Product Name

  • Name

    Farnesol

  • EINECS 225-004-1
  • CAS No. 4602-84-0
  • Article Data19
  • CAS DataBase
  • Density 0.875 g/cm3
  • Solubility insoluble
  • Melting Point 25°C
  • Formula C15H26O
  • Boiling Point 283.4 °C at 760 mmHg
  • Molecular Weight 222.371
  • Flash Point 112.5 °C
  • Transport Information
  • Appearance colourless liquid with a floral odour
  • Safety 24/25-22
  • Risk Codes 24/25-22
  • Molecular Structure Molecular Structure of 4602-84-0 (Farnesol)
  • Hazard Symbols IrritantXi
  • Synonyms Farnesol(6CI);3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol;FCI 119a;Farnesyl alcohol;NSC 60597;Nikkosome;
  • PSA 20.23000
  • LogP 4.39790

Synthetic route

1-chloro-3,7,11-trimethyldodeca-2,6,10-triene
6784-45-8

1-chloro-3,7,11-trimethyldodeca-2,6,10-triene

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
With N-chloro-succinimide In dichloromethane at 0 - 20℃; for 1.25h;98%
methyl 3,7,11-trimethyldodeca-2,6,10-trienoate
10485-70-8

methyl 3,7,11-trimethyldodeca-2,6,10-trienoate

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
With lithium aluminium tetrahydride85%
ethyl 3,7,11-trimethyldodeca-2,6,10-trienoate
20723-88-0

ethyl 3,7,11-trimethyldodeca-2,6,10-trienoate

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
With lithium aluminium tetrahydride85%
Conditions
ConditionsYield
With perchloric acid; acetone at 15 - 20℃; for 24.25h; Product distribution / selectivity;A 15.3%
B 21.3%
C 57.3%
With perchloric acid; trifluorormethanesulfonic acid; acetone In water at 15 - 20℃; for 8.16667h; Product distribution / selectivity;A 1.8%
B 52.7%
C 16.2%
With perchloric acid; methanesulfonic acid; acetone In water at 15 - 20℃; for 24.1667h; Product distribution / selectivity;A 1.9%
B 51.7%
C 16.2%
farnesal
19317-11-4

farnesal

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
With sodium amalgam; ethanol; acetic acid at 0℃;
With potassium phosphate; recombinant rat brain aldo-keto reductase R1B10; NADP In methanol Kinetics; Enzymatic reaction;
With rabbit 3-hydroxyhexobarbital dehydrogenase (AKR1C29); NADPH In aq. phosphate buffer; ethyl acetate at 37℃; for 0.5h; pH=7.4; Catalytic behavior; Kinetics; Enzymatic reaction;
(+/-)-nerolidol
7212-44-4

(+/-)-nerolidol

acetic anhydride
108-24-7

acetic anhydride

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

A

cis-α-farnesene
125037-13-0

cis-α-farnesene

B

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
at 120 - 140℃; nachfolgendes Kochen des Reaktionsprodukts mit alkoh.Kalilauge im Wasserstoffstrom; dextrorotatory form of 2.6.10-trimethyl-dodecatrien-(2.6.11)-ol-(10);
(+/-)-nerolidol
7212-44-4

(+/-)-nerolidol

acetic anhydride
108-24-7

acetic anhydride

A

cis-α-farnesene
125037-13-0

cis-α-farnesene

B

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
nachfolgendes Kochen des Reaktionsprodukts mit alkoh.Kalilauge im Wasserstoffstrom; inactive form of 2.6.10-trimethyl-dodecatrien-(2.6.11)-ol-(10);
(+/-)-nerolidol
7212-44-4

(+/-)-nerolidol

acetic anhydride
108-24-7

acetic anhydride

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
at 120 - 140℃; nachfolgenden Kochen des Reaktionprodukts mit alkoh.Kalilauge im Wasserstoffstrom;
acetic acid
64-19-7

acetic acid

isoprene
78-79-5

isoprene

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
With sulfuric acid; copper (I) acetate; hydroquinone at 24℃; und folgendes Verseifen der erhaltenen Ester mit methylalkoh.KOH;
2-methyl-3,4-epoxy-1-butene
7437-61-8

2-methyl-3,4-epoxy-1-butene

geranyl trimethylstannane
72132-87-7

geranyl trimethylstannane

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene 1.) CH2Cl2, -78 deg C, 0.5 h, 2.) 190-195 deg C, 2 h; Yield given. Multistep reaction;
dl-narolidol

dl-narolidol

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
With sulfuric acid; acetic acid
With formic acid
acetic anhydride
108-24-7

acetic anhydride

Ld"-nerolidol

Ld"-nerolidol

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
at 120 - 140℃; nachfolgenden Kochen des Reaktionprodukts mit alkoh.Kalilauge im Wasserstoffstrom;
nerolidol

nerolidol

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
With pyridine; phosphorus tribromide at -15℃; Schuetteln des erhaltenen Farnesylbromids mit Kaliumacetat in wasserfreiem Aceton und Verseifen des Farnesylacetats mit siedender methylalkoh.KOH;
ethanol
64-17-5

ethanol

farnesal
19317-11-4

farnesal

acetic acid
64-19-7

acetic acid

sodium amalgam

sodium amalgam

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
at 0℃;
(+/-)-nerolidol
7212-44-4

(+/-)-nerolidol

sulfuric acid
7664-93-9

sulfuric acid

acetic acid
64-19-7

acetic acid

A

cis-α-farnesene
125037-13-0

cis-α-farnesene

B

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
inactive form of 2.6.10-trimethyl-dodecatrien-(2.6.11)-ol-(10);
formic acid
64-18-6

formic acid

(+/-)-nerolidol
7212-44-4

(+/-)-nerolidol

A

cis-α-farnesene
125037-13-0

cis-α-farnesene

B

farnesol
4602-84-0

farnesol

C

bisabolene

bisabolene

D

α-bisabolol

α-bisabolol

Conditions
ConditionsYield
inactive form of 2.6.10-trimethyl-dodecatrien-(2.6.11)-ol-(10);
(E)-2-Methanesulfinyl-3,7,11-trimethyl-dodeca-6,10-dienoic acid ethyl ester
79858-01-8

(E)-2-Methanesulfinyl-3,7,11-trimethyl-dodeca-6,10-dienoic acid ethyl ester

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / calcium carbonate / toluene / 7 h / Heating
2: 85 percent / LiAl-hydride
View Scheme
(E)-3,7,11-Trimethyl-dodeca-6,10-dienoic acid methyl ester
863217-63-4

(E)-3,7,11-Trimethyl-dodeca-6,10-dienoic acid methyl ester

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: 1. sodium methaperiodate 2. reflux, toluene, 20 h, CaCO3
3: 85 percent / LiAlH4
View Scheme
(E)-3,7,11-Trimethyl-2-methylsulfanyl-dodeca-6,10-dienoic acid methyl ester

(E)-3,7,11-Trimethyl-2-methylsulfanyl-dodeca-6,10-dienoic acid methyl ester

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1. sodium methaperiodate 2. reflux, toluene, 20 h, CaCO3
2: 85 percent / LiAlH4
View Scheme
3,7,11-trimethyl-6,10-dodecadien-1-yn-3-ol
2387-68-0, 54325-12-1

3,7,11-trimethyl-6,10-dodecadien-1-yn-3-ol

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium; diethyl ether / 0 °C
2: 120 - 140 °C / nachfolgenden Kochen des Reaktionprodukts mit alkoh.Kalilauge im Wasserstoffstrom
View Scheme
Conditions
ConditionsYield
With perchloric acid; methanesulfonic acid In water; acetone at 10 - 15℃; for 24.5h; Product distribution / selectivity;
With phosphotungstic acid In acetone at 30℃; for 3h; Catalytic behavior; Solvent; Green chemistry; Overall yield = 55 %Chromat.;
Conditions
ConditionsYield
With perchloric acid; methanesulfonic acid In water; acetone at 15 - 20℃; for 24.67h; Product distribution / selectivity;
Conditions
ConditionsYield
With methanol; sodium hydroxide; water at 20 - 40℃; for 2.25h; Product distribution / selectivity;
farnesyl benzoate
89637-63-8

farnesyl benzoate

farnesol
4602-84-0

farnesol

Conditions
ConditionsYield
With methanol; potassium hydroxide at 20℃; Reflux;
Conditions
ConditionsYield
With Mycobacterium tuberculosis N-terminal His-tagged Rv3376 enzyme; water Enzymatic reaction;
farnesol
4602-84-0

farnesol

farnesal
19317-11-4

farnesal

Conditions
ConditionsYield
With dipyridinium dichromate In dichloromethane at 0 - 25℃; for 24h;100%
With pyridinium chlorochromate In hexane at 25℃; for 2h; Oxidation;87%
With 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl; toluene-4-sulfonic acid In dichloromethane 1) 0 deg C, 1 h, 2) r.t., 1 h;86%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

farnesol
4602-84-0

farnesol

C20H34O2
79577-53-0

C20H34O2

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In tetrahydrofuran100%
With toluene-4-sulfonic acid at 25℃;
farnesol
4602-84-0

farnesol

(2S,3S)-2,3-epoxy-3,7,11-trimethyl-6,10-dodecadienol

(2S,3S)-2,3-epoxy-3,7,11-trimethyl-6,10-dodecadienol

Conditions
ConditionsYield
With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate In dichloromethane at -50℃; Molecular sieve; Inert atmosphere; enantioselective reaction;100%
With bis(acetylacetonate)dioxotungsten(VI); C96H142N2O4; sodium chloride In dichloromethane at 20℃; for 3h;88%
farnesol
4602-84-0

farnesol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

C21H40OSi

C21H40OSi

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;100%
farnesol
4602-84-0

farnesol

Phenyl glycidyl ether
122-60-1

Phenyl glycidyl ether

C24H36O3

C24H36O3

Conditions
ConditionsYield
With potassium methanolate at 110 - 120℃; for 18.4333h; Inert atmosphere;99.3%
farnesol
4602-84-0

farnesol

3,7,11-trimethyldodecyl alcohol
6750-34-1

3,7,11-trimethyldodecyl alcohol

Conditions
ConditionsYield
With platinum/carbon xerogel catalyst; hydrogen In ethanol at 20℃; for 12h; Inert atmosphere;99%
With palladium on activated charcoal; hydrogen In ethyl acetate at 20℃;97%
With hydrogen; palladium 10% on activated carbon In ethanol for 36h;93%
farnesol
4602-84-0

farnesol

1-chloro-3,7,11-trimethyldodeca-2,6,10-triene
6784-45-8

1-chloro-3,7,11-trimethyldodeca-2,6,10-triene

Conditions
ConditionsYield
With N-chloro-succinimide; dimethylsulfide In dichloromethane at 0 - 20℃; for 2.5h;98%
With N-chloro-succinimide; dimethylsulfide In dichloromethane at 0 - 20℃; for 2.83h;98%
With N,N-dimethyl-formamide; phosphorus trichloride In tetrahydrofuran at 20℃; for 0.5h;
farnesol
4602-84-0

farnesol

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

(2E,6E)-1-((tert-butyldiphenylsilyl)oxy)-3,7,11-trimethyl-2,6,10-dodecatriene
151409-23-3

(2E,6E)-1-((tert-butyldiphenylsilyl)oxy)-3,7,11-trimethyl-2,6,10-dodecatriene

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃;97%
farnesol
4602-84-0

farnesol

farnesyl amine
6784-46-9

farnesyl amine

Conditions
ConditionsYield
Stage #1: farnesol With lithium hexamethyldisilazane at 0 - 20℃; Inert atmosphere;
Stage #2: With methanol Inert atmosphere;
97%
With dodecacarbonyl-triangulo-triruthenium; 4,5-bis((diisopropylphosphanyl)methyl)acridine; ammonia In tert-Amyl alcohol at 170℃; for 21h; Temperature; Inert atmosphere; Schlenk technique; Autoclave;
farnesol
4602-84-0

farnesol

Farnesal
502-67-0

Farnesal

Conditions
ConditionsYield
With oxygen; copper In acetonitrile for 4h; Reagent/catalyst; Temperature; Reflux;95%
With tert.-butylhydroperoxide; oxygen In decane; toluene at 80℃; under 750.075 Torr;87%
farnesol
4602-84-0

farnesol

p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

farnesol-p-methoxybenzyl ether

farnesol-p-methoxybenzyl ether

Conditions
ConditionsYield
Stage #1: farnesol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: p-methoxybenzyl chloride In N,N-dimethyl-formamide; mineral oil at 20℃;
92%
Conditions
ConditionsYield
With phosphorus tribromide; triethylamine In toluene at -5℃; for 2h; Product distribution / selectivity;91%
With methanesulfonyl chloride; triethylamine; lithium bromide In tetrahydrofuran at -45 - 0℃; for 1.91667h; Inert atmosphere;86%
With pyridine; phosphorus tribromide at -5℃;
farnesol
4602-84-0

farnesol

Farnesoic acid
7548-13-2

Farnesoic acid

Conditions
ConditionsYield
With benzotriazole*CrO3 In acetone for 5h; Heating;91%
Multi-step reaction with 2 steps
1: Cr2O3-H2SO4 / das Edukt ist natuerlich vorkommendes Farnesol
2: AgNO3; aqueous alcoholic NaOH
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / -78 - 20 °C / Inert atmosphere
2: 2-methyl-but-2-ene; sodium dihydrogenphosphate dihydrate; sodium chlorite / water; tert-butyl alcohol / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.25 h / -78 °C / Inert atmosphere
1.2: 1 h / 20 °C
2.1: 2-methyl-but-2-ene; sodium dihydrogenphosphate dihydrate; sodium chlorite / water; tert-butyl alcohol / 2 h / 20 °C
View Scheme
farnesol
4602-84-0

farnesol

aniline
62-53-3

aniline

C21H31N
1005007-58-8

C21H31N

Conditions
ConditionsYield
With {(η4-1,5-cyclooctadiene)Pd(η3-allyl)}BF4; N,N'-diethylurea; (2S)-methyl 2-(4,8-di-tert-butyl-2,10-dimethoxydibenzo[d,f][1,3,2]dioxaphosphepin-6-ylamino)benzylethanoate In toluene at 80℃; for 20h; regioselective reaction;90%
With {(η4-1,5-cyclooctadiene)Pd(η3-allyl)}BF4; N,N'-diethylurea; (2S)-methyl 2-(4,8-di-tert-butyl-2,10-dimethoxydibenzo[d,f][1,3,2]dioxaphosphepin-6-ylamino)benzylethanoate In toluene at 80℃; for 20h; regioselective reaction;57%
farnesol
4602-84-0

farnesol

benzoyl chloride
98-88-4

benzoyl chloride

farnesyl benzoate
89637-63-8

farnesyl benzoate

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 3h;90%
Stage #1: farnesol With manganese(II) iodide; naphthalene; lithium In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: benzoyl chloride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;
75%
farnesol
4602-84-0

farnesol

carbon monoxide
201230-82-2

carbon monoxide

N-ethyl-N-phenylamine
103-69-5

N-ethyl-N-phenylamine

N-ethyl-4,8,12-trimethyl-N-phenyltrideca-3,7,11-trienamide

N-ethyl-4,8,12-trimethyl-N-phenyltrideca-3,7,11-trienamide

Conditions
ConditionsYield
With triphenylphosphine; trifluoroacetic acid; palladium dichloride In toluene at 120℃; under 30003 Torr; for 24h; Inert atmosphere; Autoclave;88%
farnesol
4602-84-0

farnesol

10-(2,3-Dimethoxy-5-methyl-1,4-benzoquinon-6-yl)decanoic acid
58185-99-2

10-(2,3-Dimethoxy-5-methyl-1,4-benzoquinon-6-yl)decanoic acid

farnesyl idebenone carboxylate
1218992-05-2

farnesyl idebenone carboxylate

Conditions
ConditionsYield
novozyme 435 at 50℃; Product distribution / selectivity; Enzymatic reaction; Inert atmosphere;87%
farnesol
4602-84-0

farnesol

5-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-1-hydroxyethylidene)-2-methyl-2-phenyl-1,3-dioxane-4,6-dione

5-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-1-hydroxyethylidene)-2-methyl-2-phenyl-1,3-dioxane-4,6-dione

(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl 4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-oxobutanoate

(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl 4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-oxobutanoate

Conditions
ConditionsYield
In toluene at 50℃; for 1.5h;87%
farnesol
4602-84-0

farnesol

C14H21O13P
270076-37-4

C14H21O13P

C29H45O13P
1353002-95-5

C29H45O13P

Conditions
ConditionsYield
With pyridine; trichloroacetonitrile at 80℃; for 0.25h; Microwave irradiation;86%
farnesol
4602-84-0

farnesol

triethylammonium (2S,3R,4S,5S,6S)-3,4,5-tris-(acetyloxy)-6-(methoxycarbonyl)oxan-2-yl phosphonate

triethylammonium (2S,3R,4S,5S,6S)-3,4,5-tris-(acetyloxy)-6-(methoxycarbonyl)oxan-2-yl phosphonate

triethylammonium 3,7,11-trimethyldodeca-2,6,10-trien-1-yl (2S,3R,4S,5S,6S)-3,4,5-tris(acetyloxy)-6-(methoxycarbonyl)oxan-2-yl phosphate

triethylammonium 3,7,11-trimethyldodeca-2,6,10-trien-1-yl (2S,3R,4S,5S,6S)-3,4,5-tris(acetyloxy)-6-(methoxycarbonyl)oxan-2-yl phosphate

Conditions
ConditionsYield
Stage #1: farnesol; triethylammonium (2S,3R,4S,5S,6S)-3,4,5-tris-(acetyloxy)-6-(methoxycarbonyl)oxan-2-yl phosphonate With pyridine; pivaloyl chloride at -15℃; for 1.5h;
Stage #2: With iodine at 20℃; for 1h;
83%
farnesol
4602-84-0

farnesol

ethylene glycol
107-21-1

ethylene glycol

2-methyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-1,3-dioxolane
104000-34-2

2-methyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-1,3-dioxolane

Conditions
ConditionsYield
With pyridinium p-toluenesulfonate In benzene at 90℃; for 8h; Inert atmosphere; Dean-Stark;82.6%
farnesol
4602-84-0

farnesol

methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate
108865-84-5

methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate

C21H34O4

C21H34O4

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 95℃; under 450.045 - 525.053 Torr; for 6h;81%
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 4h;81%
farnesol
4602-84-0

farnesol

acetonitrile
75-05-8

acetonitrile

N-[(1S,5S,6S)-2,4,6-Trimethyl-2-(4-methyl-pent-3-enyl)-3-aza-bicyclo[3.3.1]non-3-en-6-yl]-acetamide; compound with perchloric acid

N-[(1S,5S,6S)-2,4,6-Trimethyl-2-(4-methyl-pent-3-enyl)-3-aza-bicyclo[3.3.1]non-3-en-6-yl]-acetamide; compound with perchloric acid

Conditions
ConditionsYield
With perchloric acid80%
farnesol
4602-84-0

farnesol

O-(2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyl)trichloroacetimidate
74808-10-9

O-(2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyl)trichloroacetimidate

C29H44O10
168133-47-9

C29H44O10

Conditions
ConditionsYield
With gold(I) chloride In dichloromethane at 20℃; for 2h; Inert atmosphere; stereoselective reaction;80%
farnesol
4602-84-0

farnesol

C15H28O3

C15H28O3

Conditions
ConditionsYield
Stage #1: farnesol With dihydrogen peroxide; bis(2,4-pentanedionato)dioxomolybdenum(VI) In acetonitrile at 20 - 50℃;
Stage #2: With diphenyl sulfide regioselective reaction;
79%
farnesol
4602-84-0

farnesol

(2Z,6E)-10-Chloro-3,7,11-trimethyl-dodeca-2,6,11-trien-1-ol
74514-28-6, 79421-93-5

(2Z,6E)-10-Chloro-3,7,11-trimethyl-dodeca-2,6,11-trien-1-ol

Conditions
ConditionsYield
With hypochloric acid In dichloromethane78%
farnesol
4602-84-0

farnesol

acetic anhydride
108-24-7

acetic anhydride

farnesyl acetate
29548-30-9

farnesyl acetate

Conditions
ConditionsYield
Stage #1: farnesol With manganese(II) iodide; naphthalene; lithium In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: acetic anhydride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
77%

Farnesol Chemical Properties

Molecular structure of Farnesol (CAS NO.4602-84-0) is:

Product Name: Farnesol
CAS Registry Number: 4602-84-0
IUPAC Name: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol
Molecular Weight: 222.36634 [g/mol]
Molecular Formula: C15H26O
XLogP3-AA: 4.8
H-Bond Donor: 1
H-Bond Acceptor: 1 
EINECS: 225-004-1
Refractive index: n20/D 1.490(lit.)
Storage temp.: -20°C
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
Surface Tension: 30.3 dyne/cm
Density: 0.875 g/cm3
Flash Point: 112.5 °C
Enthalpy of Vaporization: 60.62 kJ/mol
Boiling Point: 283.4 °C at 760 mmHg
Vapour Pressure: 0.00037 mmHg at 25°C
Product Categories: Biochemistry;Terpenes;Terpenes (Others)

Farnesol History

 Farnesol (CAS NO.4602-84-0) is from a flower extract with a long history of use in perfumery. The pure substance farnesol was named (ca. 1900-1905) from the type species Acacia farnesiana, the Farnese acacia, the flowers of which provided it commercially, as a floral essence. This particular acacia species in turn is named after Odoardo Cardinal Farnese (1573-1626) of the notable Italian Farnese family which (from 1550 though the 17th century) maintained some of the first private European botanical gardens in the Farnese gardens in Rome. The addition of the -ol ending results from it being chemically an alcohol.The plant itself was brought to the Farnese gardens from the Caribbean and Central America, where it originates.

Farnesol Uses

 Farnesol (CAS NO.4602-84-0) is the building block of most (possibly all) acyclic sesquiterpenoids and is an important starting compound for organic synthesis. It is used in perfumery to emphasize the odors of sweet floral perfumes. It is especially used in lilac perfumes.It is a natural pesticide for mites and is a pheromone for several other insects.

Farnesol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 443mg/kg (443mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ANTIPSYCHOTIC
Therapie. Vol. 27, Pg. 893, 1972.
mouse LD50 oral 7400mg/kg (7400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ANTIPSYCHOTIC
Therapie. Vol. 27, Pg. 893, 1972.
rat LD50 oral 6gm/kg (6000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ANTIPSYCHOTIC
Therapie. Vol. 27, Pg. 893, 1972.

Farnesol Safety Profile

Hazard Codes: IrritantXi
Safety Statements: 24/25-22 
R24/25:Toxic in contact with skin and if swallowed. 
R22:Harmful if swallowed.
WGK Germany: 3
RTECS: JR4979000
F: 8
Hazard Note: Irritant

Farnesol Specification

 Farnesol , its cas register number is 4602-84-0. It also can be called 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl- ; 3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol ; 3,7,11-Trimethyl-2,6,10-dodecatrienol ; Farnesyl alcohol .It is a colorless liquid with a delicate floral odor. It is a natural organic compound which is an acyclic sesquiterpene alcohol found as a colorless liquid. It is insoluble in water, but miscible with oils. It is the alcohol derivative of Farnesol Pyrophosphate. It is the building block of most (possibly all) acyclic sesquiterpenoids and is an important starting compound for organic synthesis.It is present in many essential oils such as citronella, neroli, cyclamen, lemon grass, tuberose, rose, musk, balsam and tolu. It is used in perfumery to emphasize the odors of sweet floral perfumes. Its method of action for enhancing perfume scent is as a co-solvent that regulates the volatility of the odorants. It is especially used in lilac perfumes.It is a natural pesticide for mites and is a pheromone for several other insects.

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