Indan-5-carbaldehyde supplier

Name
INDAN-5-CARBOXALDEHYDE
EINECS 250-036-8
CAS No. 30084-91-4
Article Data24
CAS DataBase
Density 1.123 g/cm³
Solubility
Melting Point 255-257 °C
Formula C₁₀H₁₀O
Boiling Point 262.313 °C at 760 mmHg
Molecular Weight 146.189
Flash Point 139.744 °C
Transport Information
Appearance
Safety
Risk Codes 52
Molecular Structure
Hazard Symbols
Synonyms 5-Indancarboxaldehyde(8CI);2,3-Dihydro-1H-indene-5-carboxaldehyde;3,4-Trimethylenebenzaldehyde;5-Formylindan;5-Indanecarboxaldehyde;
PSA 17.07000
LogP 1.98780

Synthetic route

: 4885-02-3
Dichloromethyl methyl ether

: 496-11-7
INDANE

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With tin(IV) chloride In dichloromethane at 0℃; for 0.5h;	98%
Stage #1: Dichloromethyl methyl ether; INDANE With tin(IV) chloride In dichloromethane at -30 - 20℃; Inert atmosphere; Stage #2: With water In dichloromethane at 0℃;	51%
With titanium tetrachloride
With tin(IV) chloride In dichloromethane

: 50978-45-5
3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide

: 143287-97-2
2,3-dihydro-1H-inden-5-yl trifluoromethanesulfonate

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With triethylsilane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium carbonate In acetonitrile at 80℃; for 16h; Inert atmosphere; Sealed tube;	82%

: 496-11-7
INDANE

: 100-97-0
hexamethylenetetramine

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With trifluoroacetic acid at 100℃; for 5h;	84%
With trifluoroacetic acid at 100℃; Duff Aldehyde Synthesis;	60%
With trifluoroacetic acid Duff Aldehyde Synthesis;	38%

: 721968-62-3
indan-5-yl-ethan-1,2-diol

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With periodic acid In ethanol; water at 20℃; for 12h;
With periodic acid In ethanol; water at 20℃; for 12h;
With periodic acid In ethanol; water at 20℃; for 12h;

: 116451-83-3
(2E,8E)-deca-2,8-diene-1,10-dial

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
Stage #1: (2E,8E)-deca-2,8-diene-1,10-dial; pyrrolidine; acetic acid In acetonitrile at -10℃; for 6h; Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; acetonitrile at 30℃; for 2h;	81%

: 116451-83-3
(2E,8E)-deca-2,8-diene-1,10-dial

A: 51932-70-8
indane-4-carboxaldehyde

B: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
Stage #1: (2E,8E)-deca-2,8-diene-1,10-dial; pyrrolidine; acetic acid In acetonitrile at 30℃; for 6h; Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; acetonitrile at 30℃; for 2h;	A n/a B 83%
Stage #1: (2E,8E)-deca-2,8-diene-1,10-dial; L-proline In acetonitrile at -10℃; for 48h; Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; acetonitrile at 30℃; for 2h;

: 28042-80-0
5-indancarboaldehyde azine

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With selenium(IV) oxide In N,N-dimethyl-formamide at 100℃; for 18h;	76%

: 51632-06-5
(2,3-dihydro-1H-inden-5-yl)methanol

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With pyridinium chlorochromate In dichloromethane for 2h; Ambient temperature;	96%
With Py*HClCrO3

: 496-11-7
INDANE

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With aluminium trichloride; hydrogen cyanide; 1,1,2,2-tetrachloroethane Reagens 4: wss. HCl; Einleiten von HCl;
With aluminium trichloride; chloromethylene-formamidine; 1,1,2,2-tetrachloroethane at 50℃; Reagens 4: wss. HCl;
Multi-step reaction with 5 steps 1: 93 percent / AlCl3 / CH2Cl2 / 4 h 2: 89 percent / NaOBr / 1.) 3 h, 0 deg C; 2.) r. t., overnight 3: 94 percent / conc. H2SO4 / Heating 4: 94 percent / LiAlH4 / diethyl ether / 12 h / Heating 5: 96 percent / PCC / CH2Cl2 / 2 h / Ambient temperature View Scheme
Multi-step reaction with 5 steps 1: 93 percent / AlCl3 / CH2Cl2 / 4 h 2: 89 percent / NaOBr / 1.) 3 h, 0 deg C; 2.) r. t., overnight 4: 94 percent / LiAlH4 / diethyl ether / 12 h / Heating 5: 96 percent / PCC / CH2Cl2 / 2 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: (i) aq. HCl, H2SO4, (ii) NaOAc, AcOH, (iii) aq. NaOH 2: Py*HClCrO3 View Scheme

: 201230-82-2
carbon monoxide

: 496-11-7
INDANE

A: 51932-70-8
indane-4-carboxaldehyde

B: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With antimony pentafluoride; fluorosulphonic acid at 0℃; under 760 Torr; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 6134-54-9
5-bromoindane

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
Stage #1: 5-bromoindane With tert.-butyl lithium In diethyl ether; pentane at -70℃; for 1h; Stage #2: N,N-dimethyl-formamide In diethyl ether at -70 - 10℃; for 1h;

: 18775-42-3
5-chloromethylindane

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With ethanol; hexamethylenetetramine

: 24425-40-9
indan-5-amine

4-formyl-3,5-dimethoxyphenoxymethylpolystyrene resin (PAL): 4-formyl-3,5-dimethoxyphenoxymethylpolystyrene resin (PAL)

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: aq. hydrobromic acid; sodium nitrite / 0.33 h / 0 - 5 °C 1.2: 42 percent / copper(I) bromide; aq. hydrobromic acid / 0.67 h / 60 °C 2.1: tert-butyllithium / diethyl ether; pentane / 1 h / -70 °C 2.2: diethyl ether / 1 h / -70 - 10 °C View Scheme

: 4228-10-8
1-indan-5-yl-ethanone

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 89 percent / NaOBr / 1.) 3 h, 0 deg C; 2.) r. t., overnight 2: 94 percent / conc. H2SO4 / Heating 3: 94 percent / LiAlH4 / diethyl ether / 12 h / Heating 4: 96 percent / PCC / CH2Cl2 / 2 h / Ambient temperature View Scheme
Multi-step reaction with 4 steps 1: 89 percent / NaOBr / 1.) 3 h, 0 deg C; 2.) r. t., overnight 3: 94 percent / LiAlH4 / diethyl ether / 12 h / Heating 4: 96 percent / PCC / CH2Cl2 / 2 h / Ambient temperature View Scheme

: 65898-38-6
indan-5-carboxylic acid

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 94 percent / conc. H2SO4 / Heating 2: 94 percent / LiAlH4 / diethyl ether / 12 h / Heating 3: 96 percent / PCC / CH2Cl2 / 2 h / Ambient temperature View Scheme
Multi-step reaction with 3 steps 2: 94 percent / LiAlH4 / diethyl ether / 12 h / Heating 3: 96 percent / PCC / CH2Cl2 / 2 h / Ambient temperature View Scheme

: 113364-54-8
1-(2-indan-5-yl-2-oxo-ethyl)-pyridinium; iodide

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 98 percent / aq. NaOH / Heating 2: 94 percent / conc. H2SO4 / Heating 3: 94 percent / LiAlH4 / diethyl ether / 12 h / Heating 4: 96 percent / PCC / CH2Cl2 / 2 h / Ambient temperature View Scheme
Multi-step reaction with 4 steps 1: 98 percent / aq. NaOH / Heating 3: 94 percent / LiAlH4 / diethyl ether / 12 h / Heating 4: 96 percent / PCC / CH2Cl2 / 2 h / Ambient temperature View Scheme

: 86031-43-8
methyl 5-indanecarboxylate

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 94 percent / LiAlH4 / diethyl ether / 12 h / Heating 2: 96 percent / PCC / CH2Cl2 / 2 h / Ambient temperature View Scheme

: 36399-21-0
1-allylcyclopentan-1-ol

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 121220-72-2
indane-4,6-dicarboxaldehyde

B: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With trichlorophosphate room temp., 30 min, then boiling water bath, 6h;	A 23% B n/a

...Expand

: 496-11-7
INDANE

CO: CO

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With hydrogenchloride; aluminium trichloride; benzene weiteres Reagens: CuCl;

: 4885-02-3
Dichloromethyl methyl ether

: 496-11-7
INDANE

A: 51932-70-8
indane-4-carboxaldehyde

B: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
With titanium(III) chloride Title compound not separated from byproducts;

...Expand

: 7647-01-0
hydrogenchloride

: 496-11-7
INDANE

carbon monoxide: carbon monoxide

: 30084-91-4
indan-5-carbaldehyde

Conditions

Conditions	Yield
bei Gegenwart von Benzol, von AlCl3 und CuCl;

...Expand

: 30084-91-4
indan-5-carbaldehyde

: 65898-38-6
indan-5-carboxylic acid

Conditions

Conditions	Yield
With copper acetylacetonate; oxygen; sodium hydroxide; 1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene In water at 50℃; under 760.051 Torr; for 12h; Sealed tube;	99%

: 30084-91-4
indan-5-carbaldehyde

: 51632-06-5
(2,3-dihydro-1H-inden-5-yl)methanol

Conditions

Conditions	Yield
Stage #1: indan-5-carbaldehyde With sodium tetrahydroborate In ethanol at 0℃; for 0.5h; Stage #2: With hydrogenchloride In water pH=2;	96%
With sodium tetrahydroborate at 0 - 20℃;	59%
With sodium tetrahydroborate In ethanol at 0 - 20℃; for 1.5h;	23.1 g

: 14927-64-1
3,5,6,7-tetrahydro-2H-s-indacen-1-one

: 30084-91-4
indan-5-carbaldehyde

: 113364-74-2
2-(5-Indanylmethylen)-s-hydrindacen-1-on

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 3h;	95%

: 141-82-2
malonic acid

: 30084-91-4
indan-5-carbaldehyde

: 56635-88-2
3-(5-Indanyl)-prop-2-ensaeure

Conditions

Conditions	Yield
With piperidine; pyridine at 80℃; for 24h;	91%

: 557-93-7
2-bromoprop-1-ene

: 30084-91-4
indan-5-carbaldehyde

: 1-(2,3-dihydro-1H-inden-5-yl)-2-methylprop-2-en-1-ol

Conditions

Conditions	Yield
Stage #1: 2-bromoprop-1-ene With lithium In diethyl ether at -30℃; for 3h; Inert atmosphere; Stage #2: indan-5-carbaldehyde In diethyl ether at -78℃; for 1.5h;	81%

: 79-24-3
Nitroethane

: 30084-91-4
indan-5-carbaldehyde

: 5-<1-(2-nitropropenyl)>-2,3-dihydro-1H-indene

Conditions

Conditions	Yield
With ammonium acetate for 4h; Heating;	76%

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

: 30084-91-4
indan-5-carbaldehyde

: N-indanylmethyl-L-serine methyl ester

Conditions

Conditions	Yield
Stage #1: methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride With triethylamine In methanol at 0℃; for 0.166667h; Stage #2: indan-5-carbaldehyde With sodium tetrahydroborate In methanol for 2.5h;	72%
Stage #1: methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride With triethylamine In methanol at 0℃; for 0.166667h; Stage #2: indan-5-carbaldehyde In methanol for 2h; Stage #3: With sodium tetrahydroborate In methanol	72%

: 418762-90-0
2-(1H-pyrrol-1-yl)benzenemethanamine hydrochloride salt

: 30084-91-4
indan-5-carbaldehyde

: 1383541-18-1
C21H19ClN2*ClH

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	69%

: 33095-94-2
N-isopropyl-N-[3,4-(methylenedioxy)phenyl]urea

: 30084-91-4
indan-5-carbaldehyde

: 243133-94-0
1-Isopropyl-6,7-methylenedioxy-4-(5-indanyl)-3,4-dihydro-quinazolin-2(1H)-one

Conditions

Conditions	Yield
	59%

: 61-54-1
tryptamine

: 30084-91-4
indan-5-carbaldehyde

: 199678-68-7
1-indan-5-yl-2,3,4,9-tetrahydro-1H-β-carboline

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane for 20h;	57%

: 693-89-0
1-methylcyclopent-1-ene

: 30084-91-4
indan-5-carbaldehyde

: (E)-7-(2,3-dihydro-1H-inden-5-yl)hept-6-en-2-one

Conditions

Conditions	Yield
With gallium(III) trichloride In 1,2-dichloro-ethane at 25℃; for 24h; Inert atmosphere;	45%

: N-(5-chloroquinolin-8-yl)-2-(1,3-dioxoisoindolin-2-yl)propanamide

: 30084-91-4
indan-5-carbaldehyde

: 3-[(5-chloroquinolin-8-yl)amino]-2-(1,3-dioxoisoindolin-2-yl)-3-oxopropyl 2,3-dihydro-1H-indene-5-carboxylate

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; palladium(II) trifluoroacetate In decane; water; toluene at 20℃; for 48h; Schlenk technique; Inert atmosphere; regioselective reaction;	44%

: 110-89-4
piperidine

: 4790-81-2
benzofuran-7-ol

: 30084-91-4
indan-5-carbaldehyde

: 6-((2,3-dihydro-1H-inden-5-yl)(piperidin-1-yl)methyl)-benzofuran-7-ol

Conditions

Conditions	Yield
In toluene at 100℃;	41%

...Expand

: 108-31-6
maleic anhydride

: 79-19-6
thiosemicarbazide

: 30084-91-4
indan-5-carbaldehyde

: C15H15N3O3S

Conditions

Conditions	Yield
Stage #1: thiosemicarbazide; indan-5-carbaldehyde With toluene-4-sulfonic acid In 1-methyl-pyrrolidin-2-one at 100℃; for 1.5h; Microwave irradiation; Stage #2: maleic anhydride In 1-methyl-pyrrolidin-2-one at 110℃; for 4h; Microwave irradiation;	28%

...Expand

: 141-82-2
malonic acid

: 30084-91-4
indan-5-carbaldehyde

: C12H15NO2

Conditions

Conditions	Yield
With ammonium acetate In methanol Reflux;	26%

: 622-42-4
1-nitro-1-phenylmethane

: 30084-91-4
indan-5-carbaldehyde

: 5-(β-Nitro-styryl)-indan

Conditions

Conditions	Yield
With ethanol; methylamine hydrochloride; sodium carbonate

: 141-84-4
2-thioxo-4-thiazolidinone

: 30084-91-4
indan-5-carbaldehyde

: 62245-77-6
5-indan-5-ylmethylene-2-thioxo-thiazolidin-4-one

Conditions

Conditions	Yield
With ammonium acetate In acetic acid; benzene Heating;

: 107-13-1
acrylonitrile

: 30084-91-4
indan-5-carbaldehyde

: 30153-72-1
3-{N'-[1-Indan-5-yl-meth-(Z)-ylidene]-hydrazino}-propionitrile

Conditions

Conditions	Yield
(i) N2H4*H2O, (ii) /BRN= 637391/; Multistep reaction;

: 30084-91-4
indan-5-carbaldehyde

: 28042-80-0
5-indancarboaldehyde azine

Conditions

Conditions	Yield
With hydrazine

Indan-5-carbaldehyde Specification

The Indan-5-carbaldehyde, with the CAS registry number 30084-91-4, is also known as 5-Formylindan. It belongs to the product category of Pharmacetical. Its EINECS registry number is 250-036-8. This chemical's molecular formula is C₁₀H₁₀O and molecular weight is 146.19. What's more, its systematic name and IUPAC name are the same which is called 2,3-Dihydro-1H-indene-5-carbaldehyde.

Physical properties about Indan-5-carbaldehyde are: (1)ACD/LogP: 2.76; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.76; (4)ACD/LogD (pH 7.4): 2.76; (5)ACD/BCF (pH 5.5): 73.89; (6)ACD/BCF (pH 7.4): 73.89; (7)ACD/KOC (pH 5.5): 757.1; (8)ACD/KOC (pH 7.4): 757.1; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 17.07 Å²; (13)Index of Refraction: 1.61; (14)Molar Refractivity: 45.18 cm³; (15)Molar Volume: 130.1 cm³; (16)Polarizability: 17.91×10^-24cm³; (17)Surface Tension: 45.7 dyne/cm; (18)Density: 1.122 g/cm³; (19)Flash Point: 139.7 °C; (20)Enthalpy of Vaporization: 50.01 kJ/mol; (21)Boiling Point: 262.3 °C at 760 mmHg; (22)Vapour Pressure: 0.011 mmHg at 25°C.

Preparation of Indan-5-carbaldehyde: this chemical is prepared by reaction of Dichloro-methoxy-methane with Indan.

The reaction occurs with reagent SnCl₄ and solvent CH₂Cl₂ at temperature of 0°C for 30 minutes. The yield is 98%.

Uses of Indan-5-carbaldehyde: it is used to produce other chemicals. For example, it is used to produce 3-(5-Indanyl)-prop-2-ensaeure.

The reaction occurs with reagent Pyridine and Peridine at temperature of 80°C for 24 hours. The yield is 91%.

You can still convert the following datas into molecular structure:
(1) SMILES: O=Cc1ccc2c(c1)CCC2
(2) InChI: InChI=1/C10H10O/c11-7-8-4-5-9-2-1-3-10(9)6-8/h4-7H,1-3H2
(3) InChIKey: YNGGRNROMJXLCP-UHFFFAOYAX

Product Name

INDAN-5-CARBOXALDEHYDE

Synthetic route

Indan-5-carbaldehyde Specification

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