Conditions | Yield |
---|---|
With sodium hydroxide In acetic acid byproducts: Na2CO3; redn. in presence of Zn dust than reflux with NaOH for 8-10 h; cooling; react. with H2SO4; | A n/a B 90% |
With sodium hydroxide In acetic acid byproducts: Na2CO3; redn. in presence of Zn dust than reflux with NaOH for 8-10 h; cooling; react. with H2SO4; | A n/a B 90% |
1,4-dihydro-1,2,4,5-tetrazine-3,6-dicarboxylic acid
A
hydrazinium sulfate
B
hydrazine
Conditions | Yield |
---|---|
With sulfuric acid In water byproducts: CO2; heating; isolation with benzaldehyde, distn. with steam; |
Conditions | Yield |
---|---|
With H2SO4; [MoCl(O)(1,2-bis(diphenylphosphino)ethane)]Cl In methanol other Radiation; γ-radiation of soln. of Mo-complex in MeOH and H2SO4 (under const. satn. of N2); |
sulfuric acid
hydrazinium sulfate
Conditions | Yield |
---|---|
With OC(NH)2(NH)2CO byproducts: CO2; dissolving paraunazine at 80°C in concd. H2SO4; 95-130°C, evaluation of CO2; | |
With OC(NH)2(NH)2CO byproducts: CO2; dissolving paraunazine at 80°C in concd. H2SO4; 95-130°C, evaluation of CO2; |
Conditions | Yield |
---|---|
With sodium hydroxide; chlorine In water addition of Cl2 to NaOH soln.; adding saturated NH3 soln. and gelatine; evapn. to half volume; addition of H2SO4 to cooled soln.; precipitn. with alcohol; | |
With NaClO; NaOH In water in presence of gelatine, addn. of H2SO4 in ice cooled soln.; recrystn. from boiling water; | 34-37 |
With NaOH; Cl2 In water addition of Cl2 to NaOH soln.; adding saturated NH3 soln. and gelatine; evapn. to half volume; addition of H2SO4 to cooled soln.; precipitn. with alcohol; | |
With sodium hydroxide; sodium hypochlorite In water in presence of gelatine, addn. of H2SO4 in ice cooled soln.; recrystn. from boiling water; | 34-37 |
Conditions | Yield |
---|---|
1:1 molar ratio of educs reacted as described by K. C. Patil, R. Soundararajan, and V. R. Pai Verneker, Proc. Indian Acad. Sci., Sect. A, 1978,87, 281; 1979, 88, 211; K. C. Patil, R. Soundrarajan, and V. R. Verneker, Inorg. Chem., 1979, 18, 1969 et. al; elem. anal.; |
monofluorourea
sulfuric acid
B
fluoroammonium ion
C
hydrazinium sulfate
Conditions | Yield |
---|---|
In not given ratio of decompn. products depends on the temp. and concn. of H2SO4; |
Conditions | Yield |
---|---|
at 302 °C dec. to give Mg(N2H4)SO4 and N2H6SO4, at 504 °Cproceed further endothermic dec.; |
Conditions | Yield |
---|---|
With NaOH; NaCl In water Kinetics; byproducts: NH3, N2O; hydrazine soln. contg. buffer and solid Fe complex mixed at 25.0°C, pH 6-10, ionic strength 0.1 M (NaCl); not isolated; monitored spectrophotometrically; | 95% |
hydrazinium sulfate
Conditions | Yield |
---|---|
In water at 60℃; for 1h; | 90% |
sodium hydrogencarbonate
hydrazinium sulfate
A
sodium nitrate
C
hydrazine nitrate
Conditions | Yield |
---|---|
In water BaSO4 filtered off; neutralization; evapn. of filtrate at 40°C; drying over P2O5; N2H5NO3 sepd. from NaNO3 by melting (100-110°C) and extn. with MeOH; | A n/a B n/a C 87% |
In water BaSO4 filtered off; neutralization; evapn. of filtrate at 40°C; drying over P2O5; N2H5NO3 sepd. from NaNO3 by melting (100-110°C) and extn. with MeOH; | A n/a B n/a C 87% |
hydrazine hydrate
hydrazinium sulfate
Conditions | Yield |
---|---|
In water mixt. of Ba-salt, N2H6SO4 and N2H4*H2O was stirred in water for 30 min under N2; filtered, allowed to crystd. overnight; elem. anal.; | 87% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 40℃; for 90h; Inert atmosphere; Glovebox; | 87% |
Conditions | Yield |
---|---|
With Na2CO3 In ethanol; water | 85% |
cis-aconitic anhydride
hydrazinium sulfate
(3,6-dioxo-1,2,3,6-tetrahydro-pyridazin-4-yl)-acetic acid
Conditions | Yield |
---|---|
In water | 82% |
Conditions | Yield |
---|---|
In 1,4-dioxane at 30℃; for 48h; Inert atmosphere; Glovebox; | 80.3% |
hydrazinium sulfate
hydrazine
Conditions | Yield |
---|---|
In neat (no solvent) mixt. of Ba-salt, N2H6SO4, N2H4 was stirred for 4 h under N2; filtered, stored at 5°C overnight; elem. anal.; | 76% |
Conditions | Yield |
---|---|
In ethanol; water | 70% |
In ethanol; water | 70% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 40℃; for 80h; Inert atmosphere; Glovebox; | 69.9% |
In tetrahydrofuran at room temp., 24h, filtration, evapn.;; | 47% |
In diethyl ether at room temp., 24h, filtration, evapn.;; | 47% |
oxygen
hydrazinium sulfate
A
nitrogen
B
water
C
dihydrogen peroxide
Conditions | Yield |
---|---|
With catalyst: brominated Pd/Al2O3 In further solvent(s) Kinetics; O2 reduced with hydrazine sulfate over halogenated Pd/Al2O3 catalyst at 25°C for 0.5 h in aq.H3PO4; | A n/a B n/a C 68% |
With catalyst:Pd/Al2O3; KF or KCl or KI or KBr In water Kinetics; O2 reduced with hydrazine sulfate over Pd/C catalyst at 25°C in H2O with or without KF, KBr, KCl, or KI for 0.5 h; | A n/a B n/a C 0% |
With catalyst: halogenated Pd/Al2O3 In water Kinetics; O2 reduced with hydrazine sulfate over halogenated Pd/Al2O3 catalyst at 25°C in H2O for 0.5 h; | A n/a B n/a C 0% |
With catalyst: halogenated Pd/Ga2O3 In water Kinetics; O2 reduced with hydrazine sulfate over halogenated Pd/Ga2O3 catalyst at 25°C in H2O for 0.5 h; | A n/a B n/a C 0% |
Conditions | Yield |
---|---|
Stage #1: sodium metavanadate; water; sodium hydroxide at 85 - 90℃; for 0.5h; pH=8.5; Stage #2: hydrazinium sulfate for 1.25h; Inert atmosphere; Sealed tube; Stage #3: sodium chloride for 24h; | 67% |
tetraethylammonium Pt(pyridine)Cl5
hydrazinium sulfate
tetraethylammonium Pt(pyridine)Cl3
Conditions | Yield |
---|---|
In water byproducts: N2; heating with stirring (70-80°C, 5-10 min), addn. of H2O; filtn. (hot), pptn. on cooling, filtn., washing (H2O), drying (air); elem. anal.; | 66% |
Conditions | Yield |
---|---|
Stage #1: sodium metavanadate; water; sodium hydroxide at 85 - 90℃; for 0.5h; pH=8.47; Stage #2: hydrazinium sulfate for 1.25h; Inert atmosphere; Sealed tube; | 63% |
lithium hydroxide monohydrate
hydrazinium sulfate
Conditions | Yield |
---|---|
In water addn. of aq. LiOH*H2O to aq. V2O5 at 84-86°C, addn. of hydrazinium sulfate, further heating (10 min), diln. with H2O, addn. of FeCl2*4H2O, heating 3-7 h; standing (stoppered flask, room temp., 12 h), filtration, washing (cold H2O), drying in air at room temp.; | 56% |
Conditions | Yield |
---|---|
In water Ar atmosphere; addn. of hydrazine sulfate to hot soln. of Os-complex, pptn. on evapn.; filtration, washing (water), drying (vac., over P2O5); elem. anal.; | 55% |
hydrazinium sulfate
Conditions | Yield |
---|---|
In water aq. soln. of hydrazine and Co satlt was heated at 93°C for 10 min; quickly mixed with hot aq. NaN3; kept at 93°C for 10 min; cooled to room temp. at rate 5°C/min; filtered; washed (H2O, EtOH); dried (vac.); elem. anal.; | 52% |
Conditions | Yield |
---|---|
Stage #1: ammonium molybdate tetrahydrate; ammonium acetate; water; hydrazinium sulfate for 0.166667h; Stage #2: acetic acid at 22℃; | 52% |
(5-bromo-10,15,20-triphenylporphyrinato)nickel(II)
hydrazinium sulfate
5-amino-10,15,20-triphenylporphyrinatonickel(II)
Conditions | Yield |
---|---|
With catalyst: Pd(CH3CO2)2/BINAP/Cs2CO3 In tetrahydrofuran 68°C, 16 h; | 51% |
lithium hydroxide monohydrate
hydrazinium sulfate
Conditions | Yield |
---|---|
In water addn. of aq. LiOH*H2O to aq. V2O5 at 84-86°C, addn. of hydrazinium sulfate, further heating (10 min), diln. with H2O, addn. of CoSO4*6H2O, heating 3-7 h; standing (stoppered flask, room temp., 12 h), filtration, washing (cold H2O), drying in air at room temp.; | 50% |
Conditions | Yield |
---|---|
Stage #1: sodium metavanadate; α-bismuth oxide; water; sodium hydroxide at 85 - 90℃; for 0.5h; Stage #2: hydrazinium sulfate for 0.25h; Stage #3: air for 24h; | 50% |
Conditions | Yield |
---|---|
In diethyl ether at room temp., 24h, filtration, evapn.;; | 47% |
In tetrahydrofuran at room temp., 24h, filtration, evapn.;; | 47% |
In 1,4-dioxane at room temp., 24h, filtration, evapn.;; | 47% |
sodium molybdate dihydrate
sulfuric acid
water
sodium chloride
hydrazinium sulfate
Conditions | Yield |
---|---|
In sulfuric acid; water N2H6SO4 added under stirring to Na2MoO4*2H2O in water acidified with H2SO4; stirred for 30 min; NaCl added; stored in a closed flask for 2 days; filtered off; elem. anal.; | 23% |
sodium molybdate dihydrate
hydrazinium sulfate
Conditions | Yield |
---|---|
With H2SO4 In water soln. of NaVO3 in H2O heated to 80°C, cooled to room temp., addedto aq. soln. of Na2MoO4*2H2O at room temp. pH 7.6, pH adjusted to 1 or 1.4 with H2SO4, treated with N2H6SO4, stirred at room temp. for 2 h, tre ated with KCl, 3 d; elem. anal.; | 20% |
sodium molybdate dihydrate
hydrazinium sulfate
Conditions | Yield |
---|---|
With H2SO4 In water aq. soln. of Na2MoO4*2H2O acidified to pH 1 at room temp. with H2SO4, N2H6SO4 added, stirred for 30 min at room temp., left to crystd. for 3-5 d; | 17% |
Conditions | Yield |
---|---|
Stage #1: 1,10-Phenanthroline; hexaammonium heptamolybdate tetrahydrate; water In ethanol Stage #2: hydrazinium sulfate With sulfuric acid In ethanol at 120℃; for 24h; High pressure; Autoclave; | 16% |
1-phenyl-2-(acrylamidomethyl)-butane-1,3-dione
hydrazinium sulfate
[3-phenyl-4-(acrylamidomethyl)-5-methylpyrazole]
Conditions | Yield |
---|---|
With sodium acetate; acetic acid In water | 80% by weight. |
N,N-dimethyl-formamide
hydrazinium sulfate
The Hydrazine sulfate (1:1) is an organic compound with the formula H4N2.H2SO4. The IUPAC name of this chemical is hydrazine; sulfuric acid. With the CAS registry number 10034-93-2, it is also named as Diamidogen sulfate. The product's categories are Pharmaceutical Intermediates; Inorganics; ACS GradeOrganic Building Blocks; Essential Chemicals; Hydrazines; Nitrogen Compounds; Routine Reagents; Organic Building Blocks; Analytical Reagents for General Use; E-L, Puriss p.a. ACS; Puriss p.a. ACS. Besides, it is colourless crystal or white powder, which should be stored in a closed dry and well-ventilated place.
Physical properties about Hydrazine sulfate (1:1) are: (1)ACD/LogP: -1.03; (2)ACD/LogD (pH 5.5): -5.53; (3)ACD/LogD (pH 7.4): -5.53; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)#H bond acceptors: 4; (7)#H bond donors: 2; (8)Polar Surface Area: 60.98 Å2; (9)Enthalpy of Vaporization: 62.94 kJ/mol; (10)Boiling Point: 330 °C at 760 mmHg; (11)Vapour Pressure: 3.35E-05 mmHg at 25°C.
Preparation: this chemical can be prepared by urea, sodium hypochlorite, caustic soda. This reaction will need reagent sulfuric acid, catalyst potassium permanganate.
Uses of Hydrazine sulfate (1:1): it is a chemical compound that has been used as an alternative medical treatment for the loss of appetite (anorexia) and weight loss (cachexia) which is often associated with cancer. It has never been approved as a mainstream drug, although it is approved for use in clinical trials by the U.S. Food and Drug Administration (FDA) and is marketed in the United States as a dietary supplement. It is also sold over the internet by websites that promote its use as a cancer therapy. It is used in palliative care for terminal cancer patients in Russia and other countries of the former Soviet Union.
When you are using this chemical, please be cautious about it as the following:
It is toxic by inhalation, in contact with skin and if swallowed and very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible). Besides, this chemical may cause sensitisation by skin contact and may cause cancer. Please avoid exposure - obtain special instructions before use. When you are using it, avoid release to the environment. Refer to special instructions/safety data sheet. This material and its container must be disposed of as hazardous waste.
You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)(O)O.NN
(2)InChI: InChI=1/H4N2.H2O4S/c1-2;1-5(2,3)4/h1-2H2;(H2,1,2,3,4)
(3)InChIKey: ZGCHATBSUIJLRL-UHFFFAOYAL
(4)Std. InChI: InChI=1S/H4N2.H2O4S/c1-2;1-5(2,3)4/h1-2H2;(H2,1,2,3,4)
(5)Std. InChIKey: ZGCHATBSUIJLRL-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | oral | 100mg/kg (100mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
human | TDLo | oral | 201mg/kg/8D (201mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING | Cancer Chemotherapy Reports, Part 1. Vol. 59, Pg. 1151, 1975. |
mammal (species unspecified) | LC | inhalation | > 6400ug/m3 (6.4mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984. | |
mouse | LD50 | intraperitoneal | 152mg/kg (152mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Archives of Environmental Health. Vol. 17, Pg. 315, 1968. |
mouse | LD50 | oral | 434mg/kg (434mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984. | |
mouse | LD50 | subcutaneous | 455mg/kg (455mg/kg) | Acta Biologica et Medica Germanica. Vol. 21, Pg. 635, 1968. | |
rabbit | LDLo | oral | 100mg/kg (100mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
rat | LD50 | intraperitoneal | 230mg/kg (230mg/kg) | Russian Pharmacology and Toxicology Vol. 41, Pg. 74, 1978. | |
rat | LD50 | oral | 601mg/kg (601mg/kg) | "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 15, 1972. |
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