Histamine supplier | CasNO.51-45-6

Name
Histamine
EINECS 200-100-6
CAS No. 51-45-6
Article Data64
CAS DataBase
Density 1.14 g/cm³
Solubility Soluble in water, alcohol, and hot chloroform.
Melting Point 83-84 °C(lit.)
Formula C₅H₉N₃
Boiling Point 331 °C at 760 mmHg
Molecular Weight 111.147
Flash Point 180.3 °C
Transport Information UN 2811 6.1/PG 3
Appearance White to slightly yellow powder
Safety 22-26-36/37
Risk Codes 22-36/37/38-42/43
Molecular Structure
Hazard Symbols Xn
Synonyms 1H-Imidazole-4-ethanamine(9CI);Histamine (8CI);2-(1H-Imidazol-4-yl)ethanamine;2-(1H-Imidazol-5-yl)ethanamine;2-(3H-Imidazol-4-yl)ethylamine;2-(4-Imidazolyl)ethanamine;4-(2-Aminoethyl)imidazole;5-Imidazoleethylamine;Eramin;Ergamine;Ergotidine;Imidazole-4-ethylamine;NSC 33792;b-Imidazolyl-4-ethylamine;
PSA 54.70000
LogP 0.61120

Synthetic route

: 18502-05-1
4-cyanomethylimidazole

: 51-45-6
histamine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 60℃; for 1h; Autoclave; Industrial scale;	66%
With ammonia; nickel

: 13518-55-3
4-(2-chloroethyl)-1H-imidazole

: 51-45-6
histamine

Conditions

Conditions	Yield
With ethanol; ammonia

: 66348-61-6
monocloridrato di 2-(2-tiono-4-imidazolin-4-il)etilamina

: 51-45-6
histamine

Conditions

Conditions	Yield
With water; iron(III) chloride

: 71-00-1
D,L-histidine

: 51-45-6
histamine

Conditions

Conditions	Yield
bei der Zersetzung durch Bakterien der Coli-Typhus-Gruppe;
bei der Zersetzung durch Bakterien der Coli-Typhus-Gruppe in saurem Medium und bei Gegenwart von kohlenstoff- und stickstoffliefernden Substanzen;
Bakterielle Bildung bei der Faeulnis von Sojabohnen zurueckzufuehren;

: 71-00-1
L-histidine

A: 51-45-6
histamine

B: 4998-57-6
His

Conditions

Conditions	Yield
With sulfuric acid at 240 - 250℃;

: 5354-94-9
N-benzoyl-L-histidine

: 51-45-6
histamine

Conditions

Conditions	Yield
at 240℃; unter vermindertem Druck; Behandeln des Reaktionsprodukts mit konz. Salzsaeure bei 180gradC;
at 240℃; im Vakuum und Behandeln des Reaktionsprodukts mit konz.Salzsaeure bei 180grad;

: 65465-66-9
1-acetoxy-4N-phthalimidobutan-2-one

: 3473-63-0
formamidine acetic acid

: 51-45-6
histamine

Conditions

Conditions	Yield
Multistep reaction;

: 117308-63-1
Anguibactin

A: 51-45-6
histamine

B: 303-38-8
2,3-Dihydroxybenzoic acid

C: 98135-21-8
Dehydrocystine

Conditions

Conditions	Yield
With hydrogenchloride at 100℃; for 24h;

...Expand

: 2-(1H-Imidazol-4-yl)-ethylamine

: 51-45-6
histamine

Conditions

Conditions	Yield
With tri-n-propylamine In gas at 69.9℃; Thermodynamic data; δΔGH+(g), var. bases;

4(resp. 5)-cyanomethyl-imidazole: 4(resp. 5)-cyanomethyl-imidazole

: 51-45-6
histamine

Conditions

Conditions	Yield
With ethanol; sodium

: 7647-01-0
hydrogenchloride

: 71-00-1
L-histidine

: 51-45-6
histamine

Conditions

Conditions	Yield
at 265 - 270℃;

: 7664-93-9
sulfuric acid

: 71-00-1
L-histidine

: 51-45-6
histamine

Conditions

Conditions	Yield
at 265 - 270℃;

: 56-23-5
tetrachloromethane

: 7732-18-5
water

: 71-00-1
L-histidine

: 51-45-6
histamine

Conditions

Conditions	Yield
mit UV-Licht;

...Expand

: 71-00-1
L-histidine

alkaline medium: alkaline medium

: 51-45-6
histamine

Conditions

Conditions	Yield
durch Faeulnisbakterien;
durch Faeulnisbakterien;

: 71-00-1
L-histidine

neutral medium: neutral medium

: 51-45-6
histamine

Conditions

Conditions	Yield
durch Faeulnisbakterien;
durch Faeulnisbakterien;

: 71-00-1
L-histidine

: 50-81-7
ascorbic acid

oxygen: oxygen

: 51-45-6
histamine

...Expand

: 71-00-1
L-histidine

potassium disulfate: potassium disulfate

: 51-45-6
histamine

Conditions

Conditions	Yield
at 265 - 270℃;

: 71-00-1
L-histidine

weak acidic medium: weak acidic medium

: 51-45-6
histamine

Conditions

Conditions	Yield
durch Faeulnisbakterien;
durch Faeulnisbakterien;

: 71-00-1
L-histidine

alkaline medium: alkaline medium

A: 51-45-6
histamine

B β--propionic acid: β--propionic acid

Conditions

Conditions	Yield
durch Faeulnisbakterien;

...Expand

: 71-00-1
L-histidine

neutral medium: neutral medium

A: 51-45-6
histamine

B β--propionic acid: β--propionic acid

Conditions

Conditions	Yield
durch Faeulnisbakterien;

...Expand

: 71-00-1
L-histidine

weak acidic medium: weak acidic medium

A: 51-45-6
histamine

B β--propionic acid: β--propionic acid

Conditions

Conditions	Yield
durch Faeulnisbakterien;

...Expand

: 7664-93-9
sulfuric acid

: 71-00-1
L-histidine

A: 51-45-6
histamine

B: 71-00-1
D,L-histidine

Conditions

Conditions	Yield
at 240 - 250℃;

...Expand

: 7732-18-5
water

: 66348-61-6
monocloridrato di 2-(2-tiono-4-imidazolin-4-il)etilamina

: 7705-08-0
iron(III) chloride

: 51-45-6
histamine

...Expand

: 56-92-8
histamine dichloride

: 51-45-6
histamine

Conditions

Conditions	Yield
With sodium hydroxide

: 71-00-1
L-histidine

: 51-45-6
histamine

Conditions

Conditions	Yield
With Enterobacter aerogenes DL-1 histidine decarboxylase In aq. phosphate buffer at 40℃; pH=6.8; Kinetics; Concentration; Enzymatic reaction;
Multi-step reaction with 2 steps 1: trichloroisocyanuric acid; sodium hydroxide / water / 0.5 h / 20 °C / Industrial scale 2: hydrazine hydrate / ethanol / 1 h / 60 °C / Autoclave; Industrial scale View Scheme
With copper(I) bromide at 100 - 110℃; for 10h; Inert atmosphere; Darkness;
With pyridoxal 5'-phosphate; C179S/C417S double mutant of histidine decarboxylase from human In aq. phosphate buffer at 37℃; for 0.0833333h; pH=6.5; Kinetics; Reagent/catalyst; Enzymatic reaction;

: 645-14-7
4-imidazole acetaldehyde

: 51-45-6
histamine

Conditions

Conditions	Yield
With histamine dehydrogenase from Rhizobium species Enzymatic reaction;

: 71-00-1
L-histidine

: 51-45-6
histamine

Conditions

Conditions	Yield
In methanol; water at 150℃; for 1.5h; Sealed tube;

: 51-45-6
histamine

: 3680-02-2
methyl ethenyl sulphone

: N-<2-(4-imidazolyl)ethyl>-N-<2-(methylsulfonyl)ethyl>amine

Conditions

Conditions	Yield
In methanol for 4h; Ambient temperature;	100%

: 51-45-6
histamine

: 7612-98-8
4-N,N-dimethylamino-azobenzene-4'-isothiocyanate

: 1-[4-(4-dimethylamino-phenylazo)-phenyl]-3-[2-(1H-imidazol-4-yl)-ethyl]-thiourea

Conditions

Conditions	Yield
With sodium hydrogencarbonate In acetone for 0.166667h; Heating;	100%
With sodium hydrogencarbonate In acetone at 30 - 100℃; Kinetics; Product distribution;

: 51-45-6
histamine

: 407-25-0
trifluoroacetic anhydride

: 50580-77-3
2,2,2-trifluoro-N-[2-(1H-imidazol-4-yl)ethyl]acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%

: 51-45-6
histamine

: 15980-68-4
8-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepine-11-thione

: (8-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-[2-(3H-imidazol-4-yl)-ethyl]-amine

Conditions

Conditions	Yield
In 2-ethoxy-ethanol; hexane; dichloromethane; ethyl acetate	99.2%

: 51-45-6
histamine

: 27074-18-6
bis(β-isocyanatoethyl)disulfide

: bis-2-(4-imidazolyl)ethylcarbamidoethyl disulfide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 24h;	99%

: 51-45-6
histamine

: 1374765-29-3
2-phenyl-4-(adamantane-2'-spiro)-oxazolin-5-one

: 1374765-36-2
N-[(2-benzoylamino-adamantan-2-yl)carbonyl]-2-(imidazol-4-yl)-ethylamine

Conditions

Conditions	Yield
In acetonitrile at 60℃; for 0.116667h;	99%
In tetrahydrofuran; dichloromethane at 100℃; Flow reactor;	0.390 g

: 23911-26-4
diethylenetriaminepentaacetic dianhydride

: 51-45-6
histamine

: {bis-[2-(carboxymethyl-{[2-(1H-imidazol-4-yl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-acetic acid

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 6h; Acylation; addition;	95%

: 1070802-08-2
(Z)-5-[(methylthio)(4-methylphenylamino)methylidene]-1-(4-methoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

: 51-45-6
histamine

: C24H24N6O4

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 0.05h; Heating;	95%

: 1003-10-7
Thiobutyrolactone

: 51-45-6
histamine

: N-(2-(1H-imidazol-4-yl)ethyl)-4-mercaptobutanamide

Conditions

Conditions	Yield
In acetonitrile at 95℃;	95%

: 51-45-6
histamine

: 10381-82-5
8-bromocaffeine

: 8-(2-(1H-imidazol-4-yl)ethylamino)caffeine

Conditions

Conditions	Yield
In ethanol for 55h; Reflux;	95%

: 51-45-6
histamine

: 1338051-00-5
ethyl 4-amino-7-(pyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxylate

: 1338048-85-3
4-amino-N-(2-(1H-imidazol-4-yl)ethyl)-7-(4-pyridinyl)pyrrolo[2,1-f][1,2,4]triazine-5-carboxamide

Conditions

Conditions	Yield
at 100℃; for 2.5h; Inert atmosphere;	94%

: 51-45-6
histamine

: 1417818-92-8
4-((E)-2-(dimethylamino)vinyl)-5,5-dimethyl-2-oxo-2,5-dihydrofuran-3-carbonitrile

: 1417819-07-8
4-(2-(1H-imidazol-4-yl)ethylamino)-1,1-dimethylfuro[3,4-c]pyridin-3(1H)-one

Conditions

Conditions	Yield
Heating;	94%

: 51-45-6
histamine

: 187996-52-7
N-tert-butoxycarbonyl-γ-aminobutyric acid pentafluorophenyl ester

: 187996-53-8
N-tert-butoxycarbonyl-γ-aminobutyrylhistamine

Conditions

Conditions	Yield
	93%
In N,N-dimethyl-formamide a) 20 deg C, 1 h, b) 0 deg C, 24 h;	92.47%

: C50H74N2O6Si

: 51-45-6
histamine

: C55H81N5O5Si

Conditions

Conditions	Yield
Stage #1: C50H74N2O6Si With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 0.0833333h; Stage #2: histamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h;	93%

: 111-83-1
1-bromo-octane

: 51-45-6
histamine

: C13H26N3(1+)*Br(1-)

Conditions

Conditions	Yield
In isopropyl alcohol at 70℃; for 19h;	93%

: 632-79-1
Tetrabromophthalic anhydride

: 51-45-6
histamine

: 4,5,6,7-tetrabromo-2-[2-(1H-imidazol-4-yl)-ethyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
In toluene for 5h; Heating;	92%
In toluene Condensation; Heating;
In toluene for 3h; Condensation; Heating; Dean-Stark conditions;

: 51-45-6
histamine

: 7185-96-8
anthracen-9-yl isothiocyanate

: 1-anthracen-9-yl-3-[2-(1H-imidazol-4-yl)-ethyl]-thiourea

Conditions

Conditions	Yield
In chloroform Heating;	92%

: 51-45-6
histamine

: 1397-89-3
AmBisome

: amphotericin B N-histaminamide

Conditions

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl acetamide at 20℃; for 12h; Inert atmosphere; Darkness;	92%

: 51-45-6
histamine

: 622-58-2
p-Tolylisocyanate

: 1-[2-(1H-imidazol-4-yl)ethyl]-3-(4-methylphenyl)urea

Conditions

Conditions	Yield
In chloroform for 20h; Inert atmosphere; Reflux;	92%

: 51-45-6
histamine

: 13750-81-7
N-methyl-2-imidazolcarboxaldehyde

: N-[2-(1H-imidazol-4-yl)ethyl]-N-[(E)-(1-methyl-1Himidazol-2-yl)methylidene]amine

Conditions

Conditions	Yield
In ethanol for 4h; Reflux;	92%

: 1943-82-4
phenethyl isocyanate

: 51-45-6
histamine

: 1-[2-(1H-Imidazol-4-yl)-ethyl]-3-phenethyl-urea

Conditions

Conditions	Yield
In pyridine for 3h; Ambient temperature;	91%

Histamine Chemical Properties

Molecular Structure:

Molecular Formula: C₅H₉N₃
Molecular Weight: 111.1451
IUPAC Name: 2-(1H-Imidazol-5-yl)ethanamine
Synonyms of Histamine (CAS NO.51-45-6): Histamine [USAN] ; 1H-Imidazole-4-ethanamine ; 2-(4-Imidazolyl)ethylamine ; 4-(2-Aminoethyl)-1H-imidazole ; 5-Imidazoleethylamine ; CCRIS 6535 ; EINECS 200-100-6 ; Eramin ; Ergamine ; Ergotidine ; Ethylamine, 2-imidazol-4-yl- ; Free histamine ; HSDB 3338 ; Imidazole, 4-(2-aminoethyl)- ; Imidazole-4-ethylamine ; Istamina ; Istamina [Italian] ; NSC 33792 ; Theramine ; UNII-820484N8I3 ; beta-Aminoethylglyoxaline ; beta-Aminoethylimidazole ; beta-Imidazolyl-4-ethylamine ; 1H-Imidazole-5-ethanamine ; 2-Imidazol-4-ylethylamine
CAS NO: 51-45-6
Classification Code: Histamine Agents ; Histamine Agonists ; Mutation data ; Natural Product ; Neurotransmitter Agents ; Reproductive Effect
Melting point: 83-84 °C
Index of Refraction: 1.567
Molar Refractivity: 31.86 cm³
Molar Volume: 97.4 cm³
Surface Tension: 56 dyne/cm
Density: 1.14 g/cm³
Flash Point: 180.3 °C
Enthalpy of Vaporization: 57.36 kJ/mol
Boiling Point: 331 °C at 760 mmHg
Vapour Pressure: 0.00016 mmHg at 25 °C

Histamine Production

Histamine (CAS NO.51-45-6) is derived from the decarboxylation of the amino acid histidine, a reaction catalyzed by the enzyme L-histidine decarboxylase.

Histamine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	subcutaneous	34mg/kg (34mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937.
dog	LD50	intravenous	7mg/kg (7mg/kg)	CARDIAC: OTHER CHANGES	Indian Veterinary Journal. Vol. 57, Pg. 31, 1980.
dog	LDLo	subcutaneous	28500ug/kg (28.5mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.
frog	LDLo	subcutaneous	1700mg/kg (1700mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.
guinea pig	LD50	intraperitoneal	5mg/kg (5mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 736, 1948.
guinea pig	LD50	intravenous	180ug/kg (0.18mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 45, 1949.
guinea pig	LDLo	oral	200mg/kg (200mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.
guinea pig	LDLo	subcutaneous	8mg/kg (8mg/kg)		Farmaco, Edizione Scientifica. Vol. 9, Pg. 379, 1954.
monkey	LDLo	intravenous	50mg/kg (50mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.
mouse	LD50	intraperitoneal	725mg/kg (725mg/kg)		British Journal of Pharmacology and Chemotherapy. Vol. 17, Pg. 137, 1961.
mouse	LD50	intravenous	385mg/kg (385mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.
mouse	LD50	oral	220mg/kg (220mg/kg)		Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.
mouse	LD50	subcutaneous	2500mg/kg (2500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.
rabbit	LDLo	intravenous	2mg/kg (2mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 784, 1948.
rabbit	LDLo	subcutaneous	12mg/kg (12mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.
rat	LD50	intravenous	630mg/kg (630mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.
rat	LDLo	subcutaneous	250mg/kg (250mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937.

Histamine Safety Profile

Hazard Codes of Histamine (CAS NO.51-45-6): Harmful Xn
Risk Statements: 22-36/37/38-42/43
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 22-26-36/37
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MS1050000
F: 3-10-23
HazardClass: 6.1(b)
PackingGroup: III

Product Name

Histamine

Synthetic route

Histamine Chemical Properties

Histamine Production

Histamine Toxicity Data With Reference

Histamine Safety Profile

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