Product Name

  • Name

    Dimethyl 2-oxoglutarate

  • EINECS
  • CAS No. 13192-04-6
  • Article Data23
  • CAS DataBase
  • Density 1.175 g/cm3
  • Solubility
  • Melting Point
  • Formula C7H10O5
  • Boiling Point 249.4 °C at 760 mmHg
  • Molecular Weight 174.153
  • Flash Point 105 °C
  • Transport Information
  • Appearance Slight Yellow Liquid
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 13192-04-6 (Dimethyl 2-oxoglutarate)
  • Hazard Symbols
  • Synonyms Glutaricacid, 2-oxo-, dimethyl ester (6CI,7CI,8CI);Pentanedioic acid, 2-oxo-, dimethylester (9CI);2-Oxoglutaric acid dimethyl ester;Dimethyl 2-oxopentanedioate;Dimethyl a-ketoglutarate;Dimethyl a-oxoglutarate;a-Ketoglutaric acid dimethyl ester;
  • PSA 69.67000
  • LogP -0.31830

Synthetic route

methanol
67-56-1

methanol

α-ketoglutaric acid
328-50-7

α-ketoglutaric acid

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
With boron trifluoride at 65℃; for 0.333333h;100%
With toluene-4-sulfonic acid In chloroform Heating;94%
With sulfuric acid for 2h; Heating;90%
α-ketoglutaric acid
328-50-7

α-ketoglutaric acid

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
In methanol; benzene for 0.5h; Ambient temperature;85%
methanol
67-56-1

methanol

α-ketoglutaric acid
328-50-7

α-ketoglutaric acid

A

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

B

2-Oxoglutarsaeure-1-methylester
92684-01-0

2-Oxoglutarsaeure-1-methylester

Conditions
ConditionsYield
With 2,2-dimethoxy-propane for 144h; Ambient temperature;A 81%
B 7%
...Expand
diazomethane
186581-53-3, 908094-01-9

diazomethane

α-ketoglutaric acid
328-50-7

α-ketoglutaric acid

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
In diethyl ether at 0℃; for 4h;76%
4-methoxycarbonylmethyl-5-(2-methoxyphenyl)isoxazolidine-2,3-dicarboxylic acid 2-(1-chloroethyl) ester 3-methyl ester

4-methoxycarbonylmethyl-5-(2-methoxyphenyl)isoxazolidine-2,3-dicarboxylic acid 2-(1-chloroethyl) ester 3-methyl ester

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
With pyridine In tetrahydrofuran; water at 60℃;28%
4-methoxycarbonylmethyl-5-phenylisoxazolidine-2,3-dicarboxylic acid 2-(1-chloroethyl) ester 3-methyl ester

4-methoxycarbonylmethyl-5-phenylisoxazolidine-2,3-dicarboxylic acid 2-(1-chloroethyl) ester 3-methyl ester

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
With pyridine In tetrahydrofuran; water at 60℃;22%
2,5-dimethoxy-2,5-dihydro-furan-2-carboxylic acid methyl ester
62435-72-7

2,5-dimethoxy-2,5-dihydro-furan-2-carboxylic acid methyl ester

A

4-oxobutanoic acid methyl ester
13865-19-5

4-oxobutanoic acid methyl ester

B

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
With hydrogenchloride at 90℃; Erwaermen des Reaktionsprodukts mit Schwefelsaeure enthaltendem Methanol.;
2-Diaethylamino-glutaconsaeure-dimethylester

2-Diaethylamino-glutaconsaeure-dimethylester

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
With hydrogenchloride
dimethyl cis-epoxymethylsuccinate

dimethyl cis-epoxymethylsuccinate

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
at 360℃;
dimethyl trans-epoxymethylsuccinate

dimethyl trans-epoxymethylsuccinate

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
at 360℃;
N-(1-Methoxy-5,5-dimethyl-3-oxocyclohex-1-yl)benzamid
41893-54-3

N-(1-Methoxy-5,5-dimethyl-3-oxocyclohex-1-yl)benzamid

A

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

B

benzamide
55-21-0

benzamide

Conditions
ConditionsYield
With hydrogenchloride; ozone 1.) methylenechlorid, -60 deg C; 2.) methanol, room temp, 90 min.; Yield given. Multistep reaction. Yields of byproduct given;
1,3-dicarbomethoxy-1-(trimethylsilyloxy)propene
55590-96-0

1,3-dicarbomethoxy-1-(trimethylsilyloxy)propene

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
With 1-methoxy-2-(2-nitrovinyl)benzene; tin(IV) chloride other reagents: boron trifluoride etherate/2-methoxy-β-nitrostyrene, benzaldehyde, benzaldehyde, benzaldehyde dimethyl acetal;
hydrogenchloride
7647-01-0

hydrogenchloride

2,5-dimethoxy-2,5-dihydro-furan-2-carboxylic acid methyl ester
62435-72-7

2,5-dimethoxy-2,5-dihydro-furan-2-carboxylic acid methyl ester

A

4-oxobutanoic acid methyl ester
13865-19-5

4-oxobutanoic acid methyl ester

B

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
Erwaermen des Reaktionsprodukts mit Methanol und wenig Schwefelsaeure;
...Expand
N-(1-Methoxy-5,5-dimethyl-3-oxo-1-cyclohexen-1-yl)benzamid
41893-53-2

N-(1-Methoxy-5,5-dimethyl-3-oxo-1-cyclohexen-1-yl)benzamid

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 30 percent / H2 / Pd/C / methanol / 48 h
2: 1.) Ozon; 2.) HCl / 1.) methylenechlorid, -60 deg C; 2.) methanol, room temp, 90 min.
View Scheme
2-furoic acid methyl ester
611-13-2

2-furoic acid methyl ester

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid / Electrolysis
2: aqueous hydrochloric acid , 35 percent / 90 °C / Erwaermen des Reaktionsprodukts mit Schwefelsaeure enthaltendem Methanol.
View Scheme
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

3-bromo-2-oxopentane-1,5-dioic acid dimethyl ester
148728-48-7

3-bromo-2-oxopentane-1,5-dioic acid dimethyl ester

Conditions
ConditionsYield
With copper(ll) bromide In chloroform; ethyl acetate for 18h; Heating;100%
With copper(ll) bromide In chloroform; ethyl acetate at 20℃; Reflux;100%
With copper(ll) bromide In chloroform; ethyl acetate for 18h; Heating;90%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

methyl 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate
89532-94-5

methyl 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate

Conditions
ConditionsYield
With acetic acid; hydrazine In methanol at 70℃; for 18h;100%
With hydrazine hydrate; acetic acid In methanol at 70℃;100%
With acetic acid; hydrazine In methanol for 5h; Reflux; Inert atmosphere;100%
With acetic acid; hydrazine In methanol for 12h; Heating;92%
With acetic acid; hydrazine In methanol Heating;92%
tryptamine
61-54-1

tryptamine

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

methyl 2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino<8,7-b>indole-11b-carboxylate
79888-13-4

methyl 2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino<8,7-b>indole-11b-carboxylate

Conditions
ConditionsYield
With acetic acid for 4h; Reflux; Inert atmosphere;97%
With acetic acid at 120℃; for 3h; Pictet-Spengler reaction;86%
In benzene for 1.5h; Heating;58%
2-(5-methoxyindol-3-yl)ethylamine
608-07-1

2-(5-methoxyindol-3-yl)ethylamine

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

methyl 8-methoxy-2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino<8,7-b>indole-11b-carboxylate
129968-05-4

methyl 8-methoxy-2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino<8,7-b>indole-11b-carboxylate

Conditions
ConditionsYield
With acetic acid for 4h; Reflux; Inert atmosphere;97%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

propargyl bromide
106-96-7

propargyl bromide

dimethyl 2-H-hydroxy-2-<2-(propynyl)>pentanedioate
179815-16-8

dimethyl 2-H-hydroxy-2-<2-(propynyl)>pentanedioate

Conditions
ConditionsYield
With aluminium; mercury dichloride In tetrahydrofuran at -78℃; for 4h;95%
With aluminium; mercury dichloride 1.) 40 deg C, 2.) -78 deg C; Yield given. Multistep reaction;
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

3-(3-oxo-3,4-dihydro-quinoxalin-2-yl)-propionic acid methyl ester
21580-64-3

3-(3-oxo-3,4-dihydro-quinoxalin-2-yl)-propionic acid methyl ester

Conditions
ConditionsYield
In methanol94%
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

dimethyl 2-cyano-2-(trimethylsilyl)oxyglutarate
96304-82-4

dimethyl 2-cyano-2-(trimethylsilyl)oxyglutarate

Conditions
ConditionsYield
for 19h; Ambient temperature;93%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

diisopropyl (E)-azodicarboxylate
2446-83-5

diisopropyl (E)-azodicarboxylate

3-isopropyl 2-methyl 5-isopropoxy-2-(3-methoxy-3-oxopropyl)-1,3,4-oxadiazole-2,3(2H)-dicarboxylate

3-isopropyl 2-methyl 5-isopropoxy-2-(3-methoxy-3-oxopropyl)-1,3,4-oxadiazole-2,3(2H)-dicarboxylate

Conditions
ConditionsYield
With triphenylphosphine In tetrahydrofuran at 20℃;93%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

tryptamine hydochloride
343-94-2

tryptamine hydochloride

methyl 2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino<8,7-b>indole-11b-carboxylate
79888-13-4

methyl 2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino<8,7-b>indole-11b-carboxylate

Conditions
ConditionsYield
In methanol for 20h; Heating;92%
In methanol Heating;92%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

ethyl 2-diethoxyphosphorylpropionate
3699-66-9

ethyl 2-diethoxyphosphorylpropionate

C12H18O6
496919-84-7

C12H18O6

Conditions
ConditionsYield
With hydrogen; sodium hydride In tetrahydrofuran at 0℃; Inert atmosphere;91%
With sodium hydride71%
With sodium hydride Horner-Wadsworth-Emmons Olefination;71%
9-aminothioxanthene 10,10-dioxide
17313-66-5

9-aminothioxanthene 10,10-dioxide

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

2-[(E)-10,10-Dioxo-9,10-dihydro-10λ6-thioxanthen-9-ylimino]-pentanedioic acid dimethyl ester

2-[(E)-10,10-Dioxo-9,10-dihydro-10λ6-thioxanthen-9-ylimino]-pentanedioic acid dimethyl ester

Conditions
ConditionsYield
With 4 A molecular sieve In toluene for 17h; Heating;86%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

methyl 4-((E)-2-(methoxycarbonyl)vinyloxy)-2-(2-(methoxycarbonyl)ethyl)-3-((methpxycarbonyl)methyl)-2,5-dihydro-5-oxofuran-2-carboxylate

methyl 4-((E)-2-(methoxycarbonyl)vinyloxy)-2-(2-(methoxycarbonyl)ethyl)-3-((methpxycarbonyl)methyl)-2,5-dihydro-5-oxofuran-2-carboxylate

Conditions
ConditionsYield
triethylamine In dichloromethane at 0℃;85%
With triethylamine In dichloromethane at 0℃;85%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

2-amino-6-(1-benzylhydrazinyl)pyrimidin-4(3H)-one
67873-25-0

2-amino-6-(1-benzylhydrazinyl)pyrimidin-4(3H)-one

methyl 3-(7-amino-1-benzyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoate
1374603-46-9

methyl 3-(7-amino-1-benzyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoate

Conditions
ConditionsYield
In water for 3h; Reflux;85%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

methyl 3-(3-oxo-3,4-dihydroquinoxalin-2-yl)propanoate
21580-64-3

methyl 3-(3-oxo-3,4-dihydroquinoxalin-2-yl)propanoate

Conditions
ConditionsYield
In methanol for 16h; Inert atmosphere;84%
In ethanol Reflux;
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

dimethyl (E)-2-oxoglutaconate
38256-25-6

dimethyl (E)-2-oxoglutaconate

Conditions
ConditionsYield
Stage #1: dimethyl 2-ketoglutarate With bromine In dichloromethane for 4.25h; Heating / reflux;
Stage #2: With triethylamine In diethyl ether at 35℃; for 0.75h;		83.1%
Stage #1: dimethyl 2-ketoglutarate With bromine In dichloromethane for 3h; Reflux; Inert atmosphere;
Stage #2: With triethylamine In diethyl ether at 20℃; for 0.5h;		70%
Stage #1: dimethyl 2-ketoglutarate With bromine In dichloromethane for 3h; Heating;
Stage #2: With triethylamine In diethyl ether for 0.5h; Further stages.;		3.6 mmol
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

ethyl 2-diethoxyphosphorylpropionate
3699-66-9

ethyl 2-diethoxyphosphorylpropionate

C13H22O5

C13H22O5

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 0.5h;82%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

ethyl 2-diethoxyphosphorylpropionate
3699-66-9

ethyl 2-diethoxyphosphorylpropionate

C12H18O6

C12H18O6

Conditions
ConditionsYield
Stage #1: ethyl 2-diethoxyphosphorylpropionate With sodium hydride In tetrahydrofuran for 0.5h;
Stage #2: dimethyl 2-ketoglutarate In tetrahydrofuran for 0.5h;		82%
ethanol
64-17-5

ethanol

dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

(2,4-difluorobenzyl)hydrazine
627076-28-2

(2,4-difluorobenzyl)hydrazine

A

methyl 1-(2,4-difluorobenzyl)-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylate
1297284-15-1

methyl 1-(2,4-difluorobenzyl)-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylate

B

ethyl 1-(2,4-difluorobenzyl)-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate
1297284-16-2

ethyl 1-(2,4-difluorobenzyl)-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate

Conditions
ConditionsYield
hydrogenchloride Reflux;A 82%
B 6.1%
...Expand
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

benzylamine
100-46-9

benzylamine

methyl 5-(benzylamino)-4,5-dioxopentanoate
1397970-85-2

methyl 5-(benzylamino)-4,5-dioxopentanoate

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 6h; Inert atmosphere;82%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

ethyl 2-diethoxyphosphorylpropionate
3699-66-9

ethyl 2-diethoxyphosphorylpropionate

C11H16O6

C11H16O6

Conditions
ConditionsYield
Stage #1: ethyl 2-diethoxyphosphorylpropionate With sodium hydride In tetrahydrofuran; mineral oil
Stage #2: dimethyl 2-ketoglutarate In tetrahydrofuran; mineral oil for 0.5h;		82%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

6-methoxytryptamine-2-carboxylic acid
20731-72-0

6-methoxytryptamine-2-carboxylic acid

methyl 9-methoxy-2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino<8,7-b>indole-11b-carboxylate
129968-06-5

methyl 9-methoxy-2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino<8,7-b>indole-11b-carboxylate

Conditions
ConditionsYield
With trifluoroacetic acid In 1,4-dioxane; benzene Heating;80%
With trifluoroacetic acid In 1,4-dioxane; benzene for 24h; Heating;80%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

ethyl 2-diethoxyphosphorylpropionate
3699-66-9

ethyl 2-diethoxyphosphorylpropionate

2-propionic-3-methylmaleic anhydride
487-66-1

2-propionic-3-methylmaleic anhydride

Conditions
ConditionsYield
Stage #1: dimethyl 2-ketoglutarate; ethyl 2-diethoxyphosphorylpropionate With sodium hydride In tetrahydrofuran for 0.5h;
Stage #2: With water; potassium hydroxide In ethanol for 1h; Reflux;		80%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

benzylhydrazine dihydrochloride
20570-96-1

benzylhydrazine dihydrochloride

methyl 1-benzyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate
1297284-35-5

methyl 1-benzyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate

Conditions
ConditionsYield
hydrogenchloride In ethanol for 15h; Inert atmosphere; Reflux;79%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

methyl 2-hydroxy-4-(metoxycarbonyl)butanoate
81077-10-3

methyl 2-hydroxy-4-(metoxycarbonyl)butanoate

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0 - 20℃; for 24h; Inert atmosphere;78%
With sodium tetrahydroborate In methanol; dichloromethane for 0.5h; Ambient temperature;74%
With sodium tetrahydroborate65%
With sodium tetrahydroborate In methanol
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

di-isopropyl azodicarboxylate
2446-83-5

di-isopropyl azodicarboxylate

3-isopropyl 2-methyl 5-isopropoxy-2-(3-methoxy-3-oxopropyl)-1,3,4-oxadiazole-2,3(2H)-dicarboxylate

3-isopropyl 2-methyl 5-isopropoxy-2-(3-methoxy-3-oxopropyl)-1,3,4-oxadiazole-2,3(2H)-dicarboxylate

Conditions
ConditionsYield
With 9-phenyl-9-phosphafluorene; Bis(p-nitrophenyl) phosphate; phenylsilane; N-ethyl-N,N-diisopropylamine In toluene at 90℃; for 3.5h; Inert atmosphere;76%
dimethyl 2-ketoglutarate
13192-04-6

dimethyl 2-ketoglutarate

5-chloro-2-nitrophenylhydrazine
1966-16-1

5-chloro-2-nitrophenylhydrazine

dimethyl (E)-2-(5-chloro-2-nitrophenylhydrazono)glutarate
143263-49-4

dimethyl (E)-2-(5-chloro-2-nitrophenylhydrazono)glutarate

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20℃; for 1h;75%

Dimethyl 2-oxoglutarate Specification

The Pentanedioic acid,2-oxo-,1,5-dimethyl ester with CAS registry number of 13192-04-6 belongs to the classes of Amino Acids 13C, 2H, 15N; Amino Acids & Derivatives; Miscellaneous Reagents; C6 to C7; Carbonyl Compounds; Esters. The IUPAC name is dimethyl 2-oxopentanedioate. In addition, the molecula formula is C7H10O5 and the molecular weight is 174.15. It is a kind of slight yellow liquid.

Physical properties about this chemical are: (1)ACD/LogP: -0.22; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.21; (4)ACD/LogD (pH 7.4): -0.21; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 18.21; (8)ACD/KOC (pH 7.4): 18.21; (9)#H bond acceptors: 5; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 69.67 Å2; (13)Index of Refraction: 1.427; (14)Molar Refractivity: 38.05 cm3; (15)Molar Volume: 148.1 cm3; (16)Polarizability: 15.08 ×10-24cm3; (17)Surface Tension: 36.8 dyne/cm; (18)Density: 1.175 g/cm3; (19)Flash Point: 105 °C; (20)Enthalpy of Vaporization: 48.66 kJ/mol; (21)Boiling Point: 249.4 °C at 760 mmHg; (22)Vapour Pressure: 0.023 mmHg at 25°C.

Preparation of Pentanedioic acid,2-oxo-,1,5-dimethyl ester: this chemical can be prepared by 2-oxo-pentanedioic acid. This reaction will need solvents methanol and benzene. The reaction time is 30 minutes. The yield is about 85%.

Pentanedioic acid,2-oxo-,1,5-dimethyl ester can be prepared by 2-oxo-pentanedioic acid

Uses of Pentanedioic acid,2-oxo-,1,5-dimethyl ester: it can react with betrimethyl-silanecarbonitrile to get dimethyl 2-cyano-2-(trimethylsilyl)oxyglutarate. The reaction time is 19 hours at ambient temperature. The yield is about 93%.

Pentanedioic acid,2-oxo-,1,5-dimethyl ester can react with betrimethyl-silanecarbonitrile to get dimethyl 2-cyano-2-(trimethylsilyl)oxyglutarate.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(C(=O)OC)CCC(=O)OC
(2)InChI: InChI=1/C7H10O5/c1-11-6(9)4-3-5(8)7(10)12-2/h3-4H2,1-2H3
(3)InChIKey: TXIXSLPEABAEHP-UHFFFAOYAN

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