Product Name

  • Name

    Fenbendazole

  • EINECS 256-145-7
  • CAS No. 43210-67-9
  • Article Data13
  • CAS DataBase
  • Density 1.4 g/cm3
  • Solubility Insoluble in water
  • Melting Point 233 °C
  • Formula C15H13N3O2S
  • Boiling Point
  • Molecular Weight 299.353
  • Flash Point
  • Transport Information
  • Appearance Off-white solid
  • Safety 26-36
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 43210-67-9 (Fenbendazole)
  • Hazard Symbols IrritantXi
  • Synonyms Carbamicacid, [5-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester (9CI);2-(Methoxycarbonylamino)-5-(phenylthio)benzimidazole;Axilur;Fenbendazol;Fenbion;HOE 881;Methyl5-(phenylthio)-2-benzimidazolecarbamate;Methyl[5-(phenylthio)-1H-benzimidazol-2-yl]carbamate;Panacur;Safe-Guard;
  • PSA 92.31000
  • LogP 3.96540

Synthetic route

1,2-diamino-4-phenylthiobenzene
43156-48-5

1,2-diamino-4-phenylthiobenzene

S-Methylisothiourea sulfate
867-44-7

S-Methylisothiourea sulfate

methyl chloroformate
79-22-1

methyl chloroformate

Fenbendazole
43210-67-9

Fenbendazole

Conditions
ConditionsYield
Stage #1: S-Methylisothiourea sulfate; methyl chloroformate With sodium hydroxide In water at 3 - 6℃; for 0.666667h;
Stage #2: 1,2-diamino-4-phenylthiobenzene With acetic acid In ethanol; water at 95℃; for 24h;		88%
...Expand
2-nitro-5-phenylthioaniline
43156-47-4

2-nitro-5-phenylthioaniline

Fenbendazole
43210-67-9

Fenbendazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr
2.1: NaOH / H2O / 0.67 h / 3 - 6 °C
2.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C
View Scheme
5-chloro-2-nitroaniline
1635-61-6

5-chloro-2-nitroaniline

Fenbendazole
43210-67-9

Fenbendazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: K2CO3 / dimethylformamide / 6 h / Heating
2.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr
3.1: NaOH / H2O / 0.67 h / 3 - 6 °C
3.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C
View Scheme
thiophenol
108-98-5

thiophenol

Fenbendazole
43210-67-9

Fenbendazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: K2CO3 / dimethylformamide / 6 h / Heating
2.1: H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr
3.1: NaOH / H2O / 0.67 h / 3 - 6 °C
3.2: 88 percent / AcOH / H2O; ethanol / 24 h / 95 °C
View Scheme
(5-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; (6-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; mixture of

(5-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; (6-phenylsulfanyl-1-phosphonooxymethyl-1H-benzoimidazol-2-yl)carbamic acid methyl ester disodium salt; mixture of

Fenbendazole
43210-67-9

Fenbendazole

Conditions
ConditionsYield
With chicken alkaline phosphatase In water at 39℃; pH=6.5 - 9.0; Enzyme kinetics;
With porcine alkaline phosphatase In water at 37℃; pH=6.5 - 9.0; Enzyme kinetics;
Fenbendazole
43210-67-9

Fenbendazole

oxfendazole
53716-50-0, 122063-22-3, 122063-23-4

oxfendazole

Conditions
ConditionsYield
With dihydrogen peroxide; sodium sulfite In methanol; water98.8%
With urea hydrogen peroxide adduct In formic acid; water at 25 - 45℃; for 5.5h; Temperature; Concentration;98%
Fenbendazole
43210-67-9

Fenbendazole

5-(phenylthio)-1H-benzo[d]imidazol-2-amine
53065-28-4

5-(phenylthio)-1H-benzo[d]imidazol-2-amine

Conditions
ConditionsYield
With potassium hydroxide In methanol; water for 48h; Heating;98%
In N,N-dimethyl-formamide for 12h; Heating;50%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

Fenbendazole
43210-67-9

Fenbendazole

A

2-Methoxycarbonylamino-5-phenylsulfanyl-benzoimidazole-1-carboxylic acid ethyl ester
58521-88-3

2-Methoxycarbonylamino-5-phenylsulfanyl-benzoimidazole-1-carboxylic acid ethyl ester

B

2-Methoxycarbonylamino-6-phenylsulfanyl-benzoimidazole-1-carboxylic acid ethyl ester
58522-05-7

2-Methoxycarbonylamino-6-phenylsulfanyl-benzoimidazole-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane Ambient temperature;
...Expand
methyl chloroformate
79-22-1

methyl chloroformate

Fenbendazole
43210-67-9

Fenbendazole

A

methyl 1-methoxycarbonyl-5-phenylthiobenzimidazole-2-carbamate
58521-87-2

methyl 1-methoxycarbonyl-5-phenylthiobenzimidazole-2-carbamate

B

2-Methoxycarbonylamino-6-phenylsulfanyl-benzoimidazole-1-carboxylic acid methyl ester
58522-04-6

2-Methoxycarbonylamino-6-phenylsulfanyl-benzoimidazole-1-carboxylic acid methyl ester

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane for 20h; Ambient temperature;A 12 g
B 8 g
...Expand
Fenbendazole
43210-67-9

Fenbendazole

Ethyl chlorothioformate
2941-64-2

Ethyl chlorothioformate

A

2-Methoxycarbonylamino-5-phenylsulfanyl-benzoimidazole-1-carbothioic acid S-ethyl ester
104663-11-8

2-Methoxycarbonylamino-5-phenylsulfanyl-benzoimidazole-1-carbothioic acid S-ethyl ester

B

2-Oxo-5-phenylsulfanyl-benzoimidazole-1,3-dicarbothioic acid di-S-ethyl ester
104663-33-4

2-Oxo-5-phenylsulfanyl-benzoimidazole-1,3-dicarbothioic acid di-S-ethyl ester

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane Ambient temperature;
...Expand
Fenbendazole
43210-67-9

Fenbendazole

methyl iodide
74-88-4

methyl iodide

Methyl-(1-methyl-5-phenylsulfanyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester

Methyl-(1-methyl-5-phenylsulfanyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester

Conditions
ConditionsYield
With AG-MP1 anion exchange resin In carbon dioxide at 80℃; under 150012 Torr; for 0.333333h; Product distribution; further conditions: CH3CN, room temperature, 1 h;
Fenbendazole
43210-67-9

Fenbendazole

6-Benzenesulfinyl-2-methoxycarbonylamino-benzoimidazole-1-carboxylic acid methyl ester
104663-22-1

6-Benzenesulfinyl-2-methoxycarbonylamino-benzoimidazole-1-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 8 g / 1N aq sodium hydroxide / CH2Cl2 / 20 h / Ambient temperature
2: m-chloroperbenzoic acid / CH2Cl2
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

1-carbomethoxy-2-carbomethoxyamino-5-phenylsulfinylbenzimidazole
104663-01-6

1-carbomethoxy-2-carbomethoxyamino-5-phenylsulfinylbenzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 12 g / 1N aq sodium hydroxide / CH2Cl2 / 20 h / Ambient temperature
2: 8 g / m-chloroperbenzoic acid / CH2Cl2 / 16 h / 15 - 20 °C
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

1-carbomethoxy-2-carbomethoxyamino-5-phenylsulfonylbenzimidazole
104663-08-3

1-carbomethoxy-2-carbomethoxyamino-5-phenylsulfonylbenzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 12 g / 1N aq sodium hydroxide / CH2Cl2 / 20 h / Ambient temperature
2: 1.5 g / m-chloroperbenzoic acid / CH2Cl2
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

6-Benzenesulfonyl-2-methoxycarbonylamino-benzoimidazole-1-carboxylic acid methyl ester
104663-29-8

6-Benzenesulfonyl-2-methoxycarbonylamino-benzoimidazole-1-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 8 g / 1N aq sodium hydroxide / CH2Cl2 / 20 h / Ambient temperature
2: m-chloroperbenzoic acid / CH2Cl2
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

5-Benzenesulfinyl-2-methoxycarbonylamino-benzoimidazole-1-carboxylic acid ethyl ester
104663-02-7

5-Benzenesulfinyl-2-methoxycarbonylamino-benzoimidazole-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1N aq sodium hydroxide / CH2Cl2 / Ambient temperature
2: m-chloroperbenzoic acid / CH2Cl2
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

5-Benzenesulfinyl-2-methoxycarbonylamino-benzoimidazole-1-carbothioic acid S-ethyl ester
104663-12-9

5-Benzenesulfinyl-2-methoxycarbonylamino-benzoimidazole-1-carbothioic acid S-ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1N aq sodium hydroxide / CH2Cl2 / Ambient temperature
2: m-chloroperbenzoic acid / CH2Cl2
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

6-Benzenesulfinyl-2-methoxycarbonylamino-benzoimidazole-1-carboxylic acid ethyl ester
104663-23-2

6-Benzenesulfinyl-2-methoxycarbonylamino-benzoimidazole-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1N aq sodium hydroxide / CH2Cl2 / Ambient temperature
2: m-chloroperbenzoic acid / CH2Cl2
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

2-amino-5(6)-benzenesulfonylbenzimidazole
59530-20-0

2-amino-5(6)-benzenesulfonylbenzimidazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 82 percent / pyridine / 1 h / Heating
3: 82.6 percent / KMnO4 / acetic acid / 2 h / Ambient temperature
4: 73.5 percent / aq. NaOH / ethanol / 2 h / Ambient temperature
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

2-Acetamido-5(6)-phenylthiobenzimidazole
125422-34-6

2-Acetamido-5(6)-phenylthiobenzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 82 percent / pyridine / 1 h / Heating
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

5(6)-Phenylthio-2-(carboxamidomethylamino)-benzimidazole
125422-38-0

5(6)-Phenylthio-2-(carboxamidomethylamino)-benzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 50 percent / triethylamine / acetone / 12 h / Heating
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

5(6)-Phenylthio-2-chloroacetamidobenzimidazole
125422-41-5

5(6)-Phenylthio-2-chloroacetamidobenzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 88 percent / triethylamine / acetone / 3 h / Ambient temperature
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

2-Acetamido-5(6)-phenylsulphonobenzimidazole
125422-35-7

2-Acetamido-5(6)-phenylsulphonobenzimidazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 82 percent / pyridine / 1 h / Heating
3: 82.6 percent / KMnO4 / acetic acid / 2 h / Ambient temperature
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

(5-Phenylsulfanyl-1H-benzoimidazol-2-ylamino)-acetic acid methyl ester
125422-37-9

(5-Phenylsulfanyl-1H-benzoimidazol-2-ylamino)-acetic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 64 percent / triethylamine
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

2-(Carbethoxymethylamino)-5(6)-phenylthiobenzimidazole
125443-69-8

2-(Carbethoxymethylamino)-5(6)-phenylthiobenzimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 55 percent / triethylamine / acetone / 12 h / Heating
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

2,2,2-Trifluoro-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-acetamide
125443-68-7

2,2,2-Trifluoro-N-(5-phenylsulfanyl-1H-benzoimidazol-2-yl)-acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 71 percent / 3 h / Heating
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

2-Chloroacetamido-5(6)-phenylsulphonobenzimidazole
125422-49-3

2-Chloroacetamido-5(6)-phenylsulphonobenzimidazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 82 percent / pyridine / 1 h / Heating
3: 82.6 percent / KMnO4 / acetic acid / 2 h / Ambient temperature
4: 73.5 percent / aq. NaOH / ethanol / 2 h / Ambient temperature
5: 80 percent / triethylamine / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

2-(5-Phenylsulfanyl-1H-benzoimidazol-2-ylamino)-1-piperidin-1-yl-ethanone
125422-39-1

2-(5-Phenylsulfanyl-1H-benzoimidazol-2-ylamino)-1-piperidin-1-yl-ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 56 percent / triethylamine
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

2-(1-Pyrrolidinoacetylamino)-5(6)-phenylthiobenzimidazole
125422-42-6

2-(1-Pyrrolidinoacetylamino)-5(6)-phenylthiobenzimidazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 88 percent / triethylamine / acetone / 3 h / Ambient temperature
3: 64 percent / triethylamine / acetone / 12 h / Heating
View Scheme
Fenbendazole
43210-67-9

Fenbendazole

N-(5-Phenylsulfanyl-1H-benzoimidazol-2-yl)-2-piperidin-1-yl-acetamide
125422-43-7

N-(5-Phenylsulfanyl-1H-benzoimidazol-2-yl)-2-piperidin-1-yl-acetamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98 percent / KOH / methanol; H2O / 48 h / Heating
2: 88 percent / triethylamine / acetone / 3 h / Ambient temperature
3: 67 percent / triethylamine
View Scheme

FENBENDAZOLE Chemical Properties

IUPAC:methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate
CAS:43210-67-9
The Molecular formula of Fenbendazole(43210-67-9):C15H13N3O2S
The Molecular Weight of Fenbendazole(43210-67-9):299.35
Synonyms:[5-(PHENYLTHIO)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER;HOE-881V;FENBENDAZOLE;METHYL 5-(PHENYLTHIO)-2-BENZIMIDAZOLECARBAMATE;SAFEGARD;PANACUR;(5-(phenylthio)-1h-benzimidazol-2-yl)-carbamicacimethylester;5-(phenylthio)-2-benzimidazolecarbamicacimethylester
EINECS:256-145-7
Density:1.4g/cm3
Melting Point:233oC
Appearance:white to yellowish powder
Product Categories:PHARMACEUTICALS;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Veterinaries
Mol File:43210-67-9.mol
storage temp.:0-6oC

FENBENDAZOLE Uses

Fenbendazole(43210-67-9) is known as a kind of benzimidazole anthelmintics. It is regularly used to eliminate numerous gastrointestinal parasites from animals,and it is quite effective against roundworms, hookworms, whipworms, certain tapeworms and parasites called strongyles and strongyloides.

FENBENDAZOLE Toxicity Data With Reference

1.   

oth:hmn:lym 100 mg/L

   ENMUDM    Environmental Mutagenesis. 2 (1980),67.
2.   

oth:hmn:leu 1 mg/L

   THERAP    Therapie. 31 (1976),505.

FENBENDAZOLE Safety Profile

Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.

Safty informations about Fenbendazole(43210-67-9):
Hazard Codes:Xi
Risk Statements:36/37/38
 36/37/38(Irritating to eyes, respiratory system and skin)
Safety Statements:26-36
 26(In case of contact with eyes, rinse immediately with plenty of water and seek medical advice)
 36(Wear suitable protective clothing)
WGK Germany:2
RTECS:DD6520500

FENBENDAZOLE Specification

Storage:Keep tightly closed.

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