4-Hydrazino-1-(2-methylpropyl)-1H-imidazo [4,5-c]quinoline
imiqimod
Conditions | Yield |
---|---|
With hydrogenchloride; sodium formate; palladium 10% on activated carbon In water for 84h; Product distribution / selectivity; Heating / reflux; | 98% |
Stage #1: 4-Hydrazino-1-(2-methylpropyl)-1H-imidazo [4,5-c]quinoline With hydrogenchloride; sodium formate; palladium 10% on activated carbon In water for 84h; Heating / reflux; Stage #2: With hydrogenchloride In water at 20℃; Stage #3: With ammonia In water at 20℃; Product distribution / selectivity; | 98% |
4-chloro-1H-imidazo[4,5-c]-quinoline
imiqimod
Conditions | Yield |
---|---|
Stage #1: formamide With potassium tert-butylate In dimethyl sulfoxide for 0.5h; Stage #2: 4-chloro-1H-imidazo[4,5-c]-quinoline In dimethyl sulfoxide at 105℃; for 2h; Stage #3: With hydrogenchloride In water; dimethyl sulfoxide pH=8; Product distribution / selectivity; | 98% |
imiqimod
Conditions | Yield |
---|---|
With ethylenediamine In water at 70 - 95℃; for 4h; | 91.8% |
Stage #1: N-(1-isobutyl-1H-imidazo[4,5-c]quinolin-4-yl)-phthalimide With hydrazine In water at 70℃; Stage #2: With 2,4,4-trimethylpentan-1-ol In water at 94 - 95℃; for 5h; Stage #3: In methanol; water at 60℃; for 0.25h; Heating / reflux; | 63.3% |
imiqimod
Conditions | Yield |
---|---|
With ammonia; water In methanol Product distribution / selectivity; | 90% |
5-(2-aminophenyl)-1-(2-methylpropyl)-1H-imidazole-4-carbonitrile
imiqimod
Conditions | Yield |
---|---|
With sodium amide In toluene at 20 - 100℃; for 2h; | 90% |
imiqimod
Conditions | Yield |
---|---|
Stage #1: 4-amino-1-isobutyl-1H-imidazo-[4,5-c]-quinoline maleate In methanol; water at 75℃; for 0.5h; Stage #2: With ammonia In water | 89.7% |
With ammonia; water In methanol Product distribution / selectivity; | 89.7% |
imiqimod
Conditions | Yield |
---|---|
With ammonia; water In methanol Product distribution / selectivity; | 88% |
4-iodo-1-isobutyl-1H-imidazo-[4,5-c]-quinoline
imiqimod
Conditions | Yield |
---|---|
With ammonia In methanol at 150 - 155℃; Autoclave (ca. 20 kg pressure); | 86% |
With ammonia In methanol at 150 - 155℃; under 14711.4 Torr; Product distribution / selectivity; Autoclave; | 86% |
4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline
imiqimod
Conditions | Yield |
---|---|
With ammonia In dimethyl sulfoxide at 20 - 150℃; under 1875.19 - 3750.38 Torr; for 6 - 12h; Product distribution / selectivity; | 85.7% |
With ammonia at 150℃; for 7h; | 82% |
With ammonia; formamide at 145℃; for 20 - 25h; Product distribution / selectivity; | 78% |
imiqimod
Conditions | Yield |
---|---|
Stage #1: imiquimod hydrochloride With sodium hydrogensulfide; pyrographite In water at 85 - 90℃; for 0.333333h; Stage #2: With ammonium hydroxide In water at 20 - 80℃; Purification / work up; | 80.5% |
With sodium hydroxide In water at 20℃; for 0.5h; Product distribution / selectivity; |
1-Isobutyl-2-methylsulfanyl-1H-imidazo[4,5-c]quinolin-4-ylamine
imiqimod
Conditions | Yield |
---|---|
With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene for 0.5h; Heating; | 80% |
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline 5N-oxide
imiqimod
Conditions | Yield |
---|---|
With ammonia; chloroformic acid ethyl ester In dichloromethane; water at 0 - 20℃; for 1h; Cooling with methanol-ice bath; | 76% |
With ammonium hydroxide; p-toluenesulfonyl chloride In dichloromethane at 20℃; for 0.25h; | 71% |
Multi-step reaction with 2 steps 1: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating 2: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme | |
Multi-step reaction with 2 steps 1: CH2Cl2 / 0.25 h / Heating 2: NaOMe / methanol / 2 h / Heating View Scheme |
imiqimod
Conditions | Yield |
---|---|
Stage #1: formamide With potassium tert-butylate In ISOPROPYLAMIDE for 0.5h; Stage #2: 4-bromo-1H-imidazo[4,5-c]quinoline In ISOPROPYLAMIDE at 140℃; for 2h; Product distribution / selectivity; | 75.4% |
imiqimod
Conditions | Yield |
---|---|
With hydrogenchloride; zinc In ethanol; water at 20℃; for 1h; Product distribution / selectivity; | 70% |
Stage #1: N-(1-isobutyl-1H-imidazo[4,5-c]quinolin-4-yl)-O-methyl-hydroxylamine With hydrogenchloride; zinc In ethanol; water at 20℃; for 1h; Stage #2: With sodium hydroxide In ethanol; water for 0.5h; Product distribution / selectivity; | 70% |
1-isobutyl-1H-imidazo[4,5-c]quinolin-4-guanidine
imiqimod
Conditions | Yield |
---|---|
Stage #1: 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-guanidine With sulfuric acid; water In dimethyl sulfoxide at 140℃; for 20h; Stage #2: With sodium hydroxide; water In dimethyl sulfoxide at 20 - 60℃; for 2h; pH=10 - 11; Product distribution / selectivity; | 70% |
Stage #1: 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-guanidine In dimethyl sulfoxide at 140 - 150℃; for 9h; Stage #2: With sodium hydroxide; water In dimethyl sulfoxide at 20 - 60℃; for 2h; pH=10 - 11; Product distribution / selectivity; |
4-chloro-1H-imidazo[4,5-c]-quinoline
B
imiqimod
Conditions | Yield |
---|---|
Stage #1: formamide With potassium tert-butylate In ISOPROPYLAMIDE for 0.5h; Stage #2: 4-chloro-1H-imidazo[4,5-c]-quinoline In ISOPROPYLAMIDE at 120℃; for 1h; Product distribution / selectivity; | A 54% B 39% |
N-benzoyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
imiqimod
Conditions | Yield |
---|---|
With sodium methylate In methanol for 2h; Heating; |
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: peracetic acid / ethanol / 2.5 h / 60 °C 2: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating 3: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme | |
Multi-step reaction with 2 steps 1: peracetic acid / ethanol / 2.5 h / 60 °C 2: 71 percent / aq. NH3; tosyl chloride / CH2Cl2 / 0.25 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: peracetic acid / ethanol / 2.5 h / 60 °C 2: CH2Cl2 / 0.25 h / Heating 3: NaOMe / methanol / 2 h / Heating View Scheme |
3-Amino-4-(2-methylpropylamino)-quinoline
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1 h / Heating 2: peracetic acid / ethanol / 2.5 h / 60 °C 3: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating 4: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme | |
Multi-step reaction with 3 steps 1: 1 h / Heating 2: peracetic acid / ethanol / 2.5 h / 60 °C 3: 71 percent / aq. NH3; tosyl chloride / CH2Cl2 / 0.25 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: 1 h / Heating 2: peracetic acid / ethanol / 2.5 h / 60 °C 3: CH2Cl2 / 0.25 h / Heating 4: NaOMe / methanol / 2 h / Heating View Scheme |
N-(2-methylpropyl)-3-nitro-4-quinolinamine
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 2: 1 h / Heating 3: peracetic acid / ethanol / 2.5 h / 60 °C 4: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating 5: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme | |
Multi-step reaction with 4 steps 1: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 2: 1 h / Heating 3: peracetic acid / ethanol / 2.5 h / 60 °C 4: 71 percent / aq. NH3; tosyl chloride / CH2Cl2 / 0.25 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 2: 1 h / Heating 3: peracetic acid / ethanol / 2.5 h / 60 °C 4: CH2Cl2 / 0.25 h / Heating 5: NaOMe / methanol / 2 h / Heating View Scheme |
2-chloro-N4-(2-methylpropyl)quinoline-3,4-diamine
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 61 percent / toluene / 1.5 h / Heating 2: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme |
2-chloro-N4-(2-methylpropyl)-3-nitroquinoline-4-amine
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: H2; MgSO4 / Pt/C / ethyl acetate / 2585.74 Torr 2: 61 percent / toluene / 1.5 h / Heating 3: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme |
quinolin-4-ol
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 81 percent / aq. HNO3 / propionic acid / 0.25 h / 125 °C 2: SOCl2; DMF / CH2Cl2 / 3 h / Heating 3: Et3N / CH2Cl2 / 0.25 h / Heating 4: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 5: 1 h / Heating 6: peracetic acid / ethanol / 2.5 h / 60 °C 7: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating 8: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme | |
Multi-step reaction with 7 steps 1: 81 percent / aq. HNO3 / propionic acid / 0.25 h / 125 °C 2: SOCl2; DMF / CH2Cl2 / 3 h / Heating 3: Et3N / CH2Cl2 / 0.25 h / Heating 4: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 5: 1 h / Heating 6: peracetic acid / ethanol / 2.5 h / 60 °C 7: 71 percent / aq. NH3; tosyl chloride / CH2Cl2 / 0.25 h / 20 °C View Scheme | |
Multi-step reaction with 8 steps 1: 81 percent / aq. HNO3 / propionic acid / 0.25 h / 125 °C 2: SOCl2; DMF / CH2Cl2 / 3 h / Heating 3: Et3N / CH2Cl2 / 0.25 h / Heating 4: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 5: 1 h / Heating 6: peracetic acid / ethanol / 2.5 h / 60 °C 7: CH2Cl2 / 0.25 h / Heating 8: NaOMe / methanol / 2 h / Heating View Scheme |
4-hydroxy-3-nitro-1,2-dihydroquinolin-2-one
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: POCl3; Et3N / toluene / 4 h / 80 - 90 °C 2: 17.8 g / Et3N / CH2Cl2 / 0.5 h / Heating 3: H2; MgSO4 / Pt/C / ethyl acetate / 2585.74 Torr 4: 61 percent / toluene / 1.5 h / Heating 5: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme |
3-nitro-quinolin-4-ol
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: SOCl2; DMF / CH2Cl2 / 3 h / Heating 2: Et3N / CH2Cl2 / 0.25 h / Heating 3: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 4: 1 h / Heating 5: peracetic acid / ethanol / 2.5 h / 60 °C 6: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating 7: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme | |
Multi-step reaction with 6 steps 1: SOCl2; DMF / CH2Cl2 / 3 h / Heating 2: Et3N / CH2Cl2 / 0.25 h / Heating 3: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 4: 1 h / Heating 5: peracetic acid / ethanol / 2.5 h / 60 °C 6: 71 percent / aq. NH3; tosyl chloride / CH2Cl2 / 0.25 h / 20 °C View Scheme | |
Multi-step reaction with 7 steps 1: SOCl2; DMF / CH2Cl2 / 3 h / Heating 2: Et3N / CH2Cl2 / 0.25 h / Heating 3: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 4: 1 h / Heating 5: peracetic acid / ethanol / 2.5 h / 60 °C 6: CH2Cl2 / 0.25 h / Heating 7: NaOMe / methanol / 2 h / Heating View Scheme |
4-chloro-3-nitroquinoline
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: Et3N / CH2Cl2 / 0.25 h / Heating 2: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 3: 1 h / Heating 4: peracetic acid / ethanol / 2.5 h / 60 °C 5: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating 6: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme | |
Multi-step reaction with 5 steps 1: Et3N / CH2Cl2 / 0.25 h / Heating 2: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 3: 1 h / Heating 4: peracetic acid / ethanol / 2.5 h / 60 °C 5: 71 percent / aq. NH3; tosyl chloride / CH2Cl2 / 0.25 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1: Et3N / CH2Cl2 / 0.25 h / Heating 2: H2; MgSO4 / Pt/C / ethyl acetate / 2740.88 Torr 3: 1 h / Heating 4: peracetic acid / ethanol / 2.5 h / 60 °C 5: CH2Cl2 / 0.25 h / Heating 6: NaOMe / methanol / 2 h / Heating View Scheme |
2,4-dichloro-3-nitroquinoline
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 17.8 g / Et3N / CH2Cl2 / 0.5 h / Heating 2: H2; MgSO4 / Pt/C / ethyl acetate / 2585.74 Torr 3: 61 percent / toluene / 1.5 h / Heating 4: 82 percent / methanolic NH3 / 7 h / 150 °C View Scheme |
2-bromobenzoic acid methyl ester
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: PdCl2(PPh3)2, K2CO3, Et4N(1+)Cl(1-) / dimethylformamide / 2 h / 110 °C 2: 10percent aq. NaOH / dioxane / 12 h / Heating 3: Et3N, DPPA / benzene / 1 h / 50 °C 4: 1,2-dichloro-benzene / 1 h / Heating 5: 88 percent / POCl3 / 1 h / Heating 6: 93 percent / 28percent NH4OH / methanol / 48 h / 150 °C 7: 80 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h / Heating View Scheme |
1-isobuty-1H-limidazole
imiqimod
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, RT, 12 h 2: 83 percent / NBS / CCl4 / 1 h / Ambient temperature 3: 98 percent / Pd(PPh3)4, aq. Na2CO3 / toluene; ethanol / 4 h / 110 °C 4: 98 percent / NBS / CCl4 / 1 h 5: 1.) n-BuLi / 1.) Et2O, hexane, -78 deg C, 1 h, 2.) Et2O, hexane, RT, 12 h 6: 46 percent / Et3N, PPh3, CCl4 / acetonitrile / 1.) RT, 1 h, 2.) reflux, 3 h 7: 62 percent / 1,2-dichloro-benzene / 8 h / Heating 8: 41 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 4 h / Heating 9: 93 percent / 28percent NH4OH / methanol / 48 h / 150 °C 10: 80 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h / Heating View Scheme |
Conditions | Yield |
---|---|
In methanol; water at 74℃; Heating / reflux; | 91% |
imiqimod
Conditions | Yield |
---|---|
With maleic acid In methanol; water at 74℃; for 0.5h; | 91% |
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 160℃; for 0.5h; | 90% |
(2E)-but-2-enedioic acid
imiqimod
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 160℃; for 0.5h; | 89% |
N-t-butyloxycarbonyl-N-methylglycine anhydride
imiqimod
Conditions | Yield |
---|---|
With triethylamine for 8h; Reflux; | 87.5% |
With triethylamine In ethyl acetate for 2h; Reflux; | 87.5% |
imiqimod
Conditions | Yield |
---|---|
With deuterium In N,N-dimethyl acetamide under 1500.15 Torr; for 24h; Glovebox; Heating; | 80% |
imiqimod
benzyl alcohol
N-benzyl-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
Conditions | Yield |
---|---|
With palladium diacetate; sodium 3-(diphenylphosphanyl)benzenesulfonate In water at 140℃; for 18h; Sealed tube; | 72% |
Conditions | Yield |
---|---|
With copper(l) iodide; N,N'-dibenzylethanediamide; potassium tert-butylate In tert-butyl alcohol at 100℃; for 24h; Molecular sieve; Schlenk technique; Inert atmosphere; | 43% |
(2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(2-nitro-4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
imiqimod
Conditions | Yield |
---|---|
Stage #1: imiqimod With N-ethyl-N,N-diisopropylamine In ethyl acetate for 0.333333h; Microwave irradiation; Stage #2: (2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(2-nitro-4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate In ethyl acetate at 87℃; for 0.75h; Microwave irradiation; | 40% |
Stage #1: imiqimod With N-ethyl-N,N-diisopropylamine In ethyl acetate Microwave irradiation; Stage #2: (2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(2-nitro-4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate In ethyl acetate at 87℃; for 0.75h; Microwave irradiation; | 40% |
imiqimod
Conditions | Yield |
---|---|
In tetrahydrofuran at 90℃; under 750.075 Torr; for 0.833333h; Microwave irradiation; Sealed tube; | 39% |
Conditions | Yield |
---|---|
In 1,4-dioxane at 10 - 50℃; for 6h; | 38% |
Conditions | Yield |
---|---|
With HATU In dichloromethane at 20℃; | 35% |
imiqimod
8-bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
Conditions | Yield |
---|---|
With bromine; acetic acid at 20℃; for 18h; | 26% |
Stage #1: imiqimod With bromine In acetic acid for 24h; Stage #2: With sodium carbonate In water for 18h; | |
With N-Bromosuccinimide In chloroform at 20 - 50℃; for 1.83333h; Heating / reflux; |
Molecular Structure of Imiquimod (CAS NO.99011-02-6):
IUPAC Name: 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
Empirical Formula: C14H16N4
Molecular Weight: 240.3036
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 2
Polar Surface Area: 33.95 Å2
Index of Refraction: 1.681
Molar Refractivity: 71.02 cm3
Molar Volume: 187.7 cm3
Surface Tension: 48.8 dyne/cm
Density: 1.28 g/cm3
Flash Point: 230 °C
Enthalpy of Vaporization: 71.67 kJ/mol
Boiling Point: 456.7 °C at 760 mmHg
Vapour Pressure: 1.58E-08 mmHg at 25°C
Melting point: 292-294°C
Stability: Incompatible with strong oxidizing agents
InChl
InChI=1/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
Smiles
c12c3c(nc(c1ncn2CC(C)C)N)cccc3
Product Categories: Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals
The original FDA approval was on February 27, 1997, FDA Application No. (NDA) 020723, by 3M.
Imiquimod (CAS NO.99011-02-6) is a prescription medication that acts as an immune response modifier. Imiquimod is approved to treat actinic keratosis, superficial basal cell carcinoma, and external genital warts. It has also been tested for treatment of molluscum contagiosum, vulvar intraepithelial neoplasia, common warts that have proven difficult to treat and vaginal intraepithelial neoplasia.Outstanding cosmetic result has resulted from the treatment of both large superficial basal cell carcinoma and squamous cell carcinoma in-situ, but the morbidity and discomfort of the treatment can be severe. Focal recurrence of tumor has been seen after imiquimod treatment, but appear to be amenable to surgical excision.
Imiquimod can also cause subclinical lesions to become visible. This unmasking effect is felt to be of clinical benefit as lesions that may have otherwise have been missed are being treated. Photographs of actinic keratosis and basal cell carcinomas before, during and after treatment show the unmasking of subclinical disease.
Safety Information about Imiquimod (CAS NO.99011-02-6):
Hazard Codes: T,Xi
Risk Statements: 25-36/37/38
R25 :Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-45-36/37/39-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S27:Take off immediately all contaminated clothing.
RIDADR: UN 2811 6.1/PG 3
Adverse side effects have been reported, in some cases serious and systemic, resulting in the revision of warning labels.
Imiquimod , with CAS number of 99011-02-6, can be called 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline ; 1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)- ; 1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)- . It is a white to off white crystalline powder.
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