GUANIDINE HYDROCHLORIDE supplier

Name
Guanidine hydrochloride
EINECS 200-002-3
CAS No. 50-01-1
Article Data32
CAS DataBase
Density 1.18 g/mL at 25 °C(lit.)
Solubility 2280 g/L (20 °C) in water
Melting Point 180-185 °C(lit.)
Formula CH₅N₃.HCl
Boiling Point 132.9 °C at 760 mmHg
Molecular Weight 95.5317
Flash Point 34.2 °C
Transport Information
Appearance White cryst. powder
Safety 26-36-22
Risk Codes 22-36/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Guanidine,monohydrochloride (8CI,9CI);Buffer AL;Guanidine chloride;Guanidinehydrochloride;Guanidinium chloride;Guanidinium hydrochloride;
PSA 75.89000
LogP 1.14090

Synthetic route

: guanidinium trinitromethanide

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether at 0℃; Product distribution;	78%

: 1674-62-0
N1-methyl biguanide hydrochloride

A: 420-04-2
CYANAMID

B: 471-29-4
1-methylguanidine

C: 50-01-1
guanidine hydrochloride

D: 4674-68-4
methylcyanamide

Conditions

Conditions	Yield
bei der thermischen Zersetzung;

...Expand

: 57-13-6
urea

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
With aluminium trichloride; ammonia at 300℃;

: N-methylguanidine hydrochloride

: 2-amino-4,5-dihydro-4,5-dihydroxyimidazolium chloride

A: 50-01-1
guanidine hydrochloride

B: 1-methyl-2-amino-4,5-dihydro-4,5-dihydroxyimidazolinium chloride

Conditions

Conditions	Yield
In chloroform-d1 Equilibrium constant; pH 8;

...Expand

: 127099-85-8, 780722-26-1
N-Cyanoguanidine

aqueous ammonium chloride: aqueous ammonium chloride

A: 645-93-2
ammelide

B: 50-01-1
guanidine hydrochloride

C: 56-03-1
BIGUANIDE

Conditions

Conditions	Yield
at 150℃;

...Expand

: 56-23-5
tetrachloromethane

: 7664-41-7
ammonia

: 7553-56-2
iodine

copper: copper

A: 74-90-8
hydrogen cyanide

B: 460-19-5
ethanedinitrile

C: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
at 140℃;

...Expand

: 64-17-5
ethanol

: 420-04-2
CYANAMID

: ammonium chloride

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
at 100℃;

...Expand

: 7647-01-0
hydrogenchloride

: 509-14-8
tetranitromethane

nickel coated zinc: nickel coated zinc

A: ammonium chloride

B: 50-01-1
guanidine hydrochloride

...Expand

: 7664-41-7
ammonia

: 31407-74-6
O-ethyl-isourea hydrochloride

: 50-01-1
guanidine hydrochloride

: thiocarbimidoic acid O-ethyl ester-S-methyl ester; hydrochloride

concentrated alcoholic ammonia: concentrated alcoholic ammonia

: 50-01-1
guanidine hydrochloride

: ammonium chloride

: 57-13-6
urea

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
With silica gel In melt 160 until 230°C; 1.5-fold excess of NH4Cl; in the presence of the same amt. of silica gel as urea;

: 56-23-5
tetrachloromethane

A: ammonium dicyanamide

B: 127099-85-8, 780722-26-1
dicyandiamide

C: 67-72-1
hexachloroethane

D: ammonium chloride

E: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
With ammonia In tetrachloromethane other Radiation; γ-radiation of NH3 soln. in CCl4 at 25°C; mechanism discussed; further products and further intermediates;;

...Expand

: 127099-85-8, 780722-26-1
dicyandiamide

: ammonium chloride

: 50-01-1
guanidine hydrochloride

: 7446-70-0
aluminium trichloride

: 7664-41-7
ammonia

: 57-13-6
urea

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
300°C; in autoclave;
300°C; in autoclave;

...Expand

: 56-23-5
tetrachloromethane

: 7664-41-7
ammonia

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
With iodine; copper byproducts: HCN, cyanogen; High Pressure; 140°C; 17 h;	35-40
With Cu; I2

: 1066-33-7
ammonium bicarbonate

: 50-01-1
guanidine hydrochloride

: 593-85-1
diguanidine carbonate

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

: 593-85-1
guanidine carbonate

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water for 4h;

: 50-01-1
guanidine hydrochloride

: 94012-44-9, 94012-45-0
3-methylthio-1-phenyl-4-phenylsulfonyl-2-buten-1-one

: 106808-11-1
2-amino-4-phenyl-6-(phenylsulphonyl-methyl)pyrimidine

Conditions

Conditions	Yield
With sodium In ethanol for 2h; Heating;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 50-01-1
guanidine hydrochloride

: 219511-71-4
tert-butyl N-(diaminomethylidene)carbamate

Conditions

Conditions	Yield
Stage #1: guanidine hydrochloride With sodium hydroxide In water at 0℃; for 0.166667h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In water; acetone at 0 - 20℃; for 2.5h; Inert atmosphere;	100%
With sodium hydroxide In 1,4-dioxane for 15h;	88%
With sodium hydroxide In 1,4-dioxane; water at 0 - 20℃;	66%

: 50-01-1
guanidine hydrochloride

: 126930-22-1
4-(Cyclohexyloxy)acetessigsaeure-ethylester

: 1161825-17-7
2-amino-6-(cyclohexyloxymethyl)pyrimidin-4-ol

Conditions

Conditions	Yield
With sodium methylate In ethanol Heating / reflux;	100%

: 50-01-1
guanidine hydrochloride

: 2203-24-9
N,N',N''-triaminoguanidine

Conditions

Conditions	Yield
With hydrazine hydrate In 1,4-dioxane for 2h; Reflux;	100%
With hydrazine hydrate In 1,4-dioxane for 2h; Reflux; Inert atmosphere;	100%
With hydrazine hydrate In 1,4-dioxane for 2h; Reflux;	98%

: 50-01-1
guanidine hydrochloride

: 107-15-3
ethylenediamine

: 19437-45-7
2-amino-2-imidazoline

Conditions

Conditions	Yield
In neat (no solvent) for 16h; Solvent; Reagent/catalyst; Inert atmosphere; Reflux;	100%

: 2765-59-5
2-chloro-10-(3-chloropropyl)-10H-phenothiazine

: 50-01-1
guanidine hydrochloride

: 2518-14-1
[3-(2-chloro-phenothiazin-10-yl)-propyl]-guanidine

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 80℃; for 72h;	100%

: 50-01-1
guanidine hydrochloride

: 19227-70-4
guanidinium hydroiodide

Conditions

Conditions	Yield
With sodium iodide In methanol; acetone for 12h; Reflux;	100%

: 50-01-1
guanidine hydrochloride

: C20H23N5O2

: C15H21N7O2

Conditions

Conditions	Yield
With sodium methylate In ethanol at 90℃; for 16h;	100%

: 50-01-1
guanidine hydrochloride

: guanidinium dinitramide

Conditions

Conditions	Yield
With silver(I) dinitramide In methanol	99%
With dinitramide potassium salt In water at 20℃; for 0.5h; Green chemistry;	3.3 g

: 50-01-1
guanidine hydrochloride

: 60598-48-3
5-amino-1-benzyl-1H-imidazole-4-carbonitrile

: 7674-36-4
2,6-diamino-9-benzylpurine

Conditions

Conditions	Yield
In ethanol for 10h; Heating;	99%

: 22666-07-5
di-p-tolylbutadiyne

: 50-01-1
guanidine hydrochloride

: (2-amino-6-(p-tolyl)pyrimidin-4-yl)(p-tolyl)methanone

Conditions

Conditions	Yield
With caesium carbonate; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; Schlenk technique; regioselective reaction;	99%

: 886-66-8
1,4-diphenyl-1,3-butadiyne

: 50-01-1
guanidine hydrochloride

: (2-amino-6-phenyl-pyrimidin-4-yl)(phenyl)methanone

Conditions

Conditions	Yield
With caesium carbonate; dimethyl sulfoxide at 120℃; for 12h; Reagent/catalyst; Temperature; Sealed tube; Schlenk technique; regioselective reaction;	99%
With caesium carbonate In dimethyl sulfoxide at 120℃; Reagent/catalyst; Sealed tube;	99%

: 1,4-bis(3-methylphenyl)-1,3-butadiyne

: 50-01-1
guanidine hydrochloride

: (2-amino-6-(m-tolyl)pyrimidin-4-yl)(m-tolyl)methanone

Conditions

Conditions	Yield
With caesium carbonate; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; Schlenk technique; regioselective reaction;	99%

: 886-66-8
1,4-diphenyl-1,3-butadiyne

: 50-01-1
guanidine hydrochloride

: 4-benzyl-6-phenylpyrimidin-2-amine

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide at 120℃; Temperature; Sealed tube;	99%

: 50-00-0
formaldehyd

: 50-01-1
guanidine hydrochloride

: 74-89-5
methylamine

: 2,5,8-trimethyl-2,3,5,6,8,9-hexahydro-1H,4H,7H-2,5,6a,8,9a-pentaaza-3a-azoniaphenalene chloride

Conditions

Conditions	Yield
In ethanol; water at 5 - 20℃; for 72h;	99%

...Expand

: 50-01-1
guanidine hydrochloride

: 3-dimethylamino-1-(3-nitrophenyl)-2-propen-1-one

: 4-(3-nitrophenyl)-2-aminopyrimidine

Conditions

Conditions	Yield
Stage #1: guanidine hydrochloride With potassium carbonate In ethanol at 20℃; for 0.666667h; Stage #2: 3-dimethylamino-1-(3-nitrophenyl)-2-propen-1-one In ethanol at 80℃; for 20h;	98.7%

: 50-01-1
guanidine hydrochloride

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 638-53-9
tridecanoic acid

: C37H77N11O2*ClH

Conditions

Conditions	Yield
Stage #1: N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine; tridecanoic acid With toluene-4-sulfonic acid at 155℃; for 2.75h; Stage #2: guanidine hydrochloride at 152 - 176℃; for 5h;	98.5%

...Expand

: C22H19Cl3O6S

: 50-01-1
guanidine hydrochloride

: 3,4-dichlorophenyl 3-O-[(2-amino-(4-chlorophenyl)pyrimidin-6-yl)methylene]-1-thio-α-D-galactopyranoside

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran Inert atmosphere; Reflux;	98.5%

: 50-01-1
guanidine hydrochloride

: (Z)-2-(4-Butoxy-3-methoxy-benzyl)-3-phenylamino-acrylonitrile

: 80267-19-2
5-(4-butoxy-3-methoxy-benzyl)-pyrimidine-2,4-diamine

Conditions

Conditions	Yield
With sodium methylate In ethanol for 24h; Heating;	98%

: 50-01-1
guanidine hydrochloride

: 5329-29-3
triaminoguanidine hydrochloride

Conditions

Conditions	Yield
With hydrazine hydrate In 1,4-dioxane for 2h; Heating;	98%
With hydrazine hydrate In 1,4-dioxane for 2h; Reflux;	98%
With hydrazine hydrate In isopropyl alcohol for 6h; Reflux;	97%

: 50-01-1
guanidine hydrochloride

: 657408-23-6
5-bromo-4-nitro-1-(2'-deoxy-β-D-ribofuranosyl)imidazole

: 5-guanidino-4-nitro-1-(2'-deoxy-β-D-ribofuranosyl)imidazole

Conditions

Conditions	Yield
Stage #1: guanidine hydrochloride With sodium methylate In methanol Stage #2: 5-bromo-4-nitro-1-(2'-deoxy-β-D-ribofuranosyl)imidazole In ethanol for 2h; Heating;	98%

: 1-[3-(4-chlorophenyl)-benzo[c]isoxazole-5-yl]-3-dimethylamino-propenone

: 50-01-1
guanidine hydrochloride

: 477845-12-8
4-(3-(4-chlorophenyl)benzo[c]isoxazol-5-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
With sodium In methanol at 20 - 80℃; for 18h;	98%

: 50-01-1
guanidine hydrochloride

: 7803-57-8
hydrazine hydrate

: 5329-29-3
triaminoguanidine hydrochloride

Conditions

Conditions	Yield
In 1,4-dioxane for 2h; Reflux;	98%

: 41792-58-9
1,1,3,6,8,8-Hexanitro-3,6-diaza-octan

: 50-01-1
guanidine hydrochloride

: bis(2,2-dinitroethanide-N-nitro)ethylenediamine bis(guanidium) salt

Conditions

Conditions	Yield
Stage #1: guanidine hydrochloride With sodium hydroxide In methanol at 20℃; for 0.166667h; Stage #2: 1,1,3,6,8,8-Hexanitro-3,6-diaza-octan In acetonitrile at 20℃; for 1h;	98%

: 1,4-bis(4-n-pentylphenyl)buta-1,3-diyne

: 50-01-1
guanidine hydrochloride

: (2-amino-6-(4-pentylphenyl)pyrimidin-4-yl)(4-pentylphenyl)methanone

Conditions

Conditions	Yield
With caesium carbonate; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; Schlenk technique; regioselective reaction;	98%

: 941-98-0
1'-naphthacetophenone

: 50-01-1
guanidine hydrochloride

: 642-31-9
9-anthracene aldehyde

: 4-(anthracen-9-yl)-6-(naphthalen-1-yl)-1,6-dihydropyrimidine-2-amine

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 50 - 60℃; Sonication; Green chemistry;	98%

...Expand

: 1679-39-6
3-chloro-2-methylpent-2-enal

: 50-01-1
guanidine hydrochloride

: 35733-54-1
4-ethyl-5-methylpyrimidin-2-amine

Conditions

Conditions	Yield
With potassium carbonate In methanol Reflux;	98%

: 78089-99-3
(E)-3-dimethylamino-1-(4-nitrophenyl)-2-propen-1-one

: 50-01-1
guanidine hydrochloride

: 99361-84-9
2-amino-4-(p-nitrophenyl)pyrimidine

Conditions

Conditions	Yield
Stage #1: guanidine hydrochloride With potassium carbonate In ethanol at 20℃; for 0.666667h; Stage #2: (E)-3-dimethylamino-1-(4-nitrophenyl)-2-propen-1-one In ethanol at 80℃; for 20h;	97.3%
Stage #1: guanidine hydrochloride With sodium hydroxide In ethanol for 0.5h; Stage #2: (E)-3-dimethylamino-1-(4-nitrophenyl)-2-propen-1-one In ethanol at 40℃; for 12h;	57%

: (E)-3-(dimethylamino)-1-(6-(3-nitrophenyl)-2,3-dihydroimidazo[2,1-b]thiazol-5-yl)prop-2-en-1-one

: 50-01-1
guanidine hydrochloride

: 4-(6-(3-nitrophenyl)-2,3-dihydroimidazo[2,1-b]thiazol-5-yl)pyrimidin-2-amine

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃;	97.2%

: 50-01-1
guanidine hydrochloride

: 134373-03-8
tert-butyl 4-<5,5-dicyano-4-(dimethoxymethyl)pentyl>benzoate

: 134373-08-3
tert-butyl 4-<4-(2,4,6-triaminopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol for 2h; Heating;	97%

GUANIDINE HYDROCHLORIDE Chemical Properties

Product Name: Guanidine hydrochloride (50-01-1)

Molecular Formula: CH₆ClN₃
Molecular Weight: 95.53g/mol
Mol File: 50-01-1.mol
Einecs: 200-002-3
Melting Point: 180-185 °C(lit.)
Boiling point: 132.9 °C at 760 mmHg
Storage Temperature: Store at RT.
Flash Point: 34.2 °C
Density: 1.18 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.465
Water Solubility: 2280 g/L (20 ºC)
Sensitive: Hygroscopic
Product Categories: Pharmaceutical Intermediates; Miscellaneous Biochemicals
Synonyms of Guanidine hydrochloride (50-01-1): guanidine,monohydrochloride ; guanidinechloride ; guanidinemonohydrochloride ; guanidiniumhydrochloride ; usafek-749 ; carbamidine hydrochloride ; iminourea hydrochloride ; guanidinium chloride .

GUANIDINE HYDROCHLORIDE Uses

Guanidine hydrochloride (50-01-1) is mainly used as a drug intermediate, is to create sulfadiazine, sulfa-methyl pyrimidine, sulfamethazine and folic acid an important raw material. It also can be used as medicine, pesticide, dyes and other organic synthesis intermediates. Can be used to synthesis of 2 - amino-pyrimidine, 2 - amino -6 - methyl-pyrimidine, 2 - amino -4,6 - dimethyl-pyrimidine, is to create sulfadiazine, sulfa-methyl pyrimidine, sulfamethazine and other sulfa drugs, intermediates. Guanidine (or guanidine nitrate) and ethyl cyanoacetate reaction, cyclization of 2,4 - 2-amino -6 - hydroxy-pyrimidine, folic acid used for synthesis of anti-anemia drugs. Also be used as synthetic anti-static agent.

GUANIDINE HYDROCHLORIDE Production

Double cyanide-ammonia and ammonium salt (ammonium chloride) as raw materials in the 170-230 ℃ melt under the reaction of guanidine hydrochloride were crude, after refining was finished.

GUANIDINE HYDROCHLORIDE Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.
guinea pig	LDLo	intraarterial	500mg/kg (500mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig	LDLo	intravenous	500mg/kg (500mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig	LDLo	subcutaneous	100mg/kg (100mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.
mammal (species unspecified)	LDLo	oral	300mg/kg (300mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Industrial Hygiene. Vol. 13, Pg. 87, 1931.
mouse	LD50	intraperitoneal	500mg/kg (500mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	oral	571mg/kg (571mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: IRRITABILITY	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 598, 1993.
rabbit	LD	skin	> 2gm/kg (2000mg/kg)		Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 596, 1993.
rat	LD50	oral	475mg/kg (475mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	National Technical Information Service. Vol. AD-A165-747,
rat	LDLo	subcutaneous	404mg/kg (404mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 28, Pg. 251, 1926.

GUANIDINE HYDROCHLORIDE Safety Profile

Safety Information of Guanidine hydrochloride (50-01-1):
Hazard Codes: Xn,Xi
Risk Statements: 22-36/38
22: Harmful if swallowed
36: Irritating to the eyes
38: Irritating to the skin
Safety Statements: 26-36-22
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing

Product Name

Guanidine hydrochloride

Synthetic route

GUANIDINE HYDROCHLORIDE Chemical Properties

GUANIDINE HYDROCHLORIDE Uses

GUANIDINE HYDROCHLORIDE Production

GUANIDINE HYDROCHLORIDE Toxicity Data With Reference

GUANIDINE HYDROCHLORIDE Safety Profile

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