Product Name

  • Name

    Exemestane

  • EINECS 643-090-2
  • CAS No. 107868-30-4
  • Article Data19
  • CAS DataBase
  • Density 1.13 g/cm3
  • Solubility
  • Melting Point 155.13 ºC
  • Formula C20H24O2
  • Boiling Point 453.7 ºC at 760 mmHg
  • Molecular Weight 296.409
  • Flash Point 169 ºC
  • Transport Information
  • Appearance white to light yellow crystal powder
  • Safety 53-22-36/37-57
  • Risk Codes 60-61-51
  • Molecular Structure Molecular Structure of 107868-30-4 (Exemestane)
  • Hazard Symbols T,N
  • Synonyms Exemestane [USAN:INN:BAN];Aromasil;Aromasin;FCE 24304;Exemestane Tablets;Androsta-1,4-diene-3,17-dione, 6-methylene-;Exemestano;Exemestano [INN-Spanish];Exemestanum;Exemestanum [INN-Latin];HSDB 7463;Exemestane;
  • PSA 34.14000
  • LogP 4.02950

Synthetic route

17β-hydroxy-6-methylen- androsta-1,4-dien-3-one
122370-91-6

17β-hydroxy-6-methylen- androsta-1,4-dien-3-one

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With Jones reagent In acetone at -20℃; Jones oxidation; Inert atmosphere;100%
With jones reagent In acetone at -20℃; for 0.25h;85%
With Jones reagent In acetone at 0℃; Product distribution / selectivity;
6α-hydroxymethylandrosta-1,4-diene-3,17-dione
933455-74-4

6α-hydroxymethylandrosta-1,4-diene-3,17-dione

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Stage #1: 6α-hydroxymethylandrosta-1,4-diene-3,17-dione With methanesulfonyl chloride; triethylamine In dichloromethane at 0 - 30℃;
Stage #2: With methanol; potassium hydroxide at 40 - 50℃;		90%
17-hydroxyimino-6-methylenandrosta-1,4-diene-3-one

17-hydroxyimino-6-methylenandrosta-1,4-diene-3-one

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In water; acetone at 25 - 30℃; for 10h; Solvent; Reagent/catalyst; Temperature; Jones Oxidation; Inert atmosphere;88.2%
6-methylene-androst-4-ene 3,17-dione
19457-55-7

6-methylene-androst-4-ene 3,17-dione

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With N,O-Bis(trimethylsilyl)trifluoroacetamide; chloranil; trifluorormethanesulfonic acid In toluene at 108 - 110℃; for 0.75h; Product distribution / selectivity; Heating / reflux;81.8%
With trifluorormethanesulfonic acid; N,O-Bis(trimethylsilyl)trifluoroacetamide; chloranil In toluene Inert atmosphere; Reflux;81%
With tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane at 0 - 20℃;30.2%
methanol
67-56-1

methanol

6β-hydroxymethylandrosta-1,4-diene-3,17-dione
121021-51-0

6β-hydroxymethylandrosta-1,4-diene-3,17-dione

A

(6S,8R,9S,10R,13S,14S)-6-(methoxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

(6S,8R,9S,10R,13S,14S)-6-(methoxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

B

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With hydrogenchloride at 20℃; for 24h;A 8%
B 60%
...Expand
6-Methylen-4-androsten-3,17-dion
19457-55-7, 51154-17-7

6-Methylen-4-androsten-3,17-dion

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide; toluene at 85℃; for 48h; Inert atmosphere; Large scale;56.7%
Androsta-1,4-diene-3,17-dione
897-06-3

Androsta-1,4-diene-3,17-dione

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 20 h / Heating
2: 1.10 g / benzene; ethanol; H2O / 5 h / 20 °C
3: 60 percent / conc. HCl / 24 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 6 h / Inert atmosphere; Reflux
2.1: N,N-dimethylammonium chloride / i-Amyl alcohol / 2 h / Inert atmosphere; Reflux
2.2: 15 h / 140 °C
3.1: toluene-4-sulfonic acid / water; acetone / 10 h / 25 - 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: orthoformic acid triethyl ester; toluene-4-sulfonic acid / tetrahydrofuran / 12 h / 40 - 45 °C / Large scale
2: tetrahydrofuran; ethanol / 10 h / 40 - 45 °C / Large scale
3: hydrogenchloride / tetrahydrofuran; ethanol / 1 h / Large scale
4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; toluene / 48 h / 85 °C / Inert atmosphere; Large scale
View Scheme
1α,3-dipyrrolidinylandrosta-3,5-dien-17-one
67737-88-6

1α,3-dipyrrolidinylandrosta-3,5-dien-17-one

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.10 g / benzene; ethanol; H2O / 5 h / 20 °C
2: 60 percent / conc. HCl / 24 h / 20 °C
View Scheme
1-dehydrotestosterone
846-48-0

1-dehydrotestosterone

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) Me2NH*HCl / 1.) isoamyl alcohol, reflux, 2 h, 2.) isoamyl alcohol, reflux, 15 h
2: 85 percent / Jones reagent / acetone / 0.25 h / -20 °C
View Scheme
C21H28O5S
861395-77-9

C21H28O5S

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With potassium hydroxide In methanol; dichloromethane; water at 25℃; Heating / reflux;
pyrographite
7440-44-0

pyrographite

6-methylene-androst-4-ene 3,17-dione
19457-55-7

6-methylene-androst-4-ene 3,17-dione

tert-butyl alcohol
75-65-0

tert-butyl alcohol

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With selenium(IV) oxide In ethyl acetate
...Expand
6-hydroxymethyl-androsta-1,4-diene-3,17-dione

6-hydroxymethyl-androsta-1,4-diene-3,17-dione

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 80 - 90℃; under 315 Torr; for 4h; Purification / work up;
With toluene-4-sulfonic acid In toluene at 90℃; for 3h; Purification / work up;
With camphor-10-sulfonic acid In toluene at 90℃; for 7h; Purification / work up;
With (1S)-10-camphorsulfonic acid In ethyl acetate at 70 - 80℃; for 32h; Purification / work up;
Stage #1: 6-hydroxymethyl-androsta-1,4-diene-3,17-dione With pyridine; p-toluenesulfonyl chloride at 0℃; for 48h;
Stage #2: With potassium hydroxide In methanol; water at 65℃; for 2h; Purification / work up;
dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene / 1 h / 120 °C / Inert atmosphere
1.2: 0.33 h / 20 °C / Inert atmosphere
1.3: 3 h / 20 °C / Inert atmosphere
2.1: orthoformic acid triethyl ester; toluene-4-sulfonic acid / ethanol; tetrahydrofuran / 3 h / 40 °C
2.2: 4 h / 40 °C
3.1: Arthrobacter simplex ATCC6946 culture / aq. buffer / 33 °C / Microbiological reaction
View Scheme
3-Aethoxy-androstadien-(3,5)-on-(17)
972-46-3

3-Aethoxy-androstadien-(3,5)-on-(17)

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran; ethanol / 10 h / 40 - 45 °C / Large scale
2: hydrogenchloride / tetrahydrofuran; ethanol / 1 h / Large scale
3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; toluene / 48 h / 85 °C / Inert atmosphere; Large scale
View Scheme
6-methyleneandrostenediol ketal

6-methyleneandrostenediol ketal

exemestane
107868-30-4

exemestane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran; water at 20 - 25℃; for 10h; Inert atmosphere;
exemestane
107868-30-4

exemestane

FCE27353
184972-12-1

FCE27353

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 48h; Ambient temperature;80%
exemestane
107868-30-4

exemestane

C20H24N6O2

C20H24N6O2

Conditions
ConditionsYield
With copper(l) iodide; tert-Butyl peroxybenzoate; trimethylsilylazide In acetonitrile at 50℃; for 6h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere; Green chemistry;75%
exemestane
107868-30-4

exemestane

A

6α-methylandrost-4-ene-3,17-dione
2241-94-3

6α-methylandrost-4-ene-3,17-dione

B

C20H30O2

C20H30O2

C

6β-methylandrost-4-ene-3,17-dione
5696-36-6

6β-methylandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 5%-palladium/activated carbon In ethanol for 18h; Reflux; stereoselective reaction;A n/a
B 62%
C n/a
...Expand
formaldehyd
50-00-0

formaldehyd

exemestane
107868-30-4

exemestane

C21H24O2

C21H24O2

Conditions
ConditionsYield
With N,N-dimethylammonium chloride In ethanol at 78℃; for 3h; Temperature; Mannich Aminomethylation;54.1%
4-Fluorobenzenesulfonyl chloride
349-88-2

4-Fluorobenzenesulfonyl chloride

exemestane
107868-30-4

exemestane

(6S,8R,9S,10R,13S,14S)-6-(((4-fluorophenyl)sulfonyl)methyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

(6S,8R,9S,10R,13S,14S)-6-(((4-fluorophenyl)sulfonyl)methyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

Conditions
ConditionsYield
With fac-tris(2-phenylpyridinato-N,C2')iridium(III); tris-(trimethylsilyl)silane In acetonitrile at 20℃; for 16h; Irradiation; diastereoselective reaction;50%
exemestane
107868-30-4

exemestane

A

6-methylandrosta-1,4,6-trien-17β-ol

6-methylandrosta-1,4,6-trien-17β-ol

B

17β-hydroxy-6-methylen- androsta-1,4-dien-3-one
122370-91-6

17β-hydroxy-6-methylen- androsta-1,4-dien-3-one

Conditions
ConditionsYield
With sodium tetrahydroborate; acetic acid; trifluoroacetic acid In dichloromethane; acetonitrile at 20℃; for 11h; Inert atmosphere;A 11.3 mg
B 39%
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

exemestane
107868-30-4

exemestane

A

C21H25F3O3

C21H25F3O3

B

C21H25F3O3

C21H25F3O3

Conditions
ConditionsYield
With cobalt(II) tetrafluoroborate hexahydrate; N-isopropyl-N,2-dimethylpropan-2-amine In water; N,N-dimethyl-formamide; acetonitrile at 65℃; for 24h; Sealed tube;A 30%
B 33%
...Expand
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

exemestane
107868-30-4

exemestane

A

C21H25F3O3

C21H25F3O3

B

C21H25F3O3

C21H25F3O3

Conditions
ConditionsYield
With cobalt(II) tetrafluoroborate hexahydrate; N-isopropyl-N,2-dimethylpropan-2-amine In N,N-dimethyl-formamide; acetonitrile at 65℃; for 24h;A 30%
B 33%
...Expand
nitromethane
75-52-5

nitromethane

exemestane
107868-30-4

exemestane

6α-(2-Nitroethyl)androsta-1,4-dien-3,17-dion
911856-13-8

6α-(2-Nitroethyl)androsta-1,4-dien-3,17-dion

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 22h; Michael addition; Heating;32%
exemestane
107868-30-4

exemestane

A

6α-spirooxiranandrosta-1,4-diene-3,17-dione

6α-spirooxiranandrosta-1,4-diene-3,17-dione

B

6α-spirooxiranandrosta-1,4-diene-3,17-dione

6α-spirooxiranandrosta-1,4-diene-3,17-dione

Conditions
ConditionsYield
With formic acid; dihydrogen peroxide In dichloromethane at 20℃; for 96h;A 21%
B 76.1 mg
L-Cysteine
52-90-4

L-Cysteine

exemestane
107868-30-4

exemestane

6-methylcysteinylandrosta-1,4-diene-3,17-dione

6-methylcysteinylandrosta-1,4-diene-3,17-dione

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃; for 24h; Inert atmosphere;13%
exemestane
107868-30-4

exemestane

1α,2α-epoxy-6-methylenandrost-4-ene-3,17-dione

1α,2α-epoxy-6-methylenandrost-4-ene-3,17-dione

Conditions
ConditionsYield
With dihydrogen peroxide; sodium hydroxide In methanol; water at 0 - 20℃; for 24.5h;11%
exemestane
107868-30-4

exemestane

diethyl malonate
105-53-3

diethyl malonate

Diethyl-2-(3,17-dioxoandrosta-1,4-dien-6β-ylmethyl)-malonat

Diethyl-2-(3,17-dioxoandrosta-1,4-dien-6β-ylmethyl)-malonat

Conditions
ConditionsYield
With sodium In ethanol for 7h; Michael addition; Heating;6%
exemestane
107868-30-4

exemestane

6α-(2-Oxoethyl)androsta-1,4-dien-3,17-dion
911856-14-9

6α-(2-Oxoethyl)androsta-1,4-dien-3,17-dion

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 32 percent / NaOEt / ethanol / 22 h / Heating
2.1: KOH / methanol / 3 h / 20 °C
2.2: 31 percent / aq. H2SO4 / methanol / 4 h / cooling
View Scheme
exemestane
107868-30-4

exemestane

Dimethyl-4-[(3,17-dioxoandrosta-1,4-dien-6α-yl)methyl]-2,6-dimethyl-3,5-pyridindicarboxylat

Dimethyl-4-[(3,17-dioxoandrosta-1,4-dien-6α-yl)methyl]-2,6-dimethyl-3,5-pyridindicarboxylat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 32 percent / NaOEt / ethanol / 22 h / Heating
2.1: KOH / methanol / 3 h / 20 °C
2.2: 31 percent / aq. H2SO4 / methanol / 4 h / cooling
3.1: 58 percent / acetic acid / 22 h / 20 - 60 °C
4.1: 87 percent / CAN / acetone; H2O / 0.5 h
View Scheme
exemestane
107868-30-4

exemestane

Dimethyl-4-[(3,17-dioxoandrosta-1,4-dien-6α-yl)methyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridindicarboxylat
911856-15-0

Dimethyl-4-[(3,17-dioxoandrosta-1,4-dien-6α-yl)methyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridindicarboxylat

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 32 percent / NaOEt / ethanol / 22 h / Heating
2.1: KOH / methanol / 3 h / 20 °C
2.2: 31 percent / aq. H2SO4 / methanol / 4 h / cooling
3.1: 58 percent / acetic acid / 22 h / 20 - 60 °C
View Scheme
exemestane
107868-30-4

exemestane

6-Hydroxymethylexemestane

6-Hydroxymethylexemestane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / 50percent m-chloroperbenzoic acid / CH2Cl2 / 48 h / Ambient temperature
2: 38 percent / 20percent aq. HClO4 / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
exemestane
107868-30-4

exemestane

6α/β-hydroxy-6α/β-hydroxymethylandrosta-1,4-diene-3,17-dione

6α/β-hydroxy-6α/β-hydroxymethylandrosta-1,4-diene-3,17-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / 50percent m-chloroperbenzoic acid / CH2Cl2 / 48 h / Ambient temperature
2: 42 percent / 20percent aq. HClO4 / tetrahydrofuran / 3 h / Ambient temperature
View Scheme

Exemestane Specification

The Exemestane, with the CAS registry number 107868-30-4, is also known as 6-Methylenandrosta-1,4-diene-3,17-dione; 10,13-Dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene-. It belongs to the product categories of Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pfizer compounds;Steroid and Hormone.This chemical's molecular formula is C20H24O2 and molecular weight is 296.40. What's more,Its systematic name is 6-Methyleneandrosta-1,4-diene-3,17-dione.It is a white to light yellow crystal powder.Exemestane is used as an antineoplastic.An oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive breast cancer in postmenopausal women.

Physical properties about Exemestane are:
(1)ACD/LogP: 2.432; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.43; (4)ACD/LogD (pH 7.4): 2.43; (5)ACD/BCF (pH 5.5): 41.52; (6)ACD/BCF (pH 7.4): 41.52; (7)ACD/KOC (pH 5.5): 501.13; (8)ACD/KOC (pH 7.4): 501.13; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.572; (13)Molar Refractivity: 85.797 cm3; (14)Molar Volume: 260.59 cm3; (15)Surface Tension: 42.9010009765625 dyne/cm; (16)Density: 1.137 g/cm3; (17)Flash Point: 168.985 °C; (18)Enthalpy of Vaporization: 71.317 kJ/mol; (19)Boiling Point: 453.719 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.

Preparation of Exemestane:
Triethyl orthoformate and ethanol are dissolved in tetrahydrofuran.In the presence of p-toluenesulfonic acid reaction,add N-methyl aniline and formaldehyde solution to continue to respond. The Mannich reaction products are soluble in benzoic acid and anhydrous 2 chew alkyl.Under the action of the DDQ,exemestane can be received, with a total yield of 45%. 

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