Guanidine thiocyanate supplier

Name
Guanidine thiocyanate
EINECS 209-812-1
CAS No. 593-84-0
Article Data36
CAS DataBase
Density 1.103 g/mL at 20 °C
Solubility H₂O: 6 M at 20 °C, clear, colorless
Melting Point 120-122 °C(lit.)
Formula C₂H₆N₄S
Boiling Point 132.9 °C at 760 mmHg
Molecular Weight 118.162
Flash Point 34.2 °C
Transport Information UN 1759
Appearance White cryst. powder
Safety 36/37-61-13-36-26
Risk Codes 20/21/22-32-52/53-36/37/38
Molecular Structure
Hazard Symbols Xn, T
Synonyms Isothiocyanic acid, compd. with guanidine (1:1);
PSA 138.48000
LogP 0.73618

Synthetic route

: ammonium thiocyanate

: 127099-85-8, 780722-26-1
dicyandiamide

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
In melt 55 part of dicyanodiamide reacted with 100 part of NH4SCN;	90%
In melt 55 part of dicyanodiamide reacted with 100 part of NH4SCN;	90%

: 108-78-1
2,4,6-triamino-s-triazine

: 1147550-11-5
ammonium thiocyanate

: 593-84-0
guanidinium thiocyanate

: 420-04-2
CYANAMID

: 1147550-11-5
ammonium thiocyanate

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
at 100℃;

: 1147550-11-5
ammonium thiocyanate

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
at 190℃;
at 195 - 212℃;

: 1147550-11-5
ammonium thiocyanate

: 127099-85-8, 780722-26-1
N-Cyanoguanidine

: 593-84-0
guanidinium thiocyanate

: 75-15-0
carbon disulfide

: 57-13-6
urea

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
at 250℃;

: 17356-08-0
thiourea

A: 7783-06-4
hydrogen sulfide

B: 593-84-0
guanidinium thiocyanate

C: 7664-41-7
ammonia

D CS2: CS2

Conditions

Conditions	Yield
at 195 - 230℃; under 760 Torr; Reaktion des Gleigewichtsgemisches Thioharnstoff-Ammoniumrhodanid; Produkt5:HSCN;
at 173℃; under 60 Torr; Reaktion des Gleigewichtsgemisches Thioharnstoff-Ammoniumrhodanid; Produkt5:HSCN;

...Expand

: 110-86-1
pyridine

: 17356-08-0
thiourea

A: 7783-06-4
hydrogen sulfide

B: 593-84-0
guanidinium thiocyanate

C trithiocarbonate ammonium(?): trithiocarbonate ammonium(?)

...Expand

: 75-15-0
carbon disulfide

ammonia: ammonia

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
at 200 - 350℃;

: 463-58-1
carbon oxide sulfide

ammonia: ammonia

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
at 250℃;

NH3: NH3

NH4SCN: NH4SCN

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
at 170 - 180℃;

: 17356-08-0
thiourea

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
at 180.85℃; Kinetics; Further Variations:; Temperatures;

: 57-13-6
urea

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
With hydrogen sulfide High Pressure; at 240 until 260°C; pressure 70 to 140 atm; equimolar amts. of educts;
With hydrogen sulfide High Pressure; at 240 until 260°C; pressure 70 to 140 atm; equimolar amts. of educts;

: ammonium thiocyanate

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
heating over temp. of formation of (NH4)2CS;
byproducts: NH3, CS2; 220°C;
With ammonia; ammonium chloride 300°C;	25-30

: ammonium thiocyanate

: 17356-08-0
thiourea

: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
heating; 180-218°C;

: ammonium thiocyanate

: 17356-08-0
thiourea

A: ammonium salt of trithiocarbonic acid

B: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
In neat (no solvent) heating;
In neat (no solvent) heating;

...Expand

: ammonium thiocyanate

A: ammonium salt of trithiocarbonic acid

B: 593-84-0
guanidinium thiocyanate

Conditions

Conditions	Yield
In neat (no solvent) heating to 160-185°C;
In neat (no solvent) heating to 160-185°C;

: ammonium thiocyanate

: 127099-85-8, 780722-26-1
dicyandiamide

A: 593-84-0
guanidinium thiocyanate

B: 767-17-9
4,6-diamino-1,3,5-triazine-2(1H)-thione

Conditions

Conditions	Yield
In melt 120°C;
In melt 120°C;

...Expand

: 55934-10-6
methyl 1-oxo-2,3-dihydro-1H-indene-4-carboxylate

: 593-84-0
guanidinium thiocyanate

: 3-amino-1,4-dihydroindeno[1,2-c]pyrazole-5-carboxylic acid

Conditions

Conditions	Yield
Stage #1: methyl 1-oxo-2,3-dihydro-1H-indene-4-carboxylate; guanidinium thiocyanate With lithium hexamethyldisilazane In tetrahydrofuran at 20℃; Stage #2: With hydrazine hydrate; acetic acid In tetrahydrofuran for 12h; Reflux;	82%

: 42331-17-9
N-(pent-4-enyl)aniline

: 593-84-0
guanidinium thiocyanate

: 1-phenyl-2-(thiocyanatomethyl)pyrrolidine

Conditions

Conditions	Yield
With iodine In ethyl acetate at 50℃; for 8h;	78%

: 593-84-0
guanidinium thiocyanate

: 27561-84-8
triaminoguanidinium thiocyanate

Conditions

Conditions	Yield
With hydrazine In 1,4-dioxane; water for 5.08333h; Reflux;	60%

: 593-84-0
guanidinium thiocyanate

: 4-(piperidine-1-carbonyl)-2,3-dihydro-1H-inden-1-one

: (3-amino-1,4-dihydroindeno[1,2-c]pyrazol-5-yl)(piperidin-1-yl)methanone

Conditions

Conditions	Yield
Stage #1: guanidinium thiocyanate; 4-(piperidine-1-carbonyl)-2,3-dihydro-1H-inden-1-one With lithium hexamethyldisilazane In tetrahydrofuran at 55℃; for 12h; Stage #2: With hydrazine hydrate; acetic acid In tetrahydrofuran for 24h; Reflux;	54%

: 593-84-0
guanidinium thiocyanate

: 123902-93-2
13,16,30,33,54,57,65,68,74,77,85,88-Dodecaoxa-10,19,27,36,51,60-hexaazadecacyclo-<21.19.19.810,19.827,36.851,60.13,44.14,62.121,25.138,42.145,49>-nonaconta-1,3(81),4,6,8,21,23,25(71),38,40,42,43,45,47,49-pentadecaen

: 123902-94-3
C72H102N6O12*3CH5N3*3CHNS

Conditions

Conditions	Yield
In methanol; ethyl acetate for 0.5h; Heating;	43%

: 787-07-5
diethyl 1,4-cyclohexanedione-2,5-dicarboxylate

: 593-84-0
guanidinium thiocyanate

: 2,7-diamino-3,5,8,10-tetrahydro-pyrimido[4,5-g]quinazoline-4,9-dione

Conditions

Conditions	Yield
With sodium ethanolate

: 373-44-4
1,8-diaminooctan

: 593-84-0
guanidinium thiocyanate

: 19010-48-1
1,8-Diguanidinooctane

Conditions

Conditions	Yield
at 125 - 150℃;

: 542-85-8
Ethyl isothiocyanate

: 593-84-0
guanidinium thiocyanate

: 44830-57-1
1-ethyl-3-formamidinothiocarbamide

Conditions

Conditions	Yield
With sodium ethanolate

: 646-25-3
diaminodecane

: 593-84-0
guanidinium thiocyanate

: 111-23-9
N,N'''-1,10-decanediylbisguanidine

Conditions

Conditions	Yield
at 125 - 150℃;
With ammonia; water at 80 - 120℃;
With water at 120 - 140℃;

: 628-30-8
n-Propyl isothiocyanate

: 593-84-0
guanidinium thiocyanate

: 141-52-6
sodium ethanolate

: 39140-29-9
1-amidino-3-propylthiourea

...Expand

: 628-30-8
n-Propyl isothiocyanate

: 593-84-0
guanidinium thiocyanate

: 39140-29-9
1-amidino-3-propylthiourea

Conditions

Conditions	Yield
With sodium ethanolate

: 591-82-2
isobutyl isothiocyanate

: 593-84-0
guanidinium thiocyanate

: N-carbamimidoyl-N'-isobutyl-thiourea

Conditions

Conditions	Yield
With sodium ethanolate

: 17618-65-4
2-(diethoxymethylene)malononitrile

: 593-84-0
guanidinium thiocyanate

: 18340-59-5
2,4-diamino-6-ethoxy-pyrimidine-5-carbonitrile

Conditions

Conditions	Yield
With methanol; sodium methylate

: 759-65-9
diethyl oxalpropionate

: 593-84-0
guanidinium thiocyanate

: 2-amino-5-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
(als Natrium-Verbindung);

: 2257-09-2
Phenethyl isothiocyanate

: 593-84-0
guanidinium thiocyanate

: 46463-06-3
N-carbamimidoyl-N'-phenethyl-thiourea

Conditions

Conditions	Yield
With sodium; acetone

: 4061-59-0
p-acetoxyphenyl isothiocyanate

: 593-84-0
guanidinium thiocyanate

: 123790-75-0
N-(4-acetoxy-phenyl)-N'-carbamimidoyl-thiourea

Conditions

Conditions	Yield
With sodium; acetone

: 94-22-4
propyl 4-nitrobenzoate

: 593-84-0
guanidinium thiocyanate

: 3166-02-7
(4-nitro-benzoyl)-guanidine

Conditions

Conditions	Yield
With sodium ethanolate

: 4044-65-9
1 ,4-phenylenediisothiocyanate

: 593-84-0
guanidinium thiocyanate

: N',N'''-dicarbamimidoyl-N,N''-p-phenylene-bis-thiourea

Conditions

Conditions	Yield
With sodium; acetone

: 64-17-5
ethanol

: 82-02-0
Khellin

: 593-84-0
guanidinium thiocyanate

: 141-52-6
sodium ethanolate

: 52928-07-1
5-(2-amino-6-methyl-pyrimidin-4-yl)-4,7-dimethoxy-benzofuran-6-ol

...Expand

: 82-02-0
Khellin

: 593-84-0
guanidinium thiocyanate

: 52928-07-1
5-(2-amino-6-methyl-pyrimidin-4-yl)-4,7-dimethoxy-benzofuran-6-ol

Conditions

Conditions	Yield
With ethanol; sodium ethanolate

: 35967-24-9
(3,4,5-trimethoxyphenyl)isothiocyanate

: 593-84-0
guanidinium thiocyanate

: N-carbamimidoyl-N'-(3,4,5-trimethoxy-phenyl)-thiourea

Conditions

Conditions	Yield
With sodium; acetone

: 2131-60-4
4-hydroxyphenyl isothiocyanate

: 593-84-0
guanidinium thiocyanate

: N-carbamimidoyl-N'-(4-hydroxy-phenyl)-thiourea

Conditions

Conditions	Yield
With sodium; acetone

: 593-84-0
guanidinium thiocyanate

: 141-52-6
sodium ethanolate

A: N-carbamimidoyl-N'-isopentyl-thiourea

B: N,N'-bis-(isopentyl-thiocarbamoyl)-guanidine

Conditions

Conditions	Yield
With ethanol durch anschliessendes Kochen mit Isopentyl-isothiocyanat;

...Expand

: 593-84-0
guanidinium thiocyanate

: 556-88-7
nitroguanidine

Conditions

Conditions	Yield
With sulfuric acid; nitric acid
With sulfuric acid; nitric acid

: 593-84-0
guanidinium thiocyanate

: 15989-47-6
1-phenyl-3-guanylthiourea

Conditions

Conditions	Yield
With potassium hydroxide und anschliessend mit Phenylisothiocyanat;

: 593-84-0
guanidinium thiocyanate

: 7464-17-7
1-p-chlorophenyl-3-formamidinothiocarbamide

Conditions

Conditions	Yield
With sodium; acetone anschliessend mit 4-Chlor-phenylisothiocyanat;

: 593-84-0
guanidinium thiocyanate

: 34678-12-1
N-(4-bromo-phenyl)-N'-carbamimidoyl-thiourea

Conditions

Conditions	Yield
With sodium; acetone und anschliessend mit 4-Brom-phenylisothiocyanat;

Guanidine thiocyanate Chemical Properties

Molecular structure of Guanidine thiocyanate (CAS NO.593-84-0) is:

Product Name: Guanidine thiocyanate
CAS Registry Number: 593-84-0
IUPAC Name: guanidine ; thiocyanic acid
Molecular Weight: 118.16084 [g/mol]
Molecular Formula: C₂H₆N₄S
H-Bond Donor: 3
H-Bond Acceptor: 4
EINECS: 209-812-1
Melting Point: 120-122 °C(lit.)
Refractive index: n20/D 1.482
Storage temp.: Store at RT.
Solubility: H₂O: 6 M at 20 °C, clear, colorless
Flash Point: 34.2 °C
Enthalpy of Vaporization: 37.04 kJ/mol
Boiling Point: 132.9 °C at 760 mmHg
Vapour Pressure: 8.67 mmHg at 25°C
Stability: Stability Stable, but light sensitive. Incompatible with acids (contact releases very toxic gas), strong oxidising agents.
Product Categories: Pharmaceutical Intermediates;Sulphur Derivatives

Guanidine thiocyanate Uses

Guanidine thiocyanate (CAS NO.593-84-0) is mainly used in chemical reagent, biological medicine, etc.It is also used as a general protein denaturant, which is presumably the mechanism for its aforementioned application in humans. And it can be used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action is to prevent activity of RNase enzymes and DNase enzymes by denaturing them.

Guanidine thiocyanate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	300mg/kg (300mg/kg)		National Technical Information Service. Vol. AD277-689,

Guanidine thiocyanate Consensus Reports

Reported in EPA TSCA Inventory.

Guanidine thiocyanate Safety Profile

Poison by intraperitoneal route. When heated to decomposition it emits very toxic fumes of NO_x, CN⁻, and SO_x. See also THIOCYANATES.
Hazard Codes: Harmful Xn, Toxic T
Risk Statements: 20/21/22-32-52/53-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R32:Contact with acid liberates very toxic gas.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 36/37-61-13-36-26
S36/37:Wear suitable protective clothing and gloves.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S13:Keep away from food, drink and animal foodstuffs.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 1759
WGK Germany: 2
RTECS: XL1225000
F: 3-10
HazardClass: 8
PackingGroup: III
HS Code: 29252000

Guanidine thiocyanate Specification

Guanidine thiocyanate , its cas register number is 593-84-0. It also can be called Guanidine, monothiocyanate ; Guanidinium thiocyanate ; Isothiocyanic acid, compd. with guanidine (1:1) (VAN) .It is a white powder.

Product Name

Guanidine thiocyanate

Synthetic route

Guanidine thiocyanate Chemical Properties

Guanidine thiocyanate Uses

Guanidine thiocyanate Toxicity Data With Reference

Guanidine thiocyanate Consensus Reports

Guanidine thiocyanate Safety Profile

Guanidine thiocyanate Specification

Related Products

Hot Products