Product Name

  • Name

    Glibenclamide

  • EINECS 233-570-6
  • CAS No. 10238-21-8
  • Article Data26
  • CAS DataBase
  • Density 1.36 g/cm3
  • Solubility Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96%) and in methanol. Practically insoluble in ether. It dissolves in dilute solutions of alkali hydroxides.
  • Melting Point 173-175 °C
  • Formula C23H28 Cl N3 O5 S
  • Boiling Point
  • Molecular Weight 494.011
  • Flash Point
  • Transport Information
  • Appearance white or almost white crystalline podwer
  • Safety 22-36/37/39
  • Risk Codes 20/21/22
  • Molecular Structure Molecular Structure of 10238-21-8 (Glibenclamide)
  • Hazard Symbols Xn
  • Synonyms Urea,1-[[p-[2-(5-chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexyl- (8CI);1-[4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonyl]-3-cyclohexylurea;Adiab;Antibet;Apo-Glibenclamide;Betanaz;Betanese 5;Calabren;Cytagon;Daonil;Daonil N;Debtan;Dia-basan;Diabeta;Diabiphage;Dibelet;Duraglucon;Euglucan;Euglucon;Euglucon 5;Euglykon;GBN 5;Gilemal;Gl;Glamide;Gliban;Gliben;Gliben-Puren N;Glibenclamide;Glibenil;Glibens;Glibesyn;Glibet;Glibetic;Glibil;Glibomet;Gliboral;Glicem;Glidiabet;Glucobene;Glucohexal;Glucolon;Glucomid;Glucoremed;Glucoven;Glukovital;Glyben;Glybenzcyclamide;Glycomin;HD 419;Hemi-Daonil;Libanil;Melix;N-4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonyl-N'-cyclohexylurea;N-[4-[b-(2-Methoxy-5-chlorobenzamido)ethyl]benzenesulfonyl]-N'-cyclohexylurea;Orabetic;Pira;Prodiabet;Renabetic;Semi-Daonil;
  • PSA 121.98000
  • LogP 5.89520

Synthetic route

5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide
16673-34-0

5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide

Cyclohexyl isocyanate
3173-53-3

Cyclohexyl isocyanate

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
With copper(l) chloride In nitromethane at 20℃; for 2h; Reagent/catalyst; Solvent; Concentration; Milling;100 %Spectr.
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 0.166667h; Sealed tube;81 mg
With 18-crown-6 ether; potassium tert-butylate In N,N-dimethyl-formamide at 0 - 5℃; for 6h; Reflux;4.49 g
carbon monoxide
201230-82-2

carbon monoxide

4-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl azide

4-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl azide

cyclohexylamine
108-91-8

cyclohexylamine

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
With palladium diacetate In acetonitrile at 20℃; under 15 Torr; Schlenk technique; Sealed tube;99%
...Expand
C19H21ClN2O6S*C6H13N

C19H21ClN2O6S*C6H13N

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
In toluene at 110℃; Industrial scale;
5-chloro-2-methoxybenzoic acid
3438-16-2

5-chloro-2-methoxybenzoic acid

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: oxalyl dichloride / dichloromethane / 12 h / 20 °C / Schlenk technique
2: triethylamine / dichloromethane / 6 h / 20 °C / Schlenk technique
3: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
Multi-step reaction with 5 steps
1: oxalyl dichloride / dichloromethane / 12 h / 20 °C / Schlenk technique
2: triethylamine / dichloromethane / 6 h / 20 °C / Schlenk technique
3: chlorosulfonic acid / 1,2-dichloro-ethane / 50 °C / Schlenk technique
4: sodium azide / acetonitrile / 50 °C / Schlenk technique
5: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
Multi-step reaction with 4 steps
1: phosphorus trichloride / tetrahydrofuran / 0.08 h / 150 °C / Sealed tube
2: chlorosulfonic acid / chloroform / 0.17 h / 60 °C / Sealed tube
3: ammonium hydroxide / 1,4-dioxane / 0.17 h / 120 °C / Sealed tube; Cooling with ice
4: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 80 °C / Sealed tube
View Scheme
DK13
33924-49-1

DK13

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorosulfonic acid / 1,2-dichloro-ethane / 50 °C / Schlenk technique
2: sodium azide / acetonitrile / 50 °C / Schlenk technique
3: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
Multi-step reaction with 3 steps
1: chlorosulfonic acid / chloroform / 0.17 h / 60 °C / Sealed tube
2: ammonium hydroxide / 1,4-dioxane / 0.17 h / 120 °C / Sealed tube; Cooling with ice
3: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 80 °C / Sealed tube
View Scheme
phenethylamine
64-04-0

phenethylamine

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: phosphorus trichloride / tetrahydrofuran / 0.08 h / 150 °C / Sealed tube
2: chlorosulfonic acid / chloroform / 0.17 h / 60 °C / Sealed tube
3: ammonium hydroxide / 1,4-dioxane / 0.17 h / 120 °C / Sealed tube; Cooling with ice
4: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 80 °C / Sealed tube
View Scheme
Multi-step reaction with 5 steps
1.1: pyridine / tetrahydrofuran / 4 h / 20 °C / Cooling with ice
2.1: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice
3.1: ammonium hydroxide / acetone / 20 °C
4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
4.2: 16 h / 20 °C
5.1: potassium tert-butylate; 18-crown-6 ether / N,N-dimethyl-formamide / 6 h / 0 - 5 °C / Reflux
View Scheme
2-methoxy-5-chlorobenzoyl chloride
29568-33-0

2-methoxy-5-chlorobenzoyl chloride

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 6 h / 20 °C / Schlenk technique
2: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 6 h / 20 °C / Schlenk technique
2: chlorosulfonic acid / 1,2-dichloro-ethane / 50 °C / Schlenk technique
3: sodium azide / acetonitrile / 50 °C / Schlenk technique
4: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
4-(2-[(5-chloro-2-methoxyphenyl)formamido]ethyl)benzene-1-sulfonyl chloride
33924-54-8

4-(2-[(5-chloro-2-methoxyphenyl)formamido]ethyl)benzene-1-sulfonyl chloride

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium azide / acetonitrile / 50 °C / Schlenk technique
2: palladium diacetate / acetonitrile / 20 °C / 15 Torr / Schlenk technique; Sealed tube
View Scheme
5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide
16673-34-0

5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonium hydroxide / acetone / Industrial scale
2.1: pyrographite / acetone / 1.17 h / Reflux; Industrial scale
2.2: 0.5 h / 58 °C / Industrial scale
3.1: toluene / 110 °C / Industrial scale
View Scheme
2,2,2-trifluoro-N-(2-phenylethyl)acetamide
458-85-5

2,2,2-trifluoro-N-(2-phenylethyl)acetamide

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice
2.1: ammonium hydroxide / acetone / 20 °C
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
3.2: 16 h / 20 °C
4.1: potassium tert-butylate; 18-crown-6 ether / N,N-dimethyl-formamide / 6 h / 0 - 5 °C / Reflux
View Scheme
4-[2-(2,2,2-trifluoroacetamido)ethyl]benzenesulfonyl chloride
223253-87-0

4-[2-(2,2,2-trifluoroacetamido)ethyl]benzenesulfonyl chloride

Glibenclamid
10238-21-8

Glibenclamid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonium hydroxide / acetone / 20 °C
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
2.2: 16 h / 20 °C
3.1: potassium tert-butylate; 18-crown-6 ether / N,N-dimethyl-formamide / 6 h / 0 - 5 °C / Reflux
View Scheme
C23H28ClN3O5S*C42H70O35
155021-30-0

C23H28ClN3O5S*C42H70O35

A

Glibenclamid
10238-21-8

Glibenclamid

B

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

Conditions
ConditionsYield
at 25℃; pH=7; aq. phosphate buffer;
Glibenclamid
10238-21-8

Glibenclamid

tetra(n-butyl)ammonium hydroxide
2052-49-5

tetra(n-butyl)ammonium hydroxide

glibenclamide tetrabutylammonium salt

glibenclamide tetrabutylammonium salt

Conditions
ConditionsYield
In methanol100%
Glibenclamid
10238-21-8

Glibenclamid

C23H27(2)HClN3O5S

C23H27(2)HClN3O5S

Conditions
ConditionsYield
With [(1,5-cyclooctadiene)Ir(1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene)(PPh3)]PF6; deuterium In dichloromethane at 20℃; for 2h; Sealed tube;100%
With deuterium at 100℃; Sealed tube;
Glibenclamid
10238-21-8

Glibenclamid

C23H26(2)H2ClN3O5S

C23H26(2)H2ClN3O5S

Conditions
ConditionsYield
With Kerr's catalyst; deuterium In chlorobenzene at 120℃; for 1h; Reagent/catalyst; Temperature;90%
Glibenclamid
10238-21-8

Glibenclamid

acetic anhydride
108-24-7

acetic anhydride

N-<4-<2-(5-Chlor-2-methoxybenzoylamino)ethyl>benzolsulfonyl>acetamid

N-<4-<2-(5-Chlor-2-methoxybenzoylamino)ethyl>benzolsulfonyl>acetamid

Conditions
ConditionsYield
With pyridine for 0.25h;84%
diethylenetriaminepentaacetic dianhydride
23911-26-4

diethylenetriaminepentaacetic dianhydride

Glibenclamid
10238-21-8

Glibenclamid

DTPA-glyburide
848488-96-0

DTPA-glyburide

Conditions
ConditionsYield
Stage #1: Glibenclamid With sodium amide In dimethyl sulfoxide at 20℃; for 0.166667h;
Stage #2: diethylenetriaminepentaacetic dianhydride With sodium amide In dimethyl sulfoxide for 22h;		80%
2-(2-methylphenyl)pyridine
10273-89-9

2-(2-methylphenyl)pyridine

Glibenclamid
10238-21-8

Glibenclamid

C35H38N4O5S

C35H38N4O5S

Conditions
ConditionsYield
With C17H24N5Ru(1+)*F6P(1-); Potassium benzoate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 50℃; for 72h; Inert atmosphere;78%
With C17H24N5Ru(1+)*F6P(1-); Potassium benzoate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 50℃; for 72h; Inert atmosphere; Glovebox;78%
copper(II) choride dihydrate

copper(II) choride dihydrate

Glibenclamid
10238-21-8

Glibenclamid

[Cu(glibenclamide)Cl2(H2O)2]*2H2O

[Cu(glibenclamide)Cl2(H2O)2]*2H2O

Conditions
ConditionsYield
In ethanol; water addn. of hot soln. (60°C) of CuCl2*2H2O in EtOH-H2O mixt. (1:1) to hot soln. (60°C) of MeOC6H3(Cl)CONHCH2CH2C6H4SO2NHCONHC6H11 in the same solvent; stirring under reflux for 1 h; pptn., filtration, washing several times with 1:1 EtOH:H2O mixt. and then with Et2O; elem. anal.;76%
Glibenclamid
10238-21-8

Glibenclamid

copper dichloride

copper dichloride

C46H58Cl2CuN6O10S2

C46H58Cl2CuN6O10S2

Conditions
ConditionsYield
Reflux;76%
Glibenclamid
10238-21-8

Glibenclamid

water
7732-18-5

water

Co metal salt solution

Co metal salt solution

C46H62Cl2CoN6O12S2

C46H62Cl2CoN6O12S2

Conditions
ConditionsYield
Reflux;75%
...Expand
nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

Glibenclamid
10238-21-8

Glibenclamid

[Ni(glibenclamide)Cl2(H2O)2]*3H2O

[Ni(glibenclamide)Cl2(H2O)2]*3H2O

Conditions
ConditionsYield
In ethanol; water addn. of hot soln. (60°C) of NiCl2*6H2O in EtOH-H2O mixt. (1:1) to hot soln. (60°C) of MeOC6H3(Cl)CONHCH2CH2C6H4SO2NHCONHC6H11 in the same solvent; stirring under reflux for 1 h; pptn., filtration, washing several times with 1:1 EtOH:H2O mixt. and then with Et2O; elem. anal.;74%
Glibenclamid
10238-21-8

Glibenclamid

manganese(ll) chloride

manganese(ll) chloride

[Mn(glibenclamide)Cl2]*H2O

[Mn(glibenclamide)Cl2]*H2O

Conditions
ConditionsYield
In ethanol; water addn. of hot soln. (60°C) of MnCl2 in EtOH-H2O mixt. (1:1) to hotsoln. (60°C) of MeOC6H3(Cl)CONHCH2CH2C6H4SO2NHCONHC6H11 in the s ame solvent; stirring under reflux for 1 h; pptn., filtration, washing several times with 1:1 EtOH:H2O mixt. and then with Et2O; elem. anal.;73%
Glibenclamid
10238-21-8

Glibenclamid

C13H12BFO3

C13H12BFO3

C36H38FN3O6S

C36H38FN3O6S

Conditions
ConditionsYield
With potassium phosphate monohydrate; palladium diacetate; N2Phos In water at 60℃; for 24h; Reagent/catalyst; Suzuki-Miyaura Coupling;73%
chromium chloride hexahydrate

chromium chloride hexahydrate

Glibenclamid
10238-21-8

Glibenclamid

[Cr(glibenclamide)Cl3(H2O)]*3H2O

[Cr(glibenclamide)Cl3(H2O)]*3H2O

Conditions
ConditionsYield
In ethanol; water addn. of hot soln. (60°C) of CrCl3*6H2O in EtOH-H2O mixt. (1:1) to hot soln. (60°C) of MeOC6H3(Cl)CONHCH2CH2C6H4SO2NHCONHC6H11 in the same solvent; stirring under reflux for 1 h; pptn., filtration, washing several times with 1:1 EtOH:H2O mixt. and with Et2O; elem. anal.;70%
iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

Glibenclamid
10238-21-8

Glibenclamid

[Fe(glibenclamide)Cl3(H2O)]

[Fe(glibenclamide)Cl3(H2O)]

Conditions
ConditionsYield
In ethanol; water addn. of hot soln. (60°C) of FeCl3*6H2O in EtOH-H2O mixt. (1:1) to hot soln. (60°C) of MeOC6H3(Cl)CONHCH2CH2C6H4SO2NHCONHC6H11 in the same solvent; stirring under reflux for 1 h; pptn., filtration, washing several times with 1:1 EtOH:H2O mixt. and then with Et2O; elem. anal.;68%
zinc(II) chloride dihydrate

zinc(II) chloride dihydrate

Glibenclamid
10238-21-8

Glibenclamid

[Zn(glibenclamide)Cl2]

[Zn(glibenclamide)Cl2]

Conditions
ConditionsYield
In ethanol; water addn. of hot soln. (60°C) of ZnCl2 in EtOH-H2O mixt. (1:1) to hotsoln. (60°C) of MeOC6H3(Cl)CONHCH2CH2C6H4SO2NHCONHC6H11 in the s ame solvent; stirring under reflux for 1 h; pptn., filtration, washing several times with 1:1 EtOH:H2O mixt. and then with Et2O; elem. anal.;65%
cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

Glibenclamid
10238-21-8

Glibenclamid

[Co(glibenclamide)Cl2(H2O)2]

[Co(glibenclamide)Cl2(H2O)2]

Conditions
ConditionsYield
In ethanol; water addn. of hot soln. (60°C) of CoCl2 in EtOH-H2O mixt. (1:1) to hotsoln. (60°C) of MeOC6H3(Cl)CONHCH2CH2C6H4SO2NHCONHC6H11 in the s ame solvent; stirring under reflux for 1 h; pptn., filtration, washing several times with 1:1 EtOH:H2O mixt. and then with Et2O; elem. anal.;65%
4-Methoxystyrene
637-69-4

4-Methoxystyrene

2,2,6,6-tetramethylpiperidin-1-ol
7031-93-8

2,2,6,6-tetramethylpiperidin-1-ol

Glibenclamid
10238-21-8

Glibenclamid

C41H56N4O7S

C41H56N4O7S

Conditions
ConditionsYield
With 2,6-di(t-butyl)-4-phenylphenol; caesium carbonate In dimethyl sulfoxide at 20℃; for 20h; Irradiation; Inert atmosphere;61%
...Expand
Glibenclamid
10238-21-8

Glibenclamid

N-[2-(4-[N-(cyclohexylcarbamoyl)-sulfamoyl]-phenyl)-ethyl]-5-hydroxy-2-methoxybenzamide
1334544-50-1

N-[2-(4-[N-(cyclohexylcarbamoyl)-sulfamoyl]-phenyl)-ethyl]-5-hydroxy-2-methoxybenzamide

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 20℃; for 24h;60%
Glibenclamid
10238-21-8

Glibenclamid

N-boc-2-pyrroleboronic acid
135884-31-0

N-boc-2-pyrroleboronic acid

C32H40N4O7S

C32H40N4O7S

Conditions
ConditionsYield
With O4P(3-)*3K(1+)*5H2O; tris(1-adamantyl)phosphine; C28H26N2O8Pd2S2 In tetrahydrofuran at 100℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;37%
With 1,2,3-trimethoxybenzene; O4P(3-)*3K(1+)*5H2O; tris(1-adamantyl)phosphine; {2-[((acetyl-κO)amino)phenyl-κC](tri-1-adamantylphosphine)palladium}(p-toluenesulfonate) In tetrahydrofuran at 100℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere;37%
phthalic anhydride
85-44-9

phthalic anhydride

Glibenclamid
10238-21-8

Glibenclamid

A

N-cyclohexylphthalimide
2133-65-5

N-cyclohexylphthalimide

B

5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide
16673-34-0

5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide

Conditions
ConditionsYield
With pyridine; dmap for 4h; Heating;A 34%
B 29%
...Expand
Glibenclamid
10238-21-8

Glibenclamid

A

N-cyclohexylphthalimide
2133-65-5

N-cyclohexylphthalimide

B

5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide
16673-34-0

5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide

Conditions
ConditionsYield
With pyridine; dmap; phthalic anhydride for 4h; Heating;A 34%
B 29%
Glibenclamid
10238-21-8

Glibenclamid

C23H27ClN4O7S

C23H27ClN4O7S

Conditions
ConditionsYield
Stage #1: Glibenclamid With sulfuric acid; nitric acid In 1,4-dioxane at 0 - 20℃; for 1.5h; Cooling with ice;
Stage #2: Sonication;		11%
With sulfuric acid; nitric acid In 1,4-dioxane at 0 - 20℃; for 1.5h;11%
Glibenclamid
10238-21-8

Glibenclamid

C23H27(3)HClN3O5S

C23H27(3)HClN3O5S

Conditions
ConditionsYield
With tritium; [Ir(1,5-COD)(P(C6H5)3)2]BF4 In dichloromethane for 16h; Ambient temperature;
Glibenclamid
10238-21-8

Glibenclamid

N-{4-[β-(2-hydroxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonyl}-N'-cyclohexylurea
57334-90-4

N-{4-[β-(2-hydroxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonyl}-N'-cyclohexylurea

Conditions
ConditionsYield
With boron tribromide
Glibenclamid
10238-21-8

Glibenclamid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

C4H11NO3*C23H28ClN3O5S
873552-77-3

C4H11NO3*C23H28ClN3O5S

Conditions
ConditionsYield
In methanol at 5℃;

Glyburide Specification

The Glyburide has the cas register number 10238-21-8, and it is a kind of white crystalline powder. The IUPAC name and systematic name are the same which is 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide. This chemical is insoluble in water while slightly soluble in ethanol, acetone, chloroform, and its product categories are including Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Organics; Amino Acids & Derivatis; Isotope Labeled Compounds; API's; Potassium channel; Ion Channels. When you neee to store it, keep it in a dry, cool and well-ventilated storeroom.

The physical properties of this chemical are as follows: (1)ACD/LogP: 3.75; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.58; (4)ACD/LogD (pH 7.4): 1.79; (5)ACD/BCF (pH 5.5): 27.82; (6)ACD/BCF (pH 7.4): 4.52; (7)ACD/KOC (pH 5.5): 173.93; (8)ACD/KOC (pH 7.4): 28.24; (9)#H bond acceptors: 8; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 95.61; (13)Index of Refraction: 1.616; (14)Molar Refractivity: 126.9 cm3; (15)Molar Volume: 362.9 cm3; (16)Polarizability: 50.3×10-24 cm3; (17)Surface Tension: 61.2 dyne/cm; (18)Density: 1.36 g/cm3; (19)Exact Mass: 493.143819; (20)MonoIsotopic Mass: 493.143819; (21)Topological Polar Surface Area: 122; (22)Heavy Atom Count: 33; (23)Formal Charge: 0; (24)Complexity: 746.

As to its usage, it is usually applied in pharmaceutics. It could be used as the hypoglycemicagent, with better curative effect than tolbutamide; It is often used in the curing of mild and moderate non-insulin-dependent diabetes mellitus.

When you are dealing with this kind of chemical, you should be much more careful and then take some measures to protect yourself. Being a kind of harmful chemical, it may cause damage to health. And if by inhalation, in contact with skin and if swallowed, you will be hurt by this chemical. Therefore, you should take the following instructions. Wear suitable protective clothing, gloves and eye/face protection while using and then do not breathe dust.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
(2)InChI: InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-
10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
(3)InChIKey: ZNNLBTZKUZBEKO-UHFFFAOYSA-N 

Below are the toxicity information of this chemical:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1404, 1969.
 
guinea pig LD50 oral > 15gm/kg (15000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1404, 1969.
 
man TDLo oral 209mg/kg/4Y-I (209mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LIVER: "JAUNDICE, CHOLESTATIC"

LIVER: OTHER CHANGES		 Western Journal of Medicine. Vol. 168, Pg. 274, 1998.
 
mouse LD50 intraperitoneal 2700mg/kg (2700mg/kg)   Pharmaceutical Chemistry Journal Vol. 29, Pg. 265, 1995.
mouse LD50 oral 3250mg/kg (3250mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 1640, 1966.
 
mouse LD50 subcutaneous > 20gm/kg (20000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 247, 1970.
rabbit LD oral > 20gm/kg (20000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 247, 1970.
rat LD50 intraperitoneal 3750mg/kg (3750mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1413, 1969.
 
rat LD50 oral > 20gm/kg (20000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1413, 1969.
 
rat LD50 subcutaneous > 20gm/kg (20000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1413, 1969.
 
women TDLo oral 147ug/kg (0.147mg/kg) BEHAVIORAL: COMA

ENDOCRINE: HYPOGLYCEMIA		 Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 142, 1984.
 

 

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