Product Name

  • Name

    2-METHOXYACETOPHENONE

  • EINECS 223-802-4
  • CAS No. 4079-52-1
  • Article Data77
  • CAS DataBase
  • Density 1.044 g/cm3
  • Solubility
  • Melting Point 7-8 °C(lit.)
  • Formula C9H10O2
  • Boiling Point 237.9 °C at 760 mmHg
  • Molecular Weight 150.177
  • Flash Point 94.9 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 4079-52-1 (2-METHOXYACETOPHENONE)
  • Hazard Symbols
  • Synonyms Acetophenone,2-methoxy- (8CI);2-Methoxy-1-phenylethanone;2-Methoxyacetophenone;Methoxymethyl phenyl ketone;NSC 227212;NSC 354;a-Methoxyacetophenone;w-Methoxyacetophenone;
  • PSA 26.30000
  • LogP 1.51570

Synthetic route

1-phenyl-1,1,2-trimethoxyethane
143191-51-9

1-phenyl-1,1,2-trimethoxyethane

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With hydrogenchloride100%
1-acetoxy-1-fluoro-1-phenyl-2-methoxyethane
143191-50-8

1-acetoxy-1-fluoro-1-phenyl-2-methoxyethane

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With base100%
methanol
67-56-1

methanol

acetophenone
98-86-2

acetophenone

A

iodoacetophenone
4636-16-2

iodoacetophenone

B

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With ammonium iodide; Oxone for 2.3h; Reflux;A 92%
B 6%
N-methoxy-N-methylbenzamide
6919-61-5

N-methoxy-N-methylbenzamide

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With 4,4'-di-tert-butylbiphenyl; lithium In tetrahydrofuran; mineral oil at -78℃; for 2.5h; Inert atmosphere; Schlenk technique;91%
methanol
67-56-1

methanol

2-diazo-acetophenone
3282-32-4

2-diazo-acetophenone

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
In(OSO2CF3)3 at 20℃; for 0.0333333h;90%
With montmorillonite K-1087%
at 25℃; for 1h; Green chemistry;87%
methanol
67-56-1

methanol

1-styrenyloxytrimethylsilane
13735-81-4

1-styrenyloxytrimethylsilane

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With Ph[I(OH)OTf] 18-crown-6 complex monohydrate at -78 - 20℃; for 7h;87%
With C6H6BF4IO*C12H24O6 In dichloromethane at -70 - 20℃; for 4.5h; Reagent/catalyst; Inert atmosphere;87%
With iodosylbenzene; boron trifluoride diethyl etherate at -70 - 25℃; for 3.5h; Mechanism; var. silyl enol ethers;78%
methoxydimethyl((1-phenylvinyl)oxy)silane
1638623-53-6

methoxydimethyl((1-phenylvinyl)oxy)silane

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene In dichloromethane at 25℃; Inert atmosphere; Schlenk technique;86%
1-styrenyloxytrimethylsilane
13735-81-4

1-styrenyloxytrimethylsilane

methyl hypofluorite
36336-08-0

methyl hypofluorite

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
In chloroform; acetonitrile at -40 - 20℃;85%
2-methoxy-1-phenylethanol
3587-84-6

2-methoxy-1-phenylethanol

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With 2-Picolinic acid; manganese(II) perchlorate hexahydrate; butanedial; dihydrogen peroxide; sodium acetate In acetonitrile at 0 - 20℃; for 1h;83%
With chlorine-triphenylphosphine; dimethyl sulfoxide; triethylamine In dichloromethane at -78 - 20℃; for 3.25h;70%
With bromopentacarbonylmanganese(I); N-methyl-N,N-di(2-pyridylmethyl)amine; acetone; sodium t-butanolate In toluene at 90℃; for 24h; Inert atmosphere; Schlenk technique; Darkness;35 %Chromat.
methanol
67-56-1

methanol

acetophenone
98-86-2

acetophenone

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid hydrazide In water at 20℃; for 16h; Mechanism; Temperature; Reagent/catalyst; Schlenk technique;83%
2-methoxy-1-phenylethanol
3587-84-6

2-methoxy-1-phenylethanol

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

benzoic acid
65-85-0

benzoic acid

Conditions
ConditionsYield
With 2-Picolinic acid; manganese(II) perchlorate hexahydrate; butanedial; dihydrogen peroxide; sodium acetate In acetonitrile at 0 - 20℃; for 1h;A 83%
B n/a
2-methoxyacetonitrile
1738-36-9

2-methoxyacetonitrile

phenylmagnesium chloride
100-59-4

phenylmagnesium chloride

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
Stage #1: 2-methoxyacetonitrile; phenylmagnesium chloride With copper(l) iodide In tetrahydrofuran for 0.5h; Reflux; Inert atmosphere;
Stage #2: With sulfuric acid In tetrahydrofuran; water at 0 - 20℃; for 18h; Inert atmosphere;
82%
Stage #1: 2-methoxyacetonitrile; phenylmagnesium chloride With copper(l) iodide In tetrahydrofuran for 0.5h; Reflux;
Stage #2: With sulfuric acid In tetrahydrofuran; water at 20℃;
15%
(methoxymethyl)triphenylphosphonium chloride
4009-98-7

(methoxymethyl)triphenylphosphonium chloride

benzonitrile
100-47-0

benzonitrile

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With phenyllithium In tetrahydrofuran at 0℃; for 0.166667h; Dehydrochlorination;
Stage #2: benzonitrile In tetrahydrofuran at 20℃; for 2h; Alkylation;
Stage #3: With water In tetrahydrofuran Hydrolysis;
81%
methanol
67-56-1

methanol

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

2,2-dimethoxy-1-phenylethanone
6956-56-5

2,2-dimethoxy-1-phenylethanone

C

methyl 2-methoxy-2-phenylacetate
3558-61-0

methyl 2-methoxy-2-phenylacetate

Conditions
ConditionsYield
With perchloric acid; thallium(III) nitrate at 20℃; for 5h;A 8%
B 80%
C 11%
benzonitrile
100-47-0

benzonitrile

(methoxymethyl)diphenylphosphine oxide
4455-77-0

(methoxymethyl)diphenylphosphine oxide

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With phenyllithium In tetrahydrofuran Alkylation;80%
bromobenzene
108-86-1

bromobenzene

2-methoxyacetonitrile
1738-36-9

2-methoxyacetonitrile

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
Stage #1: bromobenzene With iodine; magnesium In tetrahydrofuran at 40 - 70℃; for 3h; Inert atmosphere;
Stage #2: 2-methoxyacetonitrile In tetrahydrofuran for 48h; Inert atmosphere;
80%
sodium methylate
124-41-4

sodium methylate

1-chloroacetophenone
532-27-4

1-chloroacetophenone

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

1-phenyl-2-hydroxyethanone
582-24-1

1-phenyl-2-hydroxyethanone

Conditions
ConditionsYield
In methanol at 25℃; Kinetics; Concentration;A 27.3%
B 73.8%
1-benzoyl-1,3-dimethoxyacetone
130895-63-5

1-benzoyl-1,3-dimethoxyacetone

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With hydrogenchloride In methanol at 50℃; for 20h;71%
methanol
67-56-1

methanol

acetophenone
98-86-2

acetophenone

A

benzoic acid methyl ester
93-58-3

benzoic acid methyl ester

B

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

C

2,2-dimethoxy-1-phenylethanone
6956-56-5

2,2-dimethoxy-1-phenylethanone

D

benzeneacetic acid methyl ester
101-41-7

benzeneacetic acid methyl ester

Conditions
ConditionsYield
With perchloric acid; thallium(III) nitrate at 20℃; for 5h; Product distribution; Mechanism; effect of the presence of HClO4;A 2%
B 8%
C 2%
D 71%
3-(methoxymethyl)-3-phenyldioxetane
161925-21-9

3-(methoxymethyl)-3-phenyldioxetane

A

2-amino-1,9-dihydro-6H-purin-6-one
73-40-5

2-amino-1,9-dihydro-6H-purin-6-one

B

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

C

3-methoxy-2-phenylpropane-1,2-diol

3-methoxy-2-phenylpropane-1,2-diol

D

2',3',5'-tri-O-acetyl-8-methoxyguanosine

2',3',5'-tri-O-acetyl-8-methoxyguanosine

Conditions
ConditionsYield
With 2',3',5'-triacetylguanosine In methanol at 0℃; for 36h; Further byproducts given;A n/a
B 70%
C 12%
D n/a
sodium methylate
124-41-4

sodium methylate

α-bromoacetophenone
70-11-1

α-bromoacetophenone

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

1-phenyl-2-hydroxyethanone
582-24-1

1-phenyl-2-hydroxyethanone

Conditions
ConditionsYield
In methanol at 25℃; Kinetics; Concentration;A 36.3%
B 67.2%
ethyl 2-methoxyacetate
3938-96-3

ethyl 2-methoxyacetate

phenylmagnesium bromide

phenylmagnesium bromide

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

1-hydroxy-2-methoxy-1,1-diphenylethane
14704-09-7

1-hydroxy-2-methoxy-1,1-diphenylethane

Conditions
ConditionsYield
In diethyl ether at -78 - 20℃;A 29%
B 67%
methanol
67-56-1

methanol

para-methylacetophenone
122-00-9

para-methylacetophenone

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

methyl p-tolylacetate
23786-13-2

methyl p-tolylacetate

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; hydrogen cation at 60℃; for 1h; oxidative rearrangement;A 11%
B 67%
methanol
67-56-1

methanol

[bis(acetoxy)iodo]benzene
3240-34-4

[bis(acetoxy)iodo]benzene

phenylacetylene
536-74-3

phenylacetylene

A

2-acetoxyacetophenone
2243-35-8

2-acetoxyacetophenone

B

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

C

2-methoxy-1-phenylvinyl acetate
1191256-36-6

2-methoxy-1-phenylvinyl acetate

Conditions
ConditionsYield
at 70℃; for 12h;A 66%
B 13%
C 6%
methanol
67-56-1

methanol

C17H14F3O3Tl
112481-60-4

C17H14F3O3Tl

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Conditions
ConditionsYield
With iodosylbenzene; boron trifluoride diethyl etherate Product distribution; other α-metallo ketones; other alcohol;65%
methanol
67-56-1

methanol

1-phenylbutan-1,3-dione
93-91-4

1-phenylbutan-1,3-dione

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

benzeneacetic acid methyl ester
101-41-7

benzeneacetic acid methyl ester

Conditions
ConditionsYield
With iodosylbenzene; boron trifluoride diethyl etherate for 8h; Mechanism; Ambient temperature;A 63%
B 24%
With iodosylbenzene; boron trifluoride diethyl etherate for 8h; Ambient temperature;A 63%
B 24%
styrene
292638-84-7

styrene

methanol
67-56-1

methanol

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

2-methoxy-1-phenylethyl hydroperoxide

2-methoxy-1-phenylethyl hydroperoxide

C

benzaldehyde
100-52-7

benzaldehyde

Conditions
ConditionsYield
With oxygen; magnesium oxide; 9-(2-mesityl)-10-methylacridinium perchlorate In ethyl acetate at 20℃; for 10h; Reagent/catalyst; Time; Solvent; Irradiation; Green chemistry;A 6 %Spectr.
B 63%
C 8 %Spectr.
morpholine
110-91-8

morpholine

3-(methoxymethyl)-3-phenyldioxetane
161925-21-9

3-(methoxymethyl)-3-phenyldioxetane

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

N-(2-Hydroxy-3-methoxy-2-phenylpropoxy)morpholine

N-(2-Hydroxy-3-methoxy-2-phenylpropoxy)morpholine

Conditions
ConditionsYield
In dichloromethane at 0℃; for 0.2h;A 1%
B 62%
3-(methoxymethyl)-3-phenyldioxetane
161925-21-9

3-(methoxymethyl)-3-phenyldioxetane

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

N-(2-Hydroxy-3-methoxy-2-phenylpropoxy)morpholine

N-(2-Hydroxy-3-methoxy-2-phenylpropoxy)morpholine

Conditions
ConditionsYield
With morpholine In dichloromethane at 0℃; for 0.2h;A 1%
B 62%
methanol
67-56-1

methanol

acetophenone
98-86-2

acetophenone

A

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

B

benzeneacetic acid methyl ester
101-41-7

benzeneacetic acid methyl ester

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene at 60℃; for 1h;A 17%
B 59%
With [hydroxy(tosyloxy)]iodobenzene for 36h; Mechanism; Ambient temperature; var. p-substituted acetophenones, other reagents;A 10%
B 57%
With [hydroxy(tosyloxy)]iodobenzene for 36h; Ambient temperature;A 10%
B 57%
With [bis(acetoxy)iodo]benzene; sulfuric acid at 60℃; for 1h;A 21%
B 56%
With [bis(acetoxy)iodo]benzene; hydrogen cation at 60℃; for 1h; oxidative rearrangement;A 21%
B 56%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

(R)-Phenylglycinol
56613-80-0

(R)-Phenylglycinol

(R)-2,4-diphenyl-2-(methoxymethyl)-1,3-oxazolidine
103621-11-0, 103621-12-1

(R)-2,4-diphenyl-2-(methoxymethyl)-1,3-oxazolidine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 72h; Heating;100%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

allyltributylstanane
24850-33-7

allyltributylstanane

1-methoxy-2-phenylpent-4-en-2-ol

1-methoxy-2-phenylpent-4-en-2-ol

Conditions
ConditionsYield
With tin(ll) chloride In acetonitrile for 1h;100%
5-iodoisatin
20780-76-1

5-iodoisatin

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

6-iodo-3-methoxy-2-phenylquinoline-4-carboxylic acid hydrochloride

6-iodo-3-methoxy-2-phenylquinoline-4-carboxylic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide In ethanol for 72h; Heating;100%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

allylmagnesium bromide
2622-05-1

allylmagnesium bromide

1-methoxy-2-phenylpent-4-en-2-ol

1-methoxy-2-phenylpent-4-en-2-ol

Conditions
ConditionsYield
Stage #1: methoxymethyl phenyl ketone; allylmagnesium bromide In tetrahydrofuran at 20℃; for 3h;
Stage #2: With water; ammonium chloride In tetrahydrofuran
100%
In tetrahydrofuran at -78℃; Inert atmosphere;100%
Stage #1: methoxymethyl phenyl ketone; allylmagnesium bromide In tetrahydrofuran at 20℃; for 3h;
Stage #2: With water; ammonium chloride In tetrahydrofuran
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

3-methoxy-2-phenyl-2-(trimethylsilyloxy)propionitrile
137057-20-6

3-methoxy-2-phenyl-2-(trimethylsilyloxy)propionitrile

Conditions
ConditionsYield
indium(III) bromide In dichloromethane at 20℃; for 0.5h;99%
With indium(III) bromide In dichloromethane at 20℃; for 0.5h;99%
With zinc(II) iodide In dichloromethane for 24h; Ambient temperature;
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

(E)-cinnamyl(tributyl)tin
74785-32-3

(E)-cinnamyl(tributyl)tin

(2S,3R)-1-methoxy-2,3-diphenyl-4-penten-2-ol

(2S,3R)-1-methoxy-2,3-diphenyl-4-penten-2-ol

Conditions
ConditionsYield
With tin(ll) chloride In acetonitrile at 20℃; for 3h;99%
4-bromo-trans-crotonic acid ethyl ester
37746-78-4

4-bromo-trans-crotonic acid ethyl ester

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

ethyl (E)-5-hydroxy-6-methoxy-5-phenylhex-2-enoate

ethyl (E)-5-hydroxy-6-methoxy-5-phenylhex-2-enoate

Conditions
ConditionsYield
With indium In tetrahydrofuran at 20℃; for 20h;99%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

benzaldehyde
100-52-7

benzaldehyde

(l,u,l,l)-3,5-dimethoxy-2,4,6-triphenyltetrahydro-2H-pyran-2,4-diol

(l,u,l,l)-3,5-dimethoxy-2,4,6-triphenyltetrahydro-2H-pyran-2,4-diol

Conditions
ConditionsYield
Stage #1: methoxymethyl phenyl ketone With lithium diisopropyl amide In tetrahydrofuran; hexane at -40℃; for 1h; Inert atmosphere; Schlenk technique;
Stage #2: With indium(III) chloride In tetrahydrofuran; hexane at -40 - 25℃; for 1.5h; Inert atmosphere; Schlenk technique;
Stage #3: benzaldehyde In tetrahydrofuran; hexane at 67℃; for 1h; Reagent/catalyst; Temperature; Aldol Addition; Inert atmosphere; Schlenk technique;
99%
2-aminopyridine
504-29-0

2-aminopyridine

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

3-Methoxy-2-phenylimidazo<1,2-a>pyridine
89192-94-9

3-Methoxy-2-phenylimidazo<1,2-a>pyridine

Conditions
ConditionsYield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;96%
With copper(l) iodide; oxygen In 1,2-dichloro-ethane at 100℃; under 760.051 Torr; Sealed tube;71%
With copper(l) iodide; oxygen In 1,2-dichloro-ethane at 100℃; for 16h;71%
3-chloro-cyclohexene
2441-97-6

3-chloro-cyclohexene

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

C15H20O2

C15H20O2

Conditions
ConditionsYield
With indium In tetrahydrofuran at 20℃; for 5h;95%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

Cinnamyl bromide
4392-24-9

Cinnamyl bromide

C18H20O2

C18H20O2

Conditions
ConditionsYield
With indium In tetrahydrofuran; water at 20℃; for 16h;95%
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

(R)-3-methoxy-2-phenyl-2-trimethylsilyloxypropanenitrile
1402458-64-3

(R)-3-methoxy-2-phenyl-2-trimethylsilyloxypropanenitrile

Conditions
ConditionsYield
With tert-butyl methyl ether; Ru[t-leu]2[(S)-binap]; lithium phenolate at -40℃; for 2h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;95%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

C6H5COCH2OCH(2)H2

C6H5COCH2OCH(2)H2

Conditions
ConditionsYield
With [D]-sodium hydroxide; deuteromethanol; water-d2 for 21h; Reflux;95%
iodobenzene
591-50-4

iodobenzene

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

benzoin monomethyl ether
3524-62-7

benzoin monomethyl ether

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 60℃; for 13h; Inert atmosphere; Schlenk technique;94%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

acetophenone
98-86-2

acetophenone

Conditions
ConditionsYield
With ammonium chloride; zinc In ethanol for 0.5h; Heating;93%
With 2,6-bis[1-(2,6-dimethylphenylimino)ethyl]pyridine cobalt(II)dichloride; bis(pinacol)diborane; sodium t-butanolate In tetrahydrofuran; methanol at 65℃; for 24h; Schlenk technique; Inert atmosphere;30%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

2-methoxy-1-phenylethanol
3587-84-6

2-methoxy-1-phenylethanol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0 - 20℃; for 3.5h;92%
With sodium tetrahydroborate In methanol at 0 - 20℃; Inert atmosphere;86%
84%
methanol
67-56-1

methanol

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

methyl 2-oxo-2-phenylacetate
15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions
ConditionsYield
With bromine for 1h; Heating;92%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

tributyl(cyclohex-2-en-1-yl)stannane
112520-99-7, 1177092-71-5

tributyl(cyclohex-2-en-1-yl)stannane

(S)-1-((R)-cyclohex-2-enyl)-2-methoxy-1-phenylethanol

(S)-1-((R)-cyclohex-2-enyl)-2-methoxy-1-phenylethanol

Conditions
ConditionsYield
With tin(ll) chloride In acetonitrile at 20℃; for 3h;92%
2-methoxyacetophene

2-methoxyacetophene

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

isopropyl alcohol
67-63-0

isopropyl alcohol

(R)-2-methoxy-1-phenyl-ethanol
109459-34-9

(R)-2-methoxy-1-phenyl-ethanol

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol92%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

methyl 2-oxo-2-phenylacetate
15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions
ConditionsYield
With iodine; sodium carbonate In 1,2-dichloro-ethane at 60℃; for 3h; Time;92%
6-fluoroisatin
324-03-8

6-fluoroisatin

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

7-fluoro-3-methoxy-2-phenylquinoline-4-carboxylic acid hydrochloride

7-fluoro-3-methoxy-2-phenylquinoline-4-carboxylic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide In ethanol for 72h; Heating;90%
7-iodoisatin
20780-78-3

7-iodoisatin

methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

8-iodo-3-methoxy-2-phenylquinoline-4-carboxylic acid hydrochloride

8-iodo-3-methoxy-2-phenylquinoline-4-carboxylic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide In ethanol for 72h; Heating;90%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

2-bromobutyric acid ethyl ester
533-68-6

2-bromobutyric acid ethyl ester

ethyl 3-hydroxy-4-methoxy-2-methyl-3-phenylbutyrate

ethyl 3-hydroxy-4-methoxy-2-methyl-3-phenylbutyrate

Conditions
ConditionsYield
With indium In tetrahydrofuran Reformatsky-type reaction; Heating;90%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

2,3-dimethyl-buta-1,3-diene
513-81-5

2,3-dimethyl-buta-1,3-diene

C15H22O2
1046828-28-7

C15H22O2

Conditions
ConditionsYield
Stage #1: 2,3-dimethyl-buta-1,3-diene With dichloroindium hydride In tetrahydrofuran at 20℃; for 5h;
Stage #2: methoxymethyl phenyl ketone With water In tetrahydrofuran at 20℃; for 14h; regioselective reaction;
90%
methoxymethyl phenyl ketone
4079-52-1

methoxymethyl phenyl ketone

tetraphenylethane-1,2-diol
464-72-2

tetraphenylethane-1,2-diol

A

benzophenone
119-61-9

benzophenone

B

C22H22O3

C22H22O3

Conditions
ConditionsYield
With titanium(IV) tetrabutoxide; triethylsilyl chloride In dichloromethane at 20℃;A n/a
B 90%

Ethanone,2-methoxy-1-phenyl- Specification

The CAS register number of Ethanone,2-methoxy-1-phenyl- is 4079-52-1. It also can be called as alpha-Methoxyacetophenone and the IUPAC name about this chemical is 2-methoxy-1-phenylethanone. The molecular formula about this chemical is C9H10O2 and the molecular weight is 150.17. It belongs to the following product categories which include C9; Carbonyl Compounds; Ketones and so on.

Physical properties about Ethanone,2-methoxy-1-phenyl- are: (1)ACD/LogP: 1.40; (2)ACD/LogD (pH 5.5): 1.4; (3)ACD/LogD (pH 7.4): 1.4; (4)ACD/BCF (pH 5.5): 6.78; (5)ACD/BCF (pH 7.4): 6.78; (6)ACD/KOC (pH 5.5): 137.02; (7)ACD/KOC (pH 7.4): 137.02; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 26.3Å2; (11)Index of Refraction: 1.504; (12)Molar Refractivity: 42.65 cm3; (13)Molar Volume: 143.8 cm3; (14)Polarizability: 16.91x10-24cm3; (15)Surface Tension: 35.8 dyne/cm; (16)Flash Point: 94.9 °C; (17)Enthalpy of Vaporization: 47.48 kJ/mol; (18)Boiling Point: 237.9 °C at 760 mmHg; (19)Vapour Pressure: 0.0436 mmHg at 25°C.

Preparation: this chemical can be prepared by 2-diazo-1-phenyl-ethanone and methanol. This reaction will need reagent copper.

 

Uses of Ethanone,2-methoxy-1-phenyl-: it can be used to produce oxo-phenyl-acetic acid methyl ester with methanol at heating. This reaction will need reagent Br2 with reaction time of 1 hours. The yield is about 92%.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(c1ccccc1)COC
(2)InChI: InChI=1/C9H10O2/c1-11-7-9(10)8-5-3-2-4-6-8/h2-6H,7H2,1H3
(3)InChIKey: YRNDGUSDBCARGC-UHFFFAOYAV
(4)Std. InChI: InChI=1S/C9H10O2/c1-11-7-9(10)8-5-3-2-4-6-8/h2-6H,7H2,1H3
(5)Std. InChIKey: YRNDGUSDBCARGC-UHFFFAOYSA-N

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