Conditions | Yield |
---|---|
With hydrogen In methanol at 80℃; under 37503.8 Torr; for 3h; Catalytic behavior; Reagent/catalyst; Autoclave; | 100% |
With lithium borohydride; diisopropopylaminoborane In tetrahydrofuran for 18h; Reflux; | 99% |
With samarium diiodide; water; triethylamine In tetrahydrofuran at 20℃; for 0.0833333h; Reagent/catalyst; Time; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
With samarium diiodide; water; triethylamine In tetrahydrofuran at 23℃; for 3h; Inert atmosphere; chemoselective reaction; | A 99% B 88% |
dodecyl azide
n-Dodecylamine
Conditions | Yield |
---|---|
With (Sn(SPh)3)(Et3N) In benzene at 15℃; for 0.0833333h; | 98% |
With tellurium; water at 275℃; for 4h; | 87% |
With dichloroborane-dimethyl sulfide In dichloromethane for 1h; Heating; | 78% |
Conditions | Yield |
---|---|
With 40% potassium fluoride/alumina for 0.0666667h; Microwave irradiation; Neat (no solvent); | A 93% B 96% |
n-Dodecylamine
Conditions | Yield |
---|---|
With benzyltriethylammonium tetrathiomolybdate In acetonitrile at 28℃; for 0.5h; | 95% |
N-(allyloxycarbonyl)-dodecyl amine
n-Dodecylamine
Conditions | Yield |
---|---|
With trisodium tris(3-sulfophenyl)phosphine; water; diethylamine; palladium diacetate; heptakis(2,6-di-O-methyl)cyclomaltoheptaose In toluene at 20℃; for 15h; Substitution; | 94% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In methanol at 20℃; for 12h; | 88% |
C14H27NO2
n-Dodecylamine
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water for 2h; Heating; | 93% |
Conditions | Yield |
---|---|
With sodium azide; triphenylphosphine In dichloromethane; N,N-dimethyl-formamide at 90℃; for 5h; Substitution; Mitsunobu reaction; Staudinger reaction; | 91% |
With aluminum oxide; ammonia; magnesium oxide at 400℃; under 95616 Torr; | |
With L-alanin; L-alanine dehydrogenase; ω-transaminase from Chromobacterium violaceum; alcohol dehydrogenase from Bacillus stearothermophilus; pyridoxal 5'-phosphate; NAD; ammonium chloride; sodium hydroxide In 1,2-dimethoxyethane; water at 20℃; for 24h; pH=8.5; Enzymatic reaction; | 10 %Chromat. |
With ammonia In 5,5-dimethyl-1,3-cyclohexadiene under 7500.75 Torr; for 12h; Reflux; | 59 %Chromat. |
With aluminum oxide; ammonia; magnesium oxide at 400℃; under 95616 Torr; |
N-trityldodecan-1-amine
n-Dodecylamine
Conditions | Yield |
---|---|
With ammonium cerium (IV) nitrate; water; acetic acid In dichloromethane at 20℃; for 33h; Inert atmosphere; | 90% |
12-(phenylthio)dodecanenitrile
n-Dodecylamine
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran; methanol at 0℃; for 0.25h; | 86% |
Conditions | Yield |
---|---|
With hydrogen In methanol at 80℃; under 37503.8 Torr; for 4h; Catalytic behavior; Reagent/catalyst; Autoclave; | A 75.8% B 24.2% |
With hydrogen; potassium hydroxide In water at 119.84℃; under 15001.5 Torr; for 0.833333h; |
n-Dodecylamine
Conditions | Yield |
---|---|
With PPA at 160℃; for 1h; | 74% |
lauric acid
A
n-Dodecylamine
B
n-Undecane
C
lauric acid amide
D
N,N-didodecylamine
E
N-dodecanoyldodecanylamide
Conditions | Yield |
---|---|
Stage #1: lauric acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry; | A 74% B 1% C 3% D 15% E 5% |
2-chlorododecan-1-amine
n-Dodecylamine
Conditions | Yield |
---|---|
With tert-butyl alcohol at 30℃; regioselective reaction; | 70% |
Conditions | Yield |
---|---|
With D-glucose; pyridoxal 5'-phosphate; glucose dehydrogenase (CDX-901) from Codexis; NADP; isopropylamine; magnesium chloride In n-heptane; dimethyl sulfoxide at 30℃; for 20h; pH=8; Green chemistry; Enzymatic reaction; | 61% |
With methanol; ammonia; hydrogen; Cu/Cr/Ca; titanium(IV) oxide at 300℃; under 37503 Torr; | 27.0 % Chromat. |
Multi-step reaction with 3 steps 1: oxalyl dichloride / benzene / 1 h 2: ammonia / dichloromethane 3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h View Scheme | |
Multi-step reaction with 3 steps 1: ammonia / 0.5 h / 145 °C 2: 1 h / 290 °C 3: hydrogen / ethanol / 0.5 h / 95 °C / 52505.3 Torr View Scheme |
phthalimide
1-dodecylbromide
A
n-Dodecylamine
B
1-dodecyl alcohol
C
dilauryl ether
D
2-dodecylisoindoline-1,3-dione
Conditions | Yield |
---|---|
With sodium hydroxide; Methyl methyltrioctylammonium sulfate In toluene at 95℃; for 4h; Product distribution; different bases, other temperatures; | A 3.7% B 41.7% C 7.9% D 3.5% E n/a |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; diethyl ether | |
With ethanol; sodium | |
With pentan-1-ol; sodium | |
With lithium aluminium tetrahydride In tetrahydrofuran for 1h; | |
Multi-step reaction with 2 steps 1: 1 h / 290 °C 2: hydrogen / ethanol / 0.5 h / 95 °C / 52505.3 Torr View Scheme |
Conditions | Yield |
---|---|
With 1,4-dioxane; copper chromite at 250℃; under 147102 - 220652 Torr; Hydrogenation; | |
With 1,4-dioxane; copper chromite at 250℃; under 147102 - 220652 Torr; Hydrogenation; | |
With ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6h; Catalytic behavior; | A 80 %Chromat. B 14 %Chromat. |
Conditions | Yield |
---|---|
With copper-aluminium oxide barium oxide; ammonia; hydrogen at 270℃; under 147102 Torr; | |
With copper-aluminium oxide barium oxide; ammonia; hydrogen at 270℃; under 147102 Torr; |
tridecanoic acid[2,6-diethyl-2,3,6-trimethyl-1-(1-phenyl-ethoxy)-piperidin-4-yl]-amide
n-Dodecylamine
Conditions | Yield |
---|---|
With 1,4-dioxane; sodium hypochlorite |
Conditions | Yield |
---|---|
With potassium hydroxide durch Schmelzen; |
n-Dodecylamine
Conditions | Yield |
---|---|
With potassium hydroxide |
Conditions | Yield |
---|---|
With ammonia | |
With ethanol; ammonia | |
With ammonia; sodium amide at -50℃; |
Conditions | Yield |
---|---|
Hydrogenation; |
dimethyl amine
undecyl cyanide
A
n-Dodecylamine
B
N,N-dimethylaminododecane
Conditions | Yield |
---|---|
With nickel Fuller's earth; hydrogen at 180℃; under 147102 Torr; |
Conditions | Yield |
---|---|
With methanol; ammonia; sodium carbonate fluessiges Ammoniak; |
Conditions | Yield |
---|---|
With ammonia at 75 - 80℃; |
methylamine
undecyl cyanide
A
n-Dodecylamine
B
N-methyldodecylamine
Conditions | Yield |
---|---|
With hydrogen; tungsten trisulfide at 270℃; under 147102 Torr; |
Conditions | Yield |
---|---|
for 20h; Inert atmosphere; Reflux; | 100% |
Conditions | Yield |
---|---|
100% |
n-Dodecylamine
2-(chloroseleno)benzoyl chloride
2-dodecyl-1,2-benzisoselenazol-3(2H)-one
Conditions | Yield |
---|---|
In chloroform for 4h; Ambient temperature; | 100% |
In dichloromethane at 20℃; | 96% |
In dichloromethane |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; for 1h; | 100% |
In methanol | 93% |
In methanol | 93% |
n-Dodecylamine
2-chloro-3-methyl-1-oxa-3-aza-2-phosphacyclopentane 2-oxide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 17h; Ambient temperature; | 100% |
Conditions | Yield |
---|---|
Stage #1: 1,1'-carbonyldiimidazole; 5-methoxy-2-phenylsulfonylbenzyl alcohol In dichloromethane at 20℃; for 1h; Stage #2: n-Dodecylamine at 20℃; for 6h; | 100% |
n-Dodecylamine
Conditions | Yield |
---|---|
In toluene Heating; | 100% |
In toluene at 100℃; for 0.166667h; | 97% |
In toluene at 0 - 80℃; | 91% |
n-Dodecylamine
Conditions | Yield |
---|---|
Stage #1: 5-(2-bromo-ethyl)-phenanthridinium bromide; n-Dodecylamine With sodium carbonate In ethyl acetate at 20℃; for 3h; Stage #2: With N-Bromosuccinimide In ethyl acetate at 20℃; for 3h; | 100% |
4-[3,5-dimethyl-4-(4-nitro-benzyloxy)-phenyl]-4-oxo-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester
n-Dodecylamine
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 3h; | 100% |
Conditions | Yield |
---|---|
In 1,2-dichloro-ethane at 50℃; for 3h; | 100% |
Conditions | Yield |
---|---|
at 20℃; for 0.5h; Neat (no solvent); Trituration; | 100% |
Conditions | Yield |
---|---|
at 100℃; for 0.05h; microwave irradiation; | 100% |
With triethylamine In dichloromethane at 20℃; for 16h; Inert atmosphere; | 88% |
With triethylamine In dichloromethane |
N,N-dimethylacetamide dimethyl acetal
n-Dodecylamine
Conditions | Yield |
---|---|
With dimethyl amine In tetrahydrofuran at 20℃; for 18.25h; Darkness; chemoselective reaction; | 100% |
With dimethyl amine In tetrahydrofuran for 18h; Darkness; | 100% |
at 70℃; for 1h; |
Conditions | Yield |
---|---|
Stage #1: n-Dodecylamine; C36H56N2O5S2 With acetic acid In chloroform at 40℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In chloroform at 20℃; for 18h; chemoselective reaction; | 100% |
n-Dodecylamine
1,7-lactobioamidoheptanoic acid
C12H27N*C19H35NO13
Conditions | Yield |
---|---|
In water at 20℃; for 24h; | 100% |
Conditions | Yield |
---|---|
In water at 20℃; for 24h; | 100% |
Conditions | Yield |
---|---|
In water at 20℃; for 24h; | 100% |
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane; water at 5 - 20℃; for 2.5h; | 100% |
With potassium carbonate In dichloromethane; water at 5 - 20℃; for 4h; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 93.3% |
n-Dodecylamine
dimethylsilicon dichloride
bis(n-dodecylamino)dimethylsilane
Conditions | Yield |
---|---|
In hexane at 20℃; for 24h; Cooling; | 100% |
With triethylamine In pentane at -0.16 - 19.84℃; Inert atmosphere; |
n-Dodecylamine
(7-(carboxymethyl)-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-acetic acid
Conditions | Yield |
---|---|
In methanol at 20℃; | 100% |
n-Dodecylamine
(R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: n-Dodecylamine; (R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid With 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole In N,N-dimethyl-formamide for 0.0833333h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3.5h; | 100% |
With 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 3.5h; | 100% |
n-Dodecylamine
Conditions | Yield |
---|---|
With acetic acid In isopropyl alcohol at 80℃; pH=Ca. 4; | 100% |
Conditions | Yield |
---|---|
In dichloromethane at 40℃; for 2h; | 100% |
Conditions | Yield |
---|---|
In dichloromethane at 40℃; for 2h; | 100% |
Conditions | Yield |
---|---|
In methanol for 3h; Ambient temperature; | 99.5% |
With 3 A molecular sieve In dichloromethane at 40℃; for 6h; Condensation; | 91% |
With diethyl ether at 20℃; |
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 0℃; for 0.75h; | 99% |
With N,N'-dimethyl-N,N'-di(pyridin-4-yl)ferrocene-1,1'-dicarboxamide at 20℃; for 0.583333h; | 81% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 2h; | 80% |
n-Dodecylamine
Conditions | Yield |
---|---|
In benzene for 1h; Heating; | 99% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h; | 99% |
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere; | 95% |
In nitrobenzene at 190 - 200℃; for 6h; | 46% |
Conditions | Yield |
---|---|
With pyridine In toluene at 80℃; for 3h; Inert atmosphere; | 99% |
In chloroform Heating; |
The Molecular Structure of Dodecanamine (CAS NO.124-22-1):
Empirical Formula: C12H27N
Molecular Weight: 185.3495
IUPAC Name: dodecan-1-amine
Appearance: white solid
Nominal Mass: 185 Da
Average Mass: 185.3495 Da
Monoisotopic Mass: 185.21435 Da
Index of Refraction: 1.444
Molar Refractivity: 61.17 cm3
Molar Volume: 230.2 cm3
Surface Tension: 29.9 dyne/cm
Density: 0.804 g/cm3
Flash Point: 100.4 °C
Enthalpy of Vaporization: 49.63 kJ/mol
Boiling Point: 258.6 °C at 760 mmHg
Vapour Pressure: 0.0136 mmHg at 25°C
Synonyms: 1-Aminododecan ; 1-Dideanamine ; 1-Dodecanamin ; 1-Dodecanamine ; 1-Dodecylamin ; Alamine 4 ; alamine4 ; aminebb
Product Categories: Alkylamines;Monofunctional & alpha,omega-Bifunctional Alkanes;Monofunctional Alkanes
Water Solubility: 78 mg/L (25 °C )
Stability: Stable. Combustible. Incompatible with acid chlorides, acids, acid anhydrides, oxidizing agents
Dodecanamine (CAS NO.124-22-1) can be used in the production of medicines, pesticides, dyestuff, mineral flotation agent, emulsifier and intermediates of fine chemical ,etc.
1. | skn-rbt 500 mg/24H SEV | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,62. | ||
2. | eye-rbt 50 µg/24H SEV | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,52. | ||
3. | eye-rbt 2 mg | AEPPAE Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 219 (1953),119. | ||
4. | orl-rat LD50:1020 mg/kg | AEPPAE Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 219 (1953),119. | ||
5. | orl-mus LD50:1160 mg/kg | AEPPAE Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 219 (1953),119. | ||
6. | ipr-mus LD50:50 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD691-490 . |
Reported in EPA TSCA Inventory.
Poison by intraperitoneal route. Moderately toxic by ingestion. A severe skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.
Hazard Codes: CN
Risk Statements: 22-34-50/53-20/21/22
R22: Harmful if swallowed
R34: Causes burns
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements: 26-36/37/39-45-60-61
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60: This material and its container must be disposed of as hazardous waste
S61: Avoid release to the environment. Refer to special instructions / safety data sheets
RIDADR: UN 3259 8/PG 3
WGK Germany: 2
RTECS: JR6475000
F: 10-34
HazardClass: 8
PackingGroup: II
HS Code: 29211980
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