Iminodiacetonitrile supplier

Name
Iminodiacetonitrile
EINECS 211-058-3
CAS No. 628-87-5
Article Data28
CAS DataBase
Density 1.054 g/cm³
Solubility Soluble in water, acetone and hot methanol.
Melting Point 69-71 °C(lit.)
Formula C₄H₅N₃
Boiling Point 337.5 °C at 760 mmHg
Molecular Weight 95.1038
Flash Point 157.9 °C
Transport Information
Appearance tan to dark brown crystalline powder, crystals
Safety 26-37/39-36/37
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Acetonitrile,iminodi- (6CI,7CI,8CI);1,1'-Imidodiacetonitrile;NSC 263496;
PSA 59.61000
LogP 0.01406

Synthetic route

: 4560-87-6
1,3,5-tris(cyanomethyl)hexahydro-1,3,5-triazine

: 106491-24-1
desaminomethylporphobilinogendinitrile

A: uroporphyrinogenoctanitrile

B: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With Montmorillonite K10 In acetonitrile at 180℃; for 0.5h;	A 80% B n/a

...Expand

: 21954-96-1
2,2′-iminobis(acetamide)

: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With phosphorus pentoxide under 15.0015 - 37.5038 Torr; for 1h; Temperature; Heating;	79%
under 15.0015 - 37.5038 Torr; for 1h; Temperature; Heating;

: 2478-50-4
2-aminopentanedinitrile

: 540-61-4
2-aminoacetonitrile

A: 959051-09-3
rac-N2-(Cyanmethyl)glutamindinitril

B: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
at 80℃; for 16h; Yields of byproduct given;	A 75% B n/a

...Expand

: 74-90-8
hydrogen cyanide

: 109-82-0
methyleneaminoacetonitrile

: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With sulfuric acid In methanol at 60℃; for 3h;	52%
With hydrogenchloride

: 107-16-4
glycolonitrile

: 540-61-4
2-aminoacetonitrile

: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
In ethanol reflux, 2.5 h; -20 deg C, 10 h;	30%
With phosphoric acid

: 33898-53-2
2-cyanoaziridine

A: 593-75-9, 685498-28-6
methyl isocyanate

B: 59264-17-4
N-(methylimino)acetonitrile

C: 75-05-8
acetonitrile

D: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With 3 A molecular sieve at 370℃; under 0.1 Torr; Product distribution; flash vaccum pyrolysis at variation of temp.;	A 9.5% B 10.5% C 6% D n/a
With 3 A molecular sieve at 370℃; under 0.1 Torr;	A 9.5% B 10.5% C 6% D n/a

...Expand

: 33898-53-2
2-cyanoaziridine

A: 110-61-2
butanedinitrile

B: 19866-98-9
(E/Z)-3-aminoprop-2-enenitrile

C: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With quartz at 630℃; under 0.1 Torr; Product distribution; flash vaccum pyrolysis;	A 3% B 4.8% C 2%
With quartz at 630℃; under 0.1 Torr;	A 3% B 4.8% C 2%

...Expand

: 50-00-0
formaldehyd

: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With ammonia; water beim folgenden Behandeln mit HCN und wss.HCl;

: 74-90-8
hydrogen cyanide

: 100-97-0
hexamethylenetetramine

: 628-87-5
iminodiacetonitrile

: 100-97-0
hexamethylenetetramine

: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With hydrogen cyanide

: 107-14-2
chloroacetonitrile

: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With ammonia

: 107-16-4
glycolonitrile

: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With ammonia

: 74-90-8
hydrogen cyanide

: 540-61-4
2-aminoacetonitrile

: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant; effect of pH;

: 107-14-2
chloroacetonitrile

gaseous NH3: gaseous NH3

: 628-87-5
iminodiacetonitrile

: 540-61-4
2-aminoacetonitrile

: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With ammonia In water at 100℃; for 0.333333h; Product distribution / selectivity;

: 50-00-0
formaldehyd

: 74-90-8
hydrogen cyanide

: 628-87-5
iminodiacetonitrile

Conditions

Conditions	Yield
With hexamethylenetetramine; oxygen at 45℃; for 12h; Time; Temperature;

: iminodiacetic acid hydrochloride

: 628-87-5
iminodiacetonitrile

: 5994-61-6
phosphonomethylimino-di-acetic acid

Conditions

Conditions	Yield
Stage #1: iminodiacetonitrile With sodium hydroxide In water at 100 - 110℃; for 1h; Stage #2: iminodiacetic acid hydrochloride With dihydrogen peroxide; pyrographite at 80 - 100℃; for 0.5h; Stage #3: With formaldehyd; phosphoric acid at 110℃; for 3h; Reagent/catalyst;	98.5%

: 74-90-8
hydrogen cyanide

: 75-07-0
acetaldehyde

: 628-87-5
iminodiacetonitrile

: 185257-07-2
methylglycinenitrile-N,N-diacetonitrile

Conditions

Conditions	Yield
With sulfuric acid In water at 60 - 80℃; for 2.25h; pH=1.2 - 1.8; Product distribution / selectivity;	98%
Stage #1: iminodiacetonitrile With sulfuric acid In water at 60℃; pH=1.8; Stage #2: hydrogen cyanide; acetaldehyde In water at 60 - 80℃; for 2.25h; pH=1.2;
With sulfuric acid In water at 60 - 80℃; for 2.25h; pH=~ 1.2 - 1.8;

...Expand

: 628-87-5
iminodiacetonitrile

A: 110-85-0
piperazine

B: 111-40-0
1,5-diamino-3-azapentane

Conditions

Conditions	Yield
With ammonia; hydrogen; potassium hydroxide In ethanol at 80℃; under 90009 Torr; Pressure; Reagent/catalyst; Solvent; Temperature; Time;	A 1.03% B 97.53%

: 628-87-5
iminodiacetonitrile

: 142-73-4
iminodiacetic acid

Conditions

Conditions	Yield
With sodium hydroxide at 60 - 65℃; for 1h; Time;	97.25%
With water; calcium hydroxide at 25℃; for 5h;	90%
With Alcaligenes faecalis ZJUTBX11 cells encapsulated in alginate-chitosan-alginate membrane liquid core capsules In aq. buffer at 35℃; pH=7.5; Kinetics; Reagent/catalyst; pH-value; Enzymatic reaction;

: 111-30-8
Glutaraldehyde

: 628-87-5
iminodiacetonitrile

: 1,2-propylenebis(D,L-glycinonitrile-N,N-diacetonitrile)

Conditions

Conditions	Yield
With hydrogen isocyanide; sulfuric acid In hydrogen cyanide; water	97%

: 107-06-2
1,2-dichloro-ethane

: 628-87-5
iminodiacetonitrile

: 60-00-4
ethylenediaminetetraacetic acid

Conditions

Conditions	Yield
Stage #1: 1,2-dichloro-ethane; iminodiacetonitrile With calcium oxide In 5,5-dimethyl-1,3-cyclohexadiene at 105 - 115℃; for 9.5h; Large scale; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 9h; Reagent/catalyst; Solvent; Temperature; Large scale;	96.83%

: 107-04-0
1-Bromo-2-chloroethane

: 628-87-5
iminodiacetonitrile

: 60-00-4
ethylenediaminetetraacetic acid

Conditions

Conditions	Yield
Stage #1: 1-Bromo-2-chloroethane; iminodiacetonitrile With calcium oxide In 5,5-dimethyl-1,3-cyclohexadiene at 105 - 115℃; for 9h; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 8.5h;	95.47%

: 628-87-5
iminodiacetonitrile

: 16339-18-7
N-nitroso-bis(cyanomethyl)amine

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite In water at 0 - 30℃; for 2.5h; Temperature;	95%
With sulfuric acid; sodium nitrite In water at 0 - 30℃; for 2.5h;	89%
With sulfuric acid; sodium nitrite

: 50-00-0
formaldehyd

: 628-87-5
iminodiacetonitrile

: 5994-61-6
phosphonomethylimino-di-acetic acid

Conditions

Conditions	Yield
Stage #1: iminodiacetonitrile With sodium hydroxide In water at 45 - 50℃; for 1h; Stage #2: With phosphorus trichloride Stage #3: formaldehyd at 115 - 120℃; for 2h;	93.8%
Stage #1: iminodiacetonitrile With hydrogenchloride; sulfuric acid In water at 80 - 160℃; under 1500.15 - 15001.5 Torr; for 6h; Inert atmosphere; Autoclave; Stage #2: formaldehyd With phosphonic Acid In water for 3h; Pressure; Temperature; Inert atmosphere; Autoclave; Reflux;	90.52%

: 98-88-4
benzoyl chloride

: 628-87-5
iminodiacetonitrile

: 36130-48-0
N,N-bis(cyanomethyl)benzamide

Conditions

Conditions	Yield
With pyridine; triethylamine at 0 - 20℃; for 4.33333h;	93%
With benzene at 110 - 120℃;
With pyridine
With benzene
With potassium carbonate In dichloromethane; water for 2h; Ambient temperature;

: (2R)-2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}propanoyl chloride

: 628-87-5
iminodiacetonitrile

: (2R)-2-{4-[(6-chloro-1,3-benzoxazol-2-yl)oxy]phenoxy}-N,N-bis(cyanomethyl)propanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 35℃;	92%

: 137-07-5
2-amino-benzenethiol

: 628-87-5
iminodiacetonitrile

: 854070-43-2
bis(1,3-benzothiazol-2-ylmethyl)amine

Conditions

Conditions	Yield
With quinoline In 5,5-dimethyl-1,3-cyclohexadiene at 150℃; for 1h;	91%
In ethylene glycol Heating;

: 50-00-0
formaldehyd

: 628-87-5
iminodiacetonitrile

: 5423-24-5
N-methyliminodiacetonitrile

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 20℃; for 1h; pH=2;	89.4%

: 407-25-0
trifluoroacetic anhydride

: 628-87-5
iminodiacetonitrile

: 1182284-06-5
N-(trifluoroacetyl)iminodiacetonitrile

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 24.3333h;	89%

: 628-87-5
iminodiacetonitrile

: 20004-00-6, 76412-51-6
2,2'-imino-bis-acetamide oxime

Conditions

Conditions	Yield
With hydroxylamine In methanol; water at 20℃; for 48h;	88.7%
With hydroxylamine In methanol

: 628-87-5
iminodiacetonitrile

: 20004-00-6, 76412-51-6
2,2'-azanediylbis(N'-hydroxyacetimidamide)

Conditions

Conditions	Yield
With hydroxylamine In methanol; water	88.7%

: 2936-08-5
valproyl chloride

: 628-87-5
iminodiacetonitrile

: 89508-09-8
2-Propyl-pentanoic acid bis-cyanomethyl-amide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water for 2h; Ambient temperature;	86%

: 2719-27-9
cyclohexanylcarbonyl chloride

: 628-87-5
iminodiacetonitrile

: 87693-71-8
Cyclohexanecarboxylic acid bis-cyanomethyl-amide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water for 2h; Ambient temperature;	85%
With potassium carbonate In dichloromethane; water for 2h; Ambient temperature;

: 628-87-5
iminodiacetonitrile

: bis(cyanomethyl)ammonium hexafluorophosphate

Conditions

Conditions	Yield
Stage #1: iminodiacetonitrile With hydrogenchloride In methanol; water at 0℃; Stage #2: With silver(I) hexafluorophosphate In methanol; acetonitrile	81%

: 98-59-9
p-toluenesulfonyl chloride

: 628-87-5
iminodiacetonitrile

: 198954-96-0
N,N-Bis-cyanomethyl-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
With pyridine 1.) 0 deg C, 3 h, 2.) room temperature, 2 h;	78%

: 67-56-1
methanol

: 628-87-5
iminodiacetonitrile

: 2-(Methoxycarbonimidoylmethyl-amino)-acetimidic acid methyl ester; hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether at 0℃; Inert atmosphere;	76%
With hydrogenchloride

: 628-87-5
iminodiacetonitrile

A: α-(cyanomethylamino)acetic acid

B: 142-73-4
iminodiacetic acid

Conditions

Conditions	Yield
With Sphingomonas wittichii nitrilase NIT158; water In aq. phosphate buffer at 37℃; for 24h; pH=7.3; pH-value; Temperature; Solvent; Enzymatic reaction; enantiospecific reaction;	A 73% B n/a

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 628-87-5
iminodiacetonitrile

: 30682-50-9
2,2'-[(4-{[2-(λ2-azanylidene)-2λ3-ethyl](cyanomethyl)amino}-6-chloro-1,3,5-triazin-2-yl)azanediyl]diacetonitrile

Conditions

Conditions	Yield
With benzoyl chloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 20h; Inert atmosphere;	65%

: 189637-25-0
Toluene-4-sulfonic acid 2-(5-methyl-2,4-dioxo-6-phenylsulfanyl-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester

: 628-87-5
iminodiacetonitrile

: {Cyanomethyl-[2-(5-methyl-2,4-dioxo-6-phenylsulfanyl-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl]-amino}-acetonitrile

Conditions

Conditions	Yield
With pyridine for 24h;	58%

: 628-87-5
iminodiacetonitrile

: 21954-96-1
2,2′-iminobis(acetamide)

Conditions

Conditions	Yield
Stage #1: iminodiacetonitrile With hydrogenchloride In isopropyl alcohol at 50℃; for 15h; Stage #2: With ammonium hydroxide In water pH=10;	45%
With sulfuric acid; acetic acid

Iminodiacetonitrile Chemical Properties

Chemical Name: Iminodiacetonitrile
IUPAC NAME: 2-(Cyanomethylamino)acetonitrile
CAS No.: 628-87-5
EINECS: 211-058-3
RTECS: AM0650000
RTECS Class: Drug
Molecular Formula: C₄H₅N₃
Molecular Weight: 95.1 g/mol
Melting Point: 69-71 °C(lit.)
Density: 1.054 g/cm³
Flash Point: 157.9 °C
Boiling Point: 337.5 °C at 760 mmHg
Following is the structure of Iminodiacetonitrile(628-87-5):

Product Categories about Iminodiacetonitrile(628-87-5) are C1 to C5 ; Cyanides/Nitriles ; Nitrogen Compounds
The chemical synonymous of Iminodiacetonitrile(628-87-5) are 1,1’-Imidodiacetonitrile ; 2,2’-Iminobis-acetonitril ; 2,2’-Iminobisacetonitrile ; Acetonitrile, 2,2'-iminobis- ; Di(cianometil)ammina

Iminodiacetonitrile Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)		Farmaco, Edizione Scientifica. Vol. 17, Pg. 753, 1962.
rabbit	LDLo	skin	1500mg/kg (1500mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: FOOD INTAKE (ANIMAL)	National Technical Information Service. Vol. OTS0536765,
rat	LD50	oral	710mg/kg (710mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR GASTROINTESTINAL: OTHER CHANGES	National Technical Information Service. Vol. OTS0536765,

Iminodiacetonitrile Consensus Reports

Reported in EPA TSCA Inventory.

Iminodiacetonitrile Safety Profile

Poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NO_x.
Hazard Note: Irritant
Hazard Codes:
Xn: Harmful
Xi: Irritant
Risk Statements about Iminodiacetonitrile(628-87-5):
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements about Iminodiacetonitrile(628-87-5):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
S37/39: Wear suitable gloves and eye/face protection.
Attentions:
1. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Avoid contact with skin and eyes. Avoid ingestion and inhalation. Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas.

Product Name

Iminodiacetonitrile

Synthetic route

Iminodiacetonitrile Chemical Properties

Iminodiacetonitrile Toxicity Data With Reference

Iminodiacetonitrile Consensus Reports

Iminodiacetonitrile Safety Profile

Related Products

Hot Products