Ellagic acid supplier | CasNO.476-66-4

Name
Ellagic acid
EINECS 207-508-3
CAS No. 476-66-4
Article Data105
CAS DataBase
Density 2.066 g/cm³
Solubility <0.1 g/100 mL at 21 °C in water
Melting Point ≥350 °C
Formula C₁₄H₆O₈
Boiling Point 796.5 °C at 760 mmHg
Molecular Weight 302.197
Flash Point 310.1 °C
Transport Information
Appearance cream to light yellow crystalline solid
Safety 26-36-36/37
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Alizarinyellow;Alizarine Yellow;Benzoaric acid;C.I. 55005;C.I. 75270;Elagostasine;
PSA 141.34000
LogP 1.31280

Synthetic route

: 84316-70-1
dimethyl 4,4',5,5',6,6'-hexahydroxy-[1,1'-biphenyl]-2,2'-dicarboxylate

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
In methanol; water for 24h; Reflux;	100%
In water at 100℃; for 0.25h;	0.03 g
In methanol; water at 85℃; for 4h;

: 2292-39-9, 124854-06-4, 133358-96-0
4,5,6,4',5',6'-hexamethoxydiphenic acid

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With boron tribromide In dichloromethane at -40 - 20℃; Inert atmosphere;	100%

: tannic acid

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With sulfuric acid In water at 100℃; under 3750.38 Torr;	89%

: 2,3,7-trihydroxy-8-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)chromeno[5,4,3-cde]chromene-5,10-dione

A: 3615-41-6
L-Rhamnose

B: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 80℃; for 1h;	A n/a B 86%

: 618-73-5
3,4,5-trihydroxybenzamide

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid for 10h; Reagent/catalyst;	84%

: 99-24-1
methyl galloate

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; bis-[(trifluoroacetoxy)iodo]benzene In dichloromethane at 20℃; for 24h; Inert atmosphere;	83%
With dipotassium peroxodisulfate In acetic acid at 80℃; for 12h;	78%
With iron(III) chloride; acetic acid

: 121-79-9
Propyl gallate

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In sulfuric acid at 80℃; for 12h; Solvent; Reagent/catalyst;	82%

: ellagic acid 3-O-α-L-rhamnopyranosyl-4′-O-α-L-arabinofuranoside

A: 5328-37-0
L-arabinose

B: 3615-41-6
L-Rhamnose

C: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 80℃; for 1h;	A n/a B n/a C 77%

...Expand

: 831-61-8
Ethyl gallate

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With sodium persulfate In acetic acid at 80℃; for 12h;	74%
With sodium carbonate
With ammonia; water durch Einleiten von Luft;
With Marshall's acid
Multi-step reaction with 2 steps 1: ammonium hydroxide / 12 h / 50 °C 2: 3-chloro-benzenecarboperoxoic acid / 10 h View Scheme

: 70470-10-9
1,2,3,4,6-Penta-O-galloyl-alpha-D-glucopyranose

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With sodium carbonate at 20 - 70℃; for 6h;	50%

: 99-24-1
methyl galloate

A: 84316-70-1
dimethyl 4,4',5,5',6,6'-hexahydroxy-[1,1'-biphenyl]-2,2'-dicarboxylate

B: 476-66-4
ellagic acid

C: 91120-90-0
Purpurogallin-4-carbonsaeure-methylester

Conditions

Conditions	Yield
With dihydrogen peroxide In water for 24h; horseradish peroxidase;	A 24% B 32% C 17%

...Expand

: 149-91-7
3,4,5-trihydroxybenzoic acid

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; sulfuric acid In water at -50 - 4℃;	30%
With orthoarsenic acid
With water; iodine bei laengerem Digerieren;

: 99-24-1
methyl galloate

A: 476-66-4
ellagic acid

B: 91121-09-4
5-(2,3,4-Trihydroxy-6-methoxycarbonylphenyl)-4-methoxycarbonyl-2-furancarbonsaeure

Conditions

Conditions	Yield
With iron(III) chloride In water; acetone for 120h; Ambient temperature;	A 16% B 5%

: 99-24-1
methyl galloate

A: 476-66-4
ellagic acid

B: 91120-95-5
3-Carboxy-2,3-dihydro-6,7-dihydroxy-2,4-bis(methoxycarbonyl)-1-benzofuran-2-essigsaeure

Conditions

Conditions	Yield
With oxygen; sodium hydrogencarbonate In methanol; water for 40h;	A n/a B 7%

: 149-91-7
3,4,5-trihydroxybenzoic acid

A: 741-67-3
1,2,3,7,8-pentahydroxy-4,9-dioxa-pyren-5,10-dione

B: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With potassium peroxomonosulphate; sulfuric acid at 50℃;

: 3,4-diacetoxy-5-(3,4,5-triacetoxy-benzoyloxy)-benzoic acid

: 476-66-4
ellagic acid

: 55880-99-4
N-galloglycine

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With penicillium

: 53653-60-4
2-(3,4,5-trihydroxybenzoyloxy)ethyl 3,4,5-trihydroxybenzoate

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetone horseradish peroxidase;

: 52626-77-4
3,6-di-O-galloyl-(α/β)-4C1-glucopyranose

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetone horseradish peroxidase;

: 91120-91-1
propane-1,3-diol digallate

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetone horseradish peroxidase;

: carpinin A

A: carpinin D

B: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With hydrogenchloride Heating;

: Cornusiin B

A: 3-O-galloyl-β-D-glucopyranose

B: oenothein C

C: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With sulfuric acid at 100℃; for 2h;	A n/a B 3 mg C 2 mg
With sulfuric acid at 100℃; for 2h; Product distribution; var. reagent and time;	A n/a B 3 mg C 2 mg

...Expand

: Cornusiin B

A: oenothein C

B: 476-66-4
ellagic acid

Conditions

Conditions	Yield
In sulfuric acid; water at 100℃; for 4.5h;

: 130518-17-1, 130608-10-5
punicalgin

A: 2-O-galloyl-punicalin

B: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With sulfuric acid at 90℃; for 7h; Product distribution;

: 91120-92-2
tetramethylene-1,4-diyl-bis-(3,4,5-trihydroxybenzoate)

A: 476-66-4
ellagic acid

B: 91120-94-4
3,4,5-Trihydroxy-benzoic acid 4-hydroxy-butyl ester

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetone horseradish peroxidase;

: 111241-18-0
trans-1,2-bis[(3,4,5-trihydroxybenzoyl)oxy]cyclohexane

: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetone horseradish peroxidase;

: nobotanin G

A: 492-61-5
β-D-glucose

B: 149-91-7
3,4,5-trihydroxybenzoic acid

C: 60202-70-2
valoneaic acid dilactone

D: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With sulfuric acid for 6h; Heating; Title compound not separated from byproducts;

...Expand

: nobotanin I

A: 492-61-5
β-D-glucose

B: 149-91-7
3,4,5-trihydroxybenzoic acid

C: 60202-70-2
valoneaic acid dilactone

D: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With sulfuric acid for 6h; Heating; Title compound not separated from byproducts;

...Expand

: nobotanin H

A: 492-61-5
β-D-glucose

B: 149-91-7
3,4,5-trihydroxybenzoic acid

C: 60202-70-2
valoneaic acid dilactone

D: 476-66-4
ellagic acid

Conditions

Conditions	Yield
With sulfuric acid for 6h; Heating; Title compound not separated from byproducts;

...Expand

A: 476-66-4
ellagic acid

B: C41H30O22

Conditions

Conditions	Yield
With tannase In water for 2h; Ambient temperature;	A 10 mg B 11 mg

: 13154-24-0
triisopropylsilyl chloride

: 476-66-4
ellagic acid

: 1448297-91-3
2,3,7,8-tetrakis((triisopropylsilyl)oxy)chromeno[5,4,3-cde]chromene-5,10-dione

Conditions

Conditions	Yield
With 1H-imidazole; dmap In dichloromethane; N,N-dimethyl-formamide at 50℃; for 12h; regioselective reaction;	99%
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 80℃; for 18h;	3.91 g

: 476-66-4
ellagic acid

: C40H30O8

Conditions

Conditions	Yield
Stage #1: ellagic acid With Dichlorodiphenylmethane at 180℃; for 3h; Stage #2: With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 5h;	95%

: 108-24-7
acetic anhydride

: 476-66-4
ellagic acid

: 4274-26-4
ellagic acid tetraacetate

Conditions

Conditions	Yield
With sodium acetate at 100 - 110℃; for 2h;	90%
In pyridine at 20℃; for 12h;	85%
With pyridine for 12h;	70%

Ellagic acid Chemical Properties

Product Name: Ellagic acid
Synonyms of Ellagic acid (CAS NO.476-66-4): 2,3,7,8-Tetrahydroxy(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione ; 5-19-07-00108 (Beilstein Handbook Reference) ; Acide ellagique ; Acide ellagique [INN-French] ; Acido elagico ; Acido elagico [INN-Spanish] ; Acidum ellagicum ; Acidum ellagicum [INN-Latin] ; Alizarine Yellow ; BRN 0047549 ; Benzoaric acid ; C.I. 55005 ; C.I. 75270 ; CCRIS 774 Diphenic acid, 4,4',5,5',6,6'-hexahydroxy-, di-delta-lactone ; EINECS 207-508-3 ; Elagostasine ; Eleagic acid ; Ellagic acid ; Ellagic acid dihydrate ; Gallogen (VAN) ; Gallogen (astringent) ; HSDB 7574 ; Lagistase ; Llagic acid ; NSC 407286 ; NSC 656272 ; UNII-19YRN3ZS9P ; (1)Benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-
CAS NO: 476-66-4
Classification Code: Reproductive Effect
Molecular Formula of Ellagic acid (CAS NO.476-66-4): C₁₄H₆O₈
Molecular Weight: 302.1926
Molecular Structure:

Melting Point: ≥350 °C
Polar Surface Area: 89.52 Å²
Index of Refraction: 1.894
Molar Refractivity: 67.74 cm³
Molar Volume: 146.2 cm³
Surface Tension: 140.3 dyne/cm
Density of Ellagic acid (CAS NO.476-66-4): 2.066 g/cm³
Flash Point: 310.1 °C
Enthalpy of Vaporization: 119.86 kJ/mol
Boiling Point: 796.5 °C at 760 mmHg
Vapour Pressure: 2.32E-26 mmHg at 25°C

Ellagic acid Uses

Ellagic acid (CAS NO.476-66-4) can be used for medicine and cosmetics, and antioxidant with anti-cancer and inhibition virus role.

Ellagic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD	oral	> 20gm/kg (20000mg/kg)		Farmatsevtichnii Zhurnal Vol. 54(6), Pg. 90, 1999.
rat	LDLo	intraperitoneal	630mg/kg (630mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA	Farmatsevtichnii Zhurnal Vol. 54(6), Pg. 90, 1999.

Ellagic acid Safety Profile

Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Safety Information for Ellagic acid (CAS NO.476-66-4)
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS: DJ2620000
F: 8-10-23

Product Name

Ellagic acid

Synthetic route

Ellagic acid Chemical Properties

Ellagic acid Uses

Ellagic acid Toxicity Data With Reference

Ellagic acid Safety Profile

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