Ethyl chloride supplier | CasNO.75-00-3

Name
CHLOROETHANE
EINECS 200-830-5
CAS No. 75-00-3
Article Data749
CAS DataBase
Density 0.884 g/cm³
Solubility 6710 mg/L at 25℃
Melting Point -139 °C(lit.)
Formula C₂H₅Cl
Boiling Point 12.7 °C at 760 mmHg
Molecular Weight 64.5147
Flash Point <-30 °F
Transport Information UN 1993 3/PG 2
Appearance colourless gas
Safety 9-16-33-36/37-61-45-7-29-36/37/39-26-53
Risk Codes 45-11-20/21/22-36/37/38-52/53-40-12-39/23/24/25-23/24/25-67-66-22-19
Molecular Structure
Hazard Symbols F+,Xn,T,F
Synonyms Aethylis;Aethylis chloridum;Anodynon;Chlorethyl;Chloridum;Chloroethane;Chloryl;Chloryl Anesthetic;Chloryle anesthetic;Cloretilo;Dublofix;Ether chloratus;Ether hydrochloric;Ether muriatic;Hydrochloric ether;Kelene;Monochloroethane;Muriaticether;Narcotile;R 160;
PSA 0.00000
LogP 1.24510

Synthetic route

: 87463-00-1
O-ethyl N-methyl-N-phenylthiocarbamate

A: 75-00-3
chloroethane

B: 100244-53-9
(N-methyl-N-phenylcarbamoyl)sulfenyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride In chloroform-d1 at 5℃; for 0.166667h;	A 100% B n/a
With sulfuryl dichloride In chloroform-d1 at 25℃;

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 65039-09-0
1-ethyl-3-methyl-1H-imidazol-3-ium chloride

A: 377739-43-0
1-ethyl-3-methyl-imidazolium tris(pentafluoroethyl)trifluorophosphate

B: 60-29-7
diethyl ether

C: 75-00-3
chloroethane

Conditions

Conditions	Yield
at 80℃; for 3h; Product distribution / selectivity;	A 98.9% B n/a C n/a

...Expand

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 30388-20-6
N,N,N',N',N'',N''-hexamethylguanidinium chloride

A: hexamethylguanidinium tris(pentafluoroethyl)trifluorophosphate

B: 60-29-7
diethyl ether

C: 75-00-3
chloroethane

Conditions

Conditions	Yield
at 80℃; for 3h;	A 98.9% B n/a C n/a

...Expand

: 762-04-9
phosphonic acid diethyl ester

A: 75-00-3
chloroethane

B: phosphorous acid monoethyl ester cobaltous salt

Conditions

Conditions	Yield
With CoCl2 at 120℃; Product distribution; the thermal stability of the product was investigated by DTA, DTG and TG;	A n/a B 98%

: 945614-34-6
triethyloxonium bis(trifluoromethylsulfonyl)imide

: 65039-09-0
1-ethyl-3-methyl-1H-imidazol-3-ium chloride

A: 60-29-7
diethyl ether

B: 75-00-3
chloroethane

C: 174899-82-2
1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide

Conditions

Conditions	Yield
at 80℃; for 3h;	A n/a B n/a C 97.9%

...Expand

: 1825-69-0
dimethyl chloro ethoxy silane

: 75-36-5
acetyl chloride

A: 75-00-3
chloroethane

B: acetoxydimethylsilyl isothiocyanate

Conditions

Conditions	Yield
at 30 - 40℃; for 1h;	A 97% B 87%

...Expand

: 64-17-5
ethanol

: 75-00-3
chloroethane

Conditions

Conditions	Yield
With hydrogenchloride; aluminum (III) chloride; zinc(II) chloride at 70 - 120℃; under 900.09 - 2625.26 Torr; for 2h; Large scale;	96.3%
With hydrogenchloride; zinc(II) chloride at 8 - 130℃;	65%
With hydrogenchloride

: 50966-09-1
diethyl (1-benzamido-2,2-dichlorovinyl)phosphonate

A: 75-00-3
chloroethane

B: 77113-14-5
azlactone of (1-benzamido-2,2-dichlorovinyl)phosphonochloridic acid

Conditions

Conditions	Yield
With phosphorus pentachloride at 110 - 120℃; for 5.5h;	A n/a B 96%

: 1-(chlorodimethylsilyl)-7-(ethoxydimethylsilyl)-m-carbaborane

A: 75-00-3
chloroethane

B: B10H10C2(Si(CH3)2O)(Si(CH3)2)

Conditions

Conditions	Yield
iron(III) chloride In neat (no solvent) heating (120 - 130°C), addn. of further FeCl3, heating (180°C); reprecipitation (toluene); elem. anal.;	A 96% B 94.7%

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 1-decyl-3-methylimidazol-3-ium chloride

A: 60-29-7
diethyl ether

B: 75-00-3
chloroethane

C: 916807-26-6
1-decyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate

Conditions

Conditions	Yield
at 80℃; for 3h;	A n/a B n/a C 96%

...Expand

: 78-38-6
ethylphosphonic acid diethyl ester

A: 75-00-3
chloroethane

B: 1066-50-8
Ethylphosphonic dichloride

Conditions

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide for 18h; Heating;	A n/a B 95.8%

: 589-57-1
diethyl phosphorylchloridite

: 17640-25-4
methyl 2,2-dichloro-2-methoxyacetate

A: 5781-53-3
monomethyl oxalyl chloride

B: 553-90-2
Dimethyl oxalate

C: 75-00-3
chloroethane

D: 66298-75-7
phosphonic dichloride

E: 74813-29-9
methyl phosphonochloridate

F: 74813-30-2
ethyl phosphonochloridate

Conditions

Conditions	Yield
With iron(III) chloride at 105 - 110℃; for 1.16667h; Product distribution;	A n/a B n/a C 95% D n/a E n/a F n/a

...Expand

: 589-57-1
diethyl phosphorylchloridite

: 17640-25-4
methyl 2,2-dichloro-2-methoxyacetate

A: 553-90-2
Dimethyl oxalate

B: 1498-42-6
phosphorodichloridous acid ethyl ester

C: 75-00-3
chloroethane

D: 66298-75-7
phosphonic dichloride

E: 74813-30-2
ethyl phosphonochloridate

F: phosphonic dichloride

Conditions

Conditions	Yield
With iron(III) chloride at 105 - 110℃; for 0.833333h; Product distribution;	A n/a B n/a C 95% D n/a E n/a F n/a

...Expand

: 762-04-9
phosphonic acid diethyl ester

: 80-10-4
diphenylsilyl dichloride

A: 75-00-3
chloroethane

B: 90285-15-7
C16H22O6P2Si

Conditions

Conditions	Yield
at 102℃;	A n/a B 94.1%

...Expand

: 64-17-5
ethanol

: 7719-12-2, 52843-90-0
phosphorus trichloride

A: 75-00-3
chloroethane

B: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 85℃; under 30.003 Torr; Addition of ca.3% diethyl phosphite (triethyl phosphite or ethyl chloride are also possible);	A n/a B 94%

...Expand

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 76-83-5
trityl chloride

A: 60-29-7
diethyl ether

B: 75-00-3
chloroethane

C: tritylium tris(pentafluoroethyl)trifluorophosphate

Conditions

Conditions	Yield
at 80℃; for 10h;	A n/a B n/a C 93.6%

...Expand

: 762-04-9
phosphonic acid diethyl ester

A: 75-00-3
chloroethane

B: phosphorous acid monoethyl ester calcium salt

Conditions

Conditions	Yield
With calcium chloride at 70℃; for 1h; Product distribution; other time; also in the presence of pyridine; the thermal stability of the product was investigated by DTA, DTG and TG;	A n/a B 93.4%
With calcium chloride at 70℃; for 1h;	A n/a B 93.4%

: 762-04-9
phosphonic acid diethyl ester

A: 75-00-3
chloroethane

B: phosphorous acid monoethyl ester manganese salt

Conditions

Conditions	Yield
With manganese(II) acetate at 112℃; for 1h; Product distribution; oter time; the thermal stability of the product was investigated by DTA, DTG and TG;	A n/a B 93%

: 121-44-8
triethylamine

: 1005-56-7
phenylcarbonochloridothioate

A: 75-00-3
chloroethane

B: 24486-06-4
O-phenyl-N,N-diethyl thiocarbamate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 1h; Substitution;	A n/a B 93%

...Expand

: N-(n-hexyl)-N-methylpyrrolidinium chloride

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

A: 60-29-7
diethyl ether

B: 75-00-3
chloroethane

C: 945614-40-4
1-hexyl-1-methylpyrrolidinium tris(pentafluoroethyl)trifluorophosphate

Conditions

Conditions	Yield
at 80℃; for 3h;	A n/a B n/a C 93%

...Expand

: ethyl o-(N-methylcarbamoyl)phenyl sulphoxide

A: 2527-66-4
2-methyl-1,2-benzisothiazole-3(2H)-one

B: 75-00-3
chloroethane

Conditions

Conditions	Yield
With thionyl chloride In tetrachloromethane for 5h; Heating;	A 92% B n/a

: [2,2-Dichloro-1-(4-chloro-benzoylamino)-vinyl]-phosphonic acid diethyl ester

A: 75-00-3
chloroethane

B: 2-Chloro-5-(4-chloro-phenyl)-3-dichloromethylene-3H-[1,4,2]oxazaphosphole 2-oxide

Conditions

Conditions	Yield
With phosphorus pentachloride at 110 - 120℃; for 5.5h;	A n/a B 92%

: 139535-54-9
N-methyl-N-(2,2-dimethyl-3-chloro-3-ethoxypropyl)methanesulfonamide

A: 75-00-3
chloroethane

B: 139535-59-4
N-methyl-N-(2,2-dimethyl-3-oxopropyl)methanesulfonamide

Conditions

Conditions	Yield
under 9 Torr; Heating;	A 91% B 79%

: 589-57-1
diethyl phosphorylchloridite

: 17640-25-4
methyl 2,2-dichloro-2-methoxyacetate

A: 75-00-3
chloroethane

B: 74813-30-2
ethyl phosphonochloridate

Conditions

Conditions	Yield
With iron(III) chloride at 95 - 110℃; for 1.5h;	A 90% B 38%

...Expand

: 589-57-1
diethyl phosphorylchloridite

: 6957-89-7
Ethyl dichloro-(ethoxy)-acetate

A: 75-00-3
chloroethane

B: 67538-60-7
ethyl phosphonochloridate

C: 814-49-3
diethyl chlorophosphate

D: 5284-10-6
ethyl ethylphosphonochloridate

Conditions

Conditions	Yield
With iron(III) chloride at 95 - 110℃; for 1.5h;	A 90% B 58% C n/a D n/a

...Expand

: 371-22-2
fluorophosphoric acid diethyl ester

: 17640-25-4
methyl 2,2-dichloro-2-methoxyacetate

A: 75-00-3
chloroethane

B: 67538-58-3
ethyl phosphonofluoridate

Conditions

Conditions	Yield
With iron(III) chloride at 95 - 110℃; for 1.5h;	A 90% B 45%

...Expand

: 371-22-2
fluorophosphoric acid diethyl ester

: 6957-89-7
Ethyl dichloro-(ethoxy)-acetate

A: 75-00-3
chloroethane

B: 67538-59-4
ethyl phosphonofluoridate

Conditions

Conditions	Yield
With iron(III) chloride at 95 - 110℃; for 1.5h;	A 90% B 50%

...Expand

: [2,2-Dichloro-1-(4-methyl-benzoylamino)-vinyl]-phosphonic acid diethyl ester

A: 75-00-3
chloroethane

B: 2-Chloro-3-dichloromethylene-5-p-tolyl-3H-[1,4,2]oxazaphosphole 2-oxide

Conditions

Conditions	Yield
With phosphorus pentachloride at 110 - 120℃; for 5.5h;	A n/a B 90%

: 94703-39-6
2,3,3,3-tetrachloro-2-<amino>propionitrile

: 122-52-1
triethyl phosphite

A: 75-00-3
chloroethane

B: 814-49-3
diethyl chlorophosphate

C: 94703-45-4
3,3-dichloro-2-<amino>acrylonitrile

Conditions

Conditions	Yield
In benzene for 1h; Heating;	A n/a B 90% C 25%

...Expand

: 64317-34-6
N-(pentafluorophenyl)carbonimidoyl dichloride

: 121-44-8
triethylamine

A: 75-00-3
chloroethane

B: 120672-75-5
N,N-diethyl-N-pentafluorophenylchloroformamidine

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 6h;	A n/a B 90%

...Expand

: 616-47-7
1-methyl-1H-imidazole

: 75-00-3
chloroethane

: 65039-09-0
1-ethyl-3-methyl-1H-imidazol-3-ium chloride

Conditions

Conditions	Yield
In ethanol at 35℃; for 10h; Wavelength; UV-irradiation;	100%
	79%
In acetonitrile at 70℃; for 168h;	71%

: 75-00-3
chloroethane

: 7646-78-8
tin(IV) chloride

: 597-64-8
tetraethyltin

Conditions

Conditions	Yield
With magnesium In diethyl ether; toluene at 50℃; Inert atmosphere; Flow reactor;	99.4%

: 75-00-3
chloroethane

: 62806-88-6
N,N-dipropylcarbamothioate sodium salt

: 759-94-4
S-ethyl N,N-di-n-propylthiocarbamate

Conditions

Conditions	Yield
In water at 80℃; for 0.25h; in ultrasonic field;	99.1%

: 75-00-3
chloroethane

: methyl 2-((tert-butoxycarbonyl)(hydroxy)amino)acetate

: methyl 2-((tert-butoxycarbonyl)(ethoxy)amino)acetate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 3h;	99%

: 75-00-3
chloroethane

: 121-33-5
vanillin

: 13184-86-6
phenol, 4-(ethoxymethyl)-2-methoxy-

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at 30 - 40℃; for 4h;	98.56%

: 75-00-3
chloroethane

: sodium hexamethylenethiocarbamate

: 2212-67-1
S-ethyl N-hexamethylenethiocarbamate

Conditions

Conditions	Yield
In water at 70℃; for 0.333333h; in ultrasonic field;	98.4%

: 75-00-3
chloroethane

: 102-28-3
m-acetamide aniline

: 6375-46-8
m-acetylamino-N,N-diethylanilne

Conditions

Conditions	Yield
With ammonium hydroxide In water at 90 - 98℃; under 7500.75 Torr; for 18h; pH=5 - 7; Temperature; Large scale;	98%

: 75-00-3
chloroethane

: 21055-93-6
sodium salt of diethylthiocarbamic acid

: 2941-55-1
S-ethyl N,N-diethylthiocarbamate

Conditions

Conditions	Yield
In water at 80℃; for 0.166667h; in ultrasonic field;	97.8%

: 532-32-1
sodium benzoate

: 75-00-3
chloroethane

: 93-89-0
benzoic acid ethyl ester

Conditions

Conditions	Yield
With tetrabutylammomium bromide In toluene at 40 - 70℃; under 3000.3 - 4500.45 Torr; for 1h; Reagent/catalyst; Autoclave; Inert atmosphere;	97.63%

: 75-00-3
chloroethane

: 56368-46-8
sodium pentamethylenethiocarbamate

: 6961-73-5
piperidine-1-carbothioic acid S-ethyl ester

Conditions

Conditions	Yield
In water at 70℃; for 0.25h; in ultrasonic field;	97.3%

: 75-00-3
chloroethane

: 108-10-1
4-methyl-2-pentanone

: 91-68-9
3-diethylaminophenol

: 1864-92-2
N,N-diethyl-3-ethoxyaniline

Conditions

Conditions	Yield
With sodium hydroxide; sodium carbonate	97.1%

...Expand

: 78-10-4
tetraethoxy orthosilicate

: 75-00-3
chloroethane

: 5021-93-2
diethyldiethoxysilane

Conditions

Conditions	Yield
With magnesium at 50 - 100℃;	97%
With magnesium at 60℃; for 1h; Temperature;	94%

: 75-00-3
chloroethane

: 108-18-9
diisopropylamine

: 7087-68-5
N-ethyl-N,N-diisopropylamine

Conditions

Conditions	Yield
With lithium chloride; zinc(II) chloride at 190℃; under 16501.7 Torr; for 10h; Catalytic behavior; Temperature; Pressure; Time; Reagent/catalyst; Autoclave;	96.7%

: 17771-33-4
7-hydroxy-2,2-dimethyl-chroman-4-one

: 75-00-3
chloroethane

: 76348-94-2
2,2-dimethyl-7-ethoxy-4-chromanone

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 5h;	96%

: 15231-91-1
6-bromo-naphthalen-2-ol

: 75-00-3
chloroethane

: 66217-19-4
2-ethoxy-6-bromo-naphthalene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 3.5h;	96%

: 75-00-3
chloroethane

: 6375-47-9
3-amino-4-methoxyacetanilide

: 19433-93-3
3-acetylamino-6-methoxy-N,N-diethylaniline

Conditions

Conditions	Yield
With sodium hydroxide In water at 80 - 97℃; under 7500.75 Torr; for 22.5h; pH=6.5 - 7;	96%

: 75-00-3
chloroethane

: 603-35-0
triphenylphosphine

: 896-33-3
ethyltriphenylphosphonium chloride

Conditions

Conditions	Yield
In acetone at 150℃; under 9000.9 Torr; for 40h; Solvent; Temperature; Pressure; Autoclave;	95.23%
In acetonitrile for 10h; Inert atmosphere; Reflux;	83.2%

: 108-89-4
picoline

: 75-00-3
chloroethane

: 105757-96-8
1-Ethyl-4-methylpyridinium chloride

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 5h;	95%

Ethyl chloride Consensus Reports

ETHYL CHLORIDE is reported in EPA TSCA Inventory. Community Right-To-Know List.

Ethyl chloride Standards and Recommendations

OSHA PEL: TWA 1000 ppm
ACGIH TLV: TWA 1000 ppm
DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
NIOSH REL: (Chloroethane) Handle with caution
DOT Classification: 2.1; Label: Flammable Gas

Ethyl chloride Specification

The Ethane, chloro-, with the CAS registry number 75-00-3, is also known as Octamethylsilanetetramine. It belongs to the product categories of Refrigerants; Organics; Halides (Low Boiling point); Alkyl Chlorides; Gas Cylinders; Monofunctional & alpha,omega-Bifunctional Alkanes; Monofunctional Alkanes; Synthetic Organic Chemistry. Its EINECS number is 200-830-5. This chemical's molecular formula is C₂H₅Cl and molecular weight is 64.51. What's more, its systematic name is chloroethane. (1)Anesthetic [topical]; (2)Anesthetics; (3)Anesthetics, local; (4)Central Nervous System Agents; (5)Central Nervous System Depressants; (6)Drug / Therapeutic Agent; (7)Mutation data; (8)Peripheral Nervous System Agents; (9)Reproductive Effect; (10)Sensory System Agents; (11)TSCA Flag T [Subject to the Section 4 test rule under TSCA]; (12)Tumor data. It is stable at common pressure and temperature, and it should be sealed and stored in a cool and dry place. Moreover, it should be protected from oxides and water. It is used as a refrigerant, an aerosol spray propellant, an anesthetic, and a blowing agent for foam packaging.

Physical properties of Ethane, chloro- are: (1)ACD/LogP: 1.50; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.5; (4)ACD/LogD (pH 7.4): 1.5; (5)ACD/BCF (pH 5.5): 8.14; (6)ACD/BCF (pH 7.4): 8.14; (7)ACD/KOC (pH 5.5): 156.06; (8)ACD/KOC (pH 7.4): 156.06; (9)Index of Refraction: 1.361; (10)Molar Refractivity: 16.16 cm³; (11)Molar Volume: 72.9 cm³; (12)Polarizability: 6.4×10^-24cm³; (13)Surface Tension: 17.9 dyne/cm; (14)Density: 0.884 g/cm³; (15)Enthalpy of Vaporization: 24.97 kJ/mol; (16)Boiling Point: 12.7 °C at 760 mmHg; (17)Vapour Pressure: 1170 mmHg at 25°C.

Preparation: this chemical can be prepared by ethylphosphonic acid diethyl ester by heating. This reaction will need reagent SOCl₂ with the reaction time of 18 hours. This reaction will also need catalyst DMF. The yield is about 95.8%.

Ethane, chloro- can be prepared by ethylphosphonic acid diethyl ester by heating

Uses of Ethane, chloro-: it can be used to produce 1-Ethyl-4-methylpyridinium chloride at the temperature of 80 °C. It will need solvent acetonitrile with the reaction time of 5 hours. The yield is about 95%.

Ethane, chloro- can be used to produce 1-Ethyl-4-methylpyridinium chloride at the temperature of 80 °C

When you are using this chemical, please be cautious about it as the following:
This chemical is extremely flammable, so you should keep it away from sources of ignition - No smoking. It has a limited evidence of a carcinogenic effect. It is harmful to aquatic organisms as it may cause long-term adverse effects in the aquatic environment. You should keep the container in a well-ventilated place and take precautionary measures against static discharges. When using it, you need wear suitable protective clothing and gloves. You must avoid releasing it to the environment just refering to special instructions/safety data sheet.

You can still convert the following datas into molecular structure:
(1)SMILES: ClCC
(2)Std. InChI: InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3
(3)Std. InChIKey: HRYZWHHZPQKTII-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LCLo	inhalation	40000ppm/45M (40000ppm)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	U.S. Public Health Service, Public Health Bulletin. Vol. 185, Pg. 1, 1929.
mouse	LC50	inhalation	146gm/m³/2H (146000mg/m³)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 66, 1982.
rat	LC50	inhalation	152gm/m³/2H (152000mg/m³)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES BEHAVIORAL: GENERAL ANESTHETIC BLOOD: HEMORRHAGE	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 6, Pg. 45, 1964.

Product Name

CHLOROETHANE

Synthetic route

Ethyl chloride Consensus Reports

Ethyl chloride Standards and Recommendations

Ethyl chloride Specification

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