Product Name

  • Name

    Diflubenzuron

  • EINECS 252-529-3
  • CAS No. 35367-38-5
  • Article Data57
  • CAS DataBase
  • Density 1.471 g/cm3
  • Solubility 0.008 g/100 mL
  • Melting Point 230-232 °C
  • Formula C14H9ClF2N2O2
  • Boiling Point
  • Molecular Weight 310.687
  • Flash Point
  • Transport Information UN 3077
  • Appearance colorless to yellow crystals
  • Safety 60-61
  • Risk Codes 50/53
  • Molecular Structure Molecular Structure of 35367-38-5 (Diflubenzuron)
  • Hazard Symbols CorrosiveC,DangerousN
  • Synonyms 1-(4-chlorophenyl)-3-(2,6-ifluorobenzoyl)urea;Difluron;Larvakil;Benzamide,N-[[(4-chlorophenyl)amino]- carbonyl]-2,6-difluoro-;Micromite (Uniroyal);Dimilin;
  • PSA 58.20000
  • LogP 4.04400

Synthetic route

4-chloro-aniline
106-47-8

4-chloro-aniline

S-allyl N-(2,6-difluorobenzoyl)monothiocarbamate
148931-18-4

S-allyl N-(2,6-difluorobenzoyl)monothiocarbamate

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
With triethylamine In benzene for 2h; Heating;70%
4-chloro-aniline
106-47-8

4-chloro-aniline

N-(Bis-methylsulfanyl-methylene)-2,6-difluoro-benzamide
119448-98-5

N-(Bis-methylsulfanyl-methylene)-2,6-difluoro-benzamide

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
With acetic acid for 6h; Heating;69%
2,6-difluorobenzoylchloride
18063-02-0

2,6-difluorobenzoylchloride

N-(4-chlorophenyl)urea
140-38-5

N-(4-chlorophenyl)urea

A

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

B

N-(4-chlorophenyl)-2,6-difluorobenzamide
122987-01-3

N-(4-chlorophenyl)-2,6-difluorobenzamide

Conditions
ConditionsYield
In toluene for 7h; Heating;A 67%
B 5 g
In toluene for 7h; Heating;A 5 g
B 5 g
...Expand
1-(4-chlorophenyl)-3-(3,5-difluorobenzyl)urea

1-(4-chlorophenyl)-3-(3,5-difluorobenzyl)urea

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
With 9-(2-mesityl)-10-methylacridinium perchlorate In chloroform at 35℃; for 4h; Irradiation;64%
2,6-difluorobenzoyl isocyanate
60731-73-9

2,6-difluorobenzoyl isocyanate

C10H13ClN2O2S

C10H13ClN2O2S

A

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

B

C18H16ClF2N3O4S

C18H16ClF2N3O4S

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 20℃; for 3h;A n/a
B 60.1%
...Expand
2,6-difluorobenzoyl isocyanate
60731-73-9

2,6-difluorobenzoyl isocyanate

N-(t-butoxycarbonyl)-4-chloroaniline
18437-66-6

N-(t-butoxycarbonyl)-4-chloroaniline

A

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

B

C19H17ClF2N2O4

C19H17ClF2N2O4

Conditions
ConditionsYield
In 1,2-dichloro-ethane Heating;A n/a
B 59%
...Expand
1-bromo-2,6-difluorobenzene
64248-56-2

1-bromo-2,6-difluorobenzene

carbon monoxide
201230-82-2

carbon monoxide

N-(4-chlorophenyl)urea
140-38-5

N-(4-chlorophenyl)urea

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; under 3361.55 Torr; for 4h; Microwave irradiation;45%
...Expand
benzyl N-methylcarbamate
30379-59-0

benzyl N-methylcarbamate

2,6-difluorobenzoyl isocyanate
60731-73-9

2,6-difluorobenzoyl isocyanate

4-chloro-aniline
106-47-8

4-chloro-aniline

A

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

B

C23H18ClF2N3O4S

C23H18ClF2N3O4S

Conditions
ConditionsYield
Stage #1: benzyl N-methylcarbamate With sulfur dichloride
Stage #2: 4-chloro-aniline With pyridine In tetrahydrofuran at 20℃;
Stage #3: 2,6-difluorobenzoyl isocyanate In 1,2-dichloro-ethane at 20℃;		A n/a
B 11.9%
...Expand
2,6-difluorobenzamide
18063-03-1

2,6-difluorobenzamide

p-chlorphenylisocyanate
104-12-1

p-chlorphenylisocyanate

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
In toluene for 5h; Heating;
With sodium hydride In N,N-dimethyl-formamide 1.) 30 min., -10 to 0 deg C, 2.) 4h, room temperature;
In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 5h; Temperature; Large scale;
2,6-difluorobenzoyl isocyanate
60731-73-9

2,6-difluorobenzoyl isocyanate

phenyl N-(4-chlorophenyl)carbamate
50882-28-5

phenyl N-(4-chlorophenyl)carbamate

A

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

B

N-2,6-difluorobenzoyl-O-phenylcarbamate

N-2,6-difluorobenzoyl-O-phenylcarbamate

...Expand
4-chloro-aniline
106-47-8

4-chloro-aniline

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 51.6 percent / aq. NaOH / dioxane / 15 h / 20 °C
2: 1,2-dichloro-ethane / Heating
View Scheme
Multi-step reaction with 2 steps
1: 69 percent / pyridine / tetrahydrofuran / 0.5 h / 20 °C
2: 1,2-dichloro-ethane / 3 h / 20 °C
View Scheme
2,6-difluorobenzoyl isothiocyanate

2,6-difluorobenzoyl isothiocyanate

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: benzene / 96 h / Ambient temperature
2: 70 percent / benzene / 11 h / Heating
3: 70 percent / Et3N / benzene / 2 h / Heating
View Scheme
O-allyl N-(2,6-difluorobenzoyl)monothiocarbamate
148931-10-6

O-allyl N-(2,6-difluorobenzoyl)monothiocarbamate

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / benzene / 11 h / Heating
2: 70 percent / Et3N / benzene / 2 h / Heating
View Scheme
2,6-difluorobenzoylchloride
18063-02-0

2,6-difluorobenzoylchloride

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) CH3CN, RT, 5 min, 2.) CH3CN, reflux, 5 h
2: 70 percent / Et3N / benzene / 2 h / Heating
View Scheme
1,4-diaza-bicyclo[2.2.2]octane
280-57-9

1,4-diaza-bicyclo[2.2.2]octane

2,6-difluorobenzamide
18063-03-1

2,6-difluorobenzamide

p-chlorphenylisocyanate
104-12-1

p-chlorphenylisocyanate

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
With N-Bromosuccinimide In methanol; 1,2-dichloro-ethane
...Expand
p-chlorphenylisocyanate
104-12-1

p-chlorphenylisocyanate

1,1,2,2-tetrachloroethane
79-34-5

1,1,2,2-tetrachloroethane

A

2,6-difluorobenzamide
18063-03-1

2,6-difluorobenzamide

B

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
In n-heptane
...Expand
2,6-difluorobenzylamine
69385-30-4

2,6-difluorobenzylamine

p-chlorphenylisocyanate
104-12-1

p-chlorphenylisocyanate

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane / 0.17 h / 0 - 20 °C
2: 9-(2-mesityl)-10-methylacridinium perchlorate / chloroform / 4 h / 35 °C / Irradiation
View Scheme
1,3,5-triallylhexahydro-1,3,5-triazine
26028-43-3

1,3,5-triallylhexahydro-1,3,5-triazine

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

5-allyl-1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)tetrahydro-1,3,5-triazin-2(1H)-one

5-allyl-1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)tetrahydro-1,3,5-triazin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 1,3,5-triallylhexahydro-1,3,5-triazine With phosphorus pentachloride In dichloromethane at 40℃; for 2.5h;
Stage #2: 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea In dichloromethane at 1℃; for 0.25h;
Stage #3: With triethylamine In dichloromethane at 1 - 20℃; for 5h;		75%
PhCH2O2CN(CH2Cl)2

PhCH2O2CN(CH2Cl)2

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

5-benzyloxycarbonyl-1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)tetrahydro-1,3,5-triazin-2(1H)-one

5-benzyloxycarbonyl-1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)tetrahydro-1,3,5-triazin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea With sodium hydride In DMF (N,N-dimethyl-formamide) at 3℃; for 0.5h;
Stage #2: PhCH2O2CN(CH2Cl)2 In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 1 - 20℃; for 6h;		46.6%
bis-iodomethyl sulfide
98025-72-0

bis-iodomethyl sulfide

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

3-(4-chlorophenyl)-5-(2,6-difluorobenzoyl)tetrahydro-4H-1,3,5-thiadiazin-4-one
596848-90-7

3-(4-chlorophenyl)-5-(2,6-difluorobenzoyl)tetrahydro-4H-1,3,5-thiadiazin-4-one

Conditions
ConditionsYield
Stage #1: 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea With sodium hydride In DMF (N,N-dimethyl-formamide) at 3℃; for 0.666667h;
Stage #2: bis-iodomethyl sulfide In DMF (N,N-dimethyl-formamide) at 3 - 20℃; for 18h;		20%
1,3,5-trimethyl-1,3,5-triazacyclohexane
108-74-7

1,3,5-trimethyl-1,3,5-triazacyclohexane

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)-5-methyltetrahydro-1,3,5-triazin-2(1H)-one

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)-5-methyltetrahydro-1,3,5-triazin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 1,3,5-trimethyl-1,3,5-triazacyclohexane With phosphorus pentachloride In dichloromethane at 40℃; for 2.5h;
Stage #2: 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea In dichloromethane at 1℃; for 0.25h;
Stage #3: With sodium hydroxide; triethylamine more than 3 stages;		19%
bis(2-chloromethyl)ether
542-88-1

bis(2-chloromethyl)ether

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

3-(4-chlorophenyl)-5-(2,6-difluorobenzoyl)tetrahydro-4H-1,3,5-oxadiazin-4-one

3-(4-chlorophenyl)-5-(2,6-difluorobenzoyl)tetrahydro-4H-1,3,5-oxadiazin-4-one

Conditions
ConditionsYield
Stage #1: 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea With sodium hydride In DMF (N,N-dimethyl-formamide) at 3℃; for 0.666667h;
Stage #2: bis(2-chloromethyl)ether In DMF (N,N-dimethyl-formamide) at 3 - 20℃; for 2h;		19%
1,3,5-Triisopropyl-1,3,5-triazacyclohexane
10556-98-6

1,3,5-Triisopropyl-1,3,5-triazacyclohexane

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)-5-phenyltetrahydro-1,3,5-triazin-2(1H)-one

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)-5-phenyltetrahydro-1,3,5-triazin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 1,3,5-Triisopropyl-1,3,5-triazacyclohexane With phosphorus pentachloride In dichloromethane at 40℃; for 4h;
Stage #2: 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea In dichloromethane at 1℃; for 0.25h;
Stage #3: With sodium hydroxide; triethylamine more than 3 stages;		16%
1,3,5-Triisopropyl-1,3,5-triazacyclohexane
10556-98-6

1,3,5-Triisopropyl-1,3,5-triazacyclohexane

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)-5-isopropyltetrahydro-1,3,5-triazin-2-(1H)-one

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)-5-isopropyltetrahydro-1,3,5-triazin-2-(1H)-one

Conditions
ConditionsYield
Stage #1: 1,3,5-Triisopropyl-1,3,5-triazacyclohexane With phosphorus pentachloride In dichloromethane at 40℃; for 3h;
Stage #2: 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea In dichloromethane at 1℃; for 0.25h;
Stage #3: With sodium hydroxide; triethylamine more than 3 stages;		15%
1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea
35367-38-5

1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea

sodium methylate
124-41-4

sodium methylate

A

methyl 2,6-difluorobenzoate
13671-00-6

methyl 2,6-difluorobenzoate

B

N-(4-chlorophenyl)urea
140-38-5

N-(4-chlorophenyl)urea

Conditions
ConditionsYield
In methanol at 25℃; Kinetics; Mechanism; Rate constant;
...Expand

Diflubenzuron Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Diflubenzuron Specification

The Diflubenzuron with CAS registry number of 35367-38-5 is also called 1-(4-chlorophenyl)-3-(2,6-ifluorobenzoyl)urea. Its EINECS registry number is 252-529-3. The IUPAC name is N-[(4-chlorophenyl)carbamoyl]-2,6-difluorobenzamide. In addition, the molecular formula is C14H9ClF2N2O2 and the molecular weight is 310.68. It belongs to the classes of Insecticide; Alphabetic; D; Growth regulatorsPesticides&Metabolites; Insecticides; Others; Pesticides; Alpha sort; DAlphabetic; Pesticides&Metabolites.

Physical properties about this chemical are: (1)ACD/LogP: 3.68; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.67; (4)ACD/LogD (pH 7.4): 3.53; (5)ACD/BCF (pH 5.5): 365.08; (6)ACD/BCF (pH 7.4): 262.47; (7)ACD/KOC (pH 5.5): 2372.15; (8)ACD/KOC (pH 7.4): 1705.46; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 40.62 ?2; (13)Index of Refraction: 1.618; (14)Molar Refractivity: 73.96 cm3; (15)Molar Volume: 211.1 cm3; (16)Polarizability: 29.32 10-24cm3; (17)Surface Tension: 53 dyne/cm; (18)Density: 1.471 g/cm3.

Preparation of Diflubenzuron: it can be prepared by 4-chloro-aniline and N-(bis-methylsulfanyl-methylene)-2,6-difluoro-benzamide. This reaction will need reagent acetic acid. The reaction time is 6 hours by heating. The yield is about 69%.

Diflubenzuron can be prepared by 4-chloro-aniline and N-(bis-methylsulfanyl-methylene)-2,6-difluoro-benzamide

Uses of Diflubenzuron: It is an insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies. And it can be used to kill the armyworms of corn and wheat. In addition, it is used in forest management and on field crops to selectively control insect pests, particularly forest tent caterpillar moths, boll weevils, gypsy moths, and other types of moths.

When you are using this chemical, please be cautious about it as the following:
This chemical is very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. This material and/or its container must be disposed of as hazardous waste. You should avoid release to the environment. Moreover, you can refer to special instructions safety data sheet.

You can still convert the following datas into molecular structure:
(1)SMILES: Clc2ccc(NC(=O)NC(=O)c1c(F)cccc1F)cc2
(2)InChI: InChI=1/C14H9ClF2N2O2/c15-8-4-6-9(7-5-8)18-14(21)19-13(20)12-10(16)2-1-3-11(12)17/h1-7H,(H2,18,19,20,21)
(3)InChIKey: QQQYTWIFVNKMRW-UHFFFAOYAU

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2150mg/kg (2150mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 968, 1986.
mouse LD50 oral 4640mg/kg (4640mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 20, 1978.
mouse LD50 skin > 6200mg/kg (6200mg/kg)   Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S159, 1992.
mouse LD50 subcutaneous > 4gm/kg (4000mg/kg)   Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S159, 1992.
mouse LD50 unreported 4600mg/kg (4600mg/kg)   Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. Vol. 16(1), Pg. 45, 1982.
rabbit LD50 skin 2gm/kg (2000mg/kg)   Special Publication of the Entomological Society of America. Vol. 74-1, Pg. -, 1974.
rat LC inhalation > 35gm/m3/6H (35000mg/m3)   "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A148, Pg. 1984,
rat LD50 intraperitoneal > 7500mg/kg (7500mg/kg)   Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S159, 1992.
rat LD50 oral 4640mg/kg (4640mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 968, 1986.
rat LD50 skin > 10gm/kg (10000mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C106, 1991.
rat LD50 subcutaneous > 3400mg/kg (3400mg/kg)   Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S159, 1992.

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View