Profile

Diethyl phosphoric acid Specification

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